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84. Deep Mutational Scanning and How to Investigate Protein Behaviour (with Isabelle Zane)

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Manage episode 443310587 series 3412534
Content provided by Carolina Soares and Clara Lenherr, Carolina Soares, and Clara Lenherr. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Carolina Soares and Clara Lenherr, Carolina Soares, and Clara Lenherr or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

In this week's episode we are joined by Isabelle Zane, a PhD student at the Wellcome Sanger Institute in Cambridge who is investigating the link between genetic mutations and protein function in the Lehner & Parts labs. We discuss a novel technology- deep mutational scanning- which is used to screen how single gene mutations influence the structure and/or function of proteins, thereby testing the relationship between genotype and phenotype. We also discuss methods used to study protein dynamics, including nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography, and more! Listen to find out more about the fascinating ways in which we can interrogate the relationship between DNA and the proteins they encode.

You can find Isabelle's cartoon creations about life and people in the lab on her twitter @isabellease

Today’s episode was made possible thanks to the support of the Biochemical Society public engagement fund. We would like to thank the Biochemical Society for the generous grant supporting Science Communication initiatives like these. ⁠⁠⁠⁠https://www.google.com/search?client=safari&rls=en&q=the+biochemical+society&ie=UTF-8&oe=UTF-8⁠⁠⁠

---

We hope you enjoy the episode! Please feel free to share with your friends and family, it means a lot to us🤍

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105 episodes

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Manage episode 443310587 series 3412534
Content provided by Carolina Soares and Clara Lenherr, Carolina Soares, and Clara Lenherr. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Carolina Soares and Clara Lenherr, Carolina Soares, and Clara Lenherr or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

In this week's episode we are joined by Isabelle Zane, a PhD student at the Wellcome Sanger Institute in Cambridge who is investigating the link between genetic mutations and protein function in the Lehner & Parts labs. We discuss a novel technology- deep mutational scanning- which is used to screen how single gene mutations influence the structure and/or function of proteins, thereby testing the relationship between genotype and phenotype. We also discuss methods used to study protein dynamics, including nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography, and more! Listen to find out more about the fascinating ways in which we can interrogate the relationship between DNA and the proteins they encode.

You can find Isabelle's cartoon creations about life and people in the lab on her twitter @isabellease

Today’s episode was made possible thanks to the support of the Biochemical Society public engagement fund. We would like to thank the Biochemical Society for the generous grant supporting Science Communication initiatives like these. ⁠⁠⁠⁠https://www.google.com/search?client=safari&rls=en&q=the+biochemical+society&ie=UTF-8&oe=UTF-8⁠⁠⁠

---

We hope you enjoy the episode! Please feel free to share with your friends and family, it means a lot to us🤍

Neuroverse Website

⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://neuroversepod.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Merchandise:

⁠⁠⁠https://neuroversepod.teemill.com⁠⁠⁠

Podcast directory

⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://anchor.fm/neuroverse9⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Support us!

⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://ko-fi.com/neuroverse⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Twitter: @neuroverse_pod

⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/neuroverse_pod?s=21&t=KvAEuwGNKFQ9IPKlL7NTEg⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Instagram: @Neuroverse_pod

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Help us improve our podcast by giving us some feedback!

⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://forms.gle/PuEMC1BCWXdAqCRQA⁠⁠⁠⁠

  continue reading

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