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The Krebs Cycle

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Manage episode 444513130 series 2770060
Content provided by MedSchoolCoach. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MedSchoolCoach or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

One of the most fundamental biochemical processes is the Krebs cycle. This metabolic pathway plays a critical role in both the Chem Phys and Bio/Biochem sections of the MCAT, so understanding it is key.

In this episode, our guest host, Alex Starks, walks us through the transformation of pyruvate into acetyl CoA via the Pyruvate Dehydrogenase Complex (PDC). We’ll explore how thioester bonds help transfer energy within the cycle, how acetyl CoA combines with oxaloacetate to form citrate, the difference between enzymes like synthetases and synthases, and how GTP is produced. We’ll also make connections to the electron transport chain and discuss how the TCA cycle influences blood pH through CO2 production.

Visit medschoolcoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Intro

(01:05) Recap of glycolysis and pyruvate

(02:45) Pyruvate dehydrogenase complex (PDC)

(03:40) Role of acetyl CoA in the Krebs cycle

(05:37) How citrate is formed

(07:17) How isocitrate is formed

(10:00) How alpha-ketoglutarate is formed

(13:42) How succinate and GTP are formed

(16:28) How succinate, fumarate and oxaloacetate are formed

(18:23) Fumarate converted to malate

(21:53) Recap of the Krebs cycle and ATP yield

(25:00) Regulation of the Krebs cycle

(26:16) Quiz

  continue reading

184 episodes

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The Krebs Cycle

MCAT Basics (from MedSchoolCoach)

74 subscribers

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Manage episode 444513130 series 2770060
Content provided by MedSchoolCoach. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MedSchoolCoach or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

One of the most fundamental biochemical processes is the Krebs cycle. This metabolic pathway plays a critical role in both the Chem Phys and Bio/Biochem sections of the MCAT, so understanding it is key.

In this episode, our guest host, Alex Starks, walks us through the transformation of pyruvate into acetyl CoA via the Pyruvate Dehydrogenase Complex (PDC). We’ll explore how thioester bonds help transfer energy within the cycle, how acetyl CoA combines with oxaloacetate to form citrate, the difference between enzymes like synthetases and synthases, and how GTP is produced. We’ll also make connections to the electron transport chain and discuss how the TCA cycle influences blood pH through CO2 production.

Visit medschoolcoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Intro

(01:05) Recap of glycolysis and pyruvate

(02:45) Pyruvate dehydrogenase complex (PDC)

(03:40) Role of acetyl CoA in the Krebs cycle

(05:37) How citrate is formed

(07:17) How isocitrate is formed

(10:00) How alpha-ketoglutarate is formed

(13:42) How succinate and GTP are formed

(16:28) How succinate, fumarate and oxaloacetate are formed

(18:23) Fumarate converted to malate

(21:53) Recap of the Krebs cycle and ATP yield

(25:00) Regulation of the Krebs cycle

(26:16) Quiz

  continue reading

184 episodes

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