#09 Dr. Irina & Michael Conboy | Tissue Rejuvenation Via Plasma Dilution, Neutral Blood Exchange and Parabiosis

Live Longer World

Content provided by Aastha Jain Simes. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Aastha Jain Simes or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

3+ y ago 50:04

MP3•Episode home

My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley.

Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old mice became rejuvenated & younger. They’ve also pioneered a process called the Neutral Blood Exchange or Therapeutic Blood Exchange, through which dilution of old blood plasma can lead to true rejuvenation in the brain & other tissues of mice to a younger state!!

Further, we touch upon Irina's work showing how decreased Oxytocin levels with age contributes to poor muscle function. Their research is incredibly exciting and we discuss all about it in today’s episode.

Episode Show Notes: https://livelongerworld.substack.com/p/rejuvenation-via-plasma-dilution

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast

DR. CONBOY LINKS: Berkeley Lab: https://conboylab.berkeley.edu/

2021 Paper Plasma Dilution Improves Cognition and attenuates neuroinflammation in old mice: https://pubmed.ncbi.nlm.nih.gov/33191466/

2020 Paper Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288913/

2014 Paper Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration: https://www.nature.com/articles/ncomms5082

LIVE LONGER WORLD LINKS:

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Podcast All Platforms: https://anchor.fm/livelongerworld

Patreon: https://www.patreon.com/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Apple Podcasts: https://apple.co/3eZAoAp

Spotify: https://spoti.fi/3eZB6O5

Google Podcasts: https://bit.ly/3HN0keG

TIMESTAMPS:

00:00 Live Longer World Intro

00:35 Irina & Michael Conboy Intro

1:08 Aging is slowdown in our repair machinery

2:55 Naked Mole Rats not extreme model for longevity

5:37 Heterochronic Parabiosis

16:00 Young Blood to Old Blood Exchange

19:19 Rejuvenation via Neutral Blood Exchange (NBE)

22:56 Old Blood Degenerates Young Mice

25:29 Rejuvenation Effects on Brain, Liver, Muscle through NBE

27:16 How long do effects of NBE last?

30:15 How is NBE working mechanistically? 2 waves of rejuvenation

33:38 Inhibiting TGF-beta & Increasing Oxytocin is rejuvenative

38:12 NBE vs. Senolytics

40:53 Unanswered Questions on NBE

43:13 Oxytocin & Muscle Functioning; Notch Signaling

48:12 Chickens & Ravens as Pets!

Thanks for listening & if you enjoy the episode, please like, subscribe & share! Stay in good health - Aastha.

44 episodes

#Science #Aastha Jain