In today’s KERCast, Dr. Victor Montori interviews Dr. Peter Noseworthy, Professor of Medicine and cardiac electrophysiologist at Mayo Clinic. Dr. Noseworthy maintains a federally funded research program centered on improving the care of patients with cardiac arrhythmias and works extensively with the Optum Labs Data Warehouse dataset to examine outcomes in patients with various heart rhythm disorders, particularly the prevention of stroke related to atrial fibrillation. In this KERCast episode, Dr. Noseworthy breaks down the hot topic of artificial intelligence (AI) in clinical research, including how big data can inform patient-centered care, the role of clinicians in translating these findings into actionable recommendations for individual patients, and the importance of collaborative relationships to interrogate, strengthen, and responsibly apply this developing methodology.