In this episode of Hospital Medicine Unplugged, we break down hypertensive crisis—separating urgency from emergency, tailoring the pace of reduction, and choosing the right IV agent for the right patient.

We open with the definitions:
• Hypertensive emergency = BP >180/120 with acute target-organ damage (brain, arteries, retina, kidneys, heart). These patients need monitored ICU care and IV titratable agents.
• Hypertensive urgency = same severe BP, but no acute injury—safe to manage with oral meds + outpatient follow-up, not IV drips or rapid lowering.

Why it matters: rapid BP reduction in urgency risks AKI, cerebral hypoperfusion, and longer stays—no benefit shown. In emergency, uncontrolled pressure fuels stroke, MI, aortic dissection, renal failure—time-sensitive management prevents irreversible injury.

Management pearls:
• Emergency: drop no more than 25% in 1 hour, then target 160/100–110 over 2–6 h, then gradual normalization over 24–48 h. Exception: aortic dissection → SBP ≤120 + HR <60 within 20 min.
• Urgency: optimize oral therapy, address adherence, stressors, NSAID/cocaine use, pain. No need for hospitalization unless other issues.

IV agent playbook (scenario-driven):
• Aortic dissection: Esmolol/labetalol first (control HR), then add vasodilator (nicardipine, clevidipine).
• Acute coronary syndrome: Nitroglycerin, beta-blockers, nicardipine. Avoid nitrates if recent PDE-5 use.
• Pulmonary edema: Clevidipine, nitroglycerin, nitroprusside (avoid beta-blockers).
• Acute kidney injury: Clevidipine, nicardipine, fenoldopam (renal-protective).
• Stroke:
– Ischemic (if thrombolysis planned): get <185/110 before lysis.
– Intracerebral hemorrhage: SBP to 140–150 within 1 h.
– Avoid hydralazine—unpredictable and risky.
• Preeclampsia/eclampsia: Hydralazine, labetalol, nicardipine, oral nifedipine. No ACEi/ARB/renin inhibitors. Always add magnesium sulfate for seizure prophylaxis.
• Catecholamine excess (pheo, cocaine, amphetamines): Phentolamine, nicardipine, clevidipine—avoid β-blocker monotherapy.

Monitoring that sticks:
• ICU/stepdown with arterial line for emergencies; BP q5–15 min, continuous ECG, urine output, neuro checks.
• Labs: renal function, troponin, UA, electrolytes. Imaging: CT/MRI brain, CXR, echo, CTA aorta as indicated.
• Watch for overshoot hypotension—if SBP <100–120, hold drips immediately.

Prognosis reality check:
• Emergency: in-hospital mortality up to 10%, 1-year CV morbidity/mortality 20–30%. Prognosis varies—aortic dissection mortality 1–2% per hour untreated; ICH 30-day mortality >40%; preeclampsia/eclampsia—maternal/fetal outcomes hinge on rapid BP + seizure control.
• Urgency: short-term risk low—prognosis tied to long-term BP control, not immediate crisis.

Bottom line: check for organ damage, choose the right lane (urgency vs emergency), titrate carefully, tailor the IV agent to the scenario, and don’t overtreat stable patients. That’s how you save lives and avoid iatrogenic harm.