PHYSIO MOSMAN: https://www.fitasaphysio.com/
These sources collectively examine the anti-inflammatory effects of exercise and the underlying mechanisms involved. Multiple studies investigate how both acute and chronic exercise modulates the immune system, showing that physical activity generally reduces markers of systemic and localized inflammation, such as Tumor Necrosis Factor-alpha (TNF) and C-reactive protein (CRP), which are implicated in chronic diseases like cardiovascular disease and osteoarthritis. Specifically, one study demonstrates that moderate exercise inhibits monocytic TNF production through elevated epinephrine levels acting on beta-2 adrenergic receptors and another suggests that regular exercise activates inflammation-countering Regulatory T cells (Tregs) in muscles, leading to improved endurance. Furthermore, research on knee joints reveals that running acutely decreases the concentration of pro-inflammatory cytokines like GM-CSF and IL-15 in the synovial fluid, suggesting a protective mechanism for joint health, while broader reviews discuss the role of IL-6, stress hormones, and reduced visceral fat in contributing to exercise-induced anti-inflammation.
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