This article investigates the potential of curcumin, a polyphenolic substance derived from turmeric, to alleviate delayed-onset muscle soreness (DOMS), which is caused by microscopic muscle tears and inflammation following strenuous exercise. Research indicates that curcumin possesses potent anti-inflammatory and antioxidant properties, allowing it to suppress key inflammatory markers like COX-2, NF-B, IL-6, and TNF-ɑ, thereby potentially reducing muscle damage and improving athletic performance. Studies have shown that supplementation, with dosages varying widely (150 mg up to 5 g over a day), significantly reduces DOMS, especially when administered before and after exercise. However, the authors stress that curcumin is not risk-free, and chiropractors recommending its use must understand pharmacological principles. Side effects frequently reported include gastrointestinal issues (nausea, dyspepsia). Furthermore, curcumin can lead to kidney calculi in susceptible patients and acts as an iron chelator, requiring caution in patients with anemia. A key concept for practitioners is bioavailability; combining curcumin with piperine (from black pepper) can increase bioavailability by 20-fold. Chiropractors are advised to use clinical judgment, monitoring tolerance by starting with a low dose to achieve maximum therapeutic benefit with minimum side effects.