Dive into the chemistry revolution reshaping our world. In this episode of Deep Dive (Science Edition), we unpack the 2025 Nobel Prize in Chemistry and the rise of metal–organic frameworks—molecular “Legos” that self-assemble into vast, porous architectures. From Richard Robson’s crystalline breakthroughs to Susumu Kitagawa’s gas-breathing “soft porous crystals,” and Omar M. Yaghi’s MOF-5 and reticular synthesis, discover how designers now tailor matter with atomic precision. Explore how these customizable frameworks are cleaning PFAS from water, capturing carbon at scale, storing hydrogen, harvesting drinking water from desert air, and powering advances in medicine and catalysis. It’s a story of turning a “synthetic wasteland” into a playground of limitless design—where cavities the size of football fields fit inside a handful of powder, and chemistry builds the future one nanoscale room at a time.