This is an opinion from the United States Court of Appeals for the Federal Circuit regarding a patent interference proceeding between The Regents of the University of California and The Broad Institute. The core dispute involves priority of invention for a CRISPR-Cas9 system using single-guide RNA for editing DNA in eukaryotic cells. The court reviews the Patent Trial and Appeal Board's decisions on conception and written description of the invention, ultimately affirming-in-part, vacating-in-part, and remanding the case regarding the main appeal, while dismissing The Broad Institute's cross-appeal as moot. The court found that the Board legally erred in its analysis of conception by improperly requiring knowledge that the invention would work and failing to adequately consider routine methods or skill in its assessment.

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