Episode: 2 - Georges Belfort Discusses Breakthroughs in mRNA Purification
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What makes mRNA purification different from other bioprocessing methods? In this episode of Bioprocessing Unfiltered, host Alois Jungbauer, professor and head of biotechnology at the Institute of Bioprocess Science and Engineering at BOKU University, speaks with Georges Belfort, institute professor of chemical and biological engineering at Rensselaer Polytechnic Institute about his research in mRNA purification and his long, illustrious career in the industry, including the impact of his discoveries, the challenges encountered, and the lessons learned along the way. He also shares how he translates his research into products, what his lab is working on, and navigating competition from other companies.
Links from this episode:
Bioprocessing Summit
RPI Chemical & Biological Engineering
Rensselaer Polytechnic Institute
BOKU University Institute of Bioprocess Science and Engineering
BOKU University
Bioprocessing Unfiltered: Covering both upstream and downstream processing, analytics, AI and digitization, cell and gene therapy and more, Bioprocessing Unfiltered is your insider’s pass to the researchers tackling—and solving—the day-to-day challenges in the bioprocessing industry.
Chapters
1. Welcome And Guest Background (00:00:00)
2. From Antibodies To Platforms (00:02:52)
3. Why mRNA Is Hard To Purify (00:06:10)
4. Pandemic Pressure And Quick Solutions (00:11:44)
5. The Oligo dT Affinity Bottleneck (00:15:55)
6. Choosing Membranes Over Beads (00:18:43)
7. Building An RNA Lab Fast (00:22:28)
8. New Ligands And Force Measurements (00:27:01)
9. From Research To Products And Modules (00:31:35)
2 episodes