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What is the longest match between the human and chimpanzee genomes?

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Manage episode 491788396 series 3382899
Content provided by Dr. Robert Carter. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Dr. Robert Carter or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Human-chimpanzee similarity is a hotly-debated topic in the evolution-creation wars. Are we 98, 95, 90, or 85% similar? One way to get at the question is to ask what is the longest stretch of DNA that is shared between the two species. This is a very difficult question to answer! But, unperturbed, Dr Rob set out to answer it. Will our fearless hero be able to pull it off? Spoiler alert: not quite, but the path of discovery is still very interesting. LastZ github.com/lastz/lastz LastZ chaining github.com/hillerlab/make_lastz_chains Mummer4 mummer4.github.io/ Blast blast.ncbi.nlm.nih.gov/Blast.cgi Telomere-to-Telomere Consortium primate projects github.com/marbl/Primates Python python.org/ Standard Bases: A: Adenine C: Cytosine G: Guanine T: Thymine (in DNA) U: Uracil (in RNA) Ambiguous Bases (IUPAC Codes): These codes are used when there is ambiguity in the nucleotide present at a particular position: R: A or G (puRine) Y: C or T (pYrimidine) S: G or C W: A or T (Weak) K: G or T (Keto) M: A or C (aMino) B: C, G, or T (not A) (B comes after A) D: A, G, or T (not C) (D comes after C) H: A, C, or T (not G) (H comes after G) V: A, C, or G (not T) (V comes after U; U is replaced with T in DNA) N: Any base (A, C, G, T) (N for any nucleotide) Silver Comet Trail silvercometga.com/
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111 episodes

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iconShare
 
Manage episode 491788396 series 3382899
Content provided by Dr. Robert Carter. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Dr. Robert Carter or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Human-chimpanzee similarity is a hotly-debated topic in the evolution-creation wars. Are we 98, 95, 90, or 85% similar? One way to get at the question is to ask what is the longest stretch of DNA that is shared between the two species. This is a very difficult question to answer! But, unperturbed, Dr Rob set out to answer it. Will our fearless hero be able to pull it off? Spoiler alert: not quite, but the path of discovery is still very interesting. LastZ github.com/lastz/lastz LastZ chaining github.com/hillerlab/make_lastz_chains Mummer4 mummer4.github.io/ Blast blast.ncbi.nlm.nih.gov/Blast.cgi Telomere-to-Telomere Consortium primate projects github.com/marbl/Primates Python python.org/ Standard Bases: A: Adenine C: Cytosine G: Guanine T: Thymine (in DNA) U: Uracil (in RNA) Ambiguous Bases (IUPAC Codes): These codes are used when there is ambiguity in the nucleotide present at a particular position: R: A or G (puRine) Y: C or T (pYrimidine) S: G or C W: A or T (Weak) K: G or T (Keto) M: A or C (aMino) B: C, G, or T (not A) (B comes after A) D: A, G, or T (not C) (D comes after C) H: A, C, or T (not G) (H comes after G) V: A, C, or G (not T) (V comes after U; U is replaced with T in DNA) N: Any base (A, C, G, T) (N for any nucleotide) Silver Comet Trail silvercometga.com/
  continue reading

111 episodes

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