Dr. Dustin Sulak Home Healer Certification-BH Sales Kennel Kelp Holistic Healing Hour: Unlocking the Potential of Cannabinoids for Autism Support

One area of exciting research involves the impact of cannabinoids – those fascinating compounds found in cannabis – on individuals with ASD. A study examining salivary biomarkers revealed that THC, CBD, and CBG each tend to influence distinct sets of these biological markers. This suggests that different cannabinoids might exert unique effects on the body's systems.

Intriguingly, research has also indicated that some children with autism present with lower levels of certain circulating endocannabinoids – specifically AEA, OEA, and PEA. These are our body's own cannabis-like molecules, playing crucial roles in regulating various functions.

A compelling 2019 Israeli study looked at children with autism who didn't initially respond to a THC:CBD ratio of 1:20. Interestingly, a significant number of these children showed better outcomes when their treatment was switched to a THC:CBD ratio of 1:6. This underscores the importance of finding the right balance and individualizing treatment.

Grandpa Bill: So, as we digest these fascinating insights, two probing questions come to mind:

1. Given the variability of ASD and the distinct impacts of different cannabinoids, how can we best personalize cannabinoid-based approaches to optimize individual outcomes?
2. With limited FDA-approved medications for core autism symptoms, what further research is needed to rigorously evaluate the safety and efficacy of various cannabinoid ratios and combinations?

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It's crucial to acknowledge that only two medications have received FDA approval to address the core symptoms of autism, underscoring the need for continued exploration of complementary approaches.

Preclinical research also offers valuable insights. A rodent model of ASD showed that inhibiting the FAAH enzyme, which breaks down endocannabinoids, led to improvements in repetitive and compulsive behaviors. CBD is considered the most likely cannabinoid to replicate this mechanism.

However, caution is warranted. High-dose CBD treatments have been associated with adverse effects, particularly in individuals with low appetite, low body weight, or increased sedation. Personalized dosing and careful monitoring are paramount.

The "core symptoms" of autism often involve challenges in social communication and interaction, as well as restricted and repetitive behaviors. Interestingly, a specific study indicated that CBD-dominant treatment led to improvements in pica, the dangerous compulsion to consume non-food items.

The research landscape surrounding cannabinoids and ASD is evolving rapidly. Key questions remain:

• How can we leverage the unique properties of different cannabinoids to create highly personalized interventions for individuals across the autism spectrum?
• What rigorous, large-scale clinical trials are necessary to definitively establish the safety and efficacy of various cannabinoid formulations for ASD?

The journey of understanding and supporting individuals with ASD is complex and multifaceted. The potential of cannabinoids offers a promising avenue for exploration, but it must be approached with careful research, individualized strategies, and ongoing collaboration between researchers, clinicians, and the autism community, which over stating the OBVIOUS it is here!

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