Search a title or topic

Over 20 million podcasts, powered by 

Player FM logo
Artwork

Content provided by BackTable LLC. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by BackTable LLC or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Player FM - Podcast App
Go offline with the Player FM app!

Ep. 245 Understanding Keynote-689: Immunotherapy for Head & Neck Cancer with Dr. Dylan Roden, Dr. Ravi Uppaluri and Dr. Adam Luginbuhl

39:45
 
Share
 

Manage episode 516087906 series 3569300
Content provided by BackTable LLC. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by BackTable LLC or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

While the standard for adjuvant head and neck cancer treatment hasn't changed since 2004, a new trial using perioperative pembrolizumab is forcing clinicians to rethink their entire workflow, starting with diagnosis. In this episode of the BackTable Podcast, head and neck surgical oncologist Dr. Adam Luginbuhl is joined by colleagues Dr. Dylan Roden and Dr. Ravindra Uppaluri to discuss the implementation and implications of the Keynote-689 trial, which introduced neoadjuvant and adjuvant immunotherapy for locally advanced head and neck cancer.
---
SYNPOSIS
The doctors discuss the trial details, FDA approval, and practical challenges of integrating this new paradigm into clinical practice. The conversation covers critical points such as the necessity of CPS score testing, timely drug administration, patient monitoring, and the importance of collaboration among multidisciplinary teams.
---
TIMESTAMPS
00:00 - Introduction
02:18 - Keynote-689 Trial Explained
04:42 - Implementation Challenges and Strategies
06:40 - Practical Considerations for CPS Testing
13:59 - Case Studies and Real-World Applications
30:48 - Future Directions and Final Thoughts
---
RESOURCES
Keynote-689
https://www.nejm.org/doi/full/10.1056/NEJMoa2415434
2004 Cisplatin Phase III Trial
https://www.nejm.org/doi/full/10.1056/NEJMoa032646

  continue reading

247 episodes

Artwork
iconShare
 
Manage episode 516087906 series 3569300
Content provided by BackTable LLC. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by BackTable LLC or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

While the standard for adjuvant head and neck cancer treatment hasn't changed since 2004, a new trial using perioperative pembrolizumab is forcing clinicians to rethink their entire workflow, starting with diagnosis. In this episode of the BackTable Podcast, head and neck surgical oncologist Dr. Adam Luginbuhl is joined by colleagues Dr. Dylan Roden and Dr. Ravindra Uppaluri to discuss the implementation and implications of the Keynote-689 trial, which introduced neoadjuvant and adjuvant immunotherapy for locally advanced head and neck cancer.
---
SYNPOSIS
The doctors discuss the trial details, FDA approval, and practical challenges of integrating this new paradigm into clinical practice. The conversation covers critical points such as the necessity of CPS score testing, timely drug administration, patient monitoring, and the importance of collaboration among multidisciplinary teams.
---
TIMESTAMPS
00:00 - Introduction
02:18 - Keynote-689 Trial Explained
04:42 - Implementation Challenges and Strategies
06:40 - Practical Considerations for CPS Testing
13:59 - Case Studies and Real-World Applications
30:48 - Future Directions and Final Thoughts
---
RESOURCES
Keynote-689
https://www.nejm.org/doi/full/10.1056/NEJMoa2415434
2004 Cisplatin Phase III Trial
https://www.nejm.org/doi/full/10.1056/NEJMoa032646

  continue reading

247 episodes

All episodes

×
 
Loading …

Welcome to Player FM!

Player FM is scanning the web for high-quality podcasts for you to enjoy right now. It's the best podcast app and works on Android, iPhone, and the web. Signup to sync subscriptions across devices.

 

Copyright 2025 | Privacy Policy | Terms of Service | | Copyright
Listen to this show while you explore
Play