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Dietary Fibers and Gut Signals: How Fructooligosaccharides Modulate Colonic Motility via Calcium and 5-HT3 Receptors

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Manage episode 496274235 series 3332773
Content provided by ajpgi. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by ajpgi or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

In this episode, we’re joined by coauthors Preedajit Wongkrasant and Keith A. Sharkey to discuss their recent publication, "Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT3 receptors in the proximal colon." Calcium-sensing receptors are known to play an important role in gastrointestinal physiology. This study reveals a new function of fructooligosaccharides, a type of dietary fiber, in regulating colonic motility and activating the enteric nervous system. The effects are mediated through calcium-sensing and 5-HT3 receptors, providing new insights into gut–brain communication and potential therapeutic targets for gastrointestinal disorders.

Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT3 receptors in the proximal colon Preedajit Wongkrasant, Laurie E. Wallace, Wallace K. MacNaughton, and Keith A. Sharkey

American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 328:6, G734-G745

  continue reading

50 episodes

Artwork
iconShare
 
Manage episode 496274235 series 3332773
Content provided by ajpgi. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by ajpgi or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

In this episode, we’re joined by coauthors Preedajit Wongkrasant and Keith A. Sharkey to discuss their recent publication, "Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT3 receptors in the proximal colon." Calcium-sensing receptors are known to play an important role in gastrointestinal physiology. This study reveals a new function of fructooligosaccharides, a type of dietary fiber, in regulating colonic motility and activating the enteric nervous system. The effects are mediated through calcium-sensing and 5-HT3 receptors, providing new insights into gut–brain communication and potential therapeutic targets for gastrointestinal disorders.

Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT3 receptors in the proximal colon Preedajit Wongkrasant, Laurie E. Wallace, Wallace K. MacNaughton, and Keith A. Sharkey

American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 328:6, G734-G745

  continue reading

50 episodes

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