We all have extraordinary genetic similarity, but this allows the investigation of the small but impactful variations between populations that influence disease risk and resilience. We spoke to Brendan Lee, President of the Americn Society of Human Genetics about delivering on the promise of genetic and genomic medicine. Dr. Rosario Isasi, from the University of Miami Miller School of Medicine talks about societal attitudes towards scientific innovation and the factors shaping technological uptake, public engagement, and support.