Alcohol is the world’s most popular drug—a molecule that can calm or excite and bond communities or tear them apart. We trace alcohol’s journey from ancient rituals to modern hangovers, uncover how it shaped civilizations, and dive into the neuroscience of how it affects your brain and body. With insights from leading experts, we ask: Given all that we know, why do humans continue to drink?

• David Nutt, psychiatrist and professor of psycho-pharmacology at Imperial College in London, author of Drink? The New Science of Alcohol and Your Health, and cofounder of Sentia Spirits.
• Edward Slingerland, professor of philosophy at the University of British Columbia and author of Drunk: How We Sipped, Danced, and Stumbled Our Way to Civilization.

Credits: 1440 Explores is a production of Rhyme Media for 1440 Media, hosted by Sony Kassam. This episode was produced by Dan Bobkoff and Kim Nederveen Pieterse. It was fact-checked by Sanam Skelly. Our sound designer is Jay Cowit. The executive producer at Rhyme is Dan Bobkoff, and the executive producers at 1440 are Sony Kassam and Drew Steigerwald.

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About 1440: 1440 is a community for the knowledge-obsessed, helping curious people stay informed and inspired daily. We live in an era of limitless information, yet limited understanding. Algorithms decide what we see. Misinformation spreads faster than the truth. The tools meant to expand knowledge often distort it. Enter 1440: a knowledge collective built on curiosity, connection, and care for the truth. Here, facts matter, thinking is valued, and people come together to understand the world. Curiosity isn’t just a trait—it’s a muscle. Exercised daily, it sharpens the mind, fuels discovery, and drives lifelong growth.

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