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Mind & Matter

Nick Jikomes

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Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it. The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Not medical advice. At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than second ...
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This episode covers (in detail) everything you need to know about the PhD summer school held in Taiwan in June 2026 For details on the funding announcement see the blog post https://aiesep.org/aiesep-announces-landmark-10-year-partnership-with-spectrum-institute-for-teaching-and-learning/ You can find the link to apply here https://www.dropbox.com/…
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Risto is joined by a group of colleagues to discuss one article that we feel has been most influential on our current or past research. We're talking about articles that have had a profound impact on where our research went and discuss a little about the back story from each. Here are the APA citations of the articles if you want to look them up: R…
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Send us a text Support the show Affiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your m…
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Send us a text Cellular clean up by immune cells and how early-life fructose exposure leads to neurodevelopmental problems. Episode Summary: Dr. Justin Perry talks about the body's constant cellular turnover—about 3 million cells die per second in adults (double in children and women)—handled by phagocytes like macrophages that engulf and digest de…
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Send us a text The potential link between acetaminophen (Tylenol) and autism, with a surprise phone call from RFK partway through. Episode Summary: Dr. William Parker talks about autism spectrum disorder (ASD), its rising prevalence since the 1980s, and the controversial hypothesis that acetaminophen exposure in susceptible infants and children tri…
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Send us a text Wide release date: August 25, 2025 Episode Summary: Dr. Uffe Ravnskov talks about his decades-long career challenging the idea that high cholesterol causes heart disease, discussing LDL's protective role in the immune system by binding to bacteria, the harms and biases in statin research influenced by pharmaceutical companies, eviden…
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The Aussie Book Club takes on the Spectrum of Teaching Styles, well half of it at first...they talk about pros and cons of styles A-E, Where it can be used in Australian Curriculum, Where we have used it in sport coaching Common mistakes/errors for first time users Next month is “The Production Cluster Styles F-K…
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Send us a text The appendix's hidden role and how "good" parasites like helminths shape immune health. Episode Summary: Dr. William Parker discusses gut anatomy, the appendix's role in harboring beneficial bacterial biofilms and immune tissue, and how modern hygiene depletes helminths (intestinal worms), causing immune overreactions like allergies,…
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Send us a text What is the core evolved function of the endocannabinoid system? Episode Summary: Dr. Giovanni Marsicano is a neuroscientist based in Bordeaux, France, where he leads a research group at INSERM focusing on the endocannabinoid system. About the guest: Giovanni Marsicano, PhD discusses the endocannabinoid system, starting with its core…
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Send us a text Overview and alternative interpretation to the mainstream view on how dietary fat and cholesterol relate to cardiovascular disease. Episode Summary: Tucker Goodrich is an engineer by training who has become a prominent independent researcher and blogger on nutrition and metabolic health, focusing on the harms of seed oils and polyuns…
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Send us a text Human metabolism, primate evolution, and modern health challenges with evolutionary anthropologist Herman Pontzer. Episode Summary: Anthropologist Dr. Herman Pontzer discusses human evolution and metabolism, comparing humans to primates like chimps and gorillas to explain our higher energy use, bigger brains, and longer lives despite…
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Send us a text The deep connection between sunlight and life, from the scale of the cosmos to the quantum. Episode Summary: Astrophysicist Dr. Robert Fosbury discusses the sun's characteristics as a star, its analogies to living systems via entropy and complexity, and Erwin Schrödinger's insights on life as order-maintaining entities; he explores h…
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Send us a text How brain synapses work and fuel themselves with fat. Episode Summary: Dr. Timothy Ryan talks about the high energy costs of synapses, the role of mitochondria and glycolysis, and challenge the long-held view that the brain relies solely on glucose by discussing new evidence that neurons burn fats from lipid droplets for fuel, especi…
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Send us a text Episode Summary: Dr. Eugene Chang talks about the microbiome’s role as a vital organ, the impacts of antibiotics and Western diets on microbial health, and strategies for restoring a damaged microbiome through diet and fecal microbial transplants. They delve into microbiome dysbiosis, its links to modern diseases, and Chang’s researc…
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This is the July episode of the Aussie Book Club where our Australian colleagues discuss one article in depth once a month. This month the article discussed is below: Kirschner, P. A., Sweller, J., & Clark, R. E. (2006). Why Minimal Guidance During Instruction Does Not Work: An Analysis of the Failure of Constructivist, Discovery, Problem-Based, Ex…
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Send us a text The genetics of sleep duration and sleep timing. Episode Summary: Dr. Ying-Hui Fu discusses her research on the genetics of sleep, focusing on natural short sleepers who thrive on 4-6 hours of sleep and the heritability of sleep traits like duration and timing. She explores how sleep efficiency, rather than just duration, may explain…
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Send us a text A blend of biology, philosophy, and history exploring how hormones and endocrine disruptors affect social behavior and society. Episode Summary: Dr. Charles Cornish-Dale discusses the decline of masculinity in modern society, linking it to falling testosterone levels, environmental endocrine disruptors, and the limitations of liberal…
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Send us a text How our biological clocks shape biology from the molecular to behavioral level. Episode Summary: Dr. Joseph Takahashi discusses circadian rhythms, exploring their biological basis, from molecular mechanisms to their impact on metabolism and health; the discovery of circadian clock genes; role of the suprachiasmatic nucleus, and how l…
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Send us a text Cellular self-organization, cytoskeleton dynamics, and membrane wound healing. Episode Summary: Cell Biologist Dr. Bill Bement explains the dynamic world of the cell cortex, discussing how actin filaments and microtubules drive processes like cell division and wound healing through self-assembly and self-organization; energy dynamics…
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Send us a text How brains compute and learn, blending neuroscience with AI insights. Episode Summary: Dr. Marius Pachitariu discusses how the brain computes information across scales, from single neurons to complex networks, using mice to study visual learning. He explains the differences between supervised and unsupervised learning, the brain’s hi…
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Send us a text How dietary fats and cannabinoids shape brain function and mental well-being. Episode Summary: Dr. Steven Laviolette discusses the role of lipids, particularly endocannabinoids and fatty acids, in brain signaling and mental health, discussing how dietary omega-3 and omega-6 imbalances, prenatal THC exposure, and fatty acid binding pr…
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Send us a text Are seed oils really driving chronic disease (and sunburns), or is it hype? Episode Summary: Dr. Brian Kerley talks about the health impacts of seed oils, their high omega-6 fatty acid content, and their role in chronic diseases through mechanisms like lipid peroxidation and oxidative stress. They explore how these industrially proce…
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Send us a text A critique of SSRIs and pharma’s influence on medicine, including SSRI-induced sexual dysfunction, suicidality, and violence. Long Summary: Dr. David Healy critiques modern medicine, focusing on SSRIs and psychiatric medicine, including: how pharmaceutical companies manipulate clinical trial data, ghostwrite studies, and influence me…
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This is the next issue of the Australian Book Club. This week the Aussie “blokes” talk about “what’s wright in PE” Here is a synopisis. Exploring positive narratives in physical education (PE) involves recognizing and highlighting the valuable contributions and positive impacts of PE programs. This includes understanding PE's purpose, its connectio…
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Send us a text Episode Summary: Dr. Andrew Chadeayne discusses the chemistry of psilocybin and other psychedelics, their potential therapeutic applications, and the challenges of commercializing them in a shifting biotech market. The conversation delves into the complexities of magic mushroom composition, debunking myths like "lemon tekking," and u…
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Send us a text Episode Summary: Dr. Michael Wheeler talks about neuroimmune interactions, exploring how the immune system and brain communicate, particularly through the blood-brain barrier and meninges; how chronic stress and inflammation can alter brain circuits, contributing to mood disorders like depression; how drugs like psilocybin and MDMA m…
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If you don’t understand Finnish then this episode is going to be really confusing. This is a recording of a Keynote lecture (in Finnish) that I gave in Jyväskylä on May 14th 2025 about the Finnish Model for Leisure Activities. Here is a link to the slides (in Finnish) I just ask that you please not use them in any form or share them in any form out…
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Send us a text Episode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth; role of the FABP5 protein in enhancing cancer cells’ sensitivity to omega-6 fats; differences between breast cancer…
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Send us a text Episode Summary: Dr. Gyorgy Buzsaki discusses the hippocampus’s role beyond memory and spatial navigation, delving into its broader functions in cognition, action planning, and brain-body interactions; how hippocampal rhythms, like sharp wave ripples, influence memory consolidation, glucose regulation, and metabolic health, challengi…
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This is the audio from the AIESEP Connect (an online session put on by AIESEP to share research) from May 2025, and is the first by the Technology SIG May 2025 – #AIESEPConnect #CoffeeWithColleagues Modalities and Pedagogies Exploring Digital Learning Across In-Person, Hybrid, and Remote Physical Education Contexts with Julia Sargent, Ove Østerlie,…
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This is the 6th Australian Book Club. The speakers are Brendan SueSee, Michael Davies, and Dave Robinson Synopsis/Background Most Pedagogical or curriculum models in physical education (PE) focus on various content like health, game tactics, sport cultures, and expression. The Practising model has no content as the student generates the content thr…
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Send us a text The biophysics of life, exploring how light & energy shape biology, with biophysicist Dr. Nirosha Murugan. Episode Summary: Dr. Murugan discusses the role of biophysics in biology, focusing on how light, particularly biophotons emitted by cells, influences processes like wound healing, neural activity, and cancer detection; how micro…
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Send us a text Short Summary: Dr. Alex Kwan unpacks the latest neuroscience research on how psychedelics like ketamine & psilocybin reshape the brain. About the guest: Alex Kwan, PhD, is an associate professor of biomedical engineering at Cornell University. His lab employs advanced imaging to study how psychedelics and other drugs affect the mamma…
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Send us a text Short Summary: The flaws of nutrition epidemiology with Dr. John Speakman About the guest: John Speakman, PhD is a professor at the University of Aberdeen and runs a lab in Shenzhen, China, focusing on energy balance, obesity, and aging. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone o…
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Send us a text Short Summary: Cancer’s metabolic roots with Dr. Thomas Seyfried. About the guest: Thomas Seyfried, PhD is a professor of biology at Boston College. He has researched cancer metabolism, epilepsy, and lipid biochemistry for over 40 years. Note: Podcast episodes are fully available on the M&M Substack and YouTube. Transcript and other …
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Send us a text Short Summary: Heart health and the ketogenic diet, with expert insights from a cardiologist and researcher. About the guest: Matthew Budoff, MD, is a preventive cardiologist and professor of medicine at UCLA School of Medicine. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube…
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Send us a text Short Summary: The science of obesity and appetite regulation, blending genetics and neurobiology with practical insights About the guest: Giles Yeo, PhD is a professor of molecular neuroendocrinology at the University of Cambridge. He leads a lab studying obesity and appetite regulation. Note: Podcast episodes are fully available to…
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Send us a text Short Summary: A mind-bending dive into evolutionary biology and health through a biophysicist’s lens, with Dr. Jack Kruse delivering provocative insights about biology, medicine, and health. About the guest: Jack Kruse, MD, is a neurosurgeon known for integrating biophysics into medicine. He challenges conventional biochemistry with…
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Our colleagues from University of Limerick share two amazing resources with you that are 100% free and aimed to help teacher educators. We will talk about the Justice ED and SATLE projects and share these awesome Toolkits that have been created. Below are the website links to the projects and the links to the Toolkits. Justice Ed: https://www.ul.ie…
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Send us a text Short Summary: A deep dive into the science of oxidative stress, antioxidants, aging, and neurodegenerative diseases like Alzheimer’s. About the guest: Pamela Maher, PhD is a professor at the Salk Institute in San Diego, California, with a focus on neurodegenerative diseases, oxidative stress, and antioxidants. Note: Podcast episodes…
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Send us a text Short Summary: A detailed examination of shamanism with anthropologist Manvir Singh, blending evolutionary theory and vivid storytelling. About the guest: Manvir Singh, PhD is an anthropologist at the University of California, Davis. His new book, "Shamanism: The Timeless Religion," comes out on May 25, 2025. Note: Podcast episodes a…
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Send us a text Short Summary: How environmental chemical exposures affect neurodegenerative disease and health. About the guest: Gary Miller, PhD is a Professor of Environmental Health Sciences at Columbia University. His research bridges pharmacology, toxicology, and neuroscience to explore neurodegeneration, particularly Parkinson’s and Alzheimer…
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This is a 15min presentation about my research on the Finnish Model for Leisure Activities. It was given at the Fulbright Education Forum March 26th, 2025 hosted by the Fulbright Finland Foundation which also has sponsored my stay in Finland this year to conduct the research. The study is also supported by the Ministry of Education and Culture here…
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This article club discusses Swedish researchers who asked secondary school students/Gymnasium to discuss their perceptions of HPE through their assessment experiences. Some interesting but not surprising perceptions were shared, and as is true for the Australian Article Club... good discussion was had! Here is the link to the article and the citati…
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Send us a text Short Summary: Do elephants and other animals have language-like abilities, such as the ability to use individual names to refer to themselves and others? About the guest: Michael Pardo, PhD studies animal behavior at Cornell University, where he focused on animal communication and cognition. His work includes extensive field researc…
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Today, we’re discussing the article ‘How physical education teachers are positioned in models scholarship: a scoping review. This was recently published in PESP and came up in discussion during Ash Casey’s scholar lecture at BERA. You can find that lecture in episode 350 Full Cite: Fjellner, R. L., Varea, V., & Barker, D. (2024). How physical educa…
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Send us a text Short Summary: The science of cancer and immunity with Dr. Roychoudhuri, blending cutting-edge research with everyday implications like aspirin’s role in fighting tumor metastasis. About the guest: Rahul Roychoudhuri, PhD is a Professor of Cancer Immunology at the University of Cambridge. His research bridges basic science and clinic…
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Send us a text How dietary fructose affects the growth rate of cancer. About the guest: Gary Patti, PhD is a professor at Washington University in St. Louis, holding appointments in chemistry, medicine, and genetics Episode Summary: Nick Jikomes talks to Dr. Patti, exploring how cancer cells metabolize sugars like glucose and fructose, focusing on …
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