Best Karl Keith Podcasts (2025)

Professor Andrew Wilson from NYU explains why many common-sense ideas in artificial intelligence might be wrong. For decades, the rule of thumb in machine learning has been to fear complexity. The thinking goes: if your model has too many parameters (is "too complex") for the amount of data you have, it will "overfit" by essentially memorizing the …

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Dr. Peter Fedichev: Why Aging Is Functional Decline, Not Just Disease 1:07:20

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7d ago1:07:20

1:07:20

Aging is more than disease—it’s the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives. Peter explains how his background in theoretical physics shaped his approach to biology and aging…

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Karl Pilkington's Sick Of It 18:03

12d ago18:03

18:03

By Keith McNally

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Karl Friston - Why Intelligence Can't Get Too Large (Goldilocks principle) 1:21:39

14d ago1:21:39

1:21:39

In this episode, hosts Tim and Keith finally realize their long-held dream of sitting down with their hero, the brilliant neuroscientist Professor Karl Friston. The conversation is a fascinating and mind-bending journey into Professor Friston's life's work, the Free Energy Principle, and what it reveals about life, intelligence, and consciousness i…

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The Day AI Solves My Puzzles Is The Day I Worry (Prof. Cristopher Moore) 1:34:52

20d ago1:34:52

1:34:52

We are joined by Cristopher Moore, a professor at the Santa Fe Institute with a diverse background in physics, computer science, and machine learning. The conversation begins with Cristopher, who calls himself a "frog" explaining that he prefers to dive deep into specific, concrete problems rather than taking a high-level "bird's-eye view". They ex…

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Sanford and Son, Steptoe and Son 19:45

20d ago19:45

19:45

By Keith McNally

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Dr. Eric Verdin on the Effects of Therapeutic Plasma Exchange on Longevity 52:51

21d ago52:51

52:51

In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging. Eric discusses the science behind therapeutic plasma exchange (TPE) and its potential to slow biological aging in humans. The conversation explores findings from a recent clinical trial, including measurab…

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Auds & Ends Episode 37 - A Legacy of Labor Organizing 25:57

25d ago25:57

25:57

On this episode of Auds and Ends, Auditor Keith speaks with Bill Benner, Director of Organizing, Political and Legislative Affairs for UFCW 75. They discuss Bill's family legacy of organized labor and the UFCW's work here in Montgomery County and throughout Ohio.By Karl Keith, Montgomery County Auditor

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Michael Timothy Bennett: Defining Intelligence and AGI Approaches 1:05:44

27d ago1:05:44

1:05:44

Dr. Michael Timothy Bennett is a computer scientist who's deeply interested in understanding artificial intelligence, consciousness, and what it means to be alive. He's known for his provocative paper "What the F*** is Artificial Intelligence" which challenges conventional thinking about AI and intelligence.**SPONSOR MESSAGES***Prolific: Quality da…

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Little House on the Prairie 34:19

27d ago34:19

34:19

By Keith McNally

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What Happens to Your Body When You Sit All Day, with Dr. Keith Diaz 1:05:14

1M ago1:05:14

1:05:14

In this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Keith Diaz, Associate Professor of Behavioral Medicine at Columbia University Irving Medical Center, to unpack the hidden health risks of prolonged sitting. Keith explains why even daily exercise isn't enough to counteract the effects of sedentary behavior. Drawing on his la…

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Superintelligence Strategy (Dan Hendrycks) 1:45:38

1M ago1:45:38

1:45:38

Deep dive with Dan Hendrycks, a leading AI safety researcher and co-author of the "Superintelligence Strategy" paper with former Google CEO Eric Schmidt and Scale AI CEO Alexandr Wang. *** SPONSOR MESSAGES Gemini CLI is an open-source AI agent that brings the power of Gemini directly into your terminal - https://github.com/google-gemini/gemini-cli …

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Lavender Castle 11:18

1M ago11:18

11:18

By Keith McNally

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Acetylation Insights: Unlocking Longevity Secrets with Dr. Haim Cohen 55:51

2M ago55:51

55:51

In this episode, Dr. Gil Blander welcomes Dr. Haim Cohen to Longevity by Design to explore his revolutionary approach to understanding aging. Haim's team analyzed acetylation sites across 107 mammalian species, creating its most extensive comparative study. This computational approach revealed specific post-translational modifications that evolved …

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DeepMind Genie 3 [World Exclusive] (Jack Parker Holder, Shlomi Fruchter) 58:22

2M ago58:22

58:22

This episode features Shlomi Fuchter and Jack Parker Holder from Google DeepMind, who are unveiling a new AI called Genie 3. The host, Tim Scarfe, describes it as the most mind-blowing technology he has ever seen. We were invited to their offices to conduct the interview (not sponsored).Imagine you could create a video game world just by describing…

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Auds & Ends Episode 36 - Protecting the American Dream 28:25

2M ago28:25

28:25

On this episode of Auds and Ends, Auditor Keith talks with Lori Kennedy, Montgomery County Recorder. They discuss how Lori's background in the mortgage lending industry prepared her to serve as Recorder and the work their two offices are doing to help prevent deed fraud. Visit www.mcrecorder.org to sign-up for the Fraud Alert Notification System!…

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Large Language Models and Emergence: A Complex Systems Perspective (Prof. David C. Krakauer) 49:48

2M ago49:48

49:48

Prof. David Krakauer, President of the Santa Fe Institute argues that we are fundamentally confusing knowledge with intelligence, especially when it comes to AI. He defines true intelligence as the ability to do more with less—to solve novel problems with limited information. This is contrasted with current AI models, which he describes as doing le…

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Horatio's Drive by Ken Burns 20:23

2M ago20:23

20:23

By Keith McNally

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Karl Pfleger Explains the Aging Biotech Explosion 1:18:51

2M ago1:18:51

1:18:51

On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Karl Pfleger, aging biotechnology investor and creator of AgingBiotech.info, to dissect the rapidly evolving field of aging therapeutics. Karl breaks down the sector into two main categories: interventions that slow aging rates versus rejuvenation strategies that repair accu…

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Pushing compute to the limits of physics 1:23:32

2M ago1:23:32

1:23:32

Dr. Maxwell Ramstead grills Guillaume Verdon (AKA “Beff Jezos”) who's the founder of Thermodynamic computing startup Extropic. Guillaume shares his unique path – from dreaming about space travel as a kid to becoming a physicist, then working on quantum computing at Google, to developing a radically new form of computing hardware for machine learnin…

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Young John Lennon's favorite film, The Magnet 13:44

2M ago13:44

13:44

By Keith McNally

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Dark Shadows 1991 Revival 14:42

2M ago14:42

14:42

By Keith McNally

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How to Extend Your Healthspan with Dr. Eric Topol 1:13:28

3M ago1:13:28

1:13:28

Gil and Eric discuss Eric’s book, Super Agers, and the inspiration behind it: a 98-year-old patient who exemplified healthy aging. They explore the five dimensions of healthspan optimization: lifestyle, omics, the immune system, and the role of data and AI in personalized medicine. Eric highlights how AI can analyze multi-layered data to provide pe…

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The Fractured Entangled Representation Hypothesis (Kenneth Stanley, Akarsh Kumar) 2:16:22

3M ago2:16:22

2:16:22

Are the AI models you use today imposters? Please watch the intro video we did before this: https://www.youtube.com/watch?v=o1q6Hhz0MAg In this episode, hosts Dr. Tim Scarfe and Dr. Duggar are joined by AI researcher Prof. Kenneth Stanley and MIT PhD student Akash Kumar to discuss their fascinating paper, "Questioning Representational Optimism in D…

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The Fractured Entangled Representation Hypothesis (Intro) 15:45

3M ago15:45

15:45

What if today's incredible AI is just a brilliant "impostor"? This episode features host Dr. Tim Scarfe in conversation with guests Prof. Kenneth Stanley (ex-OpenAI), Dr. Keith Duggar (MIT), and Arkash Kumar (MIT).While AI today produces amazing results on the surface, its internal understanding is a complete mess, described as "total spaghetti" [0…

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Strange Paradise, the Canadian Dark Shadows 22:31

3M ago22:31

22:31

By Keith McNally

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Auds & Ends Episode 35 - Keeping the Fair, Fair! 17:45

3M ago17:45

17:45

On this episode of Auds and Ends, Auditor Keith talks to John Friedline & Stuart Yancik, from the Montgomery County Fairgrounds. They discuss the Montgomery County Fairgrounds and the upcoming County Fair, which will be held from July 6th through July 12th.By Karl Keith, Montgomery County Auditor

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Dark Shadows 20:50

3M ago20:50

20:50

By Keith McNally

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Three Red Lines We're About to Cross Toward AGI (Daniel Kokotajlo, Gary Marcus, Dan Hendrycks) 2:07:07

3M ago2:07:07

2:07:07

What if the most powerful technology in human history is being built by people who openly admit they don't trust each other? In this explosive 2-hour debate, three AI experts pull back the curtain on the shocking psychology driving the race to Artificial General Intelligence—and why the people building it might be the biggest threat of all. Kokotaj…

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Letterkenny vs Shoresy 25:00

3M ago25:00

25:00

By Keith McNally

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The Science of Muscle, Protein, and Longevity: Insights from Dr. Layne Norton 1:19:20

3M ago1:19:20

1:19:20

In this episode of Longevity By Design, Dr. Layne Norton, Founder of BioLayne and Carbon app, joins Gil Blander to discuss optimizing nutrition and fitness for a longer, healthier life. Layne emphasizes the importance of prioritizing scientific evidence over popular narratives, highlighting how easily isolated studies can be misinterpreted. He stre…

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How AI Learned to Talk and What It Means - Prof. Christopher Summerfield 1:08:28

3M ago1:08:28

1:08:28

We interview Professor Christopher Summerfield from Oxford University about his new book "These Strange New Minds: How AI Learned to Talk and What It". AI learned to understand the world just by reading text - something scientists thought was impossible. You don't need to see a cat to know what one is; you can learn everything from words alone. Thi…

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Wojeck 28:42

3M ago28:42

28:42

By Keith McNally

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Beyond Sick Care: Evelyne Bischof on the Rise of Longevity Medicine 56:39

4M ago56:39

56:39

On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Evelyne Bischof, President of the Healthy Longevity Medicine Society. Evelyne discusses her background in internal medicine and oncology and how her work puzzling together patient diagnoses led her to the field of longevity medicine. She highlights the importance of optimizi…

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Auds & Ends Episode 34 - Meet Our County’s Newest State Representative 25:38

4M ago25:38

25:38

On this episode of Auds and Ends, Auditor Keith talks to Representative Desiree Tims, the Ohio State Representative for House District 38. They discuss her work at the Statehouse, her career journey, and her unwavering commitment to advocating for Ohio residents.By Karl Keith, Montgomery County Auditor

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Marcus Welby, M.D. 35:25

4M ago35:25

35:25

By Keith McNally

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"Blurring Reality" - Chai's Social AI Platform (SPONSORED) 50:59

4M ago50:59

50:59

"Blurring Reality" - Chai's Social AI Platform - sponsored This episode of MLST explores the groundbreaking work of Chai, a social AI platform that quietly built one of the world's largest AI companion ecosystems before ChatGPT's mainstream adoption. With over 10 million active users and just 13 engineers serving 2 trillion tokens per day, Chai dis…

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Precision Habits: How Wearables and AI Are Powering Personalized Longevity 51:06

4M ago51:06

51:06

In this episode of Longevity by Design, our host, Dr. Gil Blander talks with Dr. Renee Deehan and Paul Fabian about Inside Tracker's new Healthspan Habits Score feature. This innovative tool analyzes data from wearable devices and daily journal entries to identify the most impactful habit to improve each week for better health span and longevity. T…

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Google AlphaEvolve - Discovering new science (exclusive interview) 1:13:58

4M ago1:13:58

1:13:58

Today GoogleDeepMind released AlphaEvolve: a Gemini coding agent for algorithm discovery. It beat the famous Strassen algorithm for matrix multiplication set 56 years ago. Google has been killing it recently. We had early access to the paper and interviewed the researchers behind the work. AlphaEvolve: A Gemini-powered coding agent for designing ad…

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The Queen's Gambit 30:10

5M ago30:10

30:10

By Keith McNally

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Scanning the Future: How Whole-Body MRI is Transforming Longevity with Dr. Daniel Durand 1:22:16

5M ago1:22:16

1:22:16

Dr. Gil Blander welcomes Dr. Daniel Durand, Chief Medical Officer at Prenuvo, to Longevity by Design for a deep dive into the future of preventative healthcare. Dr. Durand shares how full-body MRI is redefining early detection by making advanced imaging accessible, non-invasive, and radiation-free. He explains why MRI, as a soft tissue imaging moda…

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Ambient AI’s Role in Operating Rooms 24:21

5M ago24:21

24:21

Documentation overload, burnout, and constant workflow disruptions—these are just a few of the daily challenges facing operating room teams. In this episode, ambient AI in the OR is explored and how it’s offering real, practical relief. Christy Gaudet is joined by Dr. Andrew Gostine, CEO and co-founder of Artisight, and Eric Passarge, Senior Market…

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Auds & Ends Episode 33 - The Voice of the Dayton Dragons 29:19

5M ago29:19

29:19

On this episode of Auds and Ends, Auditor Keith talks to Tom Nichols, Director of Media Relations and Broadcasting. They discuss Tom's career, the history of the Dayton Dragons Professional Baseball Team, and the 25th opening season of the Dayton Dragons.By Karl Keith, Montgomery County Auditor

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Father Knows Best 24:49

5M ago24:49

24:49

By Keith McNally

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Prof. Randall Balestriero - LLMs without pretraining and SSL 34:30

5M ago34:30

34:30

Randall Balestriero joins the show to discuss some counterintuitive findings in AI. He shares research showing that huge language models, even when started from scratch (randomly initialized) without massive pre-training, can learn specific tasks like sentiment analysis surprisingly well, train stably, and avoid severe overfitting, sometimes matchi…

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The O.C. vs Arrested Development 22:21

5M ago22:21

22:21

By Keith McNally

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AI, LLMs & The Future of Longevity: Unlocking Healthspan Innovations with Dr. Eran Segal 1:01:54

5M ago1:01:54

1:01:54

In this episode of Longevity by Design, host Dr. Gil Blander welcomes Dr. Eran Segal, Professor at the Weizmann Institute of Science, to explore the intersection of artificial intelligence (AI) and personalized health. The conversation dives into how AI and machine learning are transforming our understanding of nutrition, disease prediction, and ov…

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Navigating Staffing Shortages for Surgical Success 18:12

6M ago18:12

18:12

Mike Lyman, Vice President of Service and Crit Fisher, Director of Onsite Service and Operations at KARL STORZ United States, join Wendy Brauner for a compelling discussion on the lasting impact of the COVID-19 pandemic on healthcare. The episode delves into the critical staffing shortages that have strained hospitals and surgical centers, examinin…

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Arrested Development 22:01

6M ago22:01

22:01

By Keith McNally