Best Oncotarget Podcasts (2025)

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Precision Oncology in Metastatic Colorectal Cancer: A Real-World Case Study 4:41

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5h ago4:41

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Colorectal cancer is one of the most common—and deadliest—cancers worldwide. Once it spreads and reaches the metastatic stage, treatment becomes far more difficult. Tumors can also behave very differently from one patient to another, especially after multiple rounds of therapy. Precision oncology is helping to overcome these challenges by enabling …

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Loss of Trp53 Gene Promotes Tumor Growth and Immune Suppression in Ovarian Cancer 3:24

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BUFFALO, NY - September 24, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on September 22, 2025, titled “Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma.”In this study, led by first author Ja…

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Immunotherapy Response in Pancreatic Cancer: What a New Study Reveals 4:59

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Immunotherapy is not usually effective against pancreatic cancer (PC), but a new study published in Oncotarget (Volume 16, 2025) highlights rare cases where it did help. These examples, though uncommon, may offer valuable insights for future treatment.Pancreatic Cancer and ImmunotherapyPancreatic cancer is often diagnosed at an advanced stage, whic…

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Blocking Protein Control Pathway Slows Rhabdomyosarcoma Growth in Mice 3:58

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BUFFALO, NY – August 29, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on August 29, 2025, titled “In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma.”In this study led by first author Kristen Kwong and corresponding author Amit J. Sabnis from the Department of Pediatrics, Division of Oncology, Univ…

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Behind the Study: R-spondin Family Roles in Metastatic Prostate Cancer 7:06

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Aiden Deacon from the University of Minnesota-Twin Cities, Minneapolis, discusses a research paper he co-authored that was published in Volume 16 of Oncotarget, titled “Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer.”DOI - https://doi.org/10.18632/oncotarget.28758Correspondence …

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Amivantamab Monotherapy in Rare EGFR-Mutated Advanced NSCLC 5:27

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Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. While the development of targeted therapies has improved outcomes for many patients with EGFR-mutated NSCLC, those with rare EGFR variants often face limited treatment options, especially when the disease involves the central nervous system (CNS).A recent resear…

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Aramchol Boosts Regorafenib Effectiveness in Gastrointestinal Tumors 3:35

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BUFFALO, NY – August 19, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on August 19, 2025, titled “The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo.”In this study, led by first authors Laurence Booth and Michael R. Booth, along with corresponding author Paul Dent from Virgin…

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FDA-Approved MI Cancer Seek Test Enhances Tumor Profiling for Precision Oncology 4:13

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BUFFALO, NY – August 15, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on August 13, 2025, titled “Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay.”In this study, first authors Valeriy Domenyuk and Kase…

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New Compound Disrupts Survival Pathways in Aromatase Inhibitor-Resistant Breast Cancer Cells 3:57

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BUFFALO, NY - August 13, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 29, 2025, titled “PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion.”In this study, led by first author Jassy Mary S. Lazart…

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Cigarette Smoke and Weak DNA Repair: A Double Hit Behind Lung Cancer Risk 5:37

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Lung cancer, particularly non-small cell lung cancer (NSCLC), is the deadliest cancer worldwide. Cigarette smoking is one of the main causes, but not every smoker develops the disease. This suggests that other biological factors help determine who develops cancer.Researchers from the Division of Pulmonary, Critical Care, Sleep and Occupational Medi…

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New Gene Linked to Aggressive, Treatment-Resistant Prostate Cancer 3:35

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BUFFALO, NY – August 11, 2025 – A new #researchpaper was #published in Volume 16 of Oncotarget on July 25, 2025, titled “Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer.”In this study, researchers led by first author Aiden Deacon and corresponding author Justin Hwang from the Uni…

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A New Way to Target Resistant Prostate Cancer Cells 5:14

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Prostate cancer is the second most diagnosed cancer among men worldwide and remains a leading cause of cancer-related death. While early forms of the disease can usually be treated successfully, advanced cases remain a major challenge. Scientists have now discovered a new potential way to slow the growth of advanced, treatment-resistant prostate ca…

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Comprehensive Genomic Testing Reveals Treatment Targets in 90% of Advanced Solid Tumors 3:32

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BUFFALO, NY - July 29, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 25, 2025, titled “Comprehensive genomic profiling of over 10,000 advanced solid tumors.”In this study, led by Jean-Paul De La O from Exact Sciences Corporation, researchers analyzed data from over 10,000 solid tumor samples from patients with advan…

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Blood Filtration Stabilizes Advanced Pancreatic Cancer: A Case Report 3:22

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BUFFALO, NY – July 24, 2025 – A new #casereport was #published in Volume 16 of Oncotarget on July 23, 2025, titled “Extracorporeal blood filtration leading to tumor growth arrest and reduced analgesic requirements in Stage IV poorly differentiated pancreatic adenocarcinoma: A case report.”In this report, Susanna Ulahannan from the University of Okl…

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Cholesterol-Lowering Drugs Show Promise Against Colorectal Cancer 2:59

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BUFFALO, NY – July 22, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 21, 2025, titled “Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer.”In this work, led by first author Sneha Tripathi from the Indian Institute of Science Education and Research and corresponding author…

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microRNAs Emerge as Biomarkers and Diagnostic Tools in Soft Tissue Sarcoma 3:34

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BUFFALO, NY - July 18, 2025 – A new #editorial was #published in Volume 16 of Oncotarget on July 16, 2025, titled “microRNAs in soft tissue sarcoma: State of the art and barriers to translation.”In this article, Elizaveta K. Titerina, Alessandro La Ferlita, and Joal D. Beane from Ohio State University discuss the role of microRNAs in soft tissue sa…

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New Antibody Selectively Targets Immune Cells That Suppress Anti-Tumor Responses 3:49

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BUFFALO, NY - July 16, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 9, 2025, titled “A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment.”In this study, researchers from the National Institute of Allergy and Infectious Diseases, led …

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PRDX1 Identified as Key to Chemotherapy Resistance in Cancer Cells 4:41

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Scientists have uncovered a promising new strategy to weaken cancer cells’ natural defense mechanisms, potentially making chemotherapy more effective. In a study published in Volume 16 of Oncotarget, researchers identified the protein PRDX1 as a key player in helping tumors resist treatment. By targeting this protein, they propose a novel way to co…

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Prostate Cancer Cells Survive Treatment by Storing Fat in Low Oxygen Conditions 3:47

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BUFFALO, NY – July 14, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on June 25, 2025, titled “Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer.”In this study, researchers led by Shailender S. Chauhan and Noel A. Warfel from the University of Arizona discovered that prostate c…

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EGFR-Targeted Therapy Resistance in Breast and Head & Neck Cancers 4:19

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BUFFALO, NY – July 9, 2025 – A new #review was #published in Volume 16 of Oncotarget on June 25, 2025, titled “Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms.”Researchers from the University of Cincinnati and Cincinnati Veterans Affai…

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Key Genetic Alterations and Biomarker for Blastic Plasmacytoid Dendritic Cell Neoplasm 3:34

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BUFFALO, NY - July 7, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on June 17, 2025, titled “Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience.”In this study, a research team led by first author Fei Fei and corresponding author Michelle Afkhami from the City of Hope Co…

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Immunotherapy Safety for Hepatocellular Carcinoma in Latin America: Insights from a Real-World Study 4:27

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Liver cancer, especially hepatocellular carcinoma (HCC), remains a major health concern worldwide. In Latin America, the situation becomes more difficult due to limited access to advanced treatments and the high prevalence of underlying liver diseases. A recent research paper, published in Volume 16 of Oncotarget by researchers from Argentina, Braz…

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New Drug Combination Redefines First-Line Treatment for Advanced Urothelial Cancer 3:38

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BUFFALO, NY – July 1, 2025 – A new #review was #published in Volume 16 of Oncotarget on June 17, 2025, titled “Optimizing enfortumab vedotin plus pembrolizumab therapy.”First authors Elias Antoine Karam of the Gustave Roussy and Saint-Joseph University of Beirut and Yaghi César Céline from the Saint-Joseph University of Beirut, along with their col…

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HER2-Mutated NSCLC in Brazil Shows Diverse Genetic Patterns and Treatment Gaps 4:35

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BUFFALO, NY – June 27, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on June 17, 2025, titled “Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights.”In this study, researchers led by first authors Cleto Dantas Nogueira from the Federal Unive…

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WIN International Molecular Tumor Board Recommends Tailored Treatment for Advanced Colorectal Cancer 4:40

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BUFFALO, NY – June 24, 2025 – A new precision #oncology paper was #published in Volume 16 of Oncotarget on June 17, 2025, titled “Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment.”In this report, led by Alberto Hernando-Calvo from Vall d’Hebron U…

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CHEK2 Identified as a Potential Target to Improve Immunotherapy in Solid Tumors 4:34

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BUFFALO, NY – June 20, 2025 – A new #review was #published in Volume 16 of Oncotarget on June 10, 2025, titled “Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors.”In this paper, led by first author Helen Qian and corresponding author Crismita Dmello from Northwestern University Feinberg School of Medicine, researchers…

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Rare Pancreatic Cancer Patients Show Strong Response to Immunotherapy 3:53

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BUFFALO, NY - June 17, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on June 10, 2025, titled “Exceptional responders to immunotherapy in pancreatic cancer: A multi-institutional case series of a rare occurrence.”The study, led by first author Kavin Sugumar and corresponding author Jordan M. Winter, from University Hospital…

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Exploring a Combined Approach: Radiation and Immunotherapy in Bladder Cancer 6:56

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Bladder cancer remains a significant clinical concern, with more than 85,000 new diagnoses and nearly 19,000 deaths reported annually in the United States. While current treatments like surgery, chemotherapy, and radiation can be effective for early-stage disease, many patients with advanced or recurrent cancer face limited options.A recent review,…

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Balancing Time, Cost, and Quality in Cardio-Oncology Care 3:21

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BUFFALO, NY - June 13, 2025 – A new #review was #published in Volume 16 of Oncotarget on June 4, 2025, titled “Applying the unattainable triangle in cardio-oncology care: Balancing cost, quality, and time.”In this review, first author John Hoverson, corresponding author Stella Pak, and colleagues from the University of Texas Health Science Center a…

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Rare Non-Small Cell Lung Cancer with Brain Metastases Responds to Amivantamab Monotherapy 4:03

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BUFFALO, NY - June 11, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 29, 2025, titled “Durable complete response in leptomeningeal disease of EGFR mutated non-small cell lung cancer to amivantamab, an EGFR-MET receptor bispecific antibody, after progressing on osimertinib.”A team led by first author Jinah Kim, from t…

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Oncotarget Sponsors Open Access Team in 2025 Ride for Roswell 2:45

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BUFFALO, NY — June 10, 2025 — The Ride for Roswell, one of the USA’s largest cycling events supporting cancer research, returns to Buffalo on Saturday, June 28, 2025. Hosted annually by Roswell Park Comprehensive Cancer Center, this community-wide event brings together riders, volunteers, and supporters to raise funds for cancer research, celebrate…

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Cigarette Smoke and DNA Repair Deficiency Drive Lung Cancer Development 3:35

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BUFFALO, NY – June 9, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 20, 2025, titled “Cigarette smoke and decreased DNA repair by Xeroderma Pigmentosum Group C use a double hit mechanism for epithelial cell lung carcinogenesis.”In this study, led by first author Nawar Al Nasralla and corresponding author Catherine R.…

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Experimental Triple Therapy Improves Survival in Glioblastoma Mouse Model 5:38

4M ago5:38

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Researchers at Brown University have developed a combination treatment that significantly increases survival in mice with glioblastoma (GBM), a highly aggressive and treatment-resistant brain cancer. The approach uses a new class of drugs called imipridones along with radiation therapy and standard chemotherapy. This triple therapy, known as IRT, w…

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Targeting PCNA-Androgen Receptor Interaction Suppresses Prostate Cancer Cell Growth 3:55

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BUFFALO, NY - June 4, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 20, 2025, titled “Targeting PCNA/AR interaction inhibits AR-mediated signaling in castration resistant prostate cancer cells."In this study, authors Shan Lu and Zhongyun Dong from the University of Cincinnati College of Medicine investigated how inte…

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Blocking PRDX1 Protein May Improve Chemotherapy Response in Ovarian Cancer 4:10

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BUFFALO, NY - June 3, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 19, 2025, titled “PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling."In this study, led by first author Reem Ali and corresponding author Dindial Ramotar from Hamad Bin Khalifa University …

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Immune Side Effects of Liver Cancer Therapy Studied in Latin American Patients 4:16

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BUFFALO, NY - May 23, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 19, 2025, titled “Immune-mediated adverse events following atezolizumab and bevacizumab in a multinational Latin American cohort of unresectable hepatocellular carcinoma."The study, led by first authors Leonardo Gomes da Fonseca from Hospital das Clí…

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Engineered Proteins Show Promise in Stopping Glioblastoma Invasion 4:52

4M ago4:52

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Scientists have engineered small, targeted proteins that can penetrate brain cancer cells and prevent them from invading healthy tissue, offering a promising new approach to treating glioblastoma multiforme (GBM), one of the deadliest forms of brain cancer. This strategy was developed by researchers at the University of Nevada, Reno, and published …

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Combining Radiation and Immunotherapy Shows Promise for Bladder Cancer 3:45

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BUFFALO, NY - May 21, 2025 – A new #review was #published in Volume 16 of Oncotarget on May 19, 2025, titled “Advancements in bladder cancer treatment: The synergy of radiation and immunotherapy."Researchers from the University of California, Irvine, led by Nazmul Hasan, reviewed recent clinical and scientific advances in combining radiation therap…

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New Ultra-Sensitive DNA Blood Test for Detecting Residual Cancer in B-cell Lymphoma Patients 4:08

4M ago4:08

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BUFFALO, NY – May 19, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 9, 2025, titled “Analytical validation of a circulating tumor DNA assay using PhasED-Seq technology for detecting residual disease in B-cell malignancies.”In this study, a team from Foresight Diagnostics led by first author Nina Klimova and correspon…

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Blood Type A Identified as Potential Breast Cancer Risk Factor 3:19

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BUFFALO, NY - May 14, 2025 – A new #review paper was #published in Volume 16 of Oncotarget on May 9, 2025, titled “Relationship between ABO blood group antigens and Rh factor with breast cancer: A systematic review and meta-analysis."A comprehensive study, led by first authors Rahaf Alchazal from Yarmouk University and Khaled J. Zaitoun from Johns …

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METTL3 Drives Oral Cancer by Blocking Tumor-Suppressing Gene 3:37

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BUFFALO, NY - May 9, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on May 8, 2025, titled “METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis."In this study, researchers Jayasree Peroth Jayaprakash, Pragati Karemore, and Piyush Khandelia from the Birla Institute of Technology and Science, India…

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Panitumumab & Low-Dose Capecitabine: Promising Maintenance Therapy for Metastatic Colorectal Cancer 6:48

5M ago6:48

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A recent #study from Assiut University Hospital in Egypt, published in #Oncotarget, presents a promising strategy for patients with metastatic #colorectalcancer (mCRC). The #research introduces a gentler yet effective maintenance therapy that may extend survival, enhance quality of life, and offer a more accessible treatment option for mCRC patient…

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Oncotarget Participation at SSP 2025 Annual Meeting 1:37

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BUFFALO, NY - May 5, 2025 – Oncotarget, #published by Impact Journals, is proud to #announce its presence as an #exhibitor at the 47th Annual Meeting of the Society for Scholarly Publishing (SSP), taking place May 28–30, 2025, at the Hilton Baltimore in Maryland. Impact Journals publishes scholarly journals in the biomedical sciences, with a focus …

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Early Immune Evasion Found in HPV-Related Pre-Cancer Lesions of the Anogenital Region 4:28

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BUFFALO, NY - April 28, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on April 24, 2025, titled “PD-L1 and FOXP3 expression in high-grade squamous intraepithelial lesions of the anogenital region."Researchers Humberto Carvalho Carneiro, Rodrigo de Andrade Natal, José Vassallo and Fernando Augusto Soares from the Instituto D’…

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New Insights into p53: A Powerful Gene’s Role in Cancer Therapy 7:01

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A new study from the Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine, published in Oncotarget, reveals that the gene p53, long known as the “guardian of the genome,” may be even more powerful than previously thought. By studying it in non-cancerous human cells, researchers discovered how p53 stops risky cel…

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Gene Variant Linked to Benign Prostate Hyperplasia Risk in Lebanese Men 4:41

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BUFFALO, NY - April 15, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on April 4, 2025, titled “Association between two single nucleotide polymorphisms of the Prostaglandin-Endoperoxide Synthase 1 and 2 genes and cell proliferative prostatic diseases in Lebanon."The team of researchers led by first author Brock J. Sheehan an…

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Protein GSK3β Offers New Angle on Overcoming Melanoma Drug Resistance 3:59

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BUFFALO, NY - April 11, 2025 – A new research perspective was published in Oncotarget, Volume 16, on April 4, 2025, titled “GSK3β activation is a key driver of resistance to Raf inhibition in BRAF mutant melanoma cells."In this work, first author Diana Crisan and corresponding author Abhijit Basu from the University Hospital Ulm led a team that pre…

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Targeting SETDB1: A New Strategy for Treating Osteosarcoma 6:12

6M ago6:12

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Despite decades of research, treatment for osteosarcoma has remained largely unchanged, especially for patients whose cancer spreads or returns. However, a growing body of evidence, summarized in the review “SETDB1 amplification in osteosarcomas: Insights from its role in healthy tissues and other cancer types,” published in Oncotarget, highlights …

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AI That Measures Its Own Uncertainty Could Improve Liver Cancer Detection 3:37

6M ago3:37

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BUFFALO, NY - April 8, 2025 – A new #editorial was #published in Oncotarget, Volume 16, on April 4, 2025, titled “Deep learning-based uncertainty quantification for quality assurance in hepatobiliary imaging-based techniques."Dr. Yashbir Singh from Mayo Clinic and his colleagues discussed how artificial intelligence (AI) can improve liver imaging b…

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Triple Therapy Slows Glioblastoma Growth and Extends Survival in Preclinical Study 3:46

6M ago3:46

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BUFFALO, NY - April 4, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on March 27, 2025, titled “Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT."Researchers from Brown University, led by first author Lanlan …