Best Omics Podcasts (2026)

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An Effort to Detect and Treat Alzheimer’s at Its Earliest Stages 29:20

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1h ago29:20

29:20

One of the challenges in treating the neurodegenerative condition Alzheimer’s disease is intervening early enough in the course of illness to provide meaningful benefit. AltPep is developing therapeutics with companion diagnostics that target toxic α-sheet–containing oligomers, which are thought to form very early in the disease and act as molecula…

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The Year in Biotech and What’s Ahead for 2026 38:15

6d ago38:15

38:15

Biotech stocks staged a dramatic turnaround in 2025, with the XBI well outpacing the S&P 500 despite concerns over leadership changes at the U.S. Food and Drug Administration, the Trump administration’s efforts to put constraints on drug pricing, and its broader cuts to health and science agencies. A pick-up in deal-making, along with falling inter…

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How RCA supercharges NGS library prep 16:15

15d ago16:15

16:15

In this Mol Bio Minutes mini-episode, Laurynas Alijošius shares how Rolling Circle Amplification (RCA) provides a reliable, high-yield approach for amplifying circular DNA prior to next-generation sequencing (NGS). This isothermal method avoids the need for thermal cycling and even bypasses the need for specific primers—making it ideal for challeng…

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Developing an Alternative to Opioids for Post-Surgical Pain 25:47

13d ago25:47

25:47

The approach to post-surgical pain relief has relied on short-duration treatments and notably opioids. That’s led to the associated risks of dependence and abuse, prolonged hospitalizations, and slower recoveries. Allay Therapeutics is developing an alternative to opioids to treat post-surgical pain with an initial focus on knee replacement surgeri…

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Leveraging the Power of Vocal Biomarkers 22:19

20d ago22:19

22:19

Physicians can learn a lot from talking to patients, and not just from the words they say, but from millions of data points from acoustic features of their speech, such as pitch, vocal cord vibration patterns, and micro-instabilities in the voice. Canary Speech has developed an AI-based diagnostic listening tool that can detect neurological and psy…

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What Values are in AI? A Conversation with Dr. Zak Kohane 1:18:13

20d ago1:18:13

1:18:13

For Dr. Zak Kohane, this year’s advances in AI weren’t abstract. They were personal, practical, and deeply tied to care. After decades studying clinical data and diagnostic uncertainty, he finds himself building his own EHR, reviewing his child’s imaging with AI, and re-thinking the balance between incidental and missed findings. Across each story …

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No cold chain? No problem—inside the world of lyo-beads 33:44

29d ago33:44

33:44

Applyo Jena is building a freeze-dried future, one bead at a time. In this episode, Dr. Hanno Hermann and Dr. Thanh Tu Hellmich-Duong walk us through how their lyo-bead technology emerged from the challenges of field-based HIV diagnostics and evolved into a flexible platform that stabilizes everything from enzymes to magnetic nanoparticles, without…

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Determining the Cause and Severity of Sepsis with a Point-of-Care Test 37:09

27d ago37:09

37:09

Sepsis remains one of medicine’s most intractable and costly problems, arising when an infection triggers a runaway immune response that damages organs long after a pathogen is controlled. It accounts for an estimated $53 billion in Medicare spending alone, yet more than a hundred drug trials have failed to yield a single approved drug that directl…

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Separating Signal from Noise in Regenerative Therapies 32:21

1M ago32:21

32:21

Rion is developing platelet-derived exosome therapeutics as off-the-shelf, room-temperature-stable alternatives to traditional cell therapies. The company’s lead program is advancing toward phase 3 trials in diabetic foot ulcers, and it is building a broader pipeline across musculoskeletal, cardiovascular, pulmonary, dermatologic, and women’s healt…

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Rewriting Drug Discovery with an AI-Multi-Omics Approach 45:49

1M ago45:49

45:49

The genomics revolution promised to unravel diseases and lead to treatments that addressed their root causes. In reality, says Mo Jain, your zip code remains a better predictor for how healthy you will be over the course of your life than your genetic code does. That’s because, except for monogenic diseases, etiology tends to be far more complex th…

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Simmer, don’t cycle—a molecular biologist’s guide to RPA 12:14

2M ago12:14

12:14

In this Mol Bio Minutes episode, Thermo Fisher Scientific’s Monika Jazdauskaitė dives into the versatile world of Recombinase Polymerase Amplification (RPA). Unlike PCR, RPA operates at a constant, low temperature (around 37–42°C), enabling fast, equipment-light workflows that are ideal for field diagnostics and decentralized labs. Monika explains …

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From Hindsight Bias to Machine Bias: Dr. Laura Zwaan on Learning from Mistakes 38:09

2M ago38:09

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As a cognitive psychologist, Dr. Laura Zwaan studies how humans make—and learn from—mistakes. In this episode of NEJM AI Grand Rounds, she brings that lens to AI, showing how machines inherit our biases and why both need transparency and reflection. From the challenge of defining diagnostic error to the promise of “machine psychology,” Dr. Zwaan ex…

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Overcoming Chemoresistance and Activating the Immune System in Difficult-to-Treat Cancers 36:24

2M ago36:24

36:24

The enzyme GSK3β, in healthy cells, is involved in glucose metabolism. In cancer cells, though, it serves as a master regulator of tumor growth, progression, and cell survival. While GSK3β has long been an attractive target in cancer therapy, it has been difficult to inhibit due to the poor pharmaceutical characteristics and adverse effects of ther…

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Special - Inside SBI2 2025: How AI, Imaging, and Multi-Omics Are Transforming Discovery 7:07

2M ago7:07

7:07

In this episode of Science in Real Time, host Carli Reyes brings listeners a behind-the-scenes recap of SBI2 2025, the premier conference for quantitative imaging, high-content screening, and bioinformatics. Carli breaks down the biggest scientific trends shaping the future of imaging—from foundation models and AI-driven analysis to multi-omics int…

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A Hub-and-Spoke Ophthalmology Company with an Eye for Innovation 21:26

2M ago21:26

21:26

Hub-and-spoke business models—the use of a central core of business functions with pipeline assets spun out into subsidiary companies—have gained traction for the benefits they can provide in terms of capital efficiency, diversification of risks, and improved access to capital. Eyexora is applying that business model to accelerate the development o…

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An AI Collaborative that Welcomes All into the Fold 55:46

2M ago55:46

55:46

OpenFold, an open-source, collaborative initiative founded in 2022 to address the challenges of protein structure prediction and design using artificial intelligence, emerged as a response to the restricted commercial access to DeepMind’s AlphaFold platform. Leveraging public datasets and using a pre-competitive consortium model, OpenFold seeks to …

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De-risking drug development using functional human tissues 35:09

2M ago35:09

35:09

In this episode of Speaking of Mol Bio, Dr. Andre Ghetti, CEO of AnaBios, offers a deep dive into the world of translational preclinical research. AnaBios is redefining early human insights by using ethically sourced, functional human tissues and cells to generate actionable data before compounds ever enter clinical trials. Ghetti walks us through …

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Hitting the Reset Button on Cellular Aging 42:46

2M ago42:46

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Transcription factors control the genetic programs that maintain cellular balance, but while they have been seen as compelling targets for aging-related disease, they have long been considered “undruggable.” Junevity’s RESET platform leverages large-scale human omics data and AI models to pinpoint key transcriptional drivers of disease and to desig…

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Changing the Ovarian Cancer Treatment Landscape with a DNA-Mediated Immunotherapy 29:58

3M ago29:58

29:58

Ovarian cancer remains one of the deadliest cancers affecting women, and it is expected to claim nearly 13,000 lives in the United States in 2025. Despite progress in survival rates, nearly 80 percent of patients are still diagnosed at advanced stages, when the disease has already spread and is difficult to treat. Imunon’s experimental DNA-mediated…

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No lyophilizer? No problem. Dry-Ready reagents explained. 14:50

3M ago14:50

14:50

In this Mol Bio Minutes episode, Thermo Fisher Scientific's Dr. Agnė Alminaitė unveils an exciting new approach for assay developers: Dry-Ready™ reagents for RT-LAMP and RT-qPCR. These innovations eliminate the need for lyophilizers by enabling air drying of molecular assays in a standard heating oven, producing room temperature-stable assays in un…

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Spotlight - How Semarion Is Revolutionizing Cell Handling with CTO & Co-Founder Dr. Tarun Vemulkar 25:37

3M ago25:37

25:37

In this episode of Science in Real Time, host Carli Reyes sits down with Dr. Tarun Vemulkar, CTO and Co-Founder of Semarion, to explore how their groundbreaking SemaCyte® platform is reshaping the way scientists handle, study, and analyze cells. They dive into the intersection of materials science and cell biology, unpacking how Semarion’s smart ma…

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Medicine, Machines, and Magic: Dr. Jonathan Chen on Medical AI 48:17

3M ago48:17

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In this episode, Dr. Jonathan Chen joins the hosts to discuss his path from teenage programmer to Stanford physician-informatician and why machine learning has both thrilled and unnerved him. From his 2017 NEJM essay warning about “inflated expectations” to his latest studies showing GPT‑4 outperforming doctors on diagnostic tasks, Dr. Chen describ…

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Why the United States Must Fall in Love with Biotechnology, or Take a Back Seat to China 32:39

3M ago32:39

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China’s emergence as a biotech superpower may have appeared to happen suddenly, but it reflected a long-term vision and policies over many years that enabled its success. As biotechnology transforms not only medicine but also industries such as food, fuel, and materials, the competition between China and the United States to shape the future bioeco…

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Unlocking phagocytosis―a look at advanced cancer immunology 33:28

3M ago33:28

33:28

In this inspiring episode, Dr. Felipe Gálvez-Cancino, group leader at Oxford's Center for Immuno-Oncology, walks us through his team’s groundbreaking research on macrophages, T cells, and immune regulation in solid tumors. Tracing his path from early cancer vaccine work to advanced antibody-dependent cellular phagocytosis (ADCP), Felipe shares how …

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Transforming Drug Discovery and Disease Research—One Cell at a Time 39:48

3M ago39:48

39:48

The ARC Virtual Cell Atlas uses high-throughput single-cell genomics, artificial intelligence, and open science to understand the complexities of cellular behavior. Developed through a partnership between the ARC Institute, 10x Genomics, and Ultima Genomics, the public domain resource integrates data from hundreds of millions of cells. By curating …

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Interviews with Authors Selected for the Outstanding Abstract Presentation Award 12:33

3M ago12:33

12:33

Dr. Jazmin Calyeca chats with authors selected for the outstanding abstract presentation awardBy American Thoracic Society

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Scratching the Surface with a Novel Approach to Treating an Orphan Lung Disease 24:30

3M ago24:30

24:30

Bronchopulmonary dysplasia is a condition that affects preterm infants, especially those born with underdeveloped lungs who require prolonged oxygen therapy or mechanical ventilation to help them breathe after birth. It is characterized by damage and abnormal development of the lung tissue and airways, often resulting from life-saving interventions…

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Airway Macrophages Encompass Transcriptionally and Functionally Distinct Subsets Altered by Smoking 13:48

3M ago13:48

13:48

Dr. Eric Morrell sits down with Dr. Maude Liegeois to discuss her paper, "Airway Macrophages Encompass Transcriptionally and Functionally Distinct Subsets Altered by Smoking."By American Thoracic Society

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Molecule Talk - CellCLIP: When Cell Painting Meets AI and Natural Language 8:14

4M ago8:14

8:14

In this Molecule Talk episode, host Carli Reyes explores CellCLIP, a provocative new approach at the intersection of high-content imaging and AI. Based on a June 2025 preprint, CellCLIP attempts to link Cell Painting images with natural language descriptions of perturbations, making cellular data more interpretable, searchable, and useful across di…

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From seed to cDNA―lessons learned from plant RNA workflows 19:35

4M ago19:35

19:35

In this Mol Bio Minutes episode, Dr. Will Barnes, a plant biologist turned senior sales training specialist at Thermo Fisher Scientific, reflects on his time at the bench and the molecular lessons learned along the way. Will dives deep into the difficulties of RNA work in plant systems—carbohydrate contamination, genomic DNA carryover, secondary st…

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A Dual Action Approach to Treating MASH 29:37

4M ago29:37

29:37

MASH, a chronic and progressive form of fatty liver disease that until recently was known as NASH, affects millions of people in the United States, and its incidence continues to rise. In fact, MASH is now among the leading causes of liver transplantation in the United States. 89bio is developing an experimental therapy to target multiple disease m…

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Interstitial Macrophages Mediate Efferocytosis of Alveolar Epithelium during Influenza Infection 13:47

4M ago13:47

13:47

Dr. Peter Moore chats with Dr. Marilia Zuttion on her article, "Interstitial Macrophages Mediate Efferocytosis of Alveolar Epithelium during Influenza Infection."By American Thoracic Society

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From Clinician to Chief Health AI Officer: A Conversation with Dr. Karandeep Singh 1:02:32

4M ago1:02:32

1:02:32

Dr. Karandeep Singh brings two worlds together: programming and medicine. In this conversation, he explains how early experiments with code led him to biomedical informatics, why gaps between paper performance and clinical reality must be confronted, and how governance committees weigh ethics and safety. Now serving as Chief Health AI Officer at UC…

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Extending the Life of Transplanted Kidneys 30:20

4M ago30:20

30:20

The average kidney transplant recipient experiences kidney failure within 10 to 12 years after a transplant, putting them on a cycle that ends with kidney failure and a need for a new transplant. This cycle adds to strains on transplant recipients, payers, providers, and the healthcare system and taxes the limited supply of organs for transplantati…