Best Omics Podcasts (2025)

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170: Why Your DNA Is a Terrible Disease Predictor (And How Multi-Omics Changes Everything) with Mo Jain - Part 2 22:40

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13d ago22:40

22:40

For years, disease diagnosis and treatment have focused on a few biomarkers, overlooking thousands of vital biological signals. Despite biotech advances, most therapies are still based on limited data, missing countless breakthroughs. Multiomics changes that. By analyzing tens of thousands of proteins, metabolites, and lipids, it reveals hidden ins…

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173: Mastering Hybrid Model Digital Twins: From Lab Scale to Commercial Bioprocessing with Krist Gernaey - Part 1 21:04

1d ago21:04

21:04

Are you struggling to bridge the gap between lab-scale models and commercial bioprocessing reality? For many biotech innovators, the promise of digital twins meets harsh industrial constraints - where hybrid models that excel in controlled lab environments must prove themselves in the complexity of large-scale manufacturing. This week on the Smart …

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172: Reimagining Chromatography for Advanced Therapies: From Diffusion to Convection with Scott Wheelwright - Part 2 19:43

6d ago19:43

19:43

Downstream processing remains one of the most complex and critical steps in biomanufacturing, especially as new therapeutic modalities like cell and gene therapies push current technologies to their limits. The industry faces ongoing pressure to innovate, reduce costs, and improve efficiency, while still ensuring robust and reliable results. In thi…

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Can AI Accelerate Science? Dr. Andy Beam on AI’s Next Frontier 1:07:28

7d ago1:07:28

1:07:28

Dr. Andy Beam has trained models, mentored scientists, and used data to quantify the value of treatments. In this episode of NEJM AI Grand Rounds, Raj Manrai turns the table on his co-host, reflecting on how Andy’s childhood misdiagnosis, and the failure of human recall, revealed the diagnostic promise of machine learning. As a Harvard professor, h…

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#64 - Dr. Yanina Pepino | The Neuroscience of Taste, Sweeteners, and Metabolic Health 1:28:24

8d ago1:28:24

1:28:24

Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Yanina Pepino, a renowned professor of Ingestive Behavior at the University of Illinois. With a background in medicine and a research trajectory that spans Washington University’s Center for Human Nutrition to her current work in sensory biology, Dr. Pepino br…

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171: Reimagining Chromatography for Advanced Therapies: From Diffusion to Convection with Scott Wheelwright - Part 1 20:35

8d ago20:35

20:35

For decades, chromatographic purification has made use of bead-based diffusion - a reliable but limiting approach, especially as new modalities like gene therapies, mRNA, and viruses push the boundaries of what’s possible. But what if the future of downstream processing lies not in incremental improvement, but in a dramatic reimagining - from slow …

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No nucleus, no problem – platelet biology and scientific communication 30:12

14d ago30:12

30:12

In this episode of Speaking of Mol Bio, Dr. Beth Webb takes us deep into the world of platelets, often misunderstood components of blood that punch far above their weight in both physiological and pathological processes. As a postdoctoral researcher at the University of Leeds, Dr. Webb explores how endothelial signals influence platelet activity, a…

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169: Why Your DNA Is a Terrible Disease Predictor (And How Multi-Omics Changes Everything) with Mo Jain - Part 1 25:33

15d ago25:33

25:33

What if the secret to truly personalized precision medicine lies not in your genetic code, but in your zip code? For years, biotech has focused on genomics to explain disease and drug response, but DNA only accounts for a fraction of the story. The real breakthrough? Multi-omics: the large-scale analysis of proteins, metabolites, and lipids, powere…

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168: How Generative AI Is Revolutionizing Biotech Regulatory Compliance with Abhijeet Satwekar - Part 2 24:51

20d ago24:51

24:51

The promise of generative AI in pharma and biotech is huge, but it's also fraught with complexity, especially when it comes to integrating these systems into highly regulated environments. From monitoring evolving guidelines to balancing operational efficiency and data integrity, the journey from hype to real-world impact is filled with both opport…

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#63 - Dr. Dominic D'Agostino | Advancing Metabolic Therapies Through Ketosis and Resilience Research 1:11:35

21d ago1:11:35

1:11:35

Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they speak with Dr. Dominic D’Agostino, Associate Professor at the University of South Florida and research scientist at the Institute for Human and Machine Cognition (IHMC). Renowned for his work on metabolic therapies, Dr. D’Agostino has led pioneering research into how nutrit…

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167: How Generative AI Is Revolutionizing Biotech Regulatory Compliance with Abhijeet Satwekar - Part 1 13:30

22d ago13:30

13:30

Ever feel like you’re drowning in an ocean of constantly shifting regulatory guidelines? The world of biotech is a whirlwind of evolving standards, making compliance not just a headache, but sometimes the stumbling block between life-changing therapies and the patients who need them. But what if artificial intelligence could turn regulatory chaos i…

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Docosahexaenoic Acid and Its Metabolites Protects Against Ozone-induced Pulmonary Inflammation 10:34

27d ago10:34

10:34

Dr. Yogesh Saini speaks with Dr. Michael Yaeger and Dr. Kymberly Gowdy about their article, Docosahexaenoic Acid and Its Metabolites Protects Against Ozone-induced Pulmonary Inflammation.By American Thoracic Society

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166: Why Your Funding Pitches Fail Despite Brilliant Science (And How to Fix It) - Part 2 17:02

27d ago17:02

17:02

Have you ever presented a major scientific breakthrough, only to be met with blank stares and distracted executives? You're not alone. In this episode, David Brühlmann shares how he went from drowning in data to winning an innovation contest, not through better tech, but through the power of scientific storytelling. Many scientists default to metho…

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Boosting PCR accuracy – tips for maximizing amplification fidelity 18:41

28d ago18:41

18:41

In this Mol Bio Minutes episode, Laurynas Alijošius shares a personal story that every molecular biologist can relate to—running PCR, cloning, and sequencing, only to discover frustrating errors in the DNA. This episode dives deep into PCR accuracy and why it matters for everything from sequencing to cloning and long-read library prep. Laurynas bre…

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165: Why Your Funding Pitches Fail Despite Brilliant Science (And How to Fix It) - Part 1 18:44

29d ago18:44

18:44

Have you ever poured months of research into a brilliant innovation, only to watch executives’ eyes glaze over during your presentation? You’re not alone. In this episode, host David Brühlmann describes a familiar frustration: scientists are trained to perfect data, not to sell ideas. But in today’s fast-paced biotech landscape, even the most groun…

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164: How Moss Enables Production of Unproducible Protein Therapeutics with Andreas Schaaf - Part 2 19:17

1M ago19:17

19:17

From lab curiosity to commercial reality. Here's what happens when moss meets the brutal economics of bioprocessing. In Part 1, you've heard the science behind moss-based protein production. Now comes the real test: Can it survive the gauntlet of regulatory scrutiny, cost pressures, and manufacturing scale-up that crushes most biotech innovations? …

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Google’s Efforts to Build Patient-Facing AI: A Conversation with Drs. Alan Karthikesalingam and Anil Palepu 38:22

1M ago38:22

38:22

In this episode of NEJM AI Grand Rounds, guests Drs. Alan Karthikesalingam and Anil Palepu of Google walk co-hosts Raj Manrai and Andy Beam through the making and evaluation of AMIE, an AI system designed to conduct clinical conversations with patients. Alan and Anil explain how AMIE was trained using synthetic doctor-patient interactions generated…

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#62 - Dr. Jens Juul Holst | Discovering the Hormone That Changed Metabolic Medicine 1:04:38

1M ago1:04:38

1:04:38

Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they speak with Dr. Jens Juul Holst, the renowned Danish physiologist and co-discoverer of GLP-1 (glucagon-like peptide-1), one of the most significant hormones in metabolic disease research. A professor of medical physiology at the University of Copenhagen and former scientific…

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163: How Moss Enables Production of Unproducible Protein Therapeutics with Andreas Schaaf - Part 1 23:48

1M ago23:48

23:48

What if the future of "impossible" protein therapeutics is hiding in your backyard? For decades, CHO cells have ruled the biotech kingdom as the undisputed champions of complex protein production. But here's the uncomfortable truth: countless breakthrough therapies are gathering dust on laboratory shelves—not because the science failed, but because…

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162: How to Achieve 85%+ Cell Recovery Without DMSO's Toxic Side Effects with Jeffrey Allen - Part 2 15:35

1M ago15:35

15:35

The world of cell therapy is changing rapidly, with revolutionary advancements in cryopreservation and bioprocessing protocols leading the way. In a recent episode of the Smart Biotech Scientist Podcast, host David Brühlmann sat down with Jeffrey Allen, Chairman and CEO of Evia Bio, to dive deep into the “how” of implementing cutting-edge technique…

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Multiomics, systems biology, and the future of genomic research 33:16

1M ago33:16

33:16

In this episode of Speaking of Mol Bio, Dr. Cath Moore of the Australian Genome Research Facility (AGRF) discusses how molecular biology technologies are helping to shape Australia’s scientific landscape—from clinical genomics and conservation to bioremediation and agriculture. With over 20 years of experience in both academia and industry, Dr. Moo…

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161: How to Achieve 85%+ Cell Recovery Without DMSO's Toxic Side Effects with Jeffrey Allen - Part 1 25:52

1M ago25:52

25:52

If you’ve ever worked in a cell therapy lab or handled biologics, you’ve probably experienced the pitfalls of cryopreservation. We’ve all mourned the loss of precious samples after a freeze-thaw cycle gone wrong or watched viability figures plummet, wondering where it all went awry. In this episode of The Smart Biotech Scientist Podcast, Jeffrey Al…

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160: The Ultimate Guide to Accelerating Perfusion Process Development Using 96-Deep-Well Plates with Tom Valentin - Part 2 18:19

2M ago18:19

18:19

In this concluding episode of our deep dive into miniaturized perfusion systems, we tackle the most challenging aspect: implementing meaningful process analytical technology (PAT) at microscale while keeping costs realistic for high-throughput applications. Tom Valentin, group leader at CSEM for Automated Sample Handling, continues sharing CSEM's p…

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#61- SSD Interviews Brady Holmer | Exercise Physiology | Science Communication 1:19:47

2M ago1:19:47

1:19:47

Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Brady Holmer, an exercise physiologist, researcher, and science communicator whose work bridges the gap between exercise science and public health. With a background in integrative physiology and cardiovascular research, Brady brings a rigorous yet accessible pers…

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159: The Ultimate Guide to Accelerating Perfusion Process Development Using 96-Deep-Well Plates with Tom Valentin - Part 1 22:30

2M ago22:30

22:30

In bioprocess development, the ability to rapidly screen conditions and predict scale-up performance can mean the difference between a successful therapy launch and costly delays. Today's Smart Biotech Scientist episode features Tom Valentin from CSEM, who's pioneering revolutionary approaches to miniaturized perfusion systems that could transform …

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158: How to Detect Endotoxins Without Bleeding a Single Horseshoe Crab with Anika Hoffmann - Part 2 16:25

2M ago16:25

16:25

In this concluding episode of our series on revolutionary endotoxin detection, we continue our conversation with Anika Hoffmann about transitioning from theory to practice in the quest for more reliable, sustainable testing methods. Anika is a postdoctoral researcher in analytical chemistry at HES-SO Valais-Wallis, Switzerland. Having established w…

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Fast PCR fundamentals – from instruments to enzymes 16:40

2M ago16:40

16:40

In this Mol Bio Minutes episode, Laurynas Alijošius breaks down how to run fast PCR to save time and increase lab efficiency. He explains how to choose the right thermal cycler with fast ramp speeds, select low-volume and thin-walled PCR plastics, and use engineered DNA polymerases that offer rapid elongation and hot-start capability. Laurynas also…

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157: How to Detect Endotoxins Without Bleeding a Single Horseshoe Crab with Anika Hoffmann - Part 1 22:38

2M ago22:38

22:38

In biopharmaceutical manufacturing, endotoxins represent a silent but deadly threat – bacterial fragments capable of triggering severe immune responses at picogram levels, potentially leading to septic shock, organ failure, or even death in patients. In this eye-opening first episode, we speak with Anika Hoffmann, a postdoctoral researcher in analy…

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Non-Invasive Sampling of the Lungs in Translational Research 19:05

2M ago19:05

19:05

This episode originally aired on December 2nd, 2021. Drs. Julie Bastarache and Katie Wick sit down to discuss non-invasive sampling of the lungs in translational research.By American Thoracic Society

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156: The Hidden Economics of Continuous Processing That Most Biotech Companies Overlook 25:45

2M ago25:45

25:45

The world of biologics manufacturing is undergoing a major transformation. Once dominated by traditional batch processes, the industry is now experiencing a marked shift toward continuous bioprocessing. But as companies contemplate this transition, two questions dominate strategic discussions: Will regulators accept continuous manufacturing? And, p…

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Rewriting the Clinical Playbook: Dr. Shiv Rao on Scaling Empathy with AI 54:53

2M ago54:53

54:53

Dr. Shiv Rao, cardiologist and CEO of Abridge, joins hosts Raj Manrai and Andy Beam on NEJM AI Grand Rounds for an inspiring conversation at the intersection of medicine, technology, and meaning. Shiv shares the origin story of Abridge, reflecting on how a deeply human encounter in clinic sparked the idea for a company now transforming clinical doc…

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155: From Process Bottlenecks to Seamless Production: How Continuous Bioprocessing Changes Everything 24:09

2M ago24:09

24:09

In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann dives into continuous bioprocessing - a major shift in biologics manufacturing that's turning traditional batch processes into streamlined, real-time operations. Imagine running your biologics process non-stop for 30 days, with smart monitoring and smaller, more efficient …

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154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago Matos - Part 2 16:16

2M ago16:16

16:16

In this episode, Tiago Matos, Associate Principal Scientist/Associate Director in Bioprocess Drug Substance and Commercialization at Merck & Co., shares a critical insight: continuous manufacturing in biologics currently demands 2–3x more time and FTEs than traditional fed-batch approaches. This highlights both the complexity of the shift - and the…

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The hidden language of RNA – how epigenetics is shaping medicine 31:51

2M ago31:51

31:51

This episode teaches that innovation is born at the intersection of curiosity and persistence. Dr. Gudrun Stengel, co-founder and CEO of Alida Biosciences, reveals how her startup is transforming the landscape of RNA research through a novel technology called proximity barcoding. Dr. Stengel’s story exemplifies the power of entrepreneurial spirit i…

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153: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago Matos - Part 1 28:58

2M ago28:58

28:58

As the biotechnology sector races toward digital transformation, the buzz around Industry 4.0 - with its promise of interconnected systems, automation, and data-driven operations - has never been louder. But is the industry truly ready? In this episode, we speak with Tiago Matos, Associate Principal Scientist/Associate Director in Bioprocess Drug S…

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152: Is an Indian CDMO the Right Move for Your Biologics Pipeline? with Abdelaziz Toumi - Part 2 21:21

3M ago21:21

21:21

Is an Indian CDMO the right move for your biologics CMC development? Pulling back the curtain on what might be your next strategic manufacturing advantage, this episode reveals the hidden capabilities emerging from India that leading biotech companies are racing to access. As supply chain vulnerabilities continue to expose risks in traditional manu…

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151: Is an Indian CDMO the Right Move for Your Biologics Pipeline? with Abdelaziz Toumi - Part 1 26:57

3M ago26:57

26:57

Is an Indian CDMO the right move for your biologics pipeline? As Western biotech companies seek new strategic advantages, one question keeps surfacing: Is India truly becoming the next biotech manufacturing powerhouse? And what hidden capabilities are emerging that leading companies are racing to access? In this episode of the Smart Biotech Scienti…

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150: How to Leverage AI in Media Development Without Sacrificing Process Understanding with Tom Fletcher - Part 2 24:04

3M ago24:04

24:04

As biotech labs rush to adopt AI tools for cell culture media development, a critical question emerges: Are we creating a generation of scientists who know which buttons to push but not why they're pushing them? The automation trap that once transformed laboratory workflows now threatens to fundamentally alter how we understand the complex dynamics…

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149: How to Leverage AI in Media Development Without Sacrificing Process Understanding with Tom Fletcher - Part 1 18:27

3M ago18:27

18:27

From closely-guarded secrets to complex chemical interactions, cell culture media development has transformed from an afterthought to a critical competitive advantage in modern bioprocessing. But as AI and automation revolutionize the field, are we at risk of gaining speed while losing understanding? In this eye-opening episode of the Smart Biotech…

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148: Lab-Grown Blood: How Stem Cells Transform Transfusions with Ari Gargir - Part 2 16:17

3M ago16:17

16:17

In the wake of the COVID-19 pandemic, the fragility of global blood supply systems became undeniably clear. Recognizing the urgent need for a more reliable and universal solution, Ari Gargir and his team at RedC Biotech are leading an ambitious effort to transform blood supply as we know it. Their mission? To develop lab-grown red blood cells that …

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Sustainability made simple – greener choices in molecular biology 10:21

3M ago10:21

10:21

Sustainability in the lab isn't just a trend—it's a responsibility. In this quick but powerful Mol Bio Minutes episode, sustainability expert Sune Lund Sporring shares actionable tips to reduce energy use, manage lab waste, and transition to greener materials like Thermo Fisher’s Sustain Series bio-based plastics. Discover the difference between bi…

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#60- SSD Interviews Dr. Richard Miller | Delayed Aging 44:39

3M ago44:39

44:39

Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Richard Miller, a distinguished physician-scientist and one of the most influential figures in aging research. As a Professor of Pathology at the University of Michigan and Director of the Paul F. Glenn Center for Aging Research, Dr. Miller has spent decades u…

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147: Lab-Grown Blood: How Stem Cells Transform Transfusions with Ari Gargir - Part 1 22:01

3M ago22:01

22:01

Blood is critical to global healthcare - vital for surgeries, trauma care, cancer treatment, and maternal health. Yet despite 120 million donations each year, a 100 million unit shortfall means nearly half the world’s needs go unmet. One person who understands this crisis firsthand is Ari Gargir, CEO & Founder of RedC Biotech. After surviving a par…

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146: Beyond ELISA: The 10-Minute Immunoassay Enabling Real-Time Bioprocess Control with Bruno Oesch - Part 2 18:09

3M ago18:09

18:09

Stuck with outdated analytics while trying to develop cutting-edge therapies? Part 2 of our conversation with Bruno Oesch, CEO and founder of Elionova, reveals how biotech scientists can finally break free from incremental improvements and embrace the revolutionary immunoassay technology that's transforming bioprocessing workflows worldwide. For ye…

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Pixels to Protocols: Building the AI Future of Pathology with Dr. Faisal Mahmood 35:23

3M ago35:23

35:23

Dr. Faisal Mahmood, Associate Professor of Pathology at Brigham and Women’s Hospital and Harvard Medical School, joins hosts Raj Manrai and Andy Beam on NEJM AI Grand Rounds to explore the frontier of computational pathology. From pioneering foundational models for whole slide imaging to commercializing a multimodal generative AI copilot for pathol…

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145: Beyond ELISA: The 10-Minute Immunoassay Enabling Real-Time Bioprocess Control with Bruno Oesch - Part 1 27:19

3M ago27:19

27:19

Tired of waiting overnight for ELISA results? Serial entrepreneur Bruno Oesch reveals how his groundbreaking 10-minute immunoassay technology is eliminating the biggest bottleneck in bioprocessing workflows. From contributing to Nobel Prize-winning prion research to founding Prionics (the first commercial BSE test) and now revolutionizing immunoass…

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144: The Future of Biotech: Making Biotherapeutics More Accessible Faster 12:55

3M ago12:55

12:55

Imagine a future where every patient can access life-saving therapies and sustainable, high-quality food is within everyone’s reach. In this episode of the Smart Biotech Scientist, David Brühlmann explores how innovative biotech developments are making this vision a reality. Here’s a sneak peek of the breakthroughs covered: AI-Powered Picoliter Sca…

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From bats to cancer – the power of gene regulation 33:53

3M ago33:53

33:53

Join us for an insightful conversation with Dr. Nadav Ahituv, a leader in human genetics and gene regulation at UCSF. He shares his personal journey from scoliosis patient to genetic researcher, exploring the mysteries of non-coding DNA, massively parallel reporter assays, and CRISPR-based therapeutic innovations. We dive into his lab’s diverse pro…

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#59 - SSD Interviews Dr. Thomas Dayspring | Exploring Lipid Science | Cardiovascular Risk 1:15:15

4M ago1:15:15

1:15:15

Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Thomas Dayspring, a renowned expert in clinical lipidology and a leading educator in cardiovascular risk assessment. With over 37 years of medical practice and decades of experience consulting on complex lipid disorders, Dr. Dayspring has been at the forefront…

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143: Bioprocess Breakthroughs: How Smart Bioprocessing Is Democratizing Life-Saving Treatments 15:32

4M ago15:32

15:32

In the rapidly evolving world of biotechnology, innovation is not just happening at the molecular level. Industry leaders are making groundbreaking advancements in bioprocessing - a crucial component in making life-saving therapies more accessible and affordable. The journey to affordable therapies starts with the production process itself. In this…