Speed-to-data determines go-to-market success for medical devices. You need to inform critical decisions with user data, technical demonstration data, and clinical data. We interview med tech leaders about the critical data-driven decisions they make during their product development projects.
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Assays Podcasts
A podcast highlighting key articles in the current issue of Emerging Infectious Diseases, a journal from the Centers for Disease Control and Prevention (CDC).
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Analytical Chemistry is a peer-reviewed research journal that explores the latest concepts in analytical measurements and the best new ways to increase accuracy, selectivity, sensitivity, and reproducibility.
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Taking the epic conflicts of the French Revolutionary and Napoleonic Wars three months at a time. Each episode features interviews with leading historians of the period - covering the campaigns, diplomacy and political dramas of an extraordinary 24 years.
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A podcast from the Shakespeare and Music Study Group, hosted by Michael Graham and Michelle Assay. Interviews with academics, composers, performers, directors and more, about the wonderful world of Shakespeare and music. Website: shakespeareandmusic.wordpress.com; Twitter: @shakesmus
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Who was Napoleon Bonaparte? What was his legacy on history? And why, more than 200 years later, does the conflict which he gave his name to still matter? Join award-winning Napoleonic historians Dr Zack White, Dr Luke Reynolds, Liam Telfer and Josh Redden as they host Europe's leading show devoted to the American War of Independence, French Revolution and Napoleonic Wars. From interviews with leading researchers, to deep dive debates on some of the big questions, this show is ideal for those ...
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This free monthly podcast is offered by Clinical Chemistry. Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today's clinical laboratory.
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A Mayo Clinic curated podcast sharing Mayo Clinic knowledge and advancements on the state of testing, science, and people who are making it happen behind the scenes.
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The Blood Podcast summarizes content recently published in Blood, the most cited peer-reviewed publication in the field of hematology.
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Speaking of Mol Bio, a podcast series from Thermo Fisher Scientific, discusses trending applications in science and the molecular biology aspects of those applications. Our host delves in to deep discussion with CEOs, R&D scientists, researchers, and key opinion leaders across the globe. Speaking of Mol Bio helps scientific curious people - from all scientific and non-scientific backgrounds - understand how modern molecular biology applications can help push the boundaries in medicine, scien ...
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Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.
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News Releases from the TSX Venture Exchange
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Hello everyone, NerdRx podcast brings you a new scientific technique every week. I will invite scientists from various backgrounds and discuss their favorite lab techniques. Stay tuned every Tuesday for a new episode. If you have any topic suggestions or if you would like to join me for an episode please email me at [email protected]
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We invite you to "get behind the science" with SLAS Technology Editorial Board Member and Podcast Editor Dave Pechter, M.S.M.E. (PerkinElmer, Cambridge, MA) and hear from our featured SLAS Technology authors! This podcast series is a chance for readers to meet the people behind the journal science and hear directly from them about their work, their motivations, as well as the context and potential impact of their work. Watch for a new featured author interview with each published issue!
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The Listen In podcast from Bitesize Bio is a compilation of our best webinars to enjoy at your leisure, wherever and whenever. Each episode is an opportunity to gain the valuable insights you need to advance your research. From a crash course in developing fool-proof ELISAs to the latest applications and innovations in CRISPR/Cas9 and microscopy techniques, and much more—you'll hear about challenges encountered and discover practical solutions to achieve the best possible results. Tap into t ...
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Winnoz actively connecting domain experts and various players who share the same vision and currently working in the decentralized healthcare or biosensing space through our regular live webinars and discussions. We endeavor to share the latest developments in the field and create value for you, our business partners and our clients, and to create awareness and business opportunities to accelerate the development of the decentralized healthcare ecosystem. To know more about Winnoz Technology ...
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Welcome to Basics to Brilliance, the podcast created to supplement & bolster your knowledge of Haematology. Featuring a two way, non-didactic conversational-style Q&A between the SpR and SHO, this podcast will be your pocket companion no matter where you are. We aim to cover: - Malignant and non-malignant topics - Science/lab detail - UK guidelines, hallmark trials and how these translate into clinical practice - Future research directions - The whole syllabus for FRCPath part 1 All readily ...
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The Parkinson’s Research Podcast: New Discoveries in Neuroscience
The Michael J. Fox Foundation for Parkinson’s Research
In this podcast, The Michael J. Fox Foundation for Parkinson’s Research brings you right to the cutting edge of neuroscience to discuss the latest discoveries in the field of neuroscience, with a focus on Parkinson’s disease (PD). We are working at the forefront of PD research to accelerate scientific breakthroughs by providing funding opportunities, tools and resources to develop new treatments, find cures and improve quality of life for people living with Parkinson’s disease. If you’re a s ...
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145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD
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16:59️ Episode 145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD In this episode of PaperCast Base by Base, we explore a study that validates a next-generation sequencing-based highly sensitive microsatellite instability (hs-MSI) assay for the diagnosis of constitutional mismatch repair deficiency (CMMR…
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The Battle of Assaye has been called Arthur Wellesley’s first great victory, a clash that set the stage for his later fame as the Duke of Wellington. Outnumbered six to one by the mighty Maratha Confederacy, Wellesley’s 6,500 men faced a storm of cannon fire, disciplined infantry, and thousands of cavalry in a battle that could easily have ended in…
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144: Revised time estimation of the ancestral human chromosome 2 fusion
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17:10️ Episode 144: Revised time estimation of the ancestral human chromosome 2 fusion In this episode of PaperCast Base by Base, we explore a study that revisits one of the most defining events in human evolution: the fusion that gave rise to chromosome 2. This work refines previous estimates and provides a clearer timeline for when this pivotal genomi…
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143: The genetic history of the Southern Caucasus: 5,000 years of continuity despite high mobility
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18:56️ Episode 143: The genetic history of the Southern Caucasus: 5,000 years of continuity despite high mobility In this episode of PaperCast Base by Base, we explore a comprehensive archaeogenomic study tracing 230 ancient individuals from Georgia and Armenia over 5,000 years, from the Bronze Age to the Early Middle Ages. The research investigates how…
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142: Specifications of the ACMG/AMP Guidelines for PALB2 Variant Interpretation
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16:35️ Episode 142: Specifications of the ACMG/AMP Guidelines for PALB2 Variant Interpretation In this episode of PaperCast Base by Base, we explore how the Hereditary Breast, Ovarian, and Pancreatic Cancer Variant Curation Expert Panel (HBOP VCEP) developed gene-specific ACMG/AMP guidelines for the interpretation of PALB2 germline sequence variants, a …
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Review Series on Acute Lymphoblastic Leukemia (ALL)
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12:38In this Review Series episode, Associate Editor Dr. Hervé Dombret speaks with Dr. Mark Litzow about the latest immunotherapy advances for Acute Lymphoblastic Leukemia (ALL). The discussion highlights innovative treatments like blinatumomab and inotuzumab, which are showing remarkable success in clinical trials, including an 85% three-year survival …
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Azacitidine holds promise in VEXAS syndrome; a step forward in precision blood matching; identifying a new vulnerability in TP53-mutated AML
18:58
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18:58In this week's episode we'll learn about Azacitidine in VEXAS syndrome. Treatment can provide responses in patients with this complex autoinflammatory disorder. But relapse rates were high, so long-term therapy may be required to maintain disease control. After that: A step forward in precision blood matching. High-throughput array genotyping enabl…
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141: RetiGene, a comprehensive gene atlas for inherited retinal diseases
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26:12️ Episode 141: RetiGene, a comprehensive gene atlas for inherited retinal diseases In this episode of PaperCast Base by Base, we explore RetiGene, an expert-curated resource that consolidates genetic, transcriptomic, and functional information on inherited retinal diseases (IRDs). The study highlights the urgent need for a unified gene catalog to g…
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140: Landscapes of missense variant impact for human superoxide dismutase 1
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20:18️ Episode 140: Landscapes of missense variant impact for human superoxide dismutase 1 In this episode of PaperCast Base by Base, we explore a large-scale functional analysis of missense variants in SOD1, a key gene implicated in amyotrophic lateral sclerosis (ALS). The study addresses the challenge of classifying variants of uncertain significance …
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139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data
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14:03️ Episode 139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data In this episode of PaperCast Base by Base, we explore the development of MosCoverY, a computational method designed to detect and quantify mosaic loss of the Y chromosome (mLOY) from exome and whole-genome sequencing data. This condition, th…
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138: Social exposome and brain health outcomes of dementia across Latin America
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19:43️ Episode 138: Social exposome and brain health outcomes of dementia across Latin America In this episode of PaperCast Base by Base, we explore how a multidimensional social exposome across the lifespan—covering education, food insecurity, financial status, assets, access to healthcare, childhood labor, subjective socioeconomic status, childhood ex…
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Ready to blast through the walls of Napoleonic history? In this pounding episode of the Napoleonic Wars Podcast, we talk to Dr Zack White about his edited collection An Unavoidable Evil - Siege Warfare in the Age of Napoleon. Discover how the era of Napoleon wasn't all about Austerlitz and Waterloo; from the fortresses of Izmail and Braila to Welli…
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137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
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25:11️ Episode 137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views In this episode of PaperCast Base by Base, we explore how a sweeping expansion of the RNA-binding proteome has reframed long‑held assumptions about RNA–protein interactions, spotlighting ‘non‑canonical’ RBPs and the emerging concept of riboregulation—RNA dire…
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136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance
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14:48️ Episode 136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance In this episode of PaperCast Base by Base, we explore RECODR, a graph‑embedding pipeline that reads single‑cell and single‑nucleus transcriptomes as co‑expression networks to quantify “gene context drift” during therapy and expose druggable vulnerabili…
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From Toulon to the Nile: Rival fleets and the struggle for Mediterranean supremacy
57:25
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57:25Bernie Campbell is joined by Rachel Blackman-Rogers of King's College London and Olivier Aranda of the University of Western Brittany to discuss naval strategy in the Mediterranean theatre in the 1790s, with a particular emphasis on the Battle of the Nile. The episode explores the strategic importance of the Mediterranean for both France and Britai…
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135: Global impact of micronutrients in modern human evolution
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14:26️ Episode 135: Global impact of micronutrients in modern human evolution In this episode of PaperCast Base by Base, we explore how dietary micronutrients have influenced modern human evolution. The study investigates the role of essential minerals in shaping genetic adaptation and highlights the health risks posed by imbalances in micronutrient ava…
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Utilizing the Stability of Individual Homeostatic Setpoints over Time - A Step Forward on the Path to Personalized Laboratory Medicine
11:08
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11:08By Aasne Aarsand
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Diffuse large B-cell lymphoma’s long-term effects on immune profiles, plasminogen activation and prevention of venous thromboembolism, and PARP inhibitors in hematological malignancies carrying epigenetic ...
18:31
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18:31In this week's episode we'll learn about persistent changes in immune profiles in patients who have had diffuse large B-cell lymphoma, or DLBCL, and other cancers; that plasminogen activation and plasmin activity do not appear to play a role in routine physiological prevention of venous thromboembolism, or VTE; and about a novel mechanism that make…
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134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk
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15:47️ Episode 134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk In this episode of PaperCast Base by Base, we explore how single-cell RNA sequencing of Barrett’s esophagus (BE), esophageal adenocarcinoma (EAC), and matched normal tissues reveals which cell types carry germline-linked risk and shape progression toward ca…
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Flesh-Eating Organisms Making the News: Bill Morice, M.D., Ph.D.
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15:44Published September 11, 2025 In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, and William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, discuss troublesome organisms making headlines. Together, they explore: Vibrio vulnificus (01:09): How peopl…
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Advances in Syphilis Diagnostics to Address the 21st-Century Epidemic
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17:13By Joshua A Lieberman
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133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth
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24:31️ Episode 133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth In this episode of PaperCast Base by Base, we explore how long‑read metagenomics enables recovery of complete metagenome‑assembled genomes directly from fecal samples of Malawian toddlers and applies meta‑pangenomics and microbial GWAS to connect microbial …
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In this episode of Speaking of Mol Bio, host Steve Lewis speaks with Dr. Melissa Wu, co-founder and CEO of Seeding Labs, a nonprofit that’s redefining global scientific access. Dr. Wu shares the inspiring story of how Seeding Labs helps institutions in developing nations build research infrastructure by redistributing surplus laboratory equipment f…
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132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer
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20:35️ Episode 132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer In this episode of PaperCast Base by Base, we explore how transcriptome-wide RNA expression classifiers from advanced prostate cancers can inform treatment selection and improve patient outcomes. Study Highlights: Researchers analyzed tumor tran…
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131: pBI143: The Human Gut’s Hidden Heavyweight
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17:59️ Episode 131: pBI143: The Human Gut’s Hidden Heavyweight In this episode of PaperCast Base by Base, we explore how a tiny 2.7 kb cryptic plasmid, pBI143, emerges as one of the most numerous genetic elements in industrialized human gut microbiomes, mobilizes across Bacteroidales, persists as monoclonal lineages with vertical transmission, and incre…
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130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution
20:24
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20:24️ Episode 130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution In this episode of PaperCast Base by Base, we explore a large-scale study that integrates genetic association testing with functional CRISPR experiments in human adipocytes to uncover mechanisms influencing obesity …
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Bread, Boots and Bullets - Logistics of the British Army
1:10:50
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1:10:50Have you ever wondered how Britain’s redcoats marched across Europe with full bellies, coin in their pockets, and plenty of ammunition? In this episode, award winning historian Professor Kevin Linch returns to our British Army series to help us break down the gritty reality of military logistics behind the lines. We explore what was in a soldier's …
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129: Structural variation and diversification of the NPIP gene family from the human pangenome
22:11
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22:11️ Episode 129: Structural variation and diversification of the NPIP gene family from the human pangenome In this episode of PaperCast Base by Base, we explore how long-read sequencing technologies reveal the structural variation, evolutionary pressures, and expression patterns of the NPIP gene family, one of the most positively selected gene famili…
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128: LINE‑1 Promoters Orchestrate Early Human Brain Development
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15:26️ Episode 128: LINE‑1 Promoters Orchestrate Early Human Brain Development In this episode of PaperCast Base by Base, we explore how evolutionarily young LINE‑1 retrotransposons are actively expressed in human induced pluripotent stem cells and function as cis‑acting promoters that shape primate‑ and human‑specific transcript isoforms during early n…
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“Ironing out” Tet2-mutant HSPCs; A CAR-T “license to kill” in T cell leukemia/lymphoma; insights on cHL genetics, through the lens of ctDNA
20:43
20:43
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20:43In this week's episode, we'll learn about how TET2 is often mutated in myeloid malignancies and clonal hematopoiesis. In new work, expansion of Tet2-mutant HSPCs was dependent on Ncoa4, the cargo receptor mediating ferritinophagy. We’ll iron out the implications. After that: a double-oh-seven license to kill in T-cell leukemia/lymphoma. WU-CART-007…
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Machine Learning for Detecting Iron Deficiency through Comprehensive Blood Analysis
8:53
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8:53By Yu-Hsin Chang
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127: In silico generation of synthetic cancer genomes using generative AI
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17:36️ Episode 127: In silico generation of synthetic cancer genomes using generative AI In this episode of PaperCast Base by Base, we explore OncoGAN, a generative AI pipeline designed to produce highly realistic synthetic cancer genomes. The study addresses the challenge of limited access to real cancer genomes due to privacy concerns by creating shar…
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Yes, it's the planning meeting once again - this is the third go in our festival of bureaucracy, the critical discussion which sees us sort out what each of our main episodes should include as topics for their three segments. The years 1804 and 1805 are exciting times for the podcast, as we actually hit the Napoleonic Wars proper. All roads lead to…
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126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models
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20:59️ Episode 126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models In this episode of PaperCast Base by Base, we explore a study that investigates the molecular and developmental mechanisms underlying Smith-Magenis syndrome (SMS) using human induced pluripotent stem cell (hiPSC)-derived cort…
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125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities
22:46
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22:46️ Episode 125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities In this episode of PaperCast Base by Base, we explore how the Global Parkinson’s Genetics Program (GP2) is addressing the critical lack of diversity in Parkinson’s disease genetics research. The article outlines the p…
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Whole Exome Sequencing Reflex Test Offers Cost-Effective Diagnosis: Cherisse Marcou, Ph.D., and Kristen Rasmussen, M.S., CGC
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22:13Cherisse Marcou, Ph.D., and Kristen Rasmussen, M.S., CGC, explain how Mayo Clinic Laboratories' WESPR whole exome sequencing reflex test provides cost-effective diagnosis of complex genetic conditions. Using samples and data from previous targeted gene panels, WESPR's wider net can identify undetected genetic variants. (00:32) Would each of you sha…
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124: Exploring the Omnigenic Architecture of Selected Complex Traits
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23:47️ Episode 124: Exploring the Omnigenic Architecture of Selected Complex Traits In this episode of PaperCast Base by Base, we explore how researchers are uncovering the organizational principles behind complex traits through the lens of the omnigenic model. The study focuses on ulcerative colitis as a case example and investigates how core and perip…
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123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease
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18:12️ Episode 123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease In this episode of PaperCast Base by Base, we explore how de novo heterozygous ATP5F1A missense variants disrupt mitochondrial ATP synthase and manifest as pediatric neurological disorders, revealing a dominant‑negative mechanism and an isolated Comp…
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Why did Britain break its mould with the Waterloo medal? Were medals really that rare? And why do they matter? Expert auctioneer Robert Wilde-Evans joins Luke and Zack to discuss how you tell the real ones from the fakes, and what a Waterloo medal really represents. We discuss how they highlight a shift in attitudes to how the British soldier is vi…
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122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences
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19:57️ Episode 122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences In this episode of PaperCast Base by Base, we explore a study that investigates the molecular underpinnings of why certain diseases tend to co-occur. By using large-scale RNA sequencing data, the authors present a novel approach to identify disease co-occurr…
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121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma
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19:02️ Episode 121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma In this episode of PaperCast Base by Base, we explore how DNA secondary structures called G-quadruplexes (G4s) contribute to genome instability and tumor development in BRCA2-deficient cerebellar granule cell progenitors, leadi…
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Targeting NPM1 in AML with a menin inhibitor; in primates, a CD137 ADC eliminates acute GVHD
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15:10In this week's episode we'll learn about targeting NPM1 in acute myeloid leukemia. Researchers report the first clinical evidence of a menin inhibitor inducing complete remissions in AML with a NPM1 mutation. This validates NPM1 as a new therapeutic target in AML, alongside FLT3, IDH1/2, and KMT2A. Also on the podcast: targeting CD137 to prevent gr…
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How I Treat Series on Iron Overload in Hematologic Disorders
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34:17Blood Editor, Dr. Thomas Coates interviews Dr. Emanuele Angelucci on his paper, "How I manage iron overload in the hematopoietic cell transplantation setting" which is featured in Blood's "How I Treat Series on Iron Overload in Hematologic Disorders". See the full How I Treat series in volume 145 issue 4 of Blood.…
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120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment
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22:30️Episode 120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment In this episode of PaperCast Base by Base, we explore how ultrarare heterozygous variants in BMAL1—a core circadian clock gene—are associated with a neurodevelopmental syndrome featuring developmental delay, autism spectrum disorder, and musculoskeletal findings. Study H…
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Rabbits, Chikungunya, and More Viral News: Matthew Binnicker, Ph.D.
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21:21Published August 28, 2025 In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, and Matthew Binnicker, Ph.D., a microbiologist and virologist and chief scientific officer of Mayo Clinic Laboratories, discuss recent developments in viral infections. Together, they explore: S…
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119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells
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18:35️ Episode 119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells In this episode of PaperCast Base by Base, we explore how stabilizing G‑quadruplex DNA structures with small molecules reshapes genome stability in B lymphocytes, revealing fragile hotspots in pericentromeric repeats and ribosomal DNA and exposing checkpoint-de…
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Toward Improved Prostate Cancer Screening: Insights from the Göteborg-2 Trial
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24:52By Hans Lilja
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118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B
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19:11️ Episode 118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B In this episode of PaperCast Base by Base, we explore how cancer cells co-opt a primate-specific KRAB zinc finger protein, ZNF93, to fine-tune the mutagenic enzyme APOBEC3B and manage replication stress. Study Highlights: Using genome-wide KZ…
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117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection
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16:00️ Episode 117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection In this episode of PaperCast Base by Base, we explore how viral infection couples RNA polymerase III transcription with mRNA-like 3′ end processing to stabilize noncoding retrotransposon RNAs, revealing a conserved mechanism that boosts SINE RNA abundance dur…
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