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“Got Knowledge Doc” Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Eac ...
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🧬 A new epigenetic clock predicts your functional age — not just birthdays! 🕰️ Built from 91 CpGs, the IC Clock outperforms GrimAge & others at predicting mortality 💪 Linked to T-cell health, 🫁 lung function & 🐟 omega-3 intake 📖 Nature Aging: https://doi.org/10.1038/s43587-025-00883-5 #Aging #Epigenetics #Longevity #Immunosenescence Doximity…
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🥜 Daily almonds = big wins for metabolic health! ✅ ↓ LDL & total cholesterol ✅ ↑ Vitamin E (α-tocopherol) ✅ ↓ Gut inflammation (calprotectin, MPO) ❌ No change in systemic inflammation or weight Crunch wisely, live heart-smart! ❤️🧠 #Nutrition #MetabolicSyndrome #RCT #Almonds #GutHealthBy MasterMedFacts LLC
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🥗 New study in Nature Food: Greater diversity of flavonoid intake—not just quantity—linked to ↓ risk of death, diabetes, heart disease & more 🌈🍇🍵 Eat the rainbow daily: apples, tea, berries, citrus, greens = longevity boost 💪🧬 #Nutrition #Longevity #FlavonoidsBy www.MasterMedFacts.com
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Marcus Aurelius (121–180 CE), a Roman emperor and prominent Stoic philosopher, ruled from 161 to 180 CE. As the last of the Five Good Emperors, his reign marked the end of the Pax Romana, a period of relative peace in the Roman Empire. Known for his military campaigns against Parthians and Germanic tribes, he also endured the devastating Antonine P…
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🩸 New JCI study reveals how RBC-derived EVs 🧬 in #Type2Diabetes sneak into endothelial cells 🧫, delivering arginase-1 & sparking oxidative stress 🔥—a hidden cause of vascular dysfunction. Blocking EV uptake = 💡 new therapy? 📖 https://doi.org/10.1172/JCI180900 #CardioTwitter #Diabetes #VascularBiology…
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Big shift in Alzheimer’s care! We can now predict it years in advance using 🩸 biomarkers like p-tau217, 🧬 genetic risk, & 🤖 AI-analyzed retina scans. Prevention = lifestyle 🥦🏃‍♂️💤, vaccines 💉, & maybe GLP-1s 💊. Why wait to treat when you can PREVENT? 🔍 #Alzheimers #PrecisionMedicine #AIBy MasterMedFacts LLC
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🧬 Did you know your blood cell metabolism could fuel heart disease? 🔁 Disrupted haematometabolism = more inflammation, less cleanup 🧹 Efferocytosis fails → plaques grow 🧠 Aging + CHIP mutations = 🔥 risk 🥗 Fix it with fasting, fitness & future therapies! #CardioTwitter #MedEd #Haematometabolism ❤️By MasterMedFacts LLC
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🧬 The microbiome is medicine’s next frontier! From Fecal Transplants 💩 to probiotics 🦠, diagnostics 🔍 to designer bugs 🧪—we’re decoding disease, predicting treatment, and redefining care. But challenges remain. 🎙️ Dive into the FAQs with Got Knowledge Doc! #Microbiome #GutHealth #MedTwitter 🚀By MasterMedFacts LLC
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🏌️‍♂️⛳ Living near golf courses may increase Parkinson’s risk! 📊 Case-control study: Risk highest within 1–3 miles 💧 Contaminated groundwater & pesticides likely culprits 🧠 aOR up to 2.98 for 6 miles! 📉 Risk ↓ 13% per mile after 3 miles 🔗 [JAMA 2025] #Neurology #Parkinsons #EnvironmentalHealth #GolfRisk @doximity…
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🚨 BREAKING: Sotatercept cuts risk by 76% in advanced #PAH! 💉 Targets activin signaling 🫁 Fewer deaths, transplants & hospitalizations 📉 HR 0.24 | Trial stopped early for efficacy ⚠️ Epistaxis, ↑Hgb, telangiectasia noted 🔬 A new era in pulmonary hypertension care! #ZENITHTrial #CardioTwitter 🫀📊 @doximity…
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🚨New COPD diagnosis alert!🫁 A multidimensional schema using CT 🖼️ + symptoms 😮‍💨 + spirometry 📉 identified high-risk patients missed by GOLD! 📈↑Mortality (HR 1.98) 📉FEV1 decline (–7.7 mL/y) 📊 Reclassified 15% w/o obstruction as COPD! 👉CT matters. #PulmTwitter #COPD #MedTwitter @doximityBy MasterMedFacts LLC
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🚨 New data! In the KARDIA-2 trial, 🧬 zilebesiran—an RNAi therapeutic—cut SBP by up to 12 mmHg when added to common antihypertensives 💊. One shot, 6 months of BP control! 📉 Promising for poor adherence. Mild AEs. #Hypertension #Cardiology #RNAi 🌍【JAMA 2025】By MasterMedFacts LLC
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🧬 Big win for longevity! A Nature Aging study shows that combining 💊 trametinib + rapamycin extends lifespan, reduces tumors, and tames inflammation in mice 🐭🔥 Dual geroprotectors = additive benefits without added toxicity 🛡️🕰️ Future of anti-aging? Watch this space 👀 #Aging #Longevity #Geroprotectors #Science 🧪 @doximity…
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🧠💉 New Lancet study (OPTIMISTmain) shows low-intensity monitoring after thrombolysis in mild strokes may be just as safe as standard care! 💤 Less sleep disruption, 🧑‍⚕️ lighter nursing load, ⚖️ similar outcomes. Could this change global stroke care? 🌍🏥 #Stroke #Thrombolysis #OPTIMISTmain #NeurologyBy MasterMedFacts LLC
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🚨New A2B Trial in JAMA! Can 🧪dexmedetomidine or clonidine beat 💉propofol in sedating ICU patients on ventilators? ❌ No faster extubation ⚠️ More bradycardia & agitation ⚖️ Similar mortality Verdict: No clear winner—tailor sedation to patient needs 🛌👨‍⚕️ #CriticalCare #ICU #SedationTrialBy MasterMedFacts LLC
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🚨🧠 BREAKING: Tenecteplase before thrombectomy boosts chances of stroke recovery! 💉 Faster reperfusion 📈 Higher functional independence (mRS 0–2 at 90d: 52.9% vs 44.1%) ⚠️ Slight ↑ in sICH, but no major safety red flags 🧪 #BRIDGE_TNK trial rewrites the stroke playbook! #Stroke #Tenecteplase #NeuroTwitter…
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Nāgārjuna (c. 150 – c. 250 CE) was an Indian Buddhist monk and philosopher, regarded as the founder of the Madhyamaka (Middle Way) school of Mahāyāna Buddhism. His most famous work, Mūlamadhyamakakārikā (Root Verses on the Middle Way), presents the concept of śūnyatā (emptiness) and the two truths doctrine, emphasizing dependent origination and rej…
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📢 New RCT in Nature Medicine 🎯 Can zapping low-voltage areas (LVAs) reduce AF recurrence after PVI? 🔬 SUPPRESS-AF Trial 👥 342 pts with persistent AF 📉 1-yr AF/AT-free: 61% (PVI+LVA) vs 50% (PVI) ❌ Not statistically significant 🧠 Subgroup benefit in high-risk pts #EPeeps #AFib #CardioTwitter 🫀By MasterMedFacts LLC
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🧠💪 Can blood biomarkers of Alzheimer’s predict who’ll lose muscle strength with age? In a 12-year study, higher p-tau, NfL & GFAP levels forecasted faster decline in grip & leg power — even before dementia onset. 🧬🪑✊ #Aging #Alzheimers #Sarcopenia #Biomarkers #LongevityBy MasterMedFacts LLC
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📉 New JAMA study tracks U.S. #SedentaryBehavior from 2013–2023: 🪑 Sitting time fell from 7.1 to 5.9 hrs/day pre-COVID 🦠 But plateaued post-pandemic at 6.0 hrs/day 🚶‍♀️ Progress stalled—time to get moving again! #PublicHealth #NHANES #PhysicalActivity 🏃‍♂️📊🛋️By MasterMedFacts LLC
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🐒 New study finds no disorganized attachment in wild chimpanzees! 🧠 Only secure & avoidant types observed—just like humans, but without the trauma. 🌿 Evolution favors calm, connected bonds. 📍Taï National Park, Côte d’Ivoire 🔗 Nature knows best. #PrimateScience #AttachmentTheory #Chimpanzees
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🌶️ Not all chili heat is created equal! Scientists found hidden compounds—like capsianoside I & roseoside—that cool the burn without changing flavor 🔬❄️ Your next spicy dish might be hot… but not hurt. #FlavorScience #Capsaicin #TRPV1 #FoodTech 🍽️🧠🔥By MasterMedFacts LLC
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🩺 New hope for #ResistantHypertension! A 12-week RCT 🇰🇷 shows 💊 amiloride is noninferior to spironolactone in lowering SBP 📉 Fewer side effects, similar BP drop! But spironolactone may still reign 👑 for organ protection 🫀🧠 🧪 #Hypertension #Cardiology #JAMA2025By MasterMedFacts LLC
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🧬✨ A baby with deadly CPS1 deficiency (which results in elevated ammonia levels) gets a custom-made gene edit—delivered by lipid nanoparticles—in just 6 months! 🚀 Ammonia levels down, no hospitalizations, and hope up. N-of-1? More like Future-of-Many. 💡👶🔬 #GeneTherapy #PrecisionMedicine #RareDiseaseBy MasterMedFacts LLC
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Pyrrho of Elis (c. 360–270 BCE) was an ancient Greek philosopher and founder of Pyrrhonism, a school of philosophical skepticism. He advocated for epoché (suspension of judgment) as a path to ataraxia (peace of mind). Influenced by his travels to India with Alexander the Great, Pyrrho believed that nothing could be definitively known and that by re…
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🧔‍♂️ Prostate cancer is the most common cancer in US men. 🧪 PSA testing? 🔍 It’s all about shared decision-making. 🧬 From Gleason scores to PSMA-PET, precision reigns. 💉 ARPIs & ADT = survival gains in advanced disease. ⚖️ Screen smart. Treat right. Save lives. #ProstateCancer #MensHealth #Oncology 🧠💪…
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🚨 New frontier in lipid-lowering! 🧬 Blocking ANGPTL4 with MAR001 slashed triglycerides & remnant cholesterol by >50% 🛡️ Safe, well-tolerated, no lymph node issues 💡 Promising for residual ASCVD risk Next step? Big trials, big answers! 📊🫀 #LipidScience #CardioTwitter #PrecisionMedicineBy MasterMedFacts LLC
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🫀 Post-op AFib? Blame IL-6! New @JClinInvest study shows IL-6 ➡️ STAT3 ➡️ CaMKII ➡️ RyR2 leak triggers post-op AFib. 🧬 Macrophage IL-6Rα is the match. 🧯 TTI-101 & KN-93 douse the flame. ⚡ Targeting IL-6 signaling = future Rx? #CardioTwitter #AFib #Inflammation #JCIBy MasterMedFacts LLC
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🧠🫀🧫 New study in Nature Medicine shows that multiorgan MRI predicts both 💔 cardiovascular and 🩸 liver events. Cardiac (LVEF ≤50%) + Liver (cT1 ≥800ms) = 🚨 higher risk & earlier events. Integrated imaging = smarter prevention! 🔍📊 #Cardiology #Hepatology #MRI #MASLD #CVDBy MasterMedFacts LLC
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🧠💡 New Insights! The brain isn’t as “immune privileged” as once thought! 🌊🔄 Glymphatics & meningeal lymphatics reveal how the CNS clears waste & connects to immunity. 🦠 Aging & neurodegeneration challenge this balance. #Neuroscience #Immunology #BrainHealth 🧬🚀By MasterMedFacts LLC
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🌱💊 Unlocking the Power of Food! #NutritionDarkMatter holds 139,000+ molecules with therapeutic potential. 🍎 AI-driven research is paving the way for #PrecisionNutrition & innovative healthcare solutions! 🌟 #FoodAsMedicine #HealthRevolution 🚀By MasterMedFacts LLC
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Zeno of Citium (c. 334 – c. 262 BC) was a Hellenistic philosopher from Cyprus and the founder of Stoicism. His philosophy emphasized living in harmony with nature and practicing virtue to attain peace of mind (ataraxia). Zeno’s teachings influenced ethics, logic, and natural philosophy, laying the foundation for Stoicism’s prominence during the Rom…
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🚀 Tirzepatide Triumphs! 💪 In a head-to-head trial, #Tirzepatide led to greater weight loss (-20.2%) compared to #Semaglutide (-13.7%) over 72 weeks! 📉🌟 Superior waist reduction too! #ObesityManagement #WeightLoss #GLP1 #GIP 🩺💊 #CardiometabolicHealth #ClinicalResearchBy MasterMedFacts LLC
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