How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
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EP 213: Inside the science of hearing loss and gene therapy for deafness with Ellen Reisinger of the University of Tübingen
Manage episode 519228805 series 2631947
Content provided by Sano Genetics. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Sano Genetics or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
This week on The Genetics Podcast, Patrick is joined by Dr. Ellen Reisinger, Professor and group leader at the University of Tübingen. They discuss her journey into hearing loss research, why otoferlin has become a leading target for gene therapy, and the emerging science shaping the next generation of treatments.
Show Notes:
0:00 Intro to The Genetics Podcast
00:59 Welcome to Ellen
01:52 Ellen’s career path that coincidentally led to her work on otoferlin-related hearing loss
03:22 Mechanism and advantages of the dual adenoassociated virus (AAV) system
05:35 The genetic landscape of early-onset hearing loss and why otoferlin stands out
07:42 Why otoferlin-related deafness is an ideal target for postnatal gene therapy development
09:53 Potential next gene therapy targets beyond otoferlin and associated challenges
13:13 Carrier and newborn screening as approaches to preventing hereditary hearing loss
14:37 How far the field is from prenatal gene therapy and why it remains unlikely in the near term
16:07 Exploring gene-agnostic and protective approaches to prevent or slow hearing loss
18:22 How genetics and environment interact in age-related hearing loss
20:00 Current research focus of Ellen’s group on degenerative hearing loss genes and uncovering cell death mechanisms
22:05 Using mouse models and human organoids to study hearing loss mechanisms
23:42 Emerging gene editing approaches
25:20 Ellen’s research journey from biochemistry to leading gene therapy research in hearing loss
27:54 Unanswered questions about how inner hair cells release neurotransmitters
29:21 Comparing outcomes of gene therapy and cochlear implants for hearing restoration and differences across languages
34:20 Closing remarks
Please consider rating and reviewing us on your chosen podcast listening platform!
https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link
216 episodes
Share
Manage episode 519228805 series 2631947
Content provided by Sano Genetics. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Sano Genetics or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
This week on The Genetics Podcast, Patrick is joined by Dr. Ellen Reisinger, Professor and group leader at the University of Tübingen. They discuss her journey into hearing loss research, why otoferlin has become a leading target for gene therapy, and the emerging science shaping the next generation of treatments.
Show Notes:
0:00 Intro to The Genetics Podcast
00:59 Welcome to Ellen
01:52 Ellen’s career path that coincidentally led to her work on otoferlin-related hearing loss
03:22 Mechanism and advantages of the dual adenoassociated virus (AAV) system
05:35 The genetic landscape of early-onset hearing loss and why otoferlin stands out
07:42 Why otoferlin-related deafness is an ideal target for postnatal gene therapy development
09:53 Potential next gene therapy targets beyond otoferlin and associated challenges
13:13 Carrier and newborn screening as approaches to preventing hereditary hearing loss
14:37 How far the field is from prenatal gene therapy and why it remains unlikely in the near term
16:07 Exploring gene-agnostic and protective approaches to prevent or slow hearing loss
18:22 How genetics and environment interact in age-related hearing loss
20:00 Current research focus of Ellen’s group on degenerative hearing loss genes and uncovering cell death mechanisms
22:05 Using mouse models and human organoids to study hearing loss mechanisms
23:42 Emerging gene editing approaches
25:20 Ellen’s research journey from biochemistry to leading gene therapy research in hearing loss
27:54 Unanswered questions about how inner hair cells release neurotransmitters
29:21 Comparing outcomes of gene therapy and cochlear implants for hearing restoration and differences across languages
34:20 Closing remarks
Please consider rating and reviewing us on your chosen podcast listening platform!
https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link
216 episodes
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Similar to The Genetics Podcast
How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
…
continue reading
A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vineeta Agarwala, Julie Yoo, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg Verdine, Fei-Fei Li, and Suchi Saria, as they explore the i ...
…
continue reading
Whether the topic is popcorn or particle physics, you can count on BrainStuff to explore -- and explain -- the everyday science in the world around us.
…
continue reading
I discuss a variety of topics in both the natural and social sciences, exploring the many fascinating insights that the scientific method yields about the world around us.
…
continue reading
The Science Show gives Australians unique insights into the latest scientific research and debate, from the physics of cricket to prime ministerial biorhythms.
…
continue reading
The kickass science and technology radio show that delivers an irreverent look at the week in science and technology.
…
continue reading
When you hear the words Alzheimer's disease, what do you think of? The truth is, the picture most of us have of the disease is incomplete. Alzheimer's disease doesn't start when someone starts to lose their memory. It actually starts years – sometimes decades – earlier. The Rethinking Alzheimer's Disease Podcast is an engaging, narrative-style podcast miniseries for those curious or motivated to learn about Alzheimer’s disease. Perhaps you have a family member with Alzheimer’s disease, or ca ...
…
continue reading
We take a critter’s eye view to explore how animal behavior parallels humans. Join comedians and science-lovers as we get inside the minds of animals
…
continue reading
DNA science. Artificial intelligence. Smartphones and 3D printers. Science and technology have transformed the world we live in. But how did we get here? It wasn’t by accident. Well, sometimes it was. It was also the result of hard work, teamwork, and competition. And incredibly surprising moments. Hosted by bestselling author Steven Johnson (“How We Got To Now”), American Innovations uses immersive scenes to tell the stories of the scientists, engineers, and ordinary people behind the great ...
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Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
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