ATX-304 | The AMPK Activator That Mimics Exercise

The Hunter Williams Podcast

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14d ago 29:53

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In this video, I break down ATX-304 (also known as OS-01 or OS-03) — a powerful small molecule AMPK activator being studied for fat loss, metabolic health, and longevity. If you’ve heard ATX-304 described as “exercise in a capsule,” you’ll see why after going through the research, mechanisms, human trials, and potential applications.

I also share how ATX-304 works differently than GLP-1s, why it preserves muscle while supporting fat loss, and what the future may hold for this compound in anti-aging medicine.

👉 Don’t forget to download the Peptide Cheat Sheet linked below and join my email list for updates on cutting-edge research compounds.

⏱️ Timestamps

0:00 – Intro & what ATX-304 is

0:27 – Why it’s also called OS-01/OS-03

1:06 – Clearing up confusion with skincare OS-01

1:21 – Background & how I discovered ATX-304

2:15 – Why early adoption is expensive & my mission to lower costs

3:00 – What makes ATX-304 different from other mitochondrial supplements

3:14 – Mechanisms, animal trials, human data & dosage overview

4:13 – Discovery & development background (Sweden to Cambrian Biotech)

5:07 – Phase 2 trials in type 2 diabetes (glucose & vascular effects)

6:00 – AMPK explained in simple terms

7:11 – Mechanism of action: preventing dephosphorylation

8:34 – ATX-304 as a dual AMPK + mitochondrial activator

9:34 – Effects on glucose metabolism & insulin sensitivity

10:24 – Why fasting insulin improvements matter

10:42 – Lipid metabolism, fatty liver benefits & cholesterol reduction

12:15 – Fat mass reduction with muscle preservation

13:00 – Why this matters for body composition vs. GLP-1s

14:04 – Cellular stress response & autophagy benefits

15:00 – Vascular and cardiac improvements

16:16 – Diabetes studies: preventing disease progression

17:18 – Anti-aging effects in mice (exercise capacity & insulin sensitivity)

18:02 – Liver protection benefits

18:25 – Kidney protection against toxic injury

19:12 – Vascular disease, aneurysm & neurodegeneration studies

20:06 – Preclinical evidence across multiple organ systems

20:10 – Human trial: 28-day study results

21:04 – Safety profile & side effect comparison to GLP-1s

22:00 – Clinical development & obesity trials

22:18 – Potential in combination with semaglutide

23:00 – Dosage ranges (100–1000mg) & cost considerations

24:14 – Why it reduces insulin burden & cardiovascular risk factors

25:00 – Sustainable fat loss & improved exercise capacity

26:44 – Vascular protection & fatty liver disease applications

27:25 – Neurodegeneration & concussion recovery potential

27:58 – Healthy aging & safety considerations

28:38 – Summary: exercise in a bottle & proven benefits

29:23 – Closing thoughts, gratitude & community message

386 episodes

#Fitness #Hunter Williams