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Episode 80: A Spatial Map of Pulmonary Fibrosis

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Manage episode 473550970 series 1936276
Content provided by TGen Talks. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by TGen Talks or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Pulmonary Fibrosis. A debilitating disease that restricts a person’s lung capacity, controllable with drug therapies, but it’s only “cure” is a double lung transplant. Researchers at TGen have released the results of a study that investigated the disease on a cellular level. Using advanced spatial transcriptomics, they identified hidden disease markers in seemingly healthy lung tissue—offering hope for earlier, more personalized treatments. Targeting these early disruptions could improve lung function and outcomes. With current PF treatments only slowing decline, this discovery, published in Nature Genetics, marks a step toward preventing irreversible damage. In this episode of TGen Talks, Nicholas Banovich, Ph.D., discusses the Nature Genetics finding and the new spatial map of gene expression in lung cells. Instead of blending tissue together and analyzing it, scientists can now examine individual cells and pinpoint where molecular changes happen. We’ll break down what this means, how it’s done, and why it could change the way we study lung disease.
  continue reading

85 episodes

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Manage episode 473550970 series 1936276
Content provided by TGen Talks. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by TGen Talks or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Pulmonary Fibrosis. A debilitating disease that restricts a person’s lung capacity, controllable with drug therapies, but it’s only “cure” is a double lung transplant. Researchers at TGen have released the results of a study that investigated the disease on a cellular level. Using advanced spatial transcriptomics, they identified hidden disease markers in seemingly healthy lung tissue—offering hope for earlier, more personalized treatments. Targeting these early disruptions could improve lung function and outcomes. With current PF treatments only slowing decline, this discovery, published in Nature Genetics, marks a step toward preventing irreversible damage. In this episode of TGen Talks, Nicholas Banovich, Ph.D., discusses the Nature Genetics finding and the new spatial map of gene expression in lung cells. Instead of blending tissue together and analyzing it, scientists can now examine individual cells and pinpoint where molecular changes happen. We’ll break down what this means, how it’s done, and why it could change the way we study lung disease.
  continue reading

85 episodes

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