This episode of 'Medicine in five Minutes' demographics the complex topic of Fever of Unknown Origin (FUO). It outlines the definition, causes, diagnostic steps, and treatment strategies of FUO. FUO, a diagnostic mystery, is characterized by persistent fever with no diagnosis after a thorough evaluation. The causes range from infections, autoimmune diseases, malignancies, to drug reactions. While the podcast emphasizes the importance of a stepwise approach in its diagnosis, it also advises against skipping steps and recommends avoiding empiric therapy unless necessary.