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86: Menopausal Hormone Replacement Therapy Explained for Patients
Manage episode 520938234 series 3653549
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Clear guidance on benefits, risks, and how the FDA’s label changes shift conversations in the exam room about HRT
Nikki's Corner
• Philly’s first Michelin stars and what the tiers mean
• Flying taxis in Dubai
• A cold case solved by college criminology students
Learning
• What HRT is, routes of therapy, and who benefits
• Reframing WHI-era fears with age and timing data
• FDA label changes and clinical implications
• Contraindications and safer use considerations
• Women’s health bias and the cost of not listening
• Practical steps for shared decisions with clinicians
References
- The 2022 Hormone Therapy Position Statement of the North American Menopause Society. Menopause (New York, N.Y.). 2022;29(7):767-794. doi:10.1097/GME.0000000000002028.
- Management of Menopausal Symptoms: A Review. Crandall CJ, Mehta JM, Manson JE. JAMA. 2023;329(5):405-420. doi:10.1001/jama.2022.24140.
- Hormone Therapy for Postmenopausal Women. Pinkerton JV. The New England Journal of Medicine. 2020;382(5):446-455. doi:10.1056/NEJMcp1714787.
- Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: US Preventive Services Task Force Recommendation Statement. Grossman DC, Curry SJ, Owens DK, et al. JAMA. 2017;318(22):2224-2233. doi:10.1001/jama.2017.18261.
- Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. Gartlehner G, Patel SV, Reddy S, et al. JAMA. 2022;328(17):1747-1765. doi:10.1001/jama.2022.18324.
- Hormone Therapy in the Postmenopausal Years: Considering Benefits and Risks in Clinical Practice. Genazzani AR, Monteleone P, Giannini A, Simoncini T. Human Reproduction Update. 2021;27(6):1115-1150. doi:10.1093/humupd/dmab026.
- Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment. Flores VA, Pal L, Manson JE. Endocrine Reviews. 2021;42(6):720-752. doi:10.1210/endrev/bnab011.
- The Women’s Health Initiative Randomized Trials and Clinical Practice: A Review. Manson JE, Crandall CJ, Rossouw JE, et al. JAMA. 2024;331(20):1748-1760. doi:10.1001/jama.2024.6542.
- Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: US Preventive Services Task Force Recommendation Statement. Mangione CM, Barry MJ, Nic
Production and Content: Edward Delesky, MD & Nicole Aruffo, RN
Artwork: Olivia Pawlowski
Chapters
1. Kitchen Banter And Weekly Catchup (00:00:00)
2. Introducing Nikki’s Corner (00:03:16)
3. Philly’s First Michelin Stars (00:04:08)
4. Flying Taxis And Future Mobility (00:13:20)
5. Students Solve A 1991 Cold Case (00:18:40)
6. Pivot To Hormone Replacement Therapy (00:21:40)
7. What HRT Is And How It Works (00:24:06)
8. Benefits For Hot Flashes And Vaginal Symptoms (00:27:13)
9. The WHI Legacy And Misconceptions (00:30:45)
10. FDA Label Changes And What They Mean (00:34:40)
11. Who Should Avoid Or Use Caution (00:38:30)
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