Dr. Jeremy Koenig sits down with Guy Leitersdorf, founder and CEO of Longevity AI, for a powerful conversation about transforming healthcare from reactive to proactive. After losing his father to late-stage lung cancer despite premium healthcare monitoring, Guy left his role as a data scientist at IronSource to build Florence—an AI system that analyzes decades of longitudinal medical data to predict and prevent chronic disease.

Drawing from the same behavioral science techniques used to predict consumer clicks, Guy discovered that 80% of unhealthy years are preventable through early intervention in metabolic, cognitive, heart, and immune health. Today, Longevity AI partners with leading healthcare networks including Genics, Well Health Technologies, and Quadrant Management, reaching toward 200,000 practitioners to deliver personalized longevity plans that save doctors 50% of their time while empowering patients with actionable, evidence-based health guidance.

Key Takeaways

🔬 80% of chronic disease burden is preventable through early detection of patterns in metabolic, cognitive, heart, and immune health—the "four horsemen" of aging

🤖 Florence AI analyzes millions of patient records across decades to identify health trends that traditional point-in-time assessments miss, turning longitudinal data into personalized prevention strategies

💡 The same technology that predicts consumer behavior can be repurposed to predict health outcomes—Guy applied lessons from advertising AI to build predictive health intelligence

⚕️ Clinical-grade biological age assessments provide more meaningful health insights than chronological age, measuring metabolic, immune, cognitive, and cardiovascular function separately

🎯 Personalized health coaching works like "Tinder for habits"—matching evidence-based interventions with activities people actually enjoy, dramatically increasing adherence

⏱️ Longevity AI's platform saves physicians over 50% of their time by synthesizing complete patient health pictures, enabling doctors to focus on high-value clinical decisions

🔒 Privacy-first AI architecture processes health data on-device, never exposing sensitive clinical and lifestyle information to external servers

🌍 Tailored biological ages account for regional differences—the same biomarker readings can indicate different health states depending on location, air quality, food systems, and standards of care

🏥 Strategic partnerships with 200,000+ practitioners position Longevity AI to deliver 10 billion additional healthy years by making prevention accessible at scale

💪 Longevity is a decision—taking one evidence-based healthy action in 2026 can compound into years of extended healthspan

LINKS:
https://www.drjeremykoenig.com/
https://www.instagram.com/drjeremykoenig/
https://www.youtube.com/@drjeremykoenig

Here's the link for this week's episode: https://drjeremykoenig.substack.com/.