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The fusion frontier
Manage episode 518747955 series 2159061
Professor Massimo Hilliard and Dr Ramon Martinez-Marmol grew up far from Queensland – Massimo in Naples, Italy, and Ramon in Catalonia, Spain. Their passion for biology led them both overseas as postdoctoral researchers: Massimo to the United States, and then Ramon to Australia. In 2015, they met at UQ’s Queensland Brain Institute, where Ramon joined the Meunier lab before moving to the Hilliard lab in 2020 as a Research Fellow. Together, they have been extending the limits of what is known or expected about neuronal fusion.
In this fascinating conversation, Massimo and Ramon explore:
- What happens when neurons fuse
- How viral infections, like Covid-19, can induce fusion, disrupting neural circuits
- The surprising role of a tiny, transparent roundworm, C.elegans, in advancing their research
- How the lab’s discoveries of critical molecular players, like fusogens, may one day revolutionise nerve injury repair
- Advice for early-career researchers pursuing discovery science
Related resources
SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity
EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway
Fusogen-mediated neuron−neuron fusion disrupts neural circuit connectivity and alters animal behavior
Chapters
1. The fusion frontier (00:00:00)
2. What is neuronal fusion? (00:01:57)
3. How does neuronal fusion differ from other types of cell fusion? (00:05:42)
4. The exciting discoveries of neuronal fusion and its potential (00:09:30)
5. The impact on the development of new treatment strategies for nerve repair (00:21:50)
6. Advice for early-career researchers (00:26:50)
93 episodes
Manage episode 518747955 series 2159061
Professor Massimo Hilliard and Dr Ramon Martinez-Marmol grew up far from Queensland – Massimo in Naples, Italy, and Ramon in Catalonia, Spain. Their passion for biology led them both overseas as postdoctoral researchers: Massimo to the United States, and then Ramon to Australia. In 2015, they met at UQ’s Queensland Brain Institute, where Ramon joined the Meunier lab before moving to the Hilliard lab in 2020 as a Research Fellow. Together, they have been extending the limits of what is known or expected about neuronal fusion.
In this fascinating conversation, Massimo and Ramon explore:
- What happens when neurons fuse
- How viral infections, like Covid-19, can induce fusion, disrupting neural circuits
- The surprising role of a tiny, transparent roundworm, C.elegans, in advancing their research
- How the lab’s discoveries of critical molecular players, like fusogens, may one day revolutionise nerve injury repair
- Advice for early-career researchers pursuing discovery science
Related resources
SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity
EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway
Fusogen-mediated neuron−neuron fusion disrupts neural circuit connectivity and alters animal behavior
Chapters
1. The fusion frontier (00:00:00)
2. What is neuronal fusion? (00:01:57)
3. How does neuronal fusion differ from other types of cell fusion? (00:05:42)
4. The exciting discoveries of neuronal fusion and its potential (00:09:30)
5. The impact on the development of new treatment strategies for nerve repair (00:21:50)
6. Advice for early-career researchers (00:26:50)
93 episodes
All episodes
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