Hosted by Kevin Davies, PhD, GuidePost is an exciting podcast series featuring candid conversation with the pioneers and practitioners of CRISPR and gene editing research. Guests have included luminaries Emmanuelle Charpentier, Francisco Mojica, Rodolphe Barrangou, Virginijus Siksnys, Sylvain Moineau, and Jakob Sherkow, among others. GuidePost is produced by The CRISPR Journal, the only peer-reviewed journal dedicated to the science and applications of gene editing.
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The Crispr Journal Podcasts
Welcome to Tiara’s Curious Lab: Bio, Psych & Tomorrow’s Science — a personal study journal turned podcast, where Tiara dives deep into the wonders of Biology, Psychology, and the science shaping our future. Join Tiara as she explores how the brain and body connect, how our thoughts and moods are wired, and where cutting-edge research like CRISPR and brain-computer interfaces might take us next. Whether you’re a fellow student, a curious mind, or just someone who loves learning, this show mak ...
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The Role of Hormones in Decision Making and Emotions (Season 1, Episode 5: The Mind-Body Nexus)
21:40
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21:40Have you ever wondered why sometimes you feel moody, foggy, or strangely impulsive — even when nothing significant has happened? The answer might be hidden in your hormones. In this episode, we uncover the powerful role hormones play in shaping your emotions, decisions, and even how you see the world. We’ll introduce you to the key hormones that si…
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AI & Machine Learning in Medicine: The Future is Now (Season 3, Episode 6: Futuristic Bio Research)
1:17:44
1:17:44
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1:17:44What if artificial intelligence could help doctors diagnose diseases faster, design custom treatments just for you, and even assist in life-saving surgeries? That future is already here—and it’s reshaping healthcare as we know it! In this episode, we explore the incredible ways AI and machine learning are transforming medicine. You’ll learn how AI …
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Synthetic Biology: Designing Life from Scratch (Season 3, Episode 5: Futuristic Bio Research)
20:06
20:06
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20:06What if you could design living cells the way engineers build machines? In this episode, we dive deep into the amazing world of synthetic biology — where biology meets engineering to create life with entirely new abilities. From programming bacteria to fight cancer to building yeast that brews medicines and even crafting food for astronauts on Mars…
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Mapping the Human Connectome: Unraveling the Brain’s Wiring Diagram (Season 3, Episode 4: Futuristic Bio Research)
32:28
32:28
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32:28What if we could map every single connection in the human brain — all 86 billion neurons and their quadrillion synapses — like drawing a complete wiring diagram of who we are? In this episode, we journey into the fascinating world of the human connectome: neuroscience’s ultimate quest to chart the brain’s complex circuitry. We’ll explore why scient…
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Molecular Nanobots: Tiny Machines to Heal Us (Season 3, Episode 3: Futuristic Bio Research)
34:20
34:20
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34:20What if you could send microscopic robots into your body to hunt down diseases, repair tissues, or deliver medicine precisely where it’s needed? In this episode, we shrink down to the nanoscale to explore the world of molecular nanobots — tiny machines that could revolutionize the way we treat illnesses. We’ll guide you through how these nanobots w…
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Brain-Computer Interfaces: Connecting Minds to Machines (Season 3, Episode 2: Futuristic Bio Research)
1:18:19
1:18:19
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1:18:19What if you could control a computer, a robotic arm, or even type a message — just by thinking? In this episode, we explore the mind-bending world of Brain-Computer Interfaces (BCIs), the groundbreaking technology that connects your brain directly to machines. We’ll break down how BCIs work, from picking up your brain’s tiny electrical signals to t…
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CRISPR and the Future of Human Health (Season 3, Episode 1: Futuristic Bio Research)
42:58
42:58
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42:58What if we could rewrite our DNA to cure diseases once thought untouchable? In this season opener, we dive into the groundbreaking world of CRISPR — the revolutionary gene-editing tool that’s transforming medicine, science, and our very understanding of life. Join us as we break down how CRISPR works, like molecular scissors snipping and fixing fau…
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Brain Waves Explained: How Your Mind Communicates with Itself (Season 2, Episode 8: Neuroscience)
30:12
30:12
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30:12What if your brain was secretly playing music — not through instruments, but through waves of electricity? In this episode, we explore the rhythmic orchestra inside your head: brain waves. These waves are the electrical patterns that let your mind communicate with itself, shaping your thoughts, emotions, sleep, creativity, and focus. We’ll break do…
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The Power of Glial Cells: The Brain’s Hidden Helpers (Season 2, Episode 7: Neuroscience)
17:05
17:05
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17:05When you think of the brain, neurons probably come to mind first — but what if I told you they’re only half the story? In this episode, we shine a spotlight on the brain’s hidden helpers: glial cells. Long ignored as mere “support staff” for neurons, glia are now taking center stage in neuroscience, revealing a world of complexity, intelligence, an…
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Why We Remember and Forget: The Neuroscience of Memory (Season 2, Episode 6: Neuroscience)
30:33
30:33
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30:33Ever wondered why some memories stick with you forever while others fade away? Or why you can’t remember your earliest years of life? In this episode, we unlock the mysteries of memory — from how your brain stores and recalls your favorite moments to the surprising science of why forgetting is not just normal, but necessary. We’ll explore the brain…
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How the Brain Processes Emotions: From Joy to Fear (Season 2, Episode 5: Neuroscience)
19:53
19:53
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19:53Why do we feel happy one moment and anxious the next? What’s happening in our brain when we fall in love, feel disgusted, or get scared? In this episode, we take a deep dive into the emotional brain — uncovering how your mind turns everyday experiences into powerful feelings. We’ll explore the fascinating limbic system, your brain’s emotional comma…
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The Science of Sleep: How Rest Shapes Your Mind (Season 2, Episode 4: Neuroscience)
28:05
28:05
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28:05What if the secret to a sharper mind, stronger memory, and better mood was as simple as getting a good night’s sleep? In this episode, we’re unlocking the incredible science behind sleep — and why it’s so much more than just rest. Join us as we journey through the fascinating stages of sleep, from light dozing to deep, restorative slumber and vivid…
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Neurotransmitters: The Brain’s Chemical Messengers (Season 2, Episode 3: Neuroscience)
22:14
22:14
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22:14What if I told you that your thoughts, feelings, and every move you make are powered by tiny chemicals constantly zipping around your brain? In this episode, we’re diving into the captivating world of neurotransmitters — the brain’s very own chemical messengers. Join us on a journey to uncover how these microscopic messengers help your neurons comm…
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How Your Brain Learns: The Science of Memory and Plasticity (Season 2, Episode 2: Neuroscience)
28:16
28:16
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28:16🎙️ Podcast Description: Episode 2 — Have you ever wondered how your brain actually learns? Whether you're mastering a new skill, cramming for a test, or just trying to remember where you left your keys, your brain is constantly rewiring itself. In this episode, we’ll explore the remarkable science of neuroplasticity — the brain’s incredible ability…
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What is Neuroscience? A Beginner’s Guide to the Brain (Season 2, Episode 1: Neuroscience)
24:59
24:59
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24:59Have you ever wondered what’s really going on inside your head? In this episode, we’re taking you on a fascinating tour of the most powerful organ in your body — the brain. Whether you’re curious about how your thoughts form, how your body knows when to move, or even why we dream, this beginner’s guide to neuroscience will spark your imagination. W…
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How Perception Shapes Reality: The Brain’s Role in Interpretation (Season 1, Episode 9: The Mind-Body Nexus)
21:36
21:36
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21:36Have you ever argued with someone about an event you both experienced — but remembered completely differently? That’s because what we see, hear, and feel isn’t always the full story. In this episode, we explore the captivating science of perception — how your brain takes in the world and creates your personal version of reality. You’ll discover how…
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The Science of Memory: Why We Remember and Forget (Season 1, Episode 8: The Mind-Body Nexus)
34:55
34:55
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34:55Why is it that we can easily remember the lyrics to an old song but forget where we left our keys? In this episode, we explore the amazing science of memory — how our brains capture moments, store them, and sometimes, just let them slip away. Join us as we uncover the journey of a memory, from the first spark of learning to the deep vaults of long-…
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The Gut-Brain Axis: How Your Stomach Affects Your Mood (Season 1, Episode 7: The Mind-Body Nexus)
26:41
26:41
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26:41Have you ever felt your stomach churn when you’re nervous or lost your appetite when you’re stressed? That’s not just coincidence — it’s your gut talking to your brain. In this episode, we dive into the hidden world of the gut-brain axis, an extraordinary communication system that links your digestive system directly to your mind. You’ll discover h…
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How Our Genetics Shape Personality and Mental Health (Season 1, Episode 6: The Mind-Body Nexus)
19:35
19:35
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19:35Why are some people naturally more anxious, while others seem effortlessly confident? Why do certain mental health conditions run in families? In this episode, we explore the fascinating world of genetics and how the DNA you inherit shapes your personality, emotions, and even your mental health. We’ll break down what heritability really means — and…
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How Our Brain Chemistry Influences Mood and Behavior (Season 1, Episode 3: The Mind-Body Nexus)
19:20
19:20
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19:20What if your feelings of happiness, sadness, or even motivation weren’t just about life events — but about the chemicals swirling inside your brain? In this episode, we unlock the secret world of brain chemistry and reveal how tiny messengers in your brain quietly control your mood, energy, and behavior every single day. You’ll meet the brain’s key…
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What is the Mind-Body Connection? (Season 1, Episode 1: The Mind-Body Nexus)
17:13
17:13
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17:13Have you ever felt butterflies in your stomach before a big event or noticed your heart racing when you’re excited or scared? That’s not just your imagination — it’s your mind and body talking to each other. In this episode, we dive into the fascinating world of the mind-body connection, uncovering how your thoughts, emotions, and physical sensatio…
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The Role of Evolution in Shaping Human Psychology (Season 1, Episode 2: The Mind-Body Nexus)
12:30
12:30
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12:30Have you ever wondered why certain fears, feelings, or behaviors just seem to come naturally to us? Like why heights make us nervous, or why we’re drawn to sweet foods? In this episode, we journey back in time to explore how evolution has shaped not just our bodies, but our minds. We’ll uncover the hidden links between the survival struggles of our…
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The Nervous System: The Highway of Thought and Emotion (Season 1, Episode 4: The Mind-Body Nexus)
17:46
17:46
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17:46Imagine if your body had a secret superhighway, carrying messages between your brain and every part of you — from your fingertips to your heart. That’s exactly what the nervous system is: an incredible communication network that shapes how you think, feel, and react, often without you even realizing it. In this episode, we take you on a journey thr…
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GuidePost Ep. 20: Eben Kirksey, Human Futures and Gene Editing
1:03:46
1:03:46
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1:03:46Anthropologist and author Eben Kirksey discusses his interest in somatic and hereditary human genome editing, particularly the impact on patients and practitioners, the history of CCR5 gene editing, and recalls his exceptional reporting in China in the wake of the CRISPR babies scandal, all of which is included in his riveting book “The Mutant Proj…
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GuidePost Ep. 19: David Liu, Precision Chemistry on DNA
51:19
51:19
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51:19The architect of base editing and prime editing, Harvard University chemist David R. Liu, recalls the genesis of the technology and discusses exciting preclinical results and potential future applications.{Sponsored by Pegasus Books}By The CRISPR Journal
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GuidePost Ep. 18: Kevin Davies, CRISPR Chronicler
1:02:01
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1:02:01In this podcast, Mendelspod host Theral Timpson interviews Kevin Davies about his latest book, "Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing".{Episode Sponsored by Mendelspod}By The CRISPR Journal
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GuidePost Ep. 17: Dame Kay Davies, Guidance for Heritable Genome Editing
38:07
38:07
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38:07A conversation with Dame Kay Davies, University of Oxford geneticist and co-chair of the just-published international commission report on Hereditary Human Genome Editing (HHGE), which lays out a roadmap for if, when, and how we should proceed with embryo editing for couples with severe genetic diseases.…
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GuidePost Ep. 16: Luciano Marraffini, big time microbiologist
37:57
37:57
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37:57A discussion with Luciano Marraffini, the Rockefeller University microbiologist who has made several fundamental contributions in the brief history of CRISPR biology and genome editing.By The CRISPR Journal
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GuidePost Ep. 15: Bartha Knoppers, bioethics and human rights
16:34
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16:34Canadian law professor Bartha Knoppers (McGill University) talks about her long-standing interests in genetics, bioethics, human rights and her latest role studying the clinical implementation of genome editing.By The CRISPR Journal
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GuidePost Ep. 14: George Church, triple threat (reader/writer/editor)
42:10
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42:10A towering figure in genomics for three decades, George Church (Harvard Medical School) discusses pigs, mammoths, organoids, CRISPR babies, and why M stands for multiplexing.By The CRISPR Journal
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Ep. 13: Edward Lanphier, chief editing officer
40:23
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40:23The recently retired founding CEO of Sangamo Therapeutics, Edward Lanphier, shares stories from two decades at the helm of the first biotech company to develop and take genome editing, using zinc finger nucleases, into the clinic.By The CRISPR Journal
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One of the pioneers of gene editing, biochemist Dana Carroll (University of Utah), reflects on the crucial early years developing zinc finger nucleases and the prospects for genome editing.By The CRISPR Journal
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Ep. 11: Adam Bolt, editor-turned-director
32:08
32:08
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32:08The director of “Human Nature” takes us behind the camera to discuss the making of the new documentary film that superbly captures the story of CRISPR.By The CRISPR Journal
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Ep. 10: Alexis Komor & Nicole Gaudelli, base editing’s tenacious duo
1:05:08
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1:05:08While postdocs in David Liu’s lab at Harvard University, Alexis Komor (UCSD) and Nicole Gaudelli (Beam Therapeutics) developed a pair of CRISPR-based molecular machines known as base editors, capable of engineering precise single-base substitutions with enormous basic research and therapeutic implications.…
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Ep. 9: Emmanuelle Charpentier, CRISPR-Cas pioneer
50:29
50:29
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50:29In a French bistro in New York City, Emmanuelle Charpentier (Founding Director, Max Planck Unit for the Science of Pathogens, Berlin) discusses with Kevin Davies her nomadic career, the high points in her CRISPR journey, and previews her future plans.By The CRISPR Journal
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Ep. 8: Sylvain Moineau, the phage whisperer
20:03
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20:03Sylvain Moineau (Laval University, Quebec) surveys the impact of two decades’ research in phage microbiology on the CRISPR gene editing revolution.By The CRISPR Journal
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Ep. 1: Franciso Mojica, salt-lake secrets
31:47
31:47
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31:47GuidePost: A conversation with CRISPR pioneer Francisco Mojica is the first episode in a new podcast series from Mary Ann Liebert, Inc., publishers of The CRISPR Journal. Episode 1 is brought to you by MilliporeSigma CRISPR - Innovative reagents you can trust. In this episode Kevin Davis, Executive Editor of The CRISPR Journal, interviews Francisco…
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In episode #2 of GuidePost, Kevin Davies (Executive Editor, The CRISPR Journal) travels to Lithuania to meet Virginijus Šikšnys, one of the central figures in the development of CRISPR gene editing, at his lab at the Institute of Biotechnology, Vilnius University. Siksnys is an expert in DNA-protein interactions, and in 2011-12, made critical contr…
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Ep. 4: Jacob Sherkow, CRISPR patents explained
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34:40In episode #4 of GuidePost, Jacob Sherkow (New York Law School) – one of the leading academic authorities on biotech patent law – explains the twists and turns of the ongoing CRISPR patent dispute.By The CRISPR Journal
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In episode 5 of GuidePost Podcast Series Neal Gutterson, Chief Technology Officer of Dow-Dupont’s agricultural division Corteva, discusses the exciting potential of gene editing/CRISPR to spur new crop strains and circumvent the contentious debate around GMOs.By The CRISPR Journal
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In episode #6 of GuidePost, Kevin Holden, Head of Synthetic Biology at Synthego Corporation, discusses the company’s Silicon Valley culture, growth, and its approach to providing new gene editing products for the CRISPR community.By The CRISPR Journal
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Kevin Esvelt (MIT Media Lab) discusses his interest in gene drives and other gene editing approaches to combat tick-borne diseases and malaria.By The CRISPR Journal
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Ep. 3: Rodolphe Barrangou, the CRISPR craze
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36:36The CRISPR Journal Executive Editor Kevin Davis interviews Editor-In-Chief Rodolphe Barrangou. This episode of GUIDEpost is brought to you by Synthego, who's vision is to turn biology into an information science with the ultimate goal of dramatically extending the healthy human lifespan by providing genome engineering solutions. Learn more at www.s…
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