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Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health ...
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Ever wanted to know how music affects your brain, what quantum mechanics really is, or how black holes work? Do you wonder why you get emotional each time you see a certain movie, or how on earth video games are designed? Then you’ve come to the right place. Each week, Sean Carroll will host conversations with some of the most interesting thinkers in the world. From neuroscientists and engineers to authors and television producers, Sean and his guests talk about the biggest ideas in science, ...
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Join depth psychotherapist and Jungian scholar, John Price, in an exploration of extraordinary stories and phenomena that lurk beneath the surface of normal and everyday life. Listen in as John interviews experts, dilettantes, sinners, and saints to explore their professional and personal perspective on the underlying purpose of the mysteries which lurk within the seemingly mundane nature of day-to-day life. John received his Master’s degree in clinical psychology and his Doctorate degree in ...
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Think of this weekly podcast as the main-stage panel of our Adventures In Legal Tech podcast, focused on how technology can benefit your bottom line and geared for an audience of luddite-leaning lawyers. "Fun" may even ensue — within reason, of course.
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The story goes that Wolfgang Pauli, who first proposed the existence of neutrinos, was embarrassed to have done so, as it was considered uncouth to hypothesize new particles that could not be detected. Modern physicists have no such scruples, of course, but more importantly neutrinos turn out to be very detectable, given sufficient resources and ex…
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Most people think heart disease is obvious and predictable, yet women often present with completely different warning signs that traditional testing fails to catch. We now have the tools to identify risk decades earlier and reverse disease before it becomes dangerous. In this episode of Extend, we sit down with Dr. Suzanne Steinbaum, cardiologist a…
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“Our longings are much more powerful than our logic, and our desires are stronger than our reason.” (Graham Tomlin on the thought of Blaise Pascal) The Rt. Rev. Dr. Graham Tomlin (St. Mellitus College, the Centre for Cultural Witness) joins Evan Rosa for a sweeping exploration of Blaise Pascal—the 17th-century mathematician, scientist, philosopher,…
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Most people think about the gut as a digestive system, yet emerging research shows it functions more like a command center shaping immunity, metabolism, mood, and even coronary artery calcification. The surprising twist is that your gut may be influencing your brain more than your brain influences your gut. In this episode of Extend, we sit down wi…
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Game theory is a way of quantitatively describing what happens any time one thing interacts with another thing, when both things have goals and potential rewards. That's a pretty broad class of interesting events, so it is unsurprising that game theory is a useful way of thinking about everything from international relations to the evolution of pea…
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Most people hear "saturated fat" and think of something harmful, yet emerging research reveals that one specific fatty acid supports stronger cell membranes, healthier metabolic function, and better long-term resilience. C15 plays a unique role in the biology of aging and may help explain why certain populations experience longer, healthier lives. …
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Most of us think inflammation is something we can fix with supplements, lab tests, or the latest diet trend. But what if the real solution comes from ancient wisdom that modern science is finally catching up to? In this episode of Extend, we sit down with Dr. Shivani Gupta, Ayurvedic practitioner, author, and founder of Fusionary Formulas, to explo…
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Machine learning using neural networks has led to a remarkable leap forward in artificial intelligence, and the technological and social ramifications have been discussed at great length. To understand the origin and nature of this progress, it is useful to dig at least a little bit into the mathematical and algorithmic structures underlying these …
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In this solo episode, I explore the deep significance of ritual—especially as we move through the season of descent and into the longest night of the year.Modern culture has stripped ritual of its heart, reducing sacred rhythms to holidays and surface forms. What once rooted us in mystery has become spectacle or habit. In this conversation, I want …
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I spoke with a solo attorney, who gets a heck of a lot done in her unique practice niche, by leveraging AI + business planning. Episode Highlights 02:12 - Overwhelming AI solutions in law. 03:56 - Jess Birken recommends note-taking AI. 04:48 - Fathom: AI for virtual meetings. 06:31 - Flat fees vs. hourly billing for AI efficiency. 07:25 - AI in com…
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Most of us grew up thinking anything sold at the grocery store was safe to eat. But behind every "heart healthy," "high protein," or "low fat" label lies a different truth one built on ultra-processed ingredients, chemical additives, and marketing tricks. In this episode of Extend, we sit down with Julia Putzeys, founder of the Trash Panda App, to …
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Loneliness seems to be part of what it means to be a relational being. Does that mean loneliness can never really be “solved”? Here’s one way to think about loneliness: As a gap between relational expectation and social reality—something that signals our essentially relational, reciprocal nature as human beings. This episode is part 6 of a series, …
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You can eat healthy, exercise daily, and still struggle with fatigue, inflammation, or brain fog. Why? Because every system in your body is connected. The gut, brain, and immune system are constantly communicating, and most health plans ignore that network. In this episode of Extend, I sit down with Dr. Karan Rajan to explore how the gut microbiome…
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‍ ‍ Drs. Akshay Thomas and Sarwar Zahid join for a journal club episode discussion of three recent publications: ‍ ‍ ‍ ‍ Fellow Eye PVD (https://journals.sagepub.com/doi/full/10.1177/24741264251379842) ‍ ‍ Syfovre versus Izervay (https://journals.sagepub.com/doi/full/10.1177/24741264251379842) ‍ ‍ Litigation Involving Intravitreal Injections (https…
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Welcome to the November 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the que…
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I talked with an attorney who owns a law firm and real estate closing company about how he grew his organizations using acquisition as a tool, as well as about how the firm has stayed on track by adopting modern technology. Episode Highlights 01:04 - Commitment to actionable insights. 02:05 - Creating a fun workplace culture. 06:22 - Impact of cult…
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What if the future of medicine isn't about diagnosing disease, but preventing it entirely? For decades, our healthcare system has only reacted once things go wrong. We measure when there are symptoms. We intervene when there is a crisis. But what if we could see the shift before it becomes an illness? In this episode of EXTEND, I'm joined by Josh C…
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Living alone may be difficult, but what about dying alone? Physicians and nurses are the new priests accompanying people as they face death. But the experience of nursing homes, assisted living, and palliative wards are often some of the loneliest spaces in human culture. “He said, ‘Someone finally saw me. I’ve been in this hospital for 20 years an…
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In this episode of The Sacred Speaks, host Dr. John W. Price sits down with pioneering therapist and author Terry Real, whose decades of work have redefined how we understand men, relationships, and emotional life.Nearly thirty years after the release of his groundbreaking book I Don’t Want to Talk About It: Overcoming the Secret Legacy of Male Dep…
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What if the real key to longevity has nothing to do with your workouts or supplements, but with how well your brain is wired to adapt, repair, and thrive? In this episode of EXTEND, I sit down with Dr. Amir Vookshoor, a board-certified neurosurgeon and founder of NeuroVella Brain Spa, to explore how modern neuroscience and biohacking are merging to…
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Drs. Kat Talcott and Sarwar Zahid join to discuss the December 2025 edition of Retinal Physician, including an overview of TKIs for retinal disease, the fluorinated gas and sustainability question, best practices for research clinical trial sites, and fellowship selection advice.By Jayanth Sridhar
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Science has an incredibly impressive track record of uncovering nonintuitive ideas about the universe that turn out to be surprisingly accurate. It can be tempting to think of scientific discoveries as being carefully constructed atop a rock-solid foundation. In reality, scientific progress is tentative and fallible. Scientists propose models, assi…
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What if the key to living longer and feeling younger has been hidden in ancient medicine all along? Long before supplements, peptides, or wearables, healing was about restoring balance through food, movement, belief, and nature. Today, those same principles are being shown by modern science to protect your cells, extend your healthspan, and reverse…
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What is the role of solitude in Christian history? Medievalist Hetta Howes comments on the allure of enclosure, how seeking solitude supports community, and what these ancient lives reveal about our modern search for connection. “Even those moments of solitude that she’s carving for herself are surprisingly sociable.” This episode is part 1 of a 5-…
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What if the real secret to longevity isn't found in science alone, but in how we choose to live, love, and connect every day? In this special posthumous episode of EXTEND, I revisit one of the most meaningful conversations I've ever had — with Dr. Gladys McGarey, the 103-year-old physician known as the Mother of Holistic Medicine and author of The …
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The universe as revealed by physics is objective: it's out there, existing and behaving in ways that are completely independent of human thought. But the process by which we learn about the universe, and the language with which we talk about it, is extremely human-dependent. Does that mean that aliens would do science differently, and even think di…
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I spoke with a senior paralegal about best practice tips for intake + client service. Episode Highlights 02:45 - Automations in CRM to filter conversations. 04:04 - The "CRM as ATM" concept for law firms. 06:13 - The importance of cultural responsiveness in client communication. 07:46 - The value of short, effective intake forms. 11:03 - Benefits o…
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What if the real turning point for women's health isn't menopause itself, but the decade before it? Long before the symptoms hit, your brain, bones, and heart are already changing, silently. You can train hard, eat clean, and still lose strength, bone density, and cognitive sharpness if you're not addressing the biology underneath it all. In this e…
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Is technology the source or salve of social isolation? Given the realities of increasing division, the epidemic of loneliness, and unwanted isolation today, how should we think about the theological, ethical, and spiritual dimensions of the human experience of aloneness? “AI technologies aren’t capable of creating conditions in which grace can happ…
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You can eat clean, track your labs, take supplements, and still feel anxious, inflamed, tired, or flat. Why? Because the gut, brain, immune system, and hormones are in constant conversation, and most of us are only treating one side of that story. In this episode of Extend, I sit down with Dr. Will Cole to uncover the science behind the gut-brain a…
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Why are people wrong all the time, anyway? Is it because we human beings are too good at being irrational, using our biases and motivated reasoning to convince ourselves of something that isn't quite accurate? Or is it something different -- unmotivated reasoning, or "unthinkingness," an unwillingness to do the cognitive work that most of us are ac…
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You have brain fog. You're gaining weight faster and losing it slower. You think it's stress, aging, or just life… But what if it's your liver screaming for help? In this episode of Extend, I'm joined by Siggi Clavien, liver health expert and founder of The Liver Clinic, to uncover the silent epidemic destroying our health from the inside out. We e…
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Consider human ecological loneliness and our longing for reconnection with all creation. What healing is available in an era defined by environmental loss and exploitation? Can we strengthen the fragile connection between modern society and the space we inhabit? “Loneliness is the symptom that desires its cure.” In this episode Macie Bridge welcome…
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We track our sleep, count our macros, optimize every supplement, yet most people's bodies are still stuck in survival mode. What if true longevity starts not with another biohack, but with safety? When your nervous system feels safe, inflammation drops, digestion normalizes, and recovery accelerates. In this episode of Extend, I sit down with Gabby…
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Drs. Priya Vakharia and Sarwar Zahid join for a journal club discussion. Functional Benefit in Geographic Atrophy Treatment (https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2839343) GLP-1 Agonists and Uveitis (https://jamanetwork.com/journals/jamaophthalmology/article-abstract/2838119) Metformin and AMD (https://jamanetwork.com/journ…
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Music is math that you can dance to. The fact that certain notes sound good when played together, or in succession, is related to the mathematical properties of the frequencies to which they correspond, an idea that goes back as far as Pythagoras himself. These days we have a much more intricate understanding of these relationships and how to manip…
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In this heartfelt episode of The Sacred Speaks, John Price sits down with longtime spiritual guide and Franciscan friar, Father Richard Rohr. Together they explore the deeper dimensions of happiness and meaning—moving far beyond cultural clichés.Drawing on Richard’s decades of integrating psychology, spirituality, and mysticism, the conversation ch…
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What if your immune system could actually age backwards? For decades, we've accepted that inflammation, fatigue, and slower recovery are inevitable with age, but new research proves otherwise. Your immune system isn't doomed to decline; it can be retrained to act younger, stronger, and more resilient. In this episode of Extend, I sit down with Dr. …
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Theologian Miroslav Volf reflects on solitude, loneliness, and how being alone can reveal our humanity, selfhood, and relationship with God. This episode is part 1 of a 5-part series, SOLO, which explores the theological, moral, and psychological dimensions of loneliness, solitude, and being alone. “Solitude brings one back in touch with who one is…
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What if your brain's biggest limitation isn't its capacity, but your failure to train it? In this episode of Extend, Maya Raichoora joins me to share how visualization techniques helped her reverse debilitating ulcerative colitis. We explore the neuroscience behind visualization, from rewiring neural pathways to regulating the immune system through…
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