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a16z Podcast

Andreessen Horowitz

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The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
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Joe sits down with retired mixed martial artist and wrestler Mark Kerr. Kerr is the subject of the A24 feature film "The Smashing Machine," directed by Benny Safdie and starring Dwayne Johnson. Look for it in theaters on October 3, 2025. https://a24films.com/films/the-smashing-machine www.markkerr.com Buy 1 Get 1 Free Trucker Hat with code ROGAN at…
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What comes after vibe coding? Maybe vibe researching. OpenAI’s Chief Scientist, Jakub Pachocki, and Chief Research Officer, Mark Chen, join a16z general partners Anjney Midha and Sarah Wang to go deep on GPT-5—how they fused fast replies with long-horizon reasoning, how they measure progress once benchmarks saturate, and why reinforcement learning …
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Ian Edwards is a comic, actor, and host of the "Soccer Comic Rant" podcast. Watch his new comedy special, "Ian Edwards: Untitled," now streaming on YouTube. https://youtu.be/q_4pEVD6Y3k?si=b0IIPBNl-9vdx6Sb https://linktr.ee/ianedwardscomic Don’t miss out on all the action - Download the DraftKings app today! Sign-up at https://dkng.co/rogan or with…
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Should the US put a price on H-1B visas, or would that block the flow of new talent? Are AI coding agents actually making teams way more productive, or is it just hype? And in the AI platform shift, will the big winners be incumbents or new AI-native startups? Erik Torenberg is joined by Box co-founder and CEO Aaron Levie, a16z board partner Steven…
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Andrew Santino is a comic, actor, and host of the podcasts "Whiskey Ginger," "No Bad Lies," and "Bad Friends" with comic Bobby Lee. Check out his new special, "Andrew Santino: White Noise," now streaming on Hulu."Andrew Santino: White Noise": www.hulu.com/movie/andrew-santino-white-noise-ee4cb509-98e5-42f6-af6b-796b38c726ab www.youtube.com/AndrewSa…
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Dr. Jay Bhattacharya is one of the country’s top medical experts and a 24-year professor of medicine at Stanford. After being censored and deplatformed during COVID for his role in opposing harsh lockdowns, he was appointed Director of the National Institutes of Health by President Trump in 2025. a16z General Partners Erik Torenberg, Vineeta Agarwa…
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Nvidia’s $5 billion investment in Intel is one of the biggest surprises in semiconductors in years. Two longtime rivals are now teaming up, and the ripple effects could reshape AI, cloud, and the global chip race. To make sense of it all, Erik Torenberg is joined by Dylan Patel, chief analyst at SemiAnalysis, joins Sarah Wang, general partner at a1…
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In this episode of Honestly with Bari Weiss, we share a special conversation featuring a16z general partner Katherine Boyle in the wake of Charlie Kirk’s shocking assassination. Katherine reflects on what courage means in a culture where words and debate are increasingly met with violence. Drawing on faith, history, and her own response to recent t…
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Taylor Kitsch is an award-winning actor best known for his roles in films such as "X-Men Origins: Wolverine" and "Lone Survivor," as well as television shows including "Waco," "Painkiller," "American Primeval," and "The Terminal List." His new series, "The Terminal List: Dark Wolf," a prequel to "The Terminal List," is streaming exclusively on Amaz…
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Jordan Jensen is a comedian, actress, and podcaster. She is the co-host of the podcast "Bein' Ian with Jordan" with comedian Ian Fidance, and host of her own podcast, "RIP Jordan Jensen." Her new comedy special, "Jordan Jensen: Take Me With You," is streaming exclusively on Netflix. Look for her in Bradley Cooper's film, "Is This Thing On?," in the…
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The web is unhealthy, and AI agents are about to rewrite how we shop. In this episode, a16z General Partner Alex Rampell and Partner Justine Moore explore how AI agents will change commerce and the implications for Google’s business model, affiliate marketing, online shopping, and more. Timecodes: 0:00 Introduction 0:12 The Role of AI Agents in Com…
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Matthew McConaughey is an Academy Award–winning actor and #1 New York Times bestselling author. His new book, "Poems & Prayers,” comes out September 16. His latest film, "The Lost Bus," will open in select theaters in Los Angeles, New York, and London on September 19 and premiere globally on October 3 on Apple TV+. Matthew is a professor of practic…
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OpenAI’s Codex has already shipped hundreds of thousands of pull requests in its first month. But what is it really, and how will coding agents change the future of software? In this episode, General Partner Anjney Midha goes behind the scenes with one of Codex’s product leads- Alexander Embiricos - to unpack its origin story, why its PR success ra…
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Can we make science as fast as software? In this episode, Erik Torenberg talks with Patrick Hsu (cofounder of Arc Institute) and a16z general partner Jorge Conde about Arc’s “virtual cells” moonshot, which uses foundation models to simulate biology and guide experiments. They discuss why research is slow, what an AlphaFold-style moment for cell bio…
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In this conversation from Lenny’s Podcast, Ben Horowitz joins Lenny to discuss the psychological muscle every founder needs, why hesitation can be fatal for CEOs, when it’s time to replace a founder, and how to normalize failure while building confidence. They also explore the Databricks founding story, investing in Adam Neumann after WeWork, wheth…
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Charlie Sheen is an actor best known for his leading roles in films such as "Platoon," "Wall Street," "Major League," and "Rooftop Killer," and television shows including "Spin City" (for which he won a Golden Globe Award) and "Two and a Half Men." His new book, "The Book of Sheen," is available now. He is featured in the Netflix documentary, "AKA …
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The $13T U.S. mortgage market serves 50M homeowners but still runs on decades-old software. In this episode, a16z GP Angela Strange hosts Tim Mayopoulos (ex-CEO of Fannie Mae and ex-president of Blend), Mike Yu (co-founder and CEO of Vesta), and Andrew Wang (co-founder and CEO of Valon) to unpack why standardization and regulation slow change, and …
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Scott "Carrot Top" Thompson is a trailblazing comedian, television personality, and actor celebrating 16 years of residency at the Las Vegas Luxor Hotel and Casino. www.carrottop.com www.youtube.com/@CarrotTopLive Don’t miss out on all the action - Download the DraftKings app today! Sign-up at https://dkng.co/rogan or with my promo code ROGAN. GAMB…
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Why do some consumer products explode into networks that reshape the internet, while others fade away? Today on the podcast, a16z general partners Anish Acharya and Chris Dixon take on that question. Anish invests in AI-native consumer products and the next wave of consumer tech. Chris is best known for his work in Web3 and network economies, and h…
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Brigham Buhler is the founder of Ways2Well, a functional and regenerative care clinic. https://www.ways2well.com Don’t miss out on all the action - Download the DraftKings app today! Sign-up at https://dkng.co/rogan or with my promo code ROGAN. GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOP…
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What happens when AI collides with salesmanship, streaming-era sports, and healthcare? In this episode, Erik Torenberg is joined by Mark Cuban, entrepreneur, Dallas Mavericks co-owner, and founder of Cost Plus Drugs. Topics include fiery group chats and how dissent sharpens thinking, the sales playbook of modern politics, and concrete fixes for U.S…
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Who’s speaking up for startups in Washington, D.C.? In this episode, Matt Perault (Head of AI Policy, a16z) and Collin McCune (Head of Government Affairs, a16z) unpack the “Little Tech Agenda” for AI- why AI rules should regulate harmful use, not model development; how to keep open source open; the roles of the federal government vs states in regul…
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Joe is joined by Gordon Ryan, Brendan Schaub & Bryan Callen to watch the fights on September 6, 2025. Don’t miss out on all the action - Download the DraftKings app today! Sign-up at https://dkng.co/rogan or with my promo code ROGAN. GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HO…
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Stainless founder Alex Rattray joins a16z partner Jennifer Li to talk about the future of APIs, SDKs, and the rise of MCP (Model Context Protocol). Drawing on his experience at Stripe—where he helped redesign API docs and built code-generation systems—Alex explains why the SDK is the API for most developers, and why high-quality, idiomatic librarie…
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Taken from The Oprah Podcast, this special episode brings together Shaka Senghor, a16z cofounder Ben Horowitz, and Oprah Winfrey for a powerful conversation on resilience and transformation. Shaka, a resilience expert, motivational speaker, and bestselling author of Writing My Wrongs, shares his journey from incarceration to redemption along with i…
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Tim Dillon is a stand-up comic, actor, and host of "The Tim Dillon Show" podcast. His latest comedy special, "Tim Dillon: I'm Your Mother," is available on Netflix. www.youtube.com/@TimDillonShow www.timdilloncomedy.com Introducing Visible Inner Circle: Connect accounts with anyone, share the savings. Join for $25/mo. Add a premium plan and save $5…
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Is non-consensus investing overrated—or the secret to venture returns? a16z General Partner Erik Torenberg is joined by Martín Casado (General Partner, a16z) and Leo Polovets (General Partner, Humba Ventures) to unpack the debate that lit up venture Twitter/X: should founders and VCs chase consensus, or run from it? They explore what “consensus” re…
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Ben van Kerkwyk is an independent researcher exploring ancient mysteries. www.youtube.com/@unchartedx www.unchartedx.com Try ZipRecruiter FOR FREE at https://ziprecruiter.com/rogan Don’t miss out on all the action - Download the DraftKings app today! Sign-up at https://dkng.co/rogan or with my promo code ROGAN. GAMBLING PROBLEM? CALL 1-800-GAMBLER,…
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Jack Altman sits down with Martin Casado, General Partner at a16z, to unpack the shifting dynamics of venture capital and why media matters more than ever. They cover a16z’s evolution from generalists to specialized platforms, the rise of AI infrastructure, and why today’s fiercest battles are often for talent, not market share. Timecodes: 0:00 Int…
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Dave Landau is a comedian, co-host of the "Normal World" podcast, and author of "Party of One: A Fuzzy Memoir." His latest special is "A Prison 10." www.davelandau.com https://www.youtube.com/@normalworld https://a.co/d/b7rPGor Go to https://ExpressVPN.com/ROGAN to get 4 months free! Don’t miss out on all the action - Download the Pick6 app today w…
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What if the future of media isn’t controlled by algorithms or legacy institutions—but by independent voices building directly with their audiences? In this episode, Erik Torenberg is joined by Chris Best, cofounder and CEO of Substack, along with a16z general partners Katherine Boyle and Andrew Chen. We trace the origin story of Substack and its cu…
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Venture capital has powered companies like Facebook and TikTok—but what if that same urgency fueled America’s defense and industrial base? Katherine Boyle, General Partner at Andreessen Horowitz and cofounder of the firm’s American Dynamism practice, argues this is the biggest business opportunity of our time. In this conversation from The Shawn Ry…
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Garry Nolan, PhD, is an immunologist and professor at Stanford University School of Medicine. He is also a business executive and Executive Director of the Board of the Sol Foundation, a research and advocacy center focused on UAP studies. www.thesolfoundation.org Hunt with confidence using onX Hunt. Start your free trial today at: https://huntsmar…
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In this interview from the 20VC podcast, Martin Casado (a16z General Partner) joins Harry Stebbings to unpack the state of AI, the rise of coding models, the future of open vs. closed source, and how value is shifting across the stack. Martin offers a candid view of the opportunities and dangers shaping AI and venture capital today. Resources: Find…
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Fedor Gorst is a professional pool player whose career highlights include championship wins at the World Nine-Ball Championship, the U.S. Open Pool Championship, and the Derby City Classic. www.fedorgorst.com 50% off your first box at https://www.thefarmersdog.com/rogan! Don’t miss out on all the action - Download the DraftKings app today! Sign-up …
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