EP-EDGE brings you the latest in cardiac electrophysiology — from breakthrough research and clinical insights to future-shaping innovations. Hosted by Dr. Niraj Sharma, an electrophysiologist with over 15 years of experience, each episode delivers clear, evidence-based updates designed to inform, inspire, and elevate your practice.
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Niraj Sharma Podcasts
Welcome to EP Edge Journal Watch — where cardiac electrophysiology meets evidence, precision, and perspective. Hosted by Dr. Niraj Sharma, this bi-weekly podcast distills high-impact cardiovascular and EP research into clear, clinically meaningful insights. Each episode goes beyond headlines and abstracts to uncover what new studies actually mean for patient care, decision-making, and the future of electrophysiology. What EP Edge Journal Watch stands for: Evidence-based practice Precision el ...
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EP Edge Journal Watch — November 2025, Edition 2: From Lifestyle to Lifeline
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In this episode, Dr. Niraj Sharma breaks down six pivotal studies shaping today’s electrophysiology and cardiology practice—from lifestyle-driven AF control (ARREST-AF) and post-CABG atrial fibrillation management to the DOAC + aspirin conundrum in stable CAD, the return of digitoxin in HFrEF, insights from CABANA-Substudy, and the latest ICD regis…
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EP Edge Journal Watch | Episode 1, November 2025: Potassium and VT, GDMT Withdrawal & AF Risk Uncovered
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In this inaugural episode, Dr. Niraj Sharma breaks down three pivotal studies that could shift daily EP practice: How high-normal potassium targeting can reduce VT burden (POT-CAST trial). When GDMT withdrawal may be safe after recovery from tachycardia-induced cardiomyopathy. Why adverse pregnancy outcomes may predict long-term AF risk. Get the si…
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Targeting the Intrinsic Pathway: Is Factor XI Inhibition Poised to Redefine Stroke Prevention in AF: EP Edge August 2025 Issue 4A
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What if stroke prevention in atrial fibrillation no longer meant trading protection for bleeding risk? Factor XI inhibition—led by trials like AZALEA–TIMI 71, LILAC–TIMI 76, and LIBREXIA–AF—is poised to rewrite the anticoagulation playbook. By targeting the intrinsic pathway, these agents may decouple thromboembolic protection from major bleeding, …
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First-Line VT Ablation: Trials, Tools & Timing: EP Edge Newsletter June 2025
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The paradigm is shifting. Ventricular tachycardia (VT) ablation is stepping out of the shadows—from rescue therapy to first-line strategy, driven by landmark trials like VANISH2, PAUSE-SCD, and PARTITA. Meanwhile, pulse field ablation (PFA) continues its rapid evolution—crossing over from atrial to ventricular applications—but questions about durab…
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Left Atrial Appendage Occlusion (LAAO): Where We Stand in 2025: EP Edge Newsletter 4B August 2025
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Left atrial appendage occlusion (LAAO) has evolved from a niche option for oral anticoagulation–intolerant patients to a frontline procedural strategy for stroke prevention in atrial fibrillation. Landmark trials like OPTION, SWISS‑APERO, and COMBINATION are redefining how and when we use these devices. In this episode of EP Edge, Dr. Niraj Sharma …
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Pulse Field Ablation: Promise, Peril, and the AI Revolution in EP: EP Edge Newsletter May 2025
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9:22
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Pulse field ablation (PFA) has been hailed as the next frontier in atrial fibrillation therapy—nonthermal, ultra-selective, and lightning fast. But as new data emerges, important questions are rising about its systemic effects, cerebral safety, and vascular complications. In this episode of EP Edge, Dr. Niraj Sharma unpacks the latest findings from…
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Lifestyle Modification and Atrial Fibrillation: Redefining the role of the Electrophysiologist: EP Edge Newsletter July 2025
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Ablation is powerful—but lifestyle is transformative. As atrial fibrillation (AF) continues to rise globally, emerging evidence makes it clear: lifestyle modification is not just complementary care, it’s frontline therapy. In this episode of EP Edge, Dr. Niraj Sharma explores how structured lifestyle interventions—targeting weight, alcohol use, sle…
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Beyond CRT: LBBAP and the New Era of Physiological Pacing — Promise and Pitfalls: EP Edge Newsletter October 2025 Issue 5
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In this episode of EP Edge Podcast, Dr. Niraj Sharma dives deep into the clinical promise and procedural realities of LBBAP: Clinical advantages: improved LVEF, narrower QRS, lower VT/VF and AF incidence. RV protection: reduced risk of pacing-induced cardiomyopathy. Sex-specific outcomes: women with NICM + LBBB derive greater benefit. Complications…
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