Best NEJM Group Podcasts (2025)

1
#195 Antibiotic Duration & BALANCE Trial: Beyond Journal Club with NEJM Group 21:44

Play Pause

14d ago21:44

21:44

Antibiotic duration for bacteremia is something most of us learned by habit, not by trial data. In this episode, we walk through the BALANCE trial and use it as a lens to revisit how 1) host, 2) organism, and 3) source should guide treatment. When shorter really is enough, and when it isn’t? 🔹 Sponsor: Oakstone CME Use the code "CORE30" for 30% off…

1
Antibiotic Duration & BALANCE Trial: Beyond Journal Club with NEJM Group

13d ago

—

Time Stamps 02:58 Host, Organism, Source: The Core Framework Behind Duration 09:02 How Evidence Shifted Practice 11:27 The BALANCE Trial: Short-Course vs Standard-Course Therapy 18:55 Where does this leave us? Sponsor: Oakstone CME Code CORE30 for 30% from 11/1/25-1/31/26 https://www.coreimpodcast.com/MKSAP Financial Disclosures from Guests: None S…

1
NEJM Interview: Anne Zink on increases in rates of congenital syphilis and potential strategies for reversing this trend. 7:38

8h ago7:38

7:38

Anne Zink is a lecturer and senior fellow at the Yale School of Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. A.B. Zink, N.C. McCann, and R.P. Walensky. From Crisis to Action — Policy Pathways to Reverse the Rise in Congenital Syphilis. N Engl J Med 2025;393:2388-2391.…

51
NEJM This Week — December 18, 2025 23:29

1d ago23:29

23:29

This week, we look at ctDNA-guided immunotherapy for bladder cancer, cardiovascular outcomes with tirzepatide, and evidence that one HPV vaccine dose may be enough. We explore high-dose rifampin for tuberculous meningitis, review measles amid rising outbreaks, and follow a challenging case of gastrointestinal bleeding. Essays examine how clinicians…

1
What Values are in AI? A Conversation with Dr. Zak Kohane 1:18:13

2h ago1:18:13

1:18:13

For Dr. Zak Kohane, this year’s advances in AI weren’t abstract. They were personal, practical, and deeply tied to care. After decades studying clinical data and diagnostic uncertainty, he finds himself building his own EHR, reviewing his child’s imaging with AI, and re-thinking the balance between incidental and missed findings. Across each story …

1
Stories of Courage and Career Development with Horn Award

1h ago

—

Sponsor: Oakstone CME Code CORE30 for 30% from 11/1/25-1/31/26 https://www.coreimpodcast.com/MKSAP Show Notes What Is the Horn Scholars Program? A 2-year career development award for junior clinician-educators in General Internal Medicine (Primary Care • Geriatrics • Hospital Medicine) Purpose: Provide protected time + matching institutional suppor…

1
#196 Stories of Courage and Career Development with Horn Award 19:13

7d ago19:13

19:13

We hope these stories resonate with anyone who has felt pulled between professional purpose and personal life, and remind you that you’re not alone in wanting both. 🔹 Sponsor: Oakstone CME Use the code "CORE30" for 30% off: https://www.coreimpodcast.com/MKSAP 🔹 Transcript and Shownotes (1:09) | How the Horn Award Opened the Door to Growth in Dr. Ty…

1
NEJM Interview: Reshma Ramachandran on changes to the FDA’s adverse-event data releases and future directions for enhancing its safety-surveillance infrastructure. 9:57

9h ago9:57

9:57

Reshma Ramachandran is an assistant professor of medicine at the Yale School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.D. Wallach, J.S. Ross, and R. Ramachandran. Enhancing FDA Drug-Safety Surveillance — Beyond Releasing Daily Adverse-Event Data. N Engl J Med 2025;393:2284-2286.…

1
NEJM This Week — December 11, 2025 27:17

7d ago27:17

27:17

This week, we look at new studies on high-dose influenza vaccines for older adults, antiplatelet therapy after coronary surgery, and HER2-targeted immunotherapy for advanced bladder cancer. We review complex regional pain syndrome and a pediatric case of fever and rash. We also explore FDA innovation and safety, aspirin’s role in metastasis prevent…

1
NEJM Interview: Robert Huckman on the dearth of successful business models aimed at keeping people healthy. 14:43

13d ago14:43

14:43

Robert Huckman is a professor of business administration at Harvard Business School and a research associate at the National Bureau of Economic Research. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D.M. Cutler and R.S. Huckman. Has Corporatization Met Its Match? The Challenge of Making Money by Keeping Peopl…

1
NEJM This Week — December 4, 2025 21:26

15d ago21:26

21:26

This week, we look at new trials on glucocorticoids for pneumonia in Africa, shunting for normal-pressure hydrocephalus, and pegcetacoplan for two rare kidney diseases. We review updated vaccine evidence for Covid-19, RSV, and influenza, and present a case of respiratory decline and muscle weakness. Perspectives explore health care incentives, U.S.…

1
Severe Hypertriglyceridemia: 5 Pearls Segment

14d ago

—

Previous Next Time Stamps 03:19 Lipoprotein Lipase and Why Triglycerides Fluctuate Fast 05:27 Triglycerides as a Cardiovascular Risk Marker 09:28 Acute Management For Pancreatitis Induced by Triglycerides 14:34 Lifestyle Counseling 17:31 Medications That Lower Triglycerides 25:29 How to Choose the Right Triglyceride Therapy 27:56 Genetic Causes and…

1
#194: Severe Hypertriglyceridemia: 5 Pearls Segment 38:06

15d ago38:06

38:06

How quickly can triglycerides rise? At what threshold are patients at risk of pancreatitis or cardiovascular adverse outcomes? What do you have to rule out? How do you counsel on lifestyle changes? Which medications do you start with why and when? 🔹 Transcript and Shownotes (03:19) | Lipoprotein Lipase and Why Triglycerides Fluctuate Fast (05:27) |…

1
NEJM Interview: Nishant Uppal on the emergence of venture capital investing by academic medical centers and its potential implications. 11:49

21d ago11:49

11:49

Nishant Uppal is an instructor in medicine at Massachusetts General Hospital. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. N. Uppal and Z. Song. Venture Capital Investments by U.S. Academic Medical Centers. N Engl J Med 2025;393:2077-2080.

1
NEJM This Week — November 27, 2025 22:32

17d ago22:32

22:32

This week, we look at new studies on early aspirin discontinuation after myocardial infarction, an antiviral pill for dengue prevention, and CRISPR-based gene editing for lipid disorders. We review bedside clinical teaching and present a complex case of seizures and visual disturbances. Perspectives explore antidepressant safety in pregnancy, resto…

1
NEJM Interview: Jane Zhu on a new Oregon law that aims to address corporate control in medicine. 10:34

28d ago10:34

10:34

Jane Zhu is an associate professor of medicine in the Division of General Internal Medicine at Oregon Health and Science University. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.M. Zhu and H. Rooke-Ley. Regulating Corporate Control in Health Care — Oregon’s Attempt to Revive the CPOM Doctrine. N Engl J Med …

1
NEJM This Week — November 20, 2025 23:53

1M ago23:53

23:53

This week, we look at new research on potassium optimization in patients with defibrillators, reducing antihypertensive therapy in nursing homes, an mRNA influenza vaccine, and belzutifan for rare neuroendocrine tumors. We review long QT syndrome and present a case of abnormal behavior and seizures in a young man. We also explore perspectives on pr…

1
From Hindsight Bias to Machine Bias: Dr. Laura Zwaan on Learning from Mistakes 38:09

28d ago38:09

38:09

As a cognitive psychologist, Dr. Laura Zwaan studies how humans make—and learn from—mistakes. In this episode of NEJM AI Grand Rounds, she brings that lens to AI, showing how machines inherit our biases and why both need transparency and reflection. From the challenge of defining diagnostic error to the promise of “machine psychology,” Dr. Zwaan ex…

1
Venous Congestion & VEXUS: Interview with Dr. Ross Prager

28d ago

—

Time Stamps 00:00 Volume overload vs. Venous Congestion 05:49 Venous Congestion and AKI, mortality, possible delirium 10:10 Measuring Venous Congestion and the Role of VEXUS 15:05 Common Mistakes and Best Practices of VEXUS score 23:13 Assessing Fluid Tolerance and Risks with Venous Doppler in Acute Care 25:29 Fluid vs. Vasopressor Strategy Guided …

1
#193 Venous Congestion & VEXUS Interview with Dr. Ross Prager 34:44

1M ago34:44

34:44

Why is venous congestion not the same as volume overload? How can looking at IVC as well as doppler on the hepatic vein, portal vein, and/or intrarenal vein help? Can venous congestion explain someone's delirium? Or be at play in septic shock? What are the limitations of the VEXUS score? 🔹 Sponsor: Oakstone CME Use the code "CORE30" for 30% off: ht…

1
NEJM Interview: Joshua Barocas on recent federal actions related to harm-reduction programs for people with substance use disorders. 12:30

1M ago12:30

12:30

Joshua Barocas is an associate professor of medicine at the University of Colorado Anschutz Medical Campus. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.A. Barocas. The Erosion of Harm Reduction. N Engl J Med 2025;393:1865-1867. B.A. Barsky, A. Caplan-Bricker, and C. Robertson. Religious Liberty as a Shield…

1
NEJM This Week — November 13, 2025 24:31

1M ago24:31

24:31

In this episode, we look at new trials on deferring arterial catheterization in shock, beta-blocker use after myocardial infarction, and a treatment for triple-negative breast cancer. We review acromegaly. A case describes a man with dyspnea, edema, and pacemaker lead displacement. We explore perspectives on the burdens of primary care, the erosion…

1
NEJM Interview: Yashaswini Singh on antitrust enforcement as a potential counterbalance to consolidation resulting from rapid health care corporatization. 7:38

1M ago7:38

7:38

Yashaswini Singh is an assistant professor of health services, policy, and practice at Brown University. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. Y. Singh. The Antitrust Antidote to Hospital and Nursing Home Corporatization — Promises and Pitfalls. N Engl J Med 2025;393:1761-1764.…

1
NEJM This Week — November 6, 2025 18:53

1M ago18:53

18:53

In this episode, we discuss long-term outcomes after chest-wall irradiation for breast cancer, new treatments for psoriasis and obesity, and early results on a vaccine for Lassa fever. We review opioid deprescribing and a clinical case describes spiraling into a distant past. Perspectives examine the corporatization of health care, the health effec…

1
Debate on First-Line Medications for Diabetes

1M ago

—

Time Stamps 01:43 Case 1: Managing Uncontrolled Diabetes in a 47-Year-Old Male 07:15 Understanding Cost and Insurance Barriers in Diabetes Care 09:26 Case 2: Addressing Weight Gain and Financial Stress in a 52-Year-Old Male 14:16 Case 3: Managing Coronary Artery Disease and CKD in a 66-Year-Old Male 19:41 Case 4: Severe Obesity and Pain Management …

1
#192 Debate on First-Line Medications for Diabetes 36:50

1M ago36:50

36:50

SGLT-2i vs. GLP-1? vs Metformin? How do you balance the cost and coverage of first-line options like metformin, SGLT-2, and GLP-1s? How do you choose between SGLT-2 and GLP-1s for comorbidities like CAD or CKD? And how do you weigh their side effects and practical use? 🔹 Sponsor: Use the code "CORE30" for 30% off: https://www.coreimpodcast.com/MKSA…

1
NEJM This Week — October 30, 2025 25:27

2M ago25:27

25:27

This week, we look at new findings from the European prostate cancer screening study, advances in lung cancer therapy, physical therapy for meniscal tear, and a promising vaccine for Salmonella Paratyphi A. We review noninvasive liver fibrosis assessment and a complex clinical case, and explore perspectives on concierge care, kidney disease equity,…

1
NEJM Interview: Eberechi Nwogu-Onyemkpa on integrating palliative care services and resources into the management of sickle cell disease. 9:52

2M ago9:52

9:52

Eberechi Nwogu-Onyemkpa is an assistant professor in the Division of Palliative Medicine at Washington University in St. Louis. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E. Nwogu-Onyemkpa and Others. Involving Palliative Care to Improve Outcomes in Sickle Cell Disease. N Engl J Med 2025;393:1553-1556. E. C…

1
NEJM This Week — October 23, 2025 25:34

2M ago25:34

25:34

In this episode, we look at new research on mucoactive therapy for bronchiectasis, aspirin use in anticoagulated patients with coronary disease, and sotatercept for early pulmonary arterial hypertension. We explore the genetics behind misdiagnosed common diseases and review uncertainty in medical training. We also share a case of woman with abdomin…