Michael Frazis, Misha Saul and guests discuss the life sciences, technology, and their latest investment ideas.
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Michael Frazis Podcasts

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#92: Syntara Phase 2 Success, Geopolitics and Uranium
25:06
25:06
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25:06Syntara’s highly anticipated Phase 2 results in myelofibrosis—what the data tells us, why the market sold off, and what might come next in terms of funding or partnership.
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#91: ChatGPT v Google, SpaceX and Autonomous Driving
26:11
26:11
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26:11Learn more at: www.fraziscapitalpartners.comNvidia’s Q1 PerformanceImpact of the H20 Chip Ban on ChinaMary Meeker: Big Tech CapEx TrendsAutonomous Driving in San Francisco: Waymo vs. UberLidar vs. Vision Debate and Safety ImplicationsLidar Startup Failures and Industry FalloutSpaceX Starship Test Flight & 2026 Mars Launch WindowHumanoid Robots and …
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#90: HIMS and Most Favoured Nation with Mike and Elle
38:21
38:21
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38:21HIMS, NU, MELI, AMD & Aussie Biotech
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#89: Anteris CEO on the next generation of heart valves
1:08:41
1:08:41
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1:08:41Anteris CEO explains why their new biomimetic heart valve can take serious market share in a $10 billion market. It's currently implanted in over 100 patients, and surgeons are delighted with the results. The market is sleeping on this one...
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#88: Big tech earnings! Does the market settle?
28:58
28:58
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28:58Mike and Ellianna discuss
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#87 - Google earnings, and was that a low in semis and biotech?
24:44
24:44
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24:44#87 - Google earnings, and was that a low in semis and biotech? Mike and Ellianna discuss
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#86: Mike and Ellianna discuss the latest market moves.
27:37
27:37
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27:37Mike and Ellianna discuss the latest market moves.Sections00:00 - US Tariffs and Market Reactions06:35 - Managing Risk12:41 - Opportunities in Tech and Healthcare21:18 - Reddit23:54 - Market Dynamics and Short Selling28:54 - Clarity's Market Position and Future Prospects33:43 - Biotech Sector Valuation and Mispricing35:55 - Interest Rates and Econo…
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Clarity Pharmaceuticals, with Dr Alan Taylor
52:49
52:49
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52:4900:00 Welcome Back and Market Overview03:05 Navigating the Macro Environment05:59 Company Developments and Fast Track Designations09:11 Short Selling and Market Sentiment12:08 Innovations in PSMA Targeting Agents15:03 Financing Strategies and Market Positioning17:46 Clinical Trials and Sensitivity Improvements21:14 Regulatory Pathways and Market En…
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Curing prostate cancer, with research superstar Professor Louise Emmett
1:01:51
1:01:51
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1:01:5100:00 - Introduction to Radiopharmaceuticals and PSMA 03:00 - Current State of PSMA in Prostate Cancer Treatment 06:04 - Comparative Analysis: US vs Australia in Radiopharmaceuticals 09:02 - Imaging Techniques and Their Impact on Diagnosis 12:14 - The Patient Journey: From Diagnosis to Treatment 14:56 - Challenges in Sensitivity and Specificity of …
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Equity sell off - the real deal? Strategy update from Michael Frazis
34:54
34:54
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34:54Equity sell off - the real deal? Strategy update from Michael Frazis
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#82: A fresh look at true customer love and explosive growth, HIMS, Clarity Pharma and semis
35:41
35:41
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35:4100:0 True Customer Love and Explosive Growth02:05 - Portfolio update04:09 - Hims: A Case Study in True Customer Love and Explosive Growth07:18 - Defining True Customer Love11:33 - The Future of Hims and Market Dynamics in GLP-1sClarity's Fast-Tracked Approval and Market Response27:06 - Short Selling in CU629:59 - If you want to be valued like a US …
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#82: Ellianna joins to talk DeepSeek, winners and losers, and 2024 in review
44:24
44:24
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44:24#82: Ellianna joins to talk DeepSeek, winners and losers, and 2024 in review
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Timestamps00:00 - The Rise of DeepSeek: A Game Changer in AI02:52 - Impact on Valuations and Capital Expenditure05:55 - Investment Strategies in 202508:52 - Focus on Australian Biotech and HealthcareTakeawaysDeepSeek's AI system is a major disruptor in the market.The release of model weights challenges existing AI business models.Investors are reco…
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#80: Aliens, Syntara and the NDIS, with Arjun Balaji
35:17
35:17
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35:17#80: Aliens, Syntara and the NDIS with Arjun Balaji
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#79 Repairing Nerves with Orthocell CEO Paul Anderson
45:55
45:55
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45:55Paul Anderson, CEO of Orthocell, discusses the company's collagen-based medical devices aimed at regenerative medicine. He covers their products for bone regeneration, nerve repair, and tendon repair, highlighting their clinical success and market potential. The conversation also covers the company's strategic partnerships, regulatory approvals, an…
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#78 - Immutep CEO Marc Voigt discusses the latest in immunotherapy for lung cancer
51:08
51:08
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51:08Michael Frazis interviews Marc Voigt, CEO of Imutep, discussing the challenges of lung cancer, the evolution of immunotherapy, and the innovative approaches Imutep is taking in cancer treatment. They explore clinical trial data, commercial opportunities, and advancements in autoimmune disease research, while also addressing the financial health and…
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#77: Healthcare crash, Chrome vs Perplexity and a new business idea
38:30
38:30
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38:30Michael Frazis and Arjun Balaji discuss the current state of the markets, the shifts in healthcare and the performance of small-cap tech stocks. They analyze the challenges faced by major pharmaceutical companies like Pfizer and Moderna, particularly in light of political changes and scrutiny. The discussion also delves into the role of advertising…
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#76: Australia’s secret one child policy and Trump’s FDA - Arjun Balaji joins us
1:10:08
1:10:08
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1:10:0800:00 Introduction and Background 02:02 Political Landscape and Global Trends 05:58 Australia's secret One Child policy 09:59 COVID-19 Policies and Public Trust 13:49 Biotech Regulation and the FDA 18:08 Emerging Trends in Biotech 26:01AI in Drug Discovery and Development 30:03 AI's Role in Drug Development 34:49 Challenges in Drug Trials and Regul…
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#75: Big tech roundout with Meta and why the shtcos are rallying
13:56
13:56
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13:56#75: Big tech roundout with Meta and why the shtcos are rallying
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#74: Amazon, Microsoft and Google report! (and an election)
28:02
28:02
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28:02Amazon, Microsoft and Google report! (and an election)
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#73: Strategy Update - cars, semis, smartphones and algorithms
23:34
23:34
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23:34#73: Strategy Update - cars, semis, smartphones and algorithms
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#72: Hashan de Silva joins us to cover CurvebeamAI, Syntara, a new approach to Alzheimer's and his new fund
1:13:05
1:13:05
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1:13:05#72: Hashan de Silva joins us to cover CurvebeamAI, Syntara, a new approach to Alzheimer's and his new fund
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#71: Double or Nothing - Misha's new fund, the crash (and recovery), driverless cars, and UK turmoil
36:21
36:21
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36:21#71: Double or Nothing - Misha's new fund, the crash (and recovery), driverless cars, and UK turmoil
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#70: Clarity Pharmaceuticals, with Chairman Dr Alan Taylor
1:19:02
1:19:02
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1:19:02Dr Alan Taylor discusses Clarity Pharmaceuticals in depth.
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#69: Droneshield: Defending against the modern horrors of war, with CEO Oleg Vornik
1:01:46
1:01:46
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1:01:46It must be a uniquely modern horror to see a drone flying towards you with a grenade strapped, and it must be all the worse to know your last moments are being filmed. Drones are now ubiquitous across the battlefields of Ukraine, Gaza, and shipping lanes in the Middle East. Costing relative pittances, cheap drones loaded with explosives can destroy…
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Frazpod #68: Dodging the bloodbath in midcap tech
20:52
20:52
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20:52Dodging the bloodbath in midcap tech
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Frazpod #67 - Clarity Pharma, Curvebeam AI, Transmedics and AMD
19:33
19:33
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19:33Clarity Pharmaceuticals Success: Clarity Pharmaceuticals reported a significant response in a patient with metastatic castrate-resistant prostate cancer. The patient received two cycles of copper 67 Biss. PSMA, and after six months from the second dose, there was no evidence of PSA, indicating a potential cure. This is noteworthy because the patien…
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Episode #66: A crack in the semi facade? Angus Walker joins us
34:45
34:45
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34:45Episode #66: A crack in the semi facade? Angus Walker joins us
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Episode #65 - Interesting perspectives from Microsoft
23:19
23:19
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23:19Interesting perspectives from Microsoft
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Semis, Tesla and interest rates, what we're looking at right now
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Frazis Capital Podcast #63: The three revolutions of 2023 and where they will go in 2024.
22:18
22:18
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22:18The three revolutions of 2023 and where they will go in 2024. And our top ASX pick...
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Frazis Capital Podcast #62: Medtech, liquidity, and talking computers
14:40
14:40
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14:40Medtech, liquidity, and talking computers
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Frazis Capital Podcast #61: Bond yields hit cycle highs, medtech takes a GLP-pounding, Nvidia and Microsoft do some cool science, and all roads in semiconductors lead to TSMC.
37:23
37:23
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37:23Bond yields hit cycle highs, medtech takes a GLP-pounding, Nvidia and Microsoft do some cool science, and all roads in semiconductors lead to TSMC.
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Double or Nothing #16: Qantas scandal, an aggressive move in capital markets, a new IPO, and dodgy Government energy data
20:31
20:31
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20:31Double or Nothing #16: Qantas scandal, an aggressive move in capital markets, a new IPO, and dodgy Government energy data.
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Double or Nothing #15 - Ozempic, AI in the sex industry, drug discovery, Stefan Zweig
32:45
32:45
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32:45Ozempic, AI in the sex industry, drug discovery, Stefan Zweig
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Double or Nothing #14: Michael Frazis and Misha Saul talk markets
20:55
20:55
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20:55Double or Nothing #14: Michael Frazis and Misha Saul talk markets
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State of the Market: the winners and losers in big tech cost outs
27:57
27:57
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27:57State of the Market: the winners and losers in big tech cost outs
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Double or Nothing #13: Submarines and Silicon Valley Bank
29:44
29:44
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29:44Michael Frazis and Misha Saul talk Silicon Valley bank and Submarines
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Double or Nothing Episode #12: ChatGPT, Cortes and the Aztecs
38:44
38:44
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38:44Double or Nothing Episode #12: ChatGPT, Cortes and the Aztecs.
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Michael Frazis gives an update on markets and technology.
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Double or Nothing #11: Chess, inflation, AI, software, stocks
39:18
39:18
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39:18Misha Saul and Michael Frazis talk markets
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Double or Nothing #10: Crowdstrike, inflation, 2023
53:09
53:09
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53:09Double or Nothing #10: Crowdstrike, inflation, 2023
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Double or Nothing #9: Grindr IPO, Sunrise, and inflation rolls over
41:44
41:44
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41:440:12 – Latest (deflationary) inflation data 6:42 – Investing strategies 10:30 – Tesla’s journey and the switch to self-driving capabilities 12:56 – David Walsh’s presentation at Sohn Conference on professional gambling 14:46 – Grindr IPO 21:36 – Recap of Blackbird’s Sunrise startup conference and thoughts on private markets 31:44 – Lessons learned …
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Michael Frazis and Misha Saul talk SBF and inflation.
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Double or Nothing #7: Nuclear war? And Facebook, Square, Microsoft, Google
57:20
57:20
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57:20Double or Nothing #7: Nuclear war? And Facebook, Square, Microsoft, Google
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Double or Nothing #6: Run on the pound? And private equity does deals
45:44
45:44
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45:44Misha Saul and Michael Frazis discuss latest developments in global markets.
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Double or Nothing #5: Adobe buys Figma, Ancient and Modern heroes, and CPI prints
44:24
44:24
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44:24Double or Nothing with Michael Frazis and Misha Saul. Adobe buys Figma, Ancient and Modern heroes, and CPI prints
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Double or Nothing #4: Kim Kardashian's private equity play, the collapse in US gas prices, Twilio, Whitehaven and VC
32:31
32:31
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32:310:32 – Passing of Queen Elizabeth II 7:35 – Kim Kardashian’s new private equity play 9:16 – Collapse in price of crude oil 13:12 – Market and inflation outlook 15:32 – Twilio 21:19 – Whitehaven Coal 24:37 – Update on VC Fund deals 32:02 – Summary and wrap-up
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Double or Nothing #3: Artificial intelligence gets creative and Powell speaks at Jackson Hole
47:24
47:24
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47:24Artificial intelligence gets creative and Powell speaks at Jackson Hole
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Double or Nothing #2: Qantas, NVDA, Farfetch, Nathan Tinkler and Fortescue
49:50
49:50
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49:50Double or Nothing with Misha Saul and Michael Frazis 0:15 – Preview and thoughts on Jerome Powell’s upcoming speech 1:00 – Update on Nvidia’s recent earnings and the wider semiconductor industry 12:10 – Farfetch update and latest earnings 15:45 – Notable small cap and GARP stocks 17:23 – Qantas recent performance and share buyback announcement 22:4…
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