Welcome to MedEvidence Articles, where we encourage community research and education with weekly articles. Visit our website at MedEvidence.com. MedEvidence helps answer the question of “Who can you trust?” for medical information. The MedEvidence platform provides valuable information about many medical issues and the insights of evidence-based medicine. MedEvidence educates audiences through engaging and entertaining magazines, podcasts, videos, articles, and presentations. We strive to br ...
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In this episode, we delve into the science and struggle behind social anxiety disorder. This condition affects millions of people and often begins in childhood. We explore how the brain’s fear circuitry becomes overactive, and common treatments like SSRIs. We also highlight an intriguing new treatment being tested: a nasal spray of pheromone-like c…
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In this episode, we explore the complex world of gastroparesis. Gastroparesis is a condition that slows the stomach’s ability to empty food and turns mealtime into a daily challenge. From the science behind digestion to the symptoms, causes, and evolving treatments for idiopathic gastroparesis, we break down what happens when the stomach stops coop…
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Scurvy, a disease caused by vitamin C deficiency, once killed thousands of sailors during long sea voyages. The breakthrough came in 1747 when Dr. James Lind conducted the first recorded clinical trial, proving citrus fruits could prevent the illness. British sailors were later issued lime juice, earning them the nickname “limeys.” Though now consi…
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Tinnitus Treatments Result From Clinical Trials
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4:34This week we explore tinnitus, a condition marked by ringing in the ears. Tinnitus is affects roughly 10% of Americans and remains poorly understood. Unfortunately, this poor understanding means there are no disease-modifying treatments available. Luckily, clinical researchers have been hard at work looking for relief for tinnitus sufferers, and th…
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Can We Train the Immune System to Kill Cancer?
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4:55In this week's episode, we jump into the emerging field of personalized cancer vaccines. Cancer remains the second leading cause of death worldwide due to its complex nature. "Cancer" actually encompasses over 275 diseases, each driven by genetic mutations that make cancer cells act independently and harmfully within the body. Find out how scientis…
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Vascular Dementia: Causes, Symptoms, Risk Factors, and Treatment Options
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3:40In this week's episode, we talk about vascular dementia, a significant yet often overlooked brain disorder caused by reduced blood flow, usually due to stroke and/or vascular disease. It accounts for 15-20% of dementia cases and leads to cognitive decline, memory loss, and motor impairments. While no cure exists, prevention is key—controlling risk …
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Why Measles Has Gone From Eradicated To Outbreak
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6:19Measles a highly contagious virus that can cause serious complications, including pneumonia, brain swelling, and death. It was declared eradicated in the U.S. in the year 2000 but has resurfaced, with over 700 cases reported so far this year. What are the causes of this latest outbreak? Despite a long history of vaccine success, recent declines in …
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Psoriasis and the Immune System: More Confusing Than Teenage Slang
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5:00On this week, we discuss psoriasis, a chronic autoimmune disease affecting 2-3% of Americans. It's characterized by red, flaky skin and linked to serious health conditions like arthritis and cardiovascular disease. It results from an overactive immune response which may be initiated or worsened by environmental factors such as stress, obesity, and …
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Clinical Trials Have Opened Doors to COPD Medications
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6:43In this week we talk about chronic obstructive pulmonary disease (COPD), a progressive lung condition that restricts airflow due to chronic bronchitis and emphysema, which damages the alveoli. COPD affects around 11% of adults over 30 and is linked to smoking, pollution, and genetic factors. This episode relates COPD to a house with big rooms and n…
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This podcast explores Limbic-predominant Amnestic Neurodegenerative Syndrome (LANS), a newly identified condition that primarily affects episodic memory while leaving other cognitive functions relatively intact. LANS is associated with the misfolding of TDP-43, a protein that can accumulate and damage limbic structures. Unlike Alzheimer’s, LANS has…
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Medical treatments are shifting from broad approaches to precise genetic targeting, especially for finicky diseases like Alzheimer's dementia. While many past efforts focused on amyloid β plaques, new research is exploring genetic regulators like APP, which influences amyloid levels, and KDM5, an enzyme linked to memory and cognition. Clinical tria…
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This St. Patrick's Day we explore the history, nutritional profile, and potential health benefits of potatoes. Potatoes are a major global food staple, providing significant calories worldwide. Though often criticized for their high glycemic index (GI), different cooking methods, particularly chilling after cooking, can increase resistant starches,…
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In this week's episode, we discuss cluster headaches, one of the most severe pain conditions known. This rare condition affects about one in a thousand people with excruciating, clockwork-like attacks can last for weeks or months, with few effective treatment options. In this episode, we break down the causes, triggers, and latest research on clust…
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Alzheimer’s Anxiety: What’s Normal, What’s Not, and When to Act
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3:55Forgetting a name or misplacing your keys can be frustrating, but when does memory loss signal something more serious? In this episode, we explain the key differences between normal aging and Alzheimer’s disease. We break down how doctors diagnose Alzheimer’s, the role of biomarkers, and why early detection is crucial for those considering clinical…
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New Research on Heart Failure: Understanding IL-6 and Inflammation
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4:38This week, we talk about one of the big contributors to heart failure: inflammation. Heart failure affects millions and comes in two main types: HFrEF (weakened pumping) and HFpEF (thickened, stiff walls). While conditions like high blood pressure and diabetes contribute, chronic inflammation—driven in part by Interleukin 6 (IL-6)—plays a major rol…
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Short Circuits in the Heart: A Look at Atrial Fibrillation
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5:06When the hot water went out, you might call a plumber, but if the water heater is out it might instead be an electrical problem - just like how heart problems can stem from faulty electrical signals rather than the heart muscle itself. Atrial fibrillation (AFib), the most common arrhythmia affecting six million Americans, disrupts the heart’s elect…
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This week's podcast is a crash course on what the heart is, why we need it, how it works, and what can go wrong. Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram Twitter LinkedIn Tiktok Youtube For more great content, including disc…
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This week we talk about two recent studies which suggest a potential link between adult ADHD and an increased risk of developing dementia; though causation remains unproven. These studies, one in Israel and another in Sweden, found that adults with ADHD were significantly more likely to develop dementia or mild cognitive impairment. These findings …
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This week we discuss peripheral artery disease (PAD), a condition affecting blood flow in the peripheral arteries, most commonly in the legs. We cover its symptoms, such as leg pain, skin changes, and slow-healing wounds, as well as the potential risks of untreated PAD, including amputation and cardiovascular complications. We then talk about treat…
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Is the Deadliest Condition Preventable? Understanding ASCVD and LDL-C
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5:40This episode explores atherosclerotic cardiovascular disease (ASCVD), the leading cause of heart attacks and strokes worldwide. Learn about the role of LDL cholesterol in the development of fatty plaques that harden and block blood vessels, as well as the risks associated with ASCVD, including heart disease and peripheral artery disease. The episod…
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From Trials to Triumph: 2024’s FDA approvals
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7:12Join us this week for a brief tour of some body systems as we review five medications approved by the FDA in 2024. From liver disease to Alzheimer’s, we look at Rezdiffra, Iqirvo, Vafseo, Entyvio, and Kisunla, exploring the diseases they intend to treat and a brief overview of how the medicines work. We celebrate the hard work of volunteers, invest…
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In this episode, we delve into the complexities of Seasonal Affective Disorder (SAD), a subtype of Major Depressive Disorder that fluctuates with the seasons. Seasonal Affective Disorder, a condition affecting millions during the darker months. We explore its symptoms, causes, and demographic prevalence, highlighting its impact on mood, cognition, …
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Migraine vs. Komodo Dragon: A Battle of Headache Proportions
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5:58This week we discuss episodic and chronic migraines. Migraines are primary headaches that affect about a billion people globally each year. In this weeks episode, we discuss symptoms and the differences between episodic and chronic migraines. Learn about risk factors, treatment options, and why accurate and appropriate treatment is critical to keep…
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No Gym, No Problem: Making Fitness Work for You
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6:22This podcast episode examines the challenges of sticking to fitness resolutions and how to make exercise more accessible and sustainable. We discuss the health benefits of physical activity, the impact of stress on the body, and why reducing barriers like time, cost, and convenience can improve consistency. Learn practical tips for incorporating fi…
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Will the Science of Exosomes Revolutionize Medicine?
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5:24This week, we dive into the fascinating world of exosomes, the body’s nano-sized delivery drivers and communication hubs. We’ll explore what exosomes are, their role in cell-to-cell communication and healing, and the potential medical applications they offer. These include drug delivery, regenerative medicine, and combating diseases like cancer and…
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Are You Treating Your Sinus Headache All Wrong?
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4:29Sinus headaches are annoying, bothersome, and might not really be sinus-related for most people! We look at research that explains why sinus inflammation is rarely the cause headaches above the sinuses and how accurate diagnosis is essential for effective treatment. Learn about the role of sinuses, why facial pain isn’t always what it seems, and ho…
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Lipoprotein (a): The Cholesterol You Inherit, Not Eat
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7:05As we approach Thanksgiving and gather with family, it's the perfect time to ponder how our genetics, from eye color to cholesterol levels, shape our lives in unique and sometimes dangerous ways. This episode sheds explores how genetic disorders run in families and looks at lipoprotein (a), a very very very very bad kind of cholesterol. We also lea…
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Statins Good or Bad: Why the Popularity of Cholesterol-Lowering Drugs Sparks Criticism
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7:08In this episode we unpack the facts, controversies, and benefits surrounding the most prescribed drugs for lowering “bad” LDL cholesterol. Statins reduce risks of heart attack, stroke, and cardiovascular death, yet concerns over side effects - like muscle pain and blood sugar increases - fuel debates around their use. We’ll explore how statins work…
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In this week's episode we explore how trauma affects many system in the body, with symptoms that can last years or even decades. PTSD impacts not only mental health but also physical health, causing chronic stress that can lead to cardiovascular issues, metabolic changes, and immune dysfunction. We’ll break down the science behind stress responses …
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Is Inflammation the Fire That Fuels Kidney and Heart Disease?
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5:07In this week's episode we dive into how chronic inflammation connects kidney disease with cardiovascular risk. Learn how inflammation, typically the body’s healing response, can become a destructive force when it lingers, contributing to kidney damage and cardiovascular issues like high blood pressure and artery hardening. We’ll also explore why CK…
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Does Intermittent Fasting Really Work – Or Is It Just About Eating Less?
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5:58This week we explore the science behind one of an increasingly popular approach to managing weight and health—intermittent fasting. We'll break down how limiting your eating window can influence everything from metabolism and inflammation to blood sugar control. With new research showing potential benefits like weight loss and improved glucose leve…
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Can an Inflammation Blood Test Detect Heart Disease Early?
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5:47In this week's episode we take a closer look at the high-sensitivity C-reactive protein (hs-CRP) test, a powerful tool which may help assess cardiovascular risk. It is a biomarker of inflammation, and hs-CRP’s ability to predict heart disease is both fascinating and complex. We’ll explore how chronic inflammation affects the heart, what high hs-CRP…
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Cat Naps and Calories: Uncovering the Link Between Sleep and Weight
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5:41In this episode we explore the surprising link between sleep deprivation and weight gain. Discover how hormones like leptin and ghrelin, which regulate hunger and metabolism, are thrown off balance when we don't get enough sleep. We'll break down the science behind why losing sleep can lead to increased hunger, stress eating, and obesity, and how e…
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In this episode we explore the vital role that HDL cholesterol plays in maintaining cardiovascular health. Known as "good cholesterol," HDL helps clear excess fats from the bloodstream, but recent research shows that its role is far more complex than we once thought. We'll discuss how low HDL levels are linked to increased heart disease risk, why s…
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Can We Outsmart Viruses by Targeting Their Shared Weakness?
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4:01In this episode, we take a microscopic look at how some of the most dangerous RNA viruses, like COVID-19, Ebola, RSV, and the flu, hijack our cells to replicate. Discover the science behind viral reproduction and RNA-dependent RNA polymerase, the specialized machinery these viruses rely on. We’ll also explore how new antiviral treatments based on R…
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Is Your Chronic Cough an Unwelcome House Guest?
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5:58This week we dive deep into the mysteries of chronic cough—a condition that affects millions worldwide and can last for months or even years. In this episode, we’ll explore the science behind why we cough, how chronic cough disrupts lives, and the latest research on treatments and potential cures. From overactive nerve responses to underlying healt…
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In this episode, we compare the looming disaster of the Death Star to the health risks of Metabolic Syndrome, a combination of factors that significantly increase the chances of serious conditions like diabetes, heart disease, and stroke. Just as the Death Star’s vulnerability came from multiple issues working together, Metabolic Syndrome results f…
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In this week's episode, we’re using a historical naval mishap as a metaphor to explain how asthma works. Much like the Spanish ships accidentally firing on their own allies in 1801, asthma is caused by your immune system misfiring—targeting harmless particles like dust or allergens and causing inflammation in your airways. We’ll dive into the mecha…
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Observations on Autosomal Dominant Polycystic Kidney Disease
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6:01In this episode, we delve into the fascinating world of kidneys, those incredible organs that tirelessly filter our blood and regulate our body’s fluids. We’ll explore the complexities of autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that affects a small percentage of the population but can lead to severe outcomes like k…
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The "Flu Fighters": Unusual Remedies from History
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6:57In this episode, we explore the fascinating history of flu treatments, from bizarre and dangerous remedies of the past to the cutting-edge vaccines of today. We'll dive into the strange and often misguided methods used before the modern era, including addictive drugs, oysters, chloroform, and even chemical warfare agents. As we move into modern tim…
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Norovirus: Stomach Flu Spreading Like Room-Temperature Butter
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4:21In this episode, we delve into the gritty details of the stomach flu, focusing on the notorious Norovirus (stomach bug). Once overshadowed by Rotavirus, Norovirus now leads the charge in causing widespread acute gastroenteritis across all ages. We'll explore its symptoms, transmission, and why it thrives in closed environments like schools and crui…
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Elevated Lipoprotein(a): Causes, Risks, and Management Strategies
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6:43In this episode, we dive deep into the world of lipids and their crucial role in our bodies. Lipids, or fats, are essential for many bodily functions but pose a challenge when circulating in our watery bloodstream. We explore how the body packages these lipids with apolipoproteins to form lipoproteins, making them safe for transport. We discuss the…
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Curious about cannabis and migraines? In this episode, we explore the intriguing connection between the two. Discover how cannabis, historically used for headache relief, is making a comeback in medical circles despite legal hurdles. We dive into the endocannabinoid system, THC, CBD, and their potential impacts on migraine pathways. Learn about the…
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Join us as we dive into the complexities of memory and its fascinating mechanisms. We'll explore the different types of memory, how they're formed, stored, and retrieved, and the various brain regions involved. Discover the stark differences between implicit and explicit memory, and learn why conditions like Alzheimer's and other forms of dementia …
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In this episode, we dive into the world of blepharitis, a common yet often misunderstood condition that causes inflammation of the eyelids. Affecting people of all ages and backgrounds, blepharitis leads to symptoms such as eye irritation, redness, swelling, and dryness, significantly impacting quality of life. We'll explore the various causes, inc…
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In this episode, we dive deep into the complexities of diabetes beyond just managing blood sugar levels. Learn how uncontrolled diabetes impacts several parts of the body, causing serious complications due to blood vessel damage. We'll explore microvascular complications like diabetic retinopathy and nephropathy, as well as macrovascular issues suc…
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Rheum for Improvement Tackling Rheumatoid Arthritis
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5:05In this episode, we explore the complexities of rheumatoid arthritis (RA), a chronic autoimmune inflammatory disease affecting millions worldwide. RA causes the immune system to attack healthy joint tissue, leading to pain, stiffness, swelling, and serious complications such as joint and bone damage, and organ issues. We'll discuss the factors cont…
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In this episode, we explore the intricate world of migraines, a condition affecting one in eight people globally. Discover the five phases of a migraine—prodrome, aura, headache, postdrome, and interictal—and how each contributes to the overall experience. We delve into the role of the hypothalamus, the brain's stability center, in triggering migra…
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In today's episode, we delve into Chronic Obstructive Pulmonary Disease (COPD), a debilitating lung condition affecting millions worldwide. Characterized by obstructed airflow, COPD's symptoms—ranging from persistent cough and phlegm to life-threatening exacerbations—stem from the progressive degradation of lung structure. This disease is exacerbat…
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In today's episode, we dive into the surprisingly nuanced world of mosquitoes, revealing their role as the deadliest animal on Earth due to their capacity as disease vectors. While shark attacks capture headlines, mosquitoes quietly claim up to a million lives annually by transmitting diseases like malaria, dengue, and yellow fever. We explore the …
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