Best Matthew Genzink Podcasts (2025)

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Asymmetric Hydroamination 36:01

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4+ y ago36:01

36:01

In this episode we discuss a report from the Hartwig lab on an enantioselective hydroamination reaction. Through rational catalyst design, a cationic iridium complex was discovered that adds an amine N–H bond across a range of unactivated, internal alkenes. DOI: 10.1038/s41586-020-2919-z Xi, Y.; Ma, S.; Hartwig, J. F. Catalytic asymmetric addition …

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Mark Levin Interview 43:52

5y ago43:52

43:52

In this episode we interview Mark Levin, an Assistant Professor at UChicago. We discuss his recent publication with the Jacobsen group, life as a new professor, and places to eat in Chicago.

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Difluorinated Alkyl Bromide Synthesis via Chiral Iodoarene Catalysis 30:11

5y ago30:11

30:11

In this episode we discuss a report from the Jacobsen lab on an enantioselective synthesis of difluorinated alkyl bromides catalyzed by a chiral iodoarene. Linear free energy relationships between experimental enantioselectivities and computed catalyst parameters helped elucidate the origins of enantioselectivity. DOI: 10.1021/jacs.0c07043…

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Marshall Brennan Interview 53:35

5y ago53:35

53:35

In this episode we interview Marshall Brennan, the founder and Senior Product Manager of ChemRxiv. We discuss open-access publishing, alternative chemistry careers, and much more.

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Daniele Leonori Interview 36:41

5y ago36:41

36:41

In this episode we interview Dr. Daniele Leonori, who is a professor of chemistry at the University of Manchester. We discuss his recent paper on dehydrogenative aniline synthesis, differences between the UK and US academic system, and much more.

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Dehydrogenative Aniline Synthesis 35:29

5y ago35:29

35:29

In this episode we discuss a report from the Leonori lab on a photochemical dehydrogenative strategy for aniline synthesis. Photoredox and cobalt catalysis are combined to transform cyclohexanones into anilines. DOI: 10.1038/s41586-020-2539-7

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M. Christina White Interview 55:22

5y ago55:22

55:22

In this episode we interview Dr. M. Christina White, who is a professor of chemistry at the University of Illinois. We discuss her recent paper on C–H methylation as well as her program on site-selective C–H oxidation chemistry.

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Late-Stage C–H Methylation 34:54

5y ago34:54

34:54

In this episode we discuss a report from the White lab on a new method for late-stage C–H methylation adjacent to heteroatoms. DOI: 10.1038/s41586-020-2137-8

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Total Synthesis of Maximiscin 37:20

5y ago37:20

37:20

In this episode we discuss the total synthesis of (–)-maximiscin reported by the Baran lab. The route takes advantage of a convergent fragment coupling strategy with a late-stage formation of the central pyridone ring. DOI: https://doi.org/10.1021/jacs.0c03202

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Photocatalytic Deracemization 33:56

5+ y ago33:56

33:56

In this episode we discuss a report from the Knowles lab on a method for catalytic deracemization using visible light. This strategy benefits from two independent stereoselective steps resulting in a highly enantioselective transformation. DOI: 10.1126/science.aay2204.

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Jake Yeston 45:18

6y ago45:18

45:18

In this episode we interview Jake Yeston, who is Science's editor for physical sciences research.

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Total Synthesis of Perseanol 23:30

6y ago23:30

23:30

In this episode we discuss the total synthesis of (+)-perseanol reported by the Reisman lab. The route proceeds in 16 steps and takes advantage of a convergent fragment coupling strategy. DOI: https://doi.org/10.1038/s41586-019-1580-x

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Silver-Catalysed Nitrene Transfer 26:17

6y ago26:17

26:17

In this episode we interview the authors of a new paper on catalyst-controlled silver-catalysed nitrene transfer. By changing the ligand on silver the catalyst selectively functionalizes beta or gamma C-H bonds to form amino alcohols. Link: https://rdcu.be/bQGsf

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Organocatalytic Mitsunobu Reactions 24:03

6y ago24:03

24:03

In this episode we analyze a new paper from the Denton lab where they report a redox-neutral organocatalytic Mitsunobu reaction eliminating the need for stoichiometric, hazardous reagents. DOI: 10.1126/science.aax3353

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Thianthrenium Salts as New Synthetic Linchpin 21:26

6y ago21:26

21:26

In this episode we analyze a set of papers from the Ritter lab where they describe a new methodology for highly selective C–H functionalization reactions. Using thianthrenium salts as a synthetic linchpin, the Ritter lab demonstrates para selective amination, trifluoromethylation, and C–C cross-coupling reactions each in an effective two-step synth…

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Electrophotocatalytic C-H Oxidation 18:07

6y ago18:07

18:07

In this episode we analyze a paper from the Lambert lab where they report a new catalyst which upon electrochemical oxidation and photochemical excitation becomes a potent oxidant. The authors apply this strategy to coupling arenes and nitrogen heterocycles. DOI: 10.1002/anie.201906381

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Total Synthesis of Arcutinidine 19:40

6y ago19:40

19:40

In this episode we analyze the total synthesis of arcutinidine developed by the Li lab and compare it to recent syntheses completed by the Sarpong and Qin labs.

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Derivatizing Chiral Phosphorothioate Salts 23:11

6y ago23:11

23:11

In this episode we discuss a new paper from the Schoenebeck lab where they report a new method to couple aryl iodides and chiral phosphorothioate salts using Pd(I) dimer catalysis.

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Cleaving Olefins through Hydrodealkenylation 24:21

6y ago24:21

24:21

In this episode we analyze a new paper from the Kwon lab where they report a deconstructive strategy to access chiral synthetic intermediates starting from terpene and terpenoid derived precursors. DOI: 10.1126/science.aaw4212

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Photochemical C-H Amination through in situ N-Chloroamines - Leonori 25:00

6+ y ago25:00

25:00

In this episode we discuss a recent report from the Leonori lab on a new method for carbon-nitrogen bond formation by direct reaction of arenes and alkyl amines using photocatalysis. DOI: https://doi.org/10.1038/s41557-019-0254-5

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Trailer 2:00

6+ y ago2:00

2:00

Introducing The Cyclo Edition—the podcast for those looking to go above and beyond in their understanding of organic literature. Episodes will be released every other week starting June 10.