Best Mark Lu Podcasts (2026)

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Wartime vs Peacetime: Ben Horowitz on Leadership 35:02

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7h ago35:02

35:02

In this exclusive conversation from a16z’s Bio and Health BUILD Summit, founding partner Ben Horowitz sits down with general partner Jorge Conde. Originally released in August 2023, the episode covers everything from the inspiration behind Ben’s book The Hard Thing About Hard Things and how the open internet was secured, to the difference between w…

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The Techno-Optimist Manifesto with Marc Andreessen and Ben Horowitz 1:06:38

1d ago1:06:38

1:06:38

Originally aired in October 2023, this episode centers on Marc Andreessen’s essay The Techno-Optimist Manifesto, which lays out his vision for the future of technology. The piece sparked widespread discussion across traditional and social media by challenging the prevailing pessimistic narrative around technology and arguing instead that it can be …

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The Inside Story of Growth Investing at a16z 28:48

2d ago28:48

28:48

This episode is a special replay of David George’s conversation with Harry Stebbings on 20VC. David is a General Partner on a16z’s growth team, and in this discussion he breaks down how he thinks about breakout growth investing: why great business models are now table stakes, where real edge comes from non-consensus views on TAM, and how to underwr…

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How Universal Vaccines Could Transform Global Health 13:16

9h ago13:16

13:16

In this episode, ⁠Adam Torres⁠ interviews ⁠Jacob Glanville⁠, CEO of Centivax, Inc., about the company’s mission to develop universal vaccines that work across all strains of infectious diseases. Jacob shares how his upbringing and scientific background led him to build a biotech company focused on long-term global health, improved patient outcomes,…

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Why a16z's Martin Casado Believes the AI Boom Still Has Years to Run 1:22:20

3d ago1:22:20

1:22:20

This episode is a special replay from The Generalist Podcast, featuring a conversation with a16z General Partner Martin Casado. Martin has lived through multiple tech waves as a founder, researcher, and investor, and in this discussion he shares how he thinks about the AI boom, why he believes we’re still early in the cycle, and how a market-first …

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Where Does Consumer AI Stand at the End of 2025? 44:22

4d ago44:22

44:22

As 2025 comes to a close, consumer AI is entering a new phase. A small number of products now dominate everyday use, multimodal models have unlocked entirely new creative workflows, and the big labs have pushed aggressively into consumer experiences. At the same time, it is becoming clearer which ideas actually changed user behavior and which ones …

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Big Ideas 2026: New Infrastructure Primitives 20:21

7d ago20:21

20:21

New infrastructure primitives are creating entirely new rails for building. In this episode of Big Ideas 2026, we explore three foundational shifts that unlock new markets and workflows, not through incremental upgrades, but through primitives that compound over time. First, programmable money evolves beyond stablecoins into on-chain credit origina…

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Big Ideas 2026: Physical AI and the Industrial Stack 21:34

8d ago21:34

21:34

AI is moving into the physical economy. In this episode of Big Ideas 2026, we explore what changes when AI leaves the screen and becomes part of factories, construction sites, supply chains, and critical infrastructure. When the product is physical, reliability matters, real-world constraints appear quickly, and the advantage shifts from standalone…

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Big Ideas 2026: Voice Agents and High-Stakes Trust 17:44

9d ago17:44

17:44

Voice is becoming one of the fastest paths for AI to do real work, especially in regulated environments where accuracy and compliance matter. In this episode, we look at voice agents replacing and augmenting phone-based workflows, what trust and measurement look like when AI runs sensitive interactions, and how healthcare and consumer products shif…

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Big Ideas 2026: The Enterprise Orchestration Layer 22:18

10d ago22:18

22:18

AI is becoming the orchestration layer inside the enterprise. In this episode of Big Ideas 2026, we explore the shift from isolated AI copilots to coordinated multi-agent systems that plan, analyze, and execute work across teams and tools. This is not a new feature, but a new way workflows run inside large organizations. You will hear from Seema Am…

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Episode 689-With Emily Mitchell 43:55

2d ago43:55

43:55

This week on the podcast, Patrick and Tracy welcome Emily Mitchell to talk about her new short story collection The Church of Divine Electricity. About The Church of Divine Electricity: Delightfully blending literary fiction with speculative genres, the stories in The Church of Divine Electricity somehow manage to feel as though they could take pla…

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#209 Anatomy Reborn: How Renaissance Italy Remade Medical Education with Professor Richard Hays 53:56

2d ago53:56

53:56

Host Dr Sam Manger is joined by Emeritus Professor Richard Hays, a well known clinical and academic GP serving rural and regional Australia. In the 1990s he became the Professor of General Practice and Rural Health at the newly established North Queensland Clinical School (NQCS) which allowed medical students to complete their training in rural and…

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Big Ideas 2026: The Agentic Interface 14:52

11d ago14:52

14:52

AI is moving from chat to action. In this episode of Big Ideas 2026, we unpack three shifts shaping what comes next for AI products. The change is not just smarter models, but software itself taking on a new form. You will hear from Marc Andrusko on the move from prompting to execution, Stephanie Zhang on building machine-legible systems, and Sarah…

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The Rise, Fall & Reset of The Fintech Industry 45:14

14d ago45:14

45:14

Fintech went from a full-blown surge to a near standstill in just two years. At its peak, about 25 percent of all venture dollars were pouring into the category. By late 2022, that number had collapsed to almost zero. In this conversation, a16z General Partner David Haber and Plaid cofounder and CEO Zach Perret unpack what actually happened during …

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Do Revenue and Margins Still Matter in AI? 1:02:30

15d ago1:02:30

1:02:30

In this episode, we’re sharing a conversation with David George, General Partner at a16z on the firm’s growth investing team. David has been involved in backing many of the defining companies of this era and is now investing behind a new wave of AI startups. This discussion goes deep into how the a16z growth practice operates: how the team hires an…

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The Crime Crisis In America and How Technology Fixes It 59:30

16d ago59:30

59:30

What if America tried to eliminate crime instead of just reacting to it? Not with slogans, but with staffing, technology, and strategy scaled to the problem. In this episode, Erik Torenberg speaks with Garrett Langley, founder and CEO of Flock Safety, and Ben Horowitz, cofounder of a16z, about what is happening in the cities that are trying. Flock …

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Ryo Lu (Cursor): AI Turns Designers to Developers 52:01

17d ago52:01

52:01

Ryo Lu spent years watching his designs die in meetings. Then he discovered the tool that lets designers ship code at the speed of thought: Cursor, the company where Ryo is now Head of Design. In this episode, a16z General Partner Jennifer Li sits down with Ryo to discuss why "taste" is the wrong framework for understanding the future, why purposef…

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Episode 688-With Jordan Marshall 50:56

9d ago50:56

50:56

This week on the podcast, Patrick and Tracy welcome Jordan Marshall, who backed the Uncanny Magazine Year 12: Fly Forever, Space Unicorns Kickstarter at the THIRD NERD level! Jordan is working with a group of game developers on a new TTRPG: WE BEGIN AT MIDNIGHT! This week’s picks: Jordan: London Fog Tracy: G-shaft candy Patrick: Southern Comfort Eg…

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#208 Holistic Women's Health with Dr Peta Wright 1:01:57

13d ago1:01:57

1:01:57

Host Dr Ashlea Broomfield is joined by Dr Peta Wright, Gynaecologist, Paediatric & Adolescent Gynaecologist, Fertility Specialist and Founder of Vera Wellness. Peta is the author of Healing Pelvic Pain, published in 2023, a book about transforming the trauma of period pain, endometriosis and chronic pelvic distress. She aims to empower women to ask…

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EP10 - Punk'n Out (w/ Jeff Suffering, Matt Johnson, Bryan Gray) 1:32:11

10d ago1:32:11

1:32:11

Bryan Gray, Matt Johnson, and Jeff Suffering sit down with Joey and a handful of club members to look back on some of the fun had in the club this past year. Together they break down thoughts on great female punk and hardcore vocalists, dive deep into The Shape of Punk to Come by Refused, gush over Dan Weyandt’s legendary vocal work in Zao, and ref…

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AI Eats the World: Benedict Evans on the Next Platform Shift 1:02:50

21d ago1:02:50

1:02:50

AI is reshaping the tech landscape, but a big question remains: is this just another platform shift, or something closer to electricity or computing in scale and impact? Some industries may be transformed. Others may barely feel it. Tech giants are racing to reorient their strategies, yet most people still struggle to find an everyday use case. Tha…

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Reimagining Screen Time: Turning Digital Distraction into Family Healing 13:00

20d ago13:00

13:00

In this episode, ⁠⁠Adam Torres⁠⁠ interviews ⁠⁠Bobby Alexis⁠⁠, Founder of Mindful Media Foundation, about transforming screen time into a tool for family connection and healing. Bobby shares how his background in entertainment and tech—and his personal mental health experience during the pandemic—led him to build a 501(c)(3) focused on ethical, rese…

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How the Best CEOs Delegate 57:34

23d ago57:34

57:34

Jonathan Swanson has built two rare successes: Thumbtack, the home-services marketplace, and Athena, the fast-growing platform that pairs ambitious people with world-class personal assistants. Today he runs a 4,000-person company, invests on the side, and raises four kids — all by designing his life around leverage. a16z General Partner, Erik Toren…

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How Dr. Tracy Gapin Helps Leaders Reclaim Their Edge with Data-Driven Health 14:06

15d ago14:06

14:06

In this episode, Adam Torres interviews Dr. Tracy Gapin, CEO & Founder of Peak Launch and the Gapin Institute, about how high-performing leaders can reclaim their edge through data-driven health optimization. Dr. Tracy explains why traditional medicine often fails executives and entrepreneurs, and how advanced diagnostics, genetics, and metrics lik…

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#207 Dysautonomia and POTS with Dr Brendan Hanrahan 53:15

16d ago53:15

53:15

Dr Brendan Hanrahan is a General Physician with over two decades of experience in evidence-based medicine. Dr Hanrahan maintains an active general medicine clinic and inpatient practice, specialising in managing complex medical issues and diagnostic challenges. His primary focus and specialized training is in bariatric medicine, with extensive expe…

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The $3 Trillion AI Coding Opportunity 37:59

24d ago37:59

37:59

Originally published on the a16z Infra podcast. We're resurfacing it here for our main feed audience. AI coding is already actively changing how software gets built. a16z Infra Partners Yoko Li and Guido Appenzeller break down how "agents with environments" are changing the dev loop; why repos and PRs may need new abstractions; and where ROI is sho…

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Episode 687-With Marie Lu 47:53

18d ago47:53

47:53

This week on the podcast, Patrick and Tracy welcome Marie Lu, author of RED CITY. About RED CITY: Alchemy is the hidden art of transformation. An exclusive power wielded by crime syndicates that market it to the world’s elites in the form of sand, a drug that enhances those who take it into a more perfect version of themselves: more beautiful, more…

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The 80-Year Bet: Why Naveen Rao Is Rebuilding the Computer from Scratch 30:11

25d ago30:11

30:11

Naveen Rao is cofounder and CEO of Unconventional AI, an AI chip startup building analog computing systems designed specifically for intelligence. Previously, Naveen led AI at Databricks and founded two successful companies: Mosaic (cloud computing) and Nervana (AI accelerators, acquired by Intel). In this episode, a16z’s Matt Bornstein sits down w…

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Nic Marks talks about happiness and psychological safety 36:39

18d ago36:39

36:39

I highly recommend Nic's new book - Happiness is a Serious Business

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What Comes After ChatGPT? The Mother of ImageNet Predicts The Future 1:01:56

28d ago1:01:56

1:01:56

Fei-Fei Li is a Stanford professor, co-director of Stanford Institute for Human-Centered Artificial Intelligence, and co-founder of World Labs. She created ImageNet, the dataset that sparked the deep learning revolution. Justin Johnson is her former PhD student, ex-professor at Michigan, ex-Meta researcher, and now co-founder of World Labs. Togethe…

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How AI Created the Fastest Product Cycle in History 50:54

29d ago50:54

50:54

Recently, a16z General Partner Anish Acharya joined Ollie Forsyth on NEW ECONOMIES. They talked about why consumer tech is surging again, how AI is enabling 100M-user products at unprecedented speed, and what founders need to understand heading into 2026 — from distribution shifts to founder mindset to the mechanics behind the fastest product cycle…

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Why AI Moats Still Matter (And How They've Changed) 51:31

1M ago51:31

51:31

a16z General Partners David Haber, Alex Rampell, and Erik Torenberg discuss why 19 out of 20 AI startups building the same thing will die - and why the survivor might charge $20,000 for what used to cost $20. They expose the "janitorial services paradox" (why the most boring software is most defensible), explain why OpenAI won't compete with your o…

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How To Lead | Ben Horowitz on My First Million 1:10:40

1M ago1:10:40

1:10:40

A16Z co-founder Ben Horowitz joins Shaan Puri and Sam Parr on My First Million to talk about how to be a great leader. Resources: Follow Ben on X: https://x.com/bhorowitz Follow Shaan on X: https://x.com/ShaanVP Follow Sam on X: https://x.com/thesamparr Stay Updated: If you enjoyed this episode, be sure to like, subscribe, and share with your frien…

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Episode 686-With Daniel H. Wilson 56:40

25d ago56:40

56:40

This week on the podcast, Patrick and Tracy welcome Daniel H. Wilson, author of Hole in the Sky. About Hole in the Sky: On the Great Plains of Oklahoma, in the heart of the Cherokee Nation, a strange atmospheric disturbance is noticed by Jim Hardgray, a down-on-his-luck single father trying to reconnect with his teenage daughter, Tawny. At NASA’s h…

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Building a Greener AI Future: Inside CHIPX GLOBAL’s Next-Gen Semiconductor Vision 14:09

1M ago14:09

14:09

In this episode, Adam Torres interviews Chinmoy Baruah, Founder and CEO of CHIPX GLOBAL. Chinmoy explains how his company is tackling AI efficiency at the semiconductor level through advanced wafer design, compound semiconductors, and sustainable Gigafactory plans. He also shares his mission to reduce carbon footprint and energy consumption across …

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The $700 Billion AI Productivity Problem No One's Talking About 58:17

1M ago58:17

58:17

Russ Fradin sold his first company for $300M. He’s back in the arena with Larridin, helping companies measure just how successful their AI actually is. In this episode, Russ sits down with a16z General Partner Alex Rampell to reveal why the measurement infrastructure that unlocked internet advertising's trillion-dollar boom is exactly what's missin…

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How OpenAI Builds for 800 Million Weekly Users: Model Specialization and Fine-Tuning 53:24

1M ago53:24

53:24

In this episode, a16z GP Martin Casado sits down with Sherwin Wu, Head of Engineering for the OpenAI Platform, to break down how OpenAI organizes its platform across models, pricing, and infrastructure, and how it is shifting from a single general-purpose model to a portfolio of specialized systems, custom fine-tuning options, and node-based agent …

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Ben Horowitz: Why Open Source AI Will Determine America's Future 46:50

1M ago46:50

46:50

Ben Horowitz reveals why the US already lost the AI culture war to China—and it wasn't the technology that failed. While Biden's team played Manhattan Project with closed models, Chinese developers quietly captured the open-source heartbeat of global AI through DeepSeek, now running inside every major US company and university lab. The kicker: Goog…

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#206 Pay Attention: To the ADHD Doctor with Dr Chris Soo 48:08

1M ago48:08

48:08

Host Dr Rob Park sits down with Dr Chris Soo — a GP with a special interest in ADHD to explore a topic that is both highly important and topical right now, with Queensland moving to allow GPs to diagnose and prescribe ADHD medications for adults from Dec 1 2025, and other states expected to follow. This is a light-hearted but deeply practical conve…

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Replay #173 Attention Deficit Hyperactivity Disorder (ADHD) with Professor Mark Bellgrove 1:24:34

29d ago1:24:34

1:24:34

Replay from July 2023, host Dr Sam Manger is joined by Professor Mark Bellgrove, the Director of Research at the Turner Institute for Brain and Mental Health, and a Professor in Cognitive Neuroscience in the School of Psychological Sciences at Monash University. Professor Bellgrove leads a multidisciplinary team studying the biological basis of att…

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The Secret Marketing Strategy That Built a16z: From Zero to Legendary VC Firm 59:55

1M ago59:55

59:55

Marc Andreessen and Ben Horowitz sit down with Margit Wennmachers—the woman who turned two unknown entrepreneurs with $300 million and zero investing track record into the most talked-about firm in venture capital. She unpacks how they weaponized transparency in an industry built on secrecy, why Fortune's cover story triggered a cartel meltdown, an…

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How Marc Andreessen Actually Uses AI 34:02

1M ago34:02

34:02

Half a billion people can access the world’s best AI on their phone. So why are most using it to write emails while only some are using it to build empires? In this conversation with Mark Halperin from Next Up, Marc Andreessen reveals why small bakeries are beating Fortune 500 companies at AI adoption, how to turn ChatGPT into your personal board o…

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Episode 685-With Sara Raasch 42:50

1M ago42:50

42:50

This week on the podcast, Patrick and Tracy welcome Sara Raasch, author of The Entanglement of Rival Wizards. About The Entanglement of Rival Wizards: Sebastian Walsh: Evocation Department. Human. The first of his family to pick college over the military. Elethior Tourael: Conjuration Department. Half-elf. Pretentious asshole. The latest legacy Tou…

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The 2045 Superintelligence Timeline: Epoch AI’s Data-Driven Forecast 1:00:10

1M ago1:00:10

1:00:10

Epoch AI researchers reveal why Anthropic might beat everyone to the first gigawatt datacenter, why AI could solve the Riemann hypothesis in 5 years, and what 30% GDP growth actually looks like. They explain why "energy bottlenecks" are just companies complaining about paying 2x for power instead of getting it cheap, why 10% of current jobs will va…

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Robinhood CEO: Making Everyone An Owner 1:05:02

1M ago1:05:02

1:05:02

Vlad Tenev built Robinhood by breaking every rule Wall Street wrote: zero commissions when competitors charged $10, mobile-first when "serious" investors demanded desktop, a brand that made finance feel like rebellion instead of a club you'd never join. By 2021 they'd forced every major brokerage to slash fees and attracted millions who'd never own…