Best Applied Software Podcasts (2025)

Prompt injections, malicious code, and AI agents: In this week’s Five-Minute Friday, Jon Krohn looks into the current security weaknesses found in AI systems. A structural vulnerability that The Economist dubs a “lethal trifecta” could cause havoc for AI users, unless we take the necessary steps to contain our systems. Additional materials: ⁠⁠⁠⁠⁠⁠⁠…

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Insiders React: ChatGPT Pulse: An Overpriced Daily Digest? + Hollywood’s First AI Actress, Amazon’s $2.5B Settlement 38:07

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6d ago38:07

38:07

OpenAI just launched ChatGPT Pulse, a succinct, personalized daily feed. Will this shift the focus of AI from performance to personal context? Or is it just an overhyped, overpriced daily digest? In this episode, Chris and Yaniv get right into this week's tech news: the reality of ChatGPT Pulse, plus the wider implications of Hollywood's first AI a…

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927: Automating Code Review with AI, feat. CodeRabbit’s David Loker 1:19:18

8d ago1:19:18

1:19:18

By Jon Krohn

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Building the internet’s next infrastructure layer | Cloudflare's Brendan Irvine-Broque 53:34

8d ago53:34

53:34

The Model Context Protocol (MCP) is evolving beyond local developer experiments and into the secure, remote infrastructure that will power the next generation of the internet. Brendan Irvine-Broque, Director of Product at Cloudflare, joins us to share a roadmap for this future. He explains how Cloudflare's "customer zero" philosophy of dogfooding t…

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How Being Genuine is a Critical Advantage For Startup Founders w/ Christine Blosdale, Expert Authority Coach (Edu) 50:45

9d ago50:45

50:45

Standing out has gotten even more difficult thanks to the flood of AI content, and many early-stage founders mistakenly believe they need to act like corporate brands to be taken seriously. In this episode, Yaniv chats with Christine Blosdale, an award-winning media coach, podcaster, and branding strategist. Together they discuss how authenticity, …

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926: AI is Disrupting the Legal Industry: Are Paralegals Doomed? 4:47

12d ago4:47

4:47

In this Five-Minute Friday, Jon Krohn explores how AI is reshaping the legal industry. He investigates how AI tools are helping lawyers make conclusions faster, how paralegals are being retrained, and the latest in-demand role in law (hint: It concerns AI). Listen to hear how Harvey AI and Thomson Reuters’ CoCounsel are using AI to help lawyers get…

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Insiders React: Tech Talent Pool to Be Decimated by New Fee + OpenAI Jobs Platform, $1B for Dishwashing Robots 53:27

13d ago53:27

53:27

What happens to Silicon Valley when the world’s best founders and engineers can no longer afford to work in the US? Today, Chris and Yaniv break down why the massive new work visa fee is a tech talent crisis waiting to happen. They discuss how Trump’s surprising $100K H-1B fee could reshape startup hiring and the tech sector at large, along with th…

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925: AI, Automation and the Future of Work, with Oxford’s Prof. Carl Benedikt Frey 1:10:06

15d ago1:10:06

1:10:06

Tech innovation’s dependence on economic systems, trust in technology throughout history, and job displacement through AI: The Dieter Schwartz Associate Professor of AI and work at the University of Oxford, Carl Benedikt Frey, talks to Jon Krohn about his latest book, How Progress Ends, as well as how different economic systems deal with innovation…

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Making tech literacy irrelevant | Infactory’s Ken Kocienda 54:21

15d ago54:21

54:21

What do you learn after spending 15 years at Apple and demoing your work directly to Steve Jobs? Ken Kocienda, Co-founder of Infactory AI and author of Creative Selection, joins us to share the answer. As a former Principal Engineer at Apple who helped create the iPhone keyboard and autocorrect, Ken discusses his incredible journey from a history m…

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Why Every Startup Founder Should Consider B2B SaaS w/ Rob Walling (Edu) 58:29

16d ago58:29

58:29

Is the new age of AI agents about to kill niche B2B SaaS businesses? Many first-time founders worry that tools like ChatGPT or custom AI builders will make off-the-shelf SaaS products obsolete, but it could simply herald a new evolution of SaaS. In this episode, Yaniv is joined by Rob Walling, serial founder, investor, and author of The SaaS Playbo…

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924: 95% of Enterprise AI Projects Fail (Per MIT Research) 5:27

19d ago5:27

5:27

MIT lab NANDA (“Networked AI Agents in Decentralized Architecture”) reveals less than promising results for the future of AI adoption in businesses. According to “The GenAI Divide: State of AI in Business 2025”, a whopping 95% of enterprise AI projects “are getting zero return” on their $30-40 billion investment. Jon Krohn takes this Five-Minute Fr…

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Insiders React: YouTube's Steady Domination + Oracle's AI Comeback, Sam Altman v. Tucker Carlson 55:08

20d ago55:08

55:08

Is YouTube quietly becoming the most powerful platform in the world? Announcements made during Made On YouTube 2025 revealed incredibly promising long-term plans, with the media giant seemingly set to dominate video, music, and podcasts with the help of Google’s AI. Too many entrepreneurs still see YouTube as ‘just’ a video host, missing the bigger…

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923: Graph Algorithms, GraphRAG and Causal Graphs, with Graph Guru Amy Hodler 1:03:47

22d ago1:03:47

1:03:47

Graphs, but not as you would expect them: Graph analytics guru Amy Hodler speaks to Jon Krohn about the graph data structure and graph applications, graph algorithms, graph RAG, and graphs as memory systems for AI agents. We can use graphs in a surprising number of ways. Money laundering and fraud, as well as supply-chain crime, leave breadcrumbs a…

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Why enterprise AI lives or dies on applied research | Contextual AI’s Elizabeth Lingg 54:12

22d ago54:12

54:12

What does it take to transform a brilliant AI model from a research paper into a product customers can rely on? We're joined by Elizabeth Lingg, Director of Applied Research at Contextual AI (the team behind RAG), to explore the immense challenge of bridging the gap between the lab and the real world. Drawing on her impressive career at Microsoft, …

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Be Persistent Without Being Stupid: We Learn from YC Founder Paul Graham 41:13

23d ago41:13

41:13

Are you truly being persistent with your startup, or just being stubborn? In the new age of AI-powered founders and hyper-fast iteration, many entrepreneurs mistake obstinacy for persistence and end up running out of time, money, and morale. Too often we glorify “hustle” and “grit” without understanding when to adapt, pivot, or quit. The misconcept…

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922: AI for Manufacturing and Industry, with Hugo Dozois-Caouette 28:29

26d ago28:29

28:29

Hugo Dozois-Caouette speaks to Jon Krohn about his startup MaintainX and how he secured $254 million in venture capital, reaching a $2.5 billion valuation. MaintainX builds computerized maintenance management systems (CMMS) and enterprise asset management (EAM) software for industrial and manufacturing companies. This "digital clipboard" delivered …

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Insiders React: Apple's Huge AI Blunder + IPO Market Heats Up, White House Tech Dinner 57:09

27d ago57:09

57:09

With Apple’s iPhone Air, iPhone 17 Pro, AirPods Pro 3, and Apple Watch 11 now unveiled, what does this mean for the future of phones and wearable tech? And does the incredible AI of Google Pixel still blow Siri out of the water? In this episode, Chris and Yaniv delve into Apple’s newest product lineup and what it reveals about the company’s long-te…

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How to Ruin an APT's Day, with Sara McBroom 44:31

27d ago44:31

44:31

This week, the B-Team gets an upgrade as we’re joined by Sara McBroom from Talos’ nation-state threat intelligence and interdiction team. Sara shares her journey from a liberal arts major to tracking some of the world’s most advanced adversaries. Along the way, she talks about moving from the U.S federal service to Talos, mentoring, leading with em…

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921: NPUs vs GPUs vs CPUs for Local AI Workloads, with Dell’s Ish Shah and Shirish Gupta 1:12:12

29d ago1:12:12

1:12:12

Using Windows for AI development and the bleeding edge of NPUs: Shirish Gupta and Ish Shah from Dell Technologies speak to Jon Krohn about the latest products from Dell, the future of neural-processing units (NPUs), and how AI developers can make sound hardware investments. This episode is brought to you by the Trainium2, the latest AI chip from AW…

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Your AI demo is a lie (and how to make it real) | Arcade’s Alex Salazar 1:01:58

29d ago1:01:58

1:01:58

AI that talks is easy, but AI that acts securely is where everything breaks down. We're joined by Alex Salazar, CEO of Arcade, to confront the massive and often underestimated gap between a flashy AI demo and a production-ready system. Drawing from his team's own pivot from building agents to building the tools that secure them, he explains why a w…

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Growing a Pre-Seed Startup? This Is The Core Knowledge You Need w/ Ashley Smith 57:54

30d ago57:54

57:54

Pre-seed founders want explosive growth early on, but are you following the wrong playbook too soon? These days strategies, acronyms, and well-intended advice are everywhere, but today's guest argues that the path forward is a simple one: talk to customers, run experiments, and embrace rejection as part of the journey. In this episode, Yaniv Bernst…

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920: In Case You Missed It in August 2025 21:57

1M ago21:57

21:57

This month’s episode of In Case You Missed It gives us reasons to be cautiously optimistic about the future of large language models (LLMs), with guests discussing what to do about recent reports that found AI agents blackmailed human users when threatened, the importance of post-training LLMs, and the training we have available for data and AI eng…

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Insiders React: Google Antitrust: Is The Ruling Fair? + YC’s Latest Request For Startups, Statsig Acquisition 47:43

1M ago47:43

47:43

Google’s long-running antitrust case has reached its remedy stage, and the outcome was far lighter than many expected. No breakup, no ban on default search deals, just a few constraints on bundling apps and some required data sharing, but it may not be quite as simple as it seems on the surface. Meanwhile, OpenAI dropped $1.1 billion to acquire Sta…

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919: Hopes and Fears of AGI, with All-Time Bestselling ML Author Aurélien Géron 1:29:51

1M ago1:29:51

1:29:51

PyTorch, AGI, and the future of alignment research: Aurélien Géron joins Jon Krohn in this live interview to talk about the fourth edition of his bestselling Hands-On Machine Learning as well as what superintelligence makes him hopeful for, as well as what concerns him about machines surpassing human intelligence. This episode is brought to you by …

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The future of the terminal is not a terminal | Warp’s Zach Lloyd 57:32

1M ago57:32

57:32

For decades, the command line has been a developer's staple. But what if its future isn't to be a better terminal, but something else entirely? We're joined by Zach Lloyd, co-founder of Warp, to discuss this groundbreaking shift in developer tooling, sharing his bold vision that the future for developers is neither the IDE nor the terminal, but a n…

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First Principles: Listen to This Before You Apply to YC 38:04

1M ago38:04

38:04

It seems like startup accelerators are everywhere these days. But what are they? What’s the point of them? And most importantly, is it worth having your startup go through one? Based on their own experience with YC and startups, Chris and Yaniv talk you through it all. In this episode, you will: Learn what startup accelerators are and how they work…

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918: Multi-Agent Systems with CrewAI 9:16

1M ago9:16

9:16

In this Five-Minute Friday, Jon Krohn introduces listeners to CrewAI, an open-source Python framework that can create and manage multi-agent teams. The clue is in the title: CrewAI assembles specialized agents into single “crews” that achieve complex goals between them. CrewAI’s agent teams can also learn and iterate, meaning that after the crew ha…

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Insiders React: Google Pixel 10 – Does It Finally Beat Apple at Its Own Game? 35:21

1M ago35:21

35:21

Is Apple’s dominance in smartphones starting to crack? Google’s Pixel 10 launch brought AI-first features, polished hardware, and bold marketing, signaling a new era in the iPhone vs. Android rivalry. For years, the iPhone has been synonymous with polish, hardware quality, and ecosystem lock-in. But with Google’s patient, decade-long investment in …

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917: 8 Steps to Becoming an AI Engineer, with Kirill Eremenko 1:15:33

1M ago1:15:33

1:15:33

Founder of SuperDataScience, Kirill Eremenko, talks to Jon Krohn about how he found the best tools and approaches to help launch his 8-week AI engineering bootcamp. He breaks down the topics participants cover each week, and he also shares his tips with listeners who might want to start their own tech bootcamp or sign up for SuperDataScience’s Sept…

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Forget vibe coding. Say hello to vibe entrepreneurship. | Shopify’s Andrew McNamara 42:43

1M ago42:43

42:43

First, there was vibe coding. Now, get ready for "vibe entrepreneurship." Andrew McNamara, Director of Applied Machine Learning at Shopify, joins us to explain how his team is making this new era of business a reality. He shares the vision behind Shopify Sidekick, an AI co-founder designed to empower merchants by acting as their on-demand e-commerc…

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Startup Tech Stacks: Make Your Product Stand Out & Get Used w/ Joseph Ruscio 1:04:17

1M ago1:04:17

1:04:17

What makes a great tech infrastructure startup? And how do the best ones successfully navigate, and stand out from, the overcrowded market? In this episode, Yaniv is joined by Joseph Ruscio, General Partner at Heavybit and former CTO of Vibrato, to unpack the dos and don'ts of tech infrastructure startups, how open source fuels growth, and why AI i…

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916: The 5 Key GPT-5 Takeaways 9:40

2M ago9:40

9:40

GPT-5 has just been released, but with not very much fanfare. In this Five-Minute Friday, Jon Krohn asks if GPT-5 deserves the community’s underwhelmed response to its release. He outlines five features of the model and explains why people might be feeling less than enthusiastic in the broader context of LLM development. Which LLMs are leading the …

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Insiders React: Meta to Shrink AI Division – Is This the Beginning of the End? 27:47

2M ago27:47

27:47

Is the AI hype cycle about to burst? For months, investors and founders have chased sky-high valuations, billion-dollar hires, and promises of superintelligence, but Meta's drastic plans to cut back its AI division seem to indicate a bleak future for LLMs and AI at large. In this episode, Chris and Yaniv unpack the latest shakeup at Meta, using the…

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153: DHH – Omarchy and Designing Your Own OS on Arch Linux 1:16:25

2M ago1:16:25

1:16:25

I talk to DHH about Omarchy, the carefully curated distribution of Arch Linux he's been refining for the last few months. We talk about stuff like: How did he discover Arch + Hyprland in the first place? What even is Arch, what even is Hyprland, and how the fuck do you make the mouse show up in Linux? Should you really be afraid of trying to mainta…

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915: How to Jailbreak LLMs (and How to Prevent It), with Michelle Yi 1:09:33

2M ago1:09:33

1:09:33

Tech leader, investor, and Generationship cofounder Michelle Yi talks to Jon Krohn about finding ways to trust and secure AI systems, the methods that hackers use to jailbreak code, and what users can do to build their own trustworthy AI systems. Learn all about “red teaming” and how tech teams can handle other key technical terms like data poisoni…

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You can't have AI without DevOps | GitHub’s Martin Woodward 57:36

2M ago57:36

57:36

The single biggest predictor of success with AI isn't the model you choose, it's the DevOps culture you've already built. Martin Woodward, VP of Developer Relations at GitHub - and the sixth person to ever use Copilot - joins us to explain why this surprising insight is key to the new era of autonomous coding agents. He traces the evolution of GitH…

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YC Founder’s 13 Timeless Startup Principles: 'Ramen Profitable’ and More 44:14

2M ago44:14

44:14

This new era of AI-driven startups has many founders still believing success is about having the perfect product roadmap. The truth, however, is far more counterintuitive. In this episode, Yaniv and Chris dive into timeless lessons from Paul Graham’s legendary essay “Startups in 13 Sentences”. Drawing from Graham’s wisdom and their own experiences,…

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914: Data Lakes 101 (and Why They’re Key for AI Models), with Oz Katz 25:52

2M ago25:52

25:52

In this Five-Minute Friday, Cofounder and CTO of lakeFS Oz Katz talks to Jon Krohn about data warehouses, data lakes, and how companies can handle increasingly complex data infrastructures and formats. Hear about lakeFS’s collaboration with Legofest, lakeFS’s approach to helping users collaborate on data lakes, and how to overcome the challenges of…

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Insiders React: GPT-5 Is ‘Fast Fashion’ For Software + Apple’s $600B Commitment, Altman vs Musk (...Again) 41:37

2M ago41:37

41:37

Is AI threatening traditional subscription software models and accelerating competitive turnover? Sam Altman thinks so. In this episode, Chris and Ray discuss OpenAI’s GPT-5 release, and Altman's prediction that AI will enable a “fast fashion” era of SaaS, where applications can be created, deployed, and discarded in rapid cycles. You'll also hear …

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913: LLM Pre-Training and Post-Training 101, with Julien Launay 1:15:16

2M ago1:15:16

1:15:16

Julien Launay launched Adaptive to give data science teams in business enterprises their “RLOps tooling” to make reinforcement learning easier. Talking to Jon Krohn, Julien says, “Most of our users are data scientists who write Python codes to interface with the system”. Adaptive is also able to work with companies without data science teams, colla…

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The art of letting go as a manager | Transcend’s Minh Nguyen 42:50

2M ago42:50

42:50

What's the hardest habit for a top engineer to unlearn in a leadership role? For Minh Nguyen, VP of Engineering at Transcend, it was breaking the "I'll do it myself" mentality. In this episode, she shares her impressive journey from individual contributor to VP at the same high-growth startup, offering a rare and honest look at this challenging tra…

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Capital for Founders: Insights From Yaniv’s New Startup Raise 50:59

2M ago50:59

50:59

Raising money for your startup isn’t just about pitching but navigating egos, timing, and a flood of contradictory feedback. Why do some founders win over early believers who open every door, while others get stuck in endless “soft nos”? And how do you avoid twisting yourself into a pretzel trying to please every investor you meet? In this episode,…

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912: In Case You Missed It in July 2025 32:38

2M ago32:38

32:38

In this episode of In Case You Missed It, we look back on five great interview episodes from July. Hear from Lilith Bat-Leah (Episode 901), Sinan Ozdemir (Episode 903), Sebastian Gehrmann (Episode 905), Zohar Bronfman (Episode 907) and Robert Ness (Episode 909). They’ll tell you why data-centric machine learning is so important across disciplines, …

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Insiders React: Cloudflare Catches Perplexity Red-Handed + Wikipedia Adopts Anti-AI Slop Policy, AWS Losing Ground 44:26

2M ago44:26

44:26

In violation of long-standing internet norms like robots.txt, Cloudflare caught Perplexity AI scraping content from websites that had explicitly opted out. The situation begs the question: what happens when AI startups prioritize growth over digital consent? Listen as Chris and Yaniv discuss the repercussions of Cloudflare's "honeypot" traps. They …

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911: The Future of Python Notebooks is Here, with Marimo’s Dr. Akshay Agrawal 58:20

2M ago58:20

58:20

Reproducibility, Python notebooks, and data science communities: Software developer Akshay Agrawal speaks to Jon Krohn about Marimo, the next-generation computational notebook for Python, how he built and fostered a thriving community around the product, and what makes this notebook so versatile and accessible for users. Additional materials: ⁠⁠⁠⁠⁠…

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AI agents are knocking. Is your API ready to answer? | GraphQL’s Matt DeBergalis 59:13

2M ago59:13

59:13

The rise of AI agents is more than a tooling upgrade - it's a fundamental rewiring of the entire developer experience, with your APIs at the very center. We're joined by Matt DeBergalis, co-founder and then-CTO-now-CEO (congrats Matt!) of Apollo GraphQL, to explore this massive transformation. He introduces the emerging concept of "agent experience…