Best Alexander Schacht And Benjamin Piske Biometricians Statisticians And Leaders In The Pharma Industry Podcasts (2025)

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Top 8: The Single Arm Studies and What are the Alternatives? 45:32

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9d ago45:32

45:32

Interview with Anja Schiel Why You Should Listen: f you’ve ever wondered whether single-arm studies are “good enough” for regulators or HTA bodies, this episode will challenge your assumptions. Anja Schiel, one of Europe’s leading voices at the regulator–HTA interface, explains why comparisons matter, where single-arm designs break down, and what s…

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Top 7: How to work with a physician within Pharma to become a valuable partner 26:40

16d ago26:40

26:40

Discussion with Benjamin Piske and Alexander Schacht Why You Should Listen: Working with physicians isn’t always easy. Different mindsets, expectations, and communication styles can get in the way. In this episode, you’ll hear how to: ✔ Build trust and respect with physicians in pharma ✔ Communicate effectively across disciplines ✔ Know when to sup…

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Top 6: What is EU HTA and why should statisticians care? 36:08

24d ago36:08

36:08

Interview with Lara Wolfson and Anders Gorst-Rasmussen Why You Should Listen: ✔ EU HTA is becoming reality: Joint Clinical Assessments begin soon with oncology/ATMPs and will expand to all medicines over the next years. ✔ Statisticians are central: Re-analyses, indirect comparisons, RWE, and quality-of-life analyses will be required—often beyond wh…

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Top 5: The analysis of adverse events done right 52:45

1M ago52:45

52:45

Interview with Kaspar Rufibach & Jan Beyersmann What You’ll Learn: ✔ Why analyzing adverse events differently from efficacy endpoints creates problems. ✔ How differing follow-up times and censoring bias AE results. ✔ The role of the Aalen–Johansen estimator and why it should be standard practice. ✔ What the SAVVY collaboration achieved by uniting p…

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Replay: R vs SAS - which is the better tool in pharmaceutical research 42:29

1M ago42:29

42:29

Interview with Sam Gardner & Thomas Neitmann What You’ll Learn: ✔ How Thomas and Sam were first introduced to SAS and R — and how their early experiences shaped their preferences. ✔ Key differences in learning curves and the resources available for beginners. ✔ How each tool fares in day-to-day work and long-term maintainability. ✔ Strengths and we…

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Replay: The Chimp Paradox 41:35

2M ago41:35

41:35

Interview with Stuart McGuire What You’ll Learn: ✔ How to recognize when your “chimp” is in control — and what to do about it ✔ The difference between emotional, rational, and programmed brain responses ✔ How to manage anxiety and fear in high-stakes situations like meetings and presentations ✔ Why we often overwork out of tribal guilt — and how to…

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Replay: Is data science something for you? 26:19

2M ago26:19

26:19

Interview with Yannis Jemiai & Rajat Mukherjee What You’ll Learn: ✔ How two leading statisticians transitioned into data science ✔ The key differences (and overlaps) between data science, statistics, big data, and machine learning ✔ Why data science is more than hype—and why statisticians are needed more than ever ✔ The role of visualization and st…

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Replay: Things we would like to have known before we started with RWE 48:53

2M ago48:53

48:53

Interview with Rachel Tham What You’ll Learn: ✔ Why “index date” is more complicated than it sounds ✔ Common mistakes around exposure definitions ✔ The importance of understanding how RWE data is generated ✔ What programmers should know about timing, variables, and algorithms ✔ Why project management in RWE must be iterative and stakeholder-driven …

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AI and Statistics Start-ups: Opportunities and Challenges 43:32

3M ago43:32

43:32

Keynote by Manjari Narayan | The Effective Statistician Conference 2024 What You’ll Learn: ✔ Why the 21st century is truly the "century of biology" and what that means for statisticians ✔ The untapped opportunity for statisticians to innovate before clinical trials begin ✔ How AI-guided experiments are changing drug discovery—and the statistical ch…

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Combining RCT and RWD – applications in rare diseases and practical recommendations 47:05

3M ago47:05

47:05

Keynote by Prof. Tim Friede | The Effective Statistician Conference 2024 What You’ll Learn: ✔ When and how to combine RCTs with real-world data (RWD) ✔ The CJD study: lessons from combining registry and trial data ✔ Hierarchical Bayesian meta-analysis and shrinkage estimators ✔ Robustness of these approaches in the face of heterogeneity ✔ Practical…

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Real-World Evidence vs. Randomized Trials: Can We Emulate Accuracy? 52:00

3M ago52:00

52:00

Keynote by Prof. Sebastian Schneeweiss | The Effective Statistician Conference 2024 What You’ll Learn: ✔ The motivation behind emulating randomized trials using real-world data ✔ How claims and EHR data can support regulatory-grade evidence ✔ What makes a trial emulation good vs. suboptimal ✔ The role of adherence, measurement limitations, and data…

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The Power of Networking 16:32

4M ago16:32

16:32

Discussion with Alun Bedding What You’ll Learn: ✔ Why networking is about curiosity—not small talk ✔ How to set clear intentions for networking at events ✔ The three biggest myths that hold people back from networking (and how to overcome them) ✔ Practical tips for PSI Conference attendees to network with confidence ✔ The real-world value of buildi…

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Inclusion for All: Rethinking Success, Neurodiversity, and Accessibility in the Workplace 36:46

4M ago36:46

36:46

Featuring Alun Bedding and Emma Crawford Learnings You’ll Gain From This Episode: ✔ Why inclusion is everyone’s responsibility—not just HR’s ✔ The difference between “reasonable adjustments” and “success enablers” ✔ How AI tools can support accessibility and productivity ✔ The hidden challenges behind late diagnoses of neurodivergence ✔ Why leaders…

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Daily updated systematic literature reviews - the future of oncology 22:57

4M ago22:57

22:57

Interview with Anna Forsythe Why You Should Listen: ✔ Discover how SLRs are evolving through automation and AI ✔ Learn how real-time data can improve cancer treatment decisions ✔ Understand the balance between innovation and clinical responsibility ✔ Hear about a tool that could change the way guidelines and clinical practice align ✔ Be inspired by…

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A novel approach for finding predictive biomarkers 35:39

5M ago35:39

35:39

Interview with Julia Geronimi and Pavel Mozgunov Why You Should Listen: ✔ You’ll learn a new method that’s both statistically sound and easy to implement ✔ You’ll see how to pre-specify your analysis strategy for biomarker evaluation ✔ You’ll understand how to get more value out of small sample sizes ✔ And you’ll come away with a fresh appreciation…

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A Webinar Recording: Redefining the Role of Statisticians in a World of Real-World Data and AI 51:48

5M ago51:48

51:48

Webinar with Yannis Jemiai, Flaminia Chiesa, and Benjamin Piske ✔ Learn how statisticians can step into leadership roles as data science becomes more strategic. ✔ Understand the impact of AI, real-world evidence, and decentralized trials on clinical trial design. ✔ Hear practical advice for staying relevant in the age of reimagined RCTs. ✔ Get insi…

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RWE and JCA - how do they go together 20:21

5M ago20:21

20:21

Interview with Katrin Kupas What You’ll Learn in This Episode: ✔ What the JCA is and why it changes how we plan evidence generation ✔ When and how RWE can help answer comparator questions in HTA ✔ The risks of non-randomized comparisons—and how to mitigate them ✔ Why we need an integrated evidence plan early in development ✔ How tools like ROBINS-I…

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Why and how you can promote more students become statisticians 29:32

5M ago29:32

29:32

Interview with Emma Crawford and Alex Spiers ✔ Why STEM outreach is so important for the future of our industry ✔ How your company, community, and even your own career can benefit from getting involved ✔ The challenges students face (especially girls and those from underserved areas) in seeing themselves in STEM ✔ How PSI’s Schools Outreach team ca…

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Clarifying confusions around interim, primary, final, and other analyses in clinical trial 31:11

5M ago31:11

31:11

Interview with Kaspar Rufibach What You’ll Learn in This Episode: ✔ The true definitions of interim, final, primary, confirmatory, and updated analyses ✔ Why a “final analysis” doesn’t always mean “last analysis” ✔ How language choice can impact stakeholder trust and regulatory interpretation ✔ The operational vs. statistical meaning of “stopping a…

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Reimagining Clinical Trials with Synthetic Data and Digital Twins 22:11

6M ago22:11

22:11

Interview with Holger Fröhlich What You’ll Learn in This Episode: ✔ What synthetic data actually is – and what it isn’t ✔ The benefits and challenges of using synthetic data in clinical research ✔ Real-world use cases, from early dementia diagnosis to trial simulation ✔ How digital twins could help predict patient outcomes ✔ Why synthetic data migh…

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Working in an english work environment as a non-native speaker 12:51

6M ago12:51

12:51

Friday Episode with Alexander 🧠 What You’ll Learn: ✔ How I improved my English on the job (despite not having great grades in school) ✔ Why consuming high-quality English content (like podcasts, TED Talks, and books) made a big difference ✔ Tips for writing regularly—even journaling—and using tools like ProWritingAid ✔ How slowing down when speakin…

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R-shiny - how to set it up effectively and avoid common mistakes 26:34

6M ago26:34

26:34

Interview with Daniel Sabanés Bové What You’ll Learn in This Episode: ✔ Why interactive visualizations are such a game changer ✔ How R-Shiny makes scenario planning and data exploration easier ✔ What to consider before you even start coding ✔ Common mistakes to avoid with larger Shiny apps ✔ How to structure your code for long-term success and main…

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3 personal stories of how soft skills have helped me as a statistician 18:39

6M ago18:39

18:39

Friday Episode with Alexander Schacht 🧠 What You’ll Learn: ✔ Why I believe “soft skills” is the wrong term—and what we should call them instead ✔ How I built trust in just 15 minutes with someone I'd never met before ✔ The story behind a data visualization that got standing ovations ✔ A negotiation win that shifted how I think about value ✔ How the…

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R-packages - best practices and useful tools 20:55

6M ago20:55

20:55

Interview with Daniel Sabanés Bové What You’ll Learn in This Episode ✔ Why creating R packages is a game-changer for code reuse and collaboration. ✔ The most common challenges we face when reusing code—and how packages help solve them. ✔ When it actually makes sense to start writing a package (spoiler: earlier than you think). ✔ Useful tools like u…

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Delegating programming tasks - how SOPs help and hinder 17:16

6M ago17:16

17:16

By Alexander Schacht and Benjamin Piske, biometricians, statisticians and leaders in the pharma industry

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Statistics and Market access - from foes to friends 44:23

6M ago44:23

44:23

Interview with Necdet Gunsoy What You’ll Learn in This Episode ✔ Necdet’s Journey ✔ Breaking Down Key Market Access Concepts ✔ The Real Cost of Poor Collaboration ✔ How We Can Work Together More Effectively ✔ Looking Ahead: The Impact of Joint Clinical Assessment (JCA) Why You Should Listen If you work in biostatistics, health economics, or market …

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Beyond logic - how to convince others of your ideas 12:52

7M ago12:52

12:52

Friday Episode with Alexander Schacht What You’ll Learn in This Episode ✔ Why logic alone isn’t enough to persuade others ✔ How emotions play a crucial role in decision-making ✔ The importance of credibility and trust in influencing others ✔ Practical strategies to make your arguments more compelling ✔ How to tailor your message to different audien…

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P-value and confidence intervals - the good, the bad, and the ugly 32:31

7M ago32:31

32:31

Interview with Kaspar RufibachIn this episode of The Effective Statistician, I sit down with Kaspar Rufibach to tackle a topic that affects statisticians every day—how to interpret p-values, confidence intervals, and statistical hypotheses. We explore the differences between Fisher’s and Neyman-Pearson’s approaches, clear up common misconceptions, …

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Building the Influence as a Statistician in a Clinical Trial Team 14:10

7M ago14:10

14:10

Friday Episode with Alexander Schacht Key Points: Building Influence Negotiation Trust Pillars Collaboration Proactivity Impact Actionable Strategies Building influence as a statistician isn’t just about being heard—it’s about driving better decisions, improving team dynamics, and ultimately making a greater impact on patient outcomes. The strategi…

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Effective self-management and taking care of your mental health 31:00

7M ago31:00

31:00

Interview with Peter M. Wehmeier Key Points: Workload & Mental Well-being Five Dimensions of Self-Management Relationships Priorities Decision-Making Taking Action Stress Management Peter’s Workshops Empowerment Take control of your well-being and success by mastering self-management. In this episode, you’ll learn practical strategies to reduce str…

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Taming AI for Biostatistics: Darko Medin on Bio AI Works & Reliable AI Models 28:38

7M ago28:38

28:38

Interview with Darko Medin Key Points: AI Challenges: Hallucinations, Accuracy, Reliability AI Solutions: Validation, Cross-checking, Domain-specific rules Use Cases: Oncology, Precision Medicine, Drug Discovery High-dimensional Data: Hidden patterns, Complex datasets AI Agents: Semi-autonomous, Goal-driven, Multi-step processes Interpretability vs…

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Slow Productivity 31:52

7M ago31:52

31:52

A book review with Steve Mallett and Alun Bedding Key Points: Slow Productivity Three Principles Workload Management Meetings Seasonality Overhead Tax Quality vs. Perfectionism Time Management Mindset Shift Slow Productivity offers valuable insights on working smarter, not just harder. By applying its principles, we can reduce stress, improve focus…

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Behind the Scenes of Writing a Book About Casual Inference 23:15

7M ago23:15

23:15

Interview with Justin Belair Key points: Causal Inference – Hot topic in statistics Justin Belair – Guest, statistician, book author Book Writing – Motivation, challenges, process Balancing Content – Theory, real-world applications, coding exercises Effective Writing – Strategies, focus, overcoming obstacles Practical Tools – Applying causal infere…

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What Is The MDLC and How It Will Help You? 13:32

8M ago13:32

13:32

Discussion with Alexander Schacht Key points MDLC Introduction Leadership Growth Career Development Three Tiers Learning Formats Real-World Application Impact on Healthcare Membership Options How to Join The Medical Data Leaders Community (MDLC) offers a unique opportunity to grow your leadership skills, expand your influence, and drive meaningful …

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Endless To-Do Lists 16:42

8M ago16:42

16:42

Friday Episode with Alexander Schacht Key points Endless To-Do Lists Causes of Overload Problems Key Strategies: Prioritization Single Bridge System Task Breakdown Say No & Delegate Two-Minute Rule Big-Picture Thinking Leadership Skills Medical Data Leaders Community Call to Action Take back control of your time and break free from endless to-do li…

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Struggling With A Full Calendar? 14:05

8M ago14:05

14:05

Discussion with Alexander Schacht Key points: Meeting Overload Root Causes Impact Strategy 1: Priorities Strategy 2: Meeting Practices Strategy 3: Saying No Long-Term Approach Bonus Take back control of your calendar and focus on what truly matters. Set clear priorities, improve meeting practices, and say no to unnecessary commitments. These strate…

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Breaking Free from the Beliefs Keeping You Stuck in Long Hours 17:57

8M ago17:57

17:57

Friday Episode with Alexander Schacht Key points Key Points from the Episode: Long Hours Trap Workload Pressure Belief Shifts Limiting Beliefs: "Hard Work = Value" "Busyness = Productivity" "Perfectionism" "Delegation is Weakness" Productivity Strategies: Prioritization Meetings Communication Automation & Templates Career Impact Health & Relationsh…

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What Are GAMS and How Can You Leverage Them? 18:39

8M ago18:39

18:39

Interview with Steve Dirkse Key Points: GAMS Overview Distinction Applications System Components Examples Mathematical Functions Convexity Getting Started Documentation and Training Final Advice GAMS opens up a world of possibilities for solving complex optimization problems, from logistics and healthcare to business and beyond. Whether you're a st…

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Why Becoming a Long-Haul Leader Matters 20:20

8M ago20:20

20:20

Discussion with Alexander Schacht Key points Hustle Culture Mental and Physical Health Long-Haul Leadership Continuous Personal Growth Adaptability and Change Nurturing Relationships Values and Principles Prioritizing Well-Being Building Consensus Leaving a Legacy Adopting the mindset of a long-haul leader isn’t just about improving your work—it’s …

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Negotiation for Statisticians: Advocating for Yourself and Your Work 20:08

8M ago20:08

20:08

Discussion with Alexander Schacht Key points Negotiation as an Essential Skill Examples of Negotiation Importance of Preparation Effective Strategies Professional Impact Broader Application Practical Insights Negotiation transforms your professional and personal interactions, empowering you to advocate for yourself and achieve better outcomes. In t…

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Trust 23:29

8M ago23:29

23:29

Friday Episode with Alun Bedding Key Points: Trust as Leadership Backbone Leadership is a Choice Leadership vs. Management Authenticity Inspiration vs. Motivation Trust Equation Nine Habits of Trust: Deliver Be open Be honest Be brave Coach Be humble Evangelize Be consistent Be kind Trust is Earned Empathy and Kindness Trust as a Bank Account Trust…

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Behind the Pages: How I Wrote 'How to Be an Effective Statistician' 11:06

9M ago11:06

11:06

Discussion with Alexander Schacht Key points New Year Episode Book Announcement Personal Journey Target Audience Content Overview Fictional Narrative Chapter Structure Book Format Launch Party Ordering Info Don’t miss this inspiring episode of The Effective Statistician! Whether you’re curious about the process of writing a book, looking for action…

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Imposter Syndrome 16:54

9M ago16:54

16:54

Friday Episode with Alun Bedding Key Points: Imposter Syndrome Personal Experience Self-Doubt Chimp Paradox (Dr. Steve Peters) Inner Chimp Confidence Slowing Down Reframing Negative Experiences Learning Opportunities Recognizing Strengths Building Confidence Growth Mindset Success Recognition Feedback as a Gift Managing Self-Doubt Actionable Strate…

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Learn, Do, Reflect, and Start Again! How to Become a Better Leader 19:38

9M ago19:38

19:38

Discussion with Alexander Schacht Key points: Effective Leadership Growth Cycle Action-Oriented Communication Impactful Initiatives Continuous Improvement Practical Tips Leadership Essentials Statistical Parallel Take Charge Becoming a better leader starts with taking intentional steps to learn, apply, and reflect on your actions. This episode offe…

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2025 Lifestyle Planning 15:43

9M ago15:43

15:43

Friday Episode with Alun Bedding Key Points: Lifestyle-Centric Career Planning Vision Boards Goal Setting Quality Over Quantity Periodic Review Books and Inspirations Balance and Avoiding Burnout Coaching Insights Planning for 2025 doesn’t have to be overwhelming—it can be a powerful exercise in aligning your goals with your ideal lifestyle and lon…

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Early Development and The Dose Selection in the Immune-oncology 21:59

9M ago21:59

21:59

Interview with Teppo Huttunen Key points: Dose Selection Challenge Limitations of 3+3 Design BOIN Design Backfilling Efficacy vs. Safety Statisticians’ Role Practical Challenges FDA Guidance Cross-Functional Approach Industry Trends Cost & Timeline Estimation Understanding dose selection in immune-oncology is crucial for developing safer and more e…

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Sharpen The Saw 18:28

10M ago18:28

18:28

Friday Episode with Alun Bedding Key Points: Sharpen the Saw Stephen Covey Continuous renewal Four Dimensions of Renewal Physical Mental Social Spiritual Practical Strategies Take breaks Solve problems Block time Reflect Key Insights Balance across dimensions Avoid multitasking Curiosity and proactive mindset Sharpening the saw is about investing i…

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Why is it important to measure exposure to digital health interventions and how to tackle the challenge 34:22

10M ago34:22

34:22

Interview with Jack Elkes Key points: Digital health interventions: Definition, scope, examples. Engagement: Definition, importance, complexity. Measurement challenges: Multidimensional data, variability, arbitrary definitions. Mental health focus: Apps, virtual reality, stigma reduction, barriers to care. Cluster analysis: Grouping users, multidim…

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Why Do Clinical Trials Impact the Climate Heavily and What We Can Do About It? 26:53

10M ago26:53

26:53

Interview with Annie Wright Key points: Environmental Impact Carbon Footprint Drivers Decentralized Trials Study Design Simplification Protocol Amendments Waste Management Greener Initiatives Technology Adoption Awareness and Collaboration Call to Action CO2 Calculators Public and Private Collaboration Clinical trials play a vital role in advancing…

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Introduction to Dealing with Non-proportional Hazards 43:25

10M ago43:25

43:25

Interview with Kaspar Rufibach Key points: Non-Proportional Hazards: Understanding when and why the proportional hazards assumption fails. Hazard Functions: Differences between survival functions and hazard functions; interpreting dynamics over time. Data Visualization: Importance of visualizing hazard functions alongside Kaplan-Meier curves. Clini…