Best Xtalks Podcasts (2025)

1
Building the Future of Brain Health: Neuroscience Drug Development with Novartis’ Dr. Norman Putzki 27:30

5d ago27:30

27:30

In this episode, Ayesha speaks with Norman Putzki, MD, Senior Vice President and Global Development Head of Neuroscience and Gene Therapy at Novartis, about the complexities and real-world challenges of bringing new therapies to patients with neurological diseases. Dr. Putzki discusses the challenges and opportunities in developing treatments for c…

1
2G1C (E90) – XTalk Uncensored, Derby Prophecies & Clichés We’d Like to Kill 1:30:34

14d ago1:30:34

1:30:34

Today on 2 Guys 1 Coup, we’re joined by the fearless and unfiltered @ZeroDarkKitty for her first exclusive interview with us. She’s the co-host of XTalk Live—a raw, no-holds-barred political talk show that airs weekdays at 12 Noon EST, where she and co-host Crash tackle the headlines the mainstream won’t touch. From government corruption to cultura…

1
The Rabbit Hole: Has The Anti-Christ Came? 1:59:30

3d ago1:59:30

1:59:30

🎙️ Sponsored by From The Farm @ In this jaw-dropping episode, Eddie and Nate dive headfirst into the strange rise of a radical religious movement forming right in the heart of Reno, Nevada. The so-called Mahdi Cult is being led by a mysterious figure who boldly claims to be the true successor to the Pope, to Christ, and to the Prophet Muhammad—all …

1
2G1C (E93) Metal, Mics & Mayhem: The Sketchy Jesus Story 2:07:11

4d ago2:07:11

2:07:11

On this episode of 2 Guys 1 Coup, we’re joined for the full ride by Ian Avina—better known as Sketchy Jesus. He’s a lifelong metalhead who picked up music at 8 years old, raised hell in the scene, hit pause to get married, then pivoted into podcasting with The Whiskey Capitalist and The Til Death Podcast. That hustle evolved into the Til Death Podc…

1
2 The Point Podcast #117 - Billions, Bombs & Big Pharma: What They’re Not Telling You 58:43

4d ago58:43

58:43

Get ready for another high-impact episode of 2 The Point Podcast as we rip through this week’s top headlines from a bold, unfiltered perspective. We’re breaking down Trump’s massive $600 billion Middle East investment tour and what it means for America’s job market, plus his sweeping executive order that crushes Big Pharma’s grip on drug pricing. W…

1
Patriot Confederation - Jericho Green Interview (May 13, 2025) 1:02:38

5d ago1:02:38

1:02:38

Every patriot has an obligation to question authority. Those who are honest are not concerned with your watchful vigilance and those with integrity are not concerned with your discernment. Every American is obligated to voice their concerns and stand up for their freedoms and liberties. Ladies and gentlemen, we are the men in the arena, we are the …

1
2G1C (E92) – Jim Pfaff Drops Truth Bombs & Our Top 5 Sporting Events of All Time 1:18:57

7d ago1:18:57

1:18:57

On today’s episode of 2 Guys 1 Coup, we welcome Jim Pfaff, President of the Conservative Caucus, for a powerful and unapologetic deep dive into the current failures of Congress, the erosion of conservative values, and what it will take to reclaim the soul of the Republic. Jim pulls no punches as he exposes the political games being played in D.C. a…

1
2 The Point Podcast #116 59:16

11d ago59:16

59:16

Wednesday, May 7, 2025 – 8 PM Tonight, we're going deep on the headlines that matter — and the ones the mainstream won't touch. Join Mike, Leo, and Vince as they break down: Is Antarctica actually growing? The climate data they don’t want you to see. P. Diddy rejects a plea deal and heads to trial — what could be revealed, and who should be nervous…

1
2G1C (E91) – Nukes, Narcos, and the Never-Ending Summer of Stupid 1:32:40

12d ago1:32:40

1:32:40

On today’s episode of 2 Guys 1 Coup, headlines get hotter than a nuclear reactor. India fires on Pakistan—yes, you read that right. What does it mean when two nuclear-armed nations are suddenly in the same crosshairs? We unpack the madness. Then, the FBI makes the biggest fentanyl bust in U.S. history, yet the media can’t stop swooning over the ver…

1
Rare Disease Innovation in an Evolving Industry with Amgen’s Dr. Sumita Bhatta 32:03

12d ago32:03

32:03

In this episode, Ayesha speaks with Sumita Bhatta, MD, Vice President and Global Development Therapeutic Head of Rare Disease at Amgen. In the conversation, Dr. Bhatta shares insights on how large pharmaceutical companies like Amgen are approaching innovation and patient-centricity in the rare disease space. She also discusses the unique challenges…

1
Patriot Confederation - Ed Fisher Interview (May 6, 2025) 1:02:39

12d ago1:02:39

1:02:39

Every patriot has an obligation to question authority. Those who are honest are not concerned with your watchful vigilance and those with integrity are not concerned with your discernment. Every American is obligated to voice their concerns and stand up for their freedoms and liberties. Ladies and gentlemen, we are the men in the arena, we are the …

1
The Raising Cain Show: Borders, Cartels & Consequences: National Security on the Line 1:34:33

17d ago1:34:33

1:34:33

The Raising Cain Show: Borders, Cartels & Consequences: National Security on the Line .📆Date: 4/15/2025 ⏰Time: 9:00 pm EST 🔗Link: https://rumble.com/v6s54al-the-raising-cain-show-borders-cartels-and-consequences-national-security-on.html LIVE TONIGHT on The Raising Cain Show 🚨 We’re joined by national security expert and former ICE agent Victor Avi…

1
Advancing Novel Immunotherapy Approaches for Osteosarcoma and Beyond with Paul Romness, CEO of OS Therapies 43:23

19d ago43:23

43:23

In this episode, Ayesha spoke with Paul Romness, MHP, chair and CEO of OS Therapies, a company developing novel immunotherapies for cancers like osteosarcoma and other solid tumors. Paul shares insights into OS Therapies’ lead program, the scientific rationale behind the company’s innovative immunotherapy approach and how the company is addressing …

1
Patriot Confederation - Elvis Sinosic Interview (April 29, 2025) 1:02:57

19d ago1:02:57

1:02:57

Every patriot has an obligation to question authority. Those who are honest are not concerned with your watchful vigilance and those with integrity are not concerned with your discernment. Every American is obligated to voice their concerns and stand up for their freedoms and liberties. Ladies and gentlemen, we are the men in the arena, we are the …

1
2G1C (E88) Activist Judges, Trump’s Wins, ICE Raids, and Vanished Companies 1:28:08

21d ago1:28:08

1:28:08

On today’s episode of 2 Guys 1 Coup, activist judges are finally being held accountable — and even CNN can’t ignore it anymore. We dive into the real numbers behind how many illegals President Trump has deported, how that compares to past presidents, and the impact of countless injunctions. Plus, ICE just raided a major underground illegal gang — a…

1
2G1C WSF(3) – Country Music & Combat Vets: Chance Showell and Sean Holcomb Stand for Our Warriors 1:26:05

25d ago1:26:05

1:26:05

On this 3rd Warrior Shield Foundation Special Episode of the 2 Guys 1 Coup Podcast, we’re honored to welcome back two incredible patriots making a real difference for our nation’s heroes. First, we’re joined by Chance Showell, President of The Warrior Shield Foundation — a nonprofit dedicated to supporting veterans through mental health services, e…

1
2G1C (E87) Media’s Soft Spot for Thugs, Trump’s Stand, & Iconic Slogans 1:32:55

26d ago1:32:55

1:32:55

On today’s episode of 2 Guys 1 Coup, the radical left can’t seem to get enough of gang bangers, wife beaters, and human traffickers—and the mainstream media is right there cheering them on. We expose the coordinated cover-ups and twisted narratives designed to make monsters look like martyrs. Plus, Democrats are now laser-focused on removing our Se…

1
Targeting the Cell’s Powerhouse: Dr. Shaharyar Khan on Rivus Pharma’s Mitochondrial Approach to Cardiometabolic Diseases 41:55

26d ago41:55

41:55

In this episode, Ayesha spoke with Dr. Shaharyar Khan, co-founder and chief scientific officer at Rivus Pharmaceuticals. Rivus is developing a new class of investigational medicines called controlled metabolic accelerators (CMAs) for cardiometabolic diseases like diabetes, heart disease, heart failure and MASH by targeting obesity. Dr. Khan is an e…

1
Patriot Confederation - Vincent Saben Interview (April 22, 2025) 1:01:22

26d ago1:01:22

1:01:22

Every patriot has an obligation to question authority. Those who are honest are not concerned with your watchful vigilance and those with integrity are not concerned with your discernment. Every American is obligated to voice their concerns and stand up for their freedoms and liberties. Ladies and gentlemen, we are the men in the arena, we are the …

1
2G1C (E86) Dems Embrace Thugs, Easter Protest Clowns, and Our Top 5 NFL Draft Picks 1:34:04

28d ago1:34:04

1:34:04

On today’s 2 Guys 1 Coup, a Democrat Senator continues his public love affair with a wife-beater, human trafficker, and MS-13 gang member — because nothing says “progress” like glorifying violent felons. Even worse? More Democrats are joining the circus, proudly waving the “Make America Unsafe Again” flag. We’ll break it down. Plus, while you were …

1
Patriot Confederation (April 15, 2025) 1:04:04

1M ago1:04:04

1:04:04

Every patriot has an obligation to question authority. Those who are honest are not concerned with your watchful vigilance and those with integrity are not concerned with your discernment. Every American is obligated to voice their concerns and stand up for their freedoms and liberties. Ladies and gentlemen, we are the men in the arena, we are the …

1
2G1C (E85) Feds Ignore Swatting, Biden Rambles, and the Left Praises MS-13 1:37:19

1M ago1:37:19

1:37:19

In this explosive episode of the 2 Guys 1 Coup Podcast, we dive into the disturbing trend of swatting—how many more lives need to be put in danger before the FBI gets off their ass and does something? Then, the left unveils their latest hero… an MS-13 gang member. Yes, really. We break down how this violent criminal somehow became the hill they’re …

1
The Rabbit Hole Agartha and The Hollow Earth 1:45:02

1M ago1:45:02

1:45:02

🎙️ The Rabbit Hole: Agartha — The Forbidden History Beneath Our Feet Beneath our feet lies a mystery older than civilization… and possibly more dangerous than anything we’ve dared to explore. In this special deep-dive episode of The Rabbit Hole, Eddie Smith pulls together threads from ancient texts, forbidden legends, military secrets, and suppress…

1
Inside the Latest in Targeted Radiotherapeutics with Plus Therapeutics CEO Dr. Marc Hedrick 46:36

1M ago46:36

46:36

In this episode, Ayesha spoke with Marc Hedrick, MD, MBA, president and CEO of Plus Therapeutics, a company focused on developing a novel class of targeted radiotherapeutics. Prior to heading Plus Therapeutics, Dr. Hedrick served in a number of executive leadership roles including president, CEO and director at Cytori Therapeutics, and president an…

1
2G1C (E84) Unmasking the Machine: Encrypted Lense Exposes the Deep State 2:01:02

1M ago2:01:02

2:01:02

On today’s episode of the 2 Guys 1 Coup Podcast, we go deep with the one and only Encrypted Lense (X: @rekal89)—a no-nonsense investigative journalist and white hat hacker who’s been tearing the mask off the Deep State, one digital footprint at a time. From shady government ops to corporate surveillance and media psyops, Encrypted Lense pulls no pu…

1
2G1C (E83) Championing Truth & Tradition: A Conversation with Ann Vandersteel 1:36:53

1M ago1:36:53

1:36:53

In this impactful episode of 2 Guys 1 Coup, we sit down with Ann Vandersteel (@annvandersteel), a respected investigative journalist and host of Right Now with Ann Vandersteel. With a strong background in media and a passion for truth, Ann shares her insights on the state of the nation, the power of citizen journalism, and the importance of civic e…

1
From Lab to Launch: Commercializing Gene Therapies for Rare Diseases with Rocket Pharma’s Carlos Martin 33:54

1M ago33:54

33:54

In this episode, Ayesha spoke with Carlos Martin, MBA, chief commercial operations and revenue officer at Rocket Pharmaceuticals, a company developing gene therapy cures for rare diseases through innovative science and platforms. Carlos joined Rocket in April 2021 and established the company’s early commercial strategy and infrastructure as Chief C…

1
Patriot Confederation - Dr. Clinton Ohlers Interview (April 8, 2025) 1:03:17

1M ago1:03:17

1:03:17

Every patriot has an obligation to question authority. Those who are honest are not concerned with your watchful vigilance and those with integrity are not concerned with your discernment. Every American is obligated to voice their concerns and stand up for their freedoms and liberties. Ladies and gentlemen, we are the men in the arena, we are the …

1
2G1C (E82) Unmasking the Deep State: Voices from X with Texas Patriot, Al Ebadi & Encrypted Lense 1:27:26

1M ago1:27:26

1:27:26

On this episode of the 2 Guys 1 Coup Podcast, we bring you an unfiltered and high-energy conversation with three powerhouse voices from the X platform: Texas Patriot (@Texasbrn), Al Ebadi (@awsalebadi), and Encrypted Lense (@rekal89). These fearless influencers and investigative journalists are on a mission to expose the deep state and reveal the t…

1
2G1C (E81) Jim Pfaff Unfiltered: Holding D.C. Accountable 1:22:17

1M ago1:22:17

1:22:17

On this episode of 2 Guys 1 Coup, we’re joined by Jim Pfaff—political strategist, grassroots powerhouse, and senior advisor to the Conservative Caucus. Jim’s been in the trenches of the conservative movement for decades, and he’s not pulling any punches. We get into the real threats facing our Constitution, the fight for limited government, and how…

1
2G1C (E80) Dugger Band: Faith, Freedom & the Song Nashville Tried to Silence 1:28:42

2M ago1:28:42

1:28:42

In today’s episode, we sit down with Dugger Band for an exclusive and powerful interview. These rising stars in country music open up about their journey from small-town Tennessee to the national stage, sharing the heart and heritage that fuel their sound. We dive into the inspiration behind their number one hit single, True Colors—a patriotic anth…

1
Combating Autoimmunity: Vera Therapeutics CEO Dr. Marshall Fordyce Discusses Advancing IgAN Treatments 44:45

2M ago44:45

44:45

In this episode, Ayesha spoke with Marshall Fordyce, MD, founder and CEO of Vera Therapeutics, a company focused on developing treatments for autoimmune diseases. Dr. Fordyce founded Vera in 2016 as an entrepreneur in residence at Kleiner Perkins Caufield and Byers, took the company public in 2021 and has advanced its lead molecule through a succes…

1
Patriot Confederation - Dan Wilson Interview (April 1, 2025) 1:01:27

2M ago1:01:27

1:01:27

Every patriot has an obligation to question authority. Those who are honest are not concerned with your watchful vigilance and those with integrity are not concerned with your discernment. Every American is obligated to voice their concerns and stand up for their freedoms and liberties. Ladies and gentlemen, we are the men in the arena, we are the …

1
2 The Point Podcast #112 – Argentina Document Dump & Trump’s Third-Term Talk 1:01:18

2M ago1:01:18

1:01:18

This week on 2 The Point Podcast, we’re diving into the explosive Argentina document dump—what’s inside, and why it matters. Plus, Trump’s recent comments on a potential third term are stirring up controversy. The 22nd Amendment prohibits more than two terms, but is there more to the conversation? We break it all down and give you the unfiltered tr…

1
2G1C (E79) Signalgate Fails, Tesla Terror, and Seattle’s Woke Hangover 1:35:53

2M ago1:35:53

1:35:53

In this episode of 2 Guys 1 Coup, we break down the latest political debacle — Signalgate. It’s a complete failure for the Dems, so what’s next on the liberal left’s agenda? Then, we dive into the Tesla Takedown — it seems the paid protestors didn’t get the memo that President Trump’s decision to eliminate overtime taxes might be a game changer. Pl…

1
The Patriots Prayer W/ Guests Agent DJ Daniel, Michaelah, Theotis D. & Tom Macdonald 1:37:11

2M ago1:37:11

1:37:11

Join hosts Eddie Smith and Maurice LaPointe for an inspiring episode featuring stories of resilience, faith, and patriotism. 🔥 🎤 This week's distinguished guests include: Theotis Daniel – Devoted father of Devarjaye "DJ" Daniel, passionate advocate for childhood cancer awareness, and steadfast supporter of law enforcement. Agent DJ Daniel – Courage…

1
The Left Flails, Trump Leads, and Our Top 5 Movie Deaths (E78) 1:28:24

2M ago1:28:24

1:28:24

On today’s episode of 2 Guys 1 Coup, the left is at it again—trying desperately to paint the Trump administration as incompetent. We break down their latest smear attempt and share our theory on what’s really going on behind the scenes. Plus, President Trump drops some powerful new executive orders that couldn’t come at a better time—now if only Co…

1
Targeting Pressing Unmet Needs in Kidney Diseases with Unicycive Therapeutics CEO Dr. Shalabh Gupta 40:04

2M ago40:04

40:04

In this episode, Ayesha spoke with Shalabh Gupta, MD, founder, chairman and CEO of Unicycive Therapeutics, a company focused on addressing unmet medical needs in renal diseases. Kidney diseases are a major global health concern. In the US, chronic kidney disease (CKD) affects more than one in seven individuals, and one in three adults with diabetes…

1
Patriot Confederation - Brad Kohler Interview (March 25, 2025) 1:02:10

2M ago1:02:10

1:02:10

Every patriot has an obligation to question authority. Those who are honest are not concerned with your watchful vigilance and those with integrity are not concerned with your discernment. Every American is obligated to voice their concerns and stand up for their freedoms and liberties. Ladies and gentlemen, we are the men in the arena, we are the …

1
2 The Point Podcast #111 -with Jordan Clark: Awakening, Resilience, and the Fight for Truth 1:01:25

2M ago1:01:25

1:01:25

This week on 2 The Point Podcast with Mike, Leo, and Vince, we're talking with Jordan Clark about current events and the shifting narrative. Jordan shares his awakening and the fight that brought him to where he is today. Follow him on X @JordanClark1776 and on Instagram @realjordanclark. Connect with him at beacons.ai/jclark. Don't miss this conve…

1
Tesla Terror, Tampon Tim, Treason Unpunished, Top Cartoons(E77) 1:20:04

2M ago1:20:04

1:20:04

The unhinged left takes their Tesla tantrum to the next level—widespread vandalism, targeted attacks, and eco-hypocrisy on full display as they wage war on Elon’s empire. Then, failed VP pick and resident clown “Tampon” Tim Walz launches another pathetic assault on Tesla, only to backpedal and cover up his latest meltdown like the professional luna…

1
The Patriots Prayer Podcast: With Guest Phil Tourey USS Liberty Survivor 2:44

2M ago2:44

2:44

In this powerful and emotional episode, The Patriots Prayer Podcast welcomes Phil Tourney, a survivor of the infamous attack on the USS Liberty. Phil has spent decades demanding the truth be told about what happened on that fateful day in 1967, when Israel, America's so-called greatest ally, opened fire on one of the most highly decorated ships in …

1
Healing Our Heroes – A Conversation with Dr. Tania Glenn & Bucket List Dreams (E76) 1:35:30

2M ago1:35:30

1:35:30

In this powerful and deeply important episode, we sit down with Dr. Tania Glenn, a nationally recognized trauma therapist and the founder of Tania Glenn & Associates. With decades of experience working with first responders, military personnel, and veterans, Dr. Glenn has dedicated her life to helping those who serve cope with PTSD, trauma, and men…

1
2 The Point Podcast #110 - "Crime, Courts, and Conflict: Gangs, Rogue Judges & Global Tensions" 1:03:09

2M ago1:03:09

1:03:09

Tonight on 2 The Point Podcast with Mike, Leo, and Vince, we’re breaking down the stories that matter most. El Salvador’s Harsh Justice: Venezuela’s most dangerous gang members are being shipped off to El Salvador’s infamous mega-prison. Is this a victory in the fight against crime, or just another chapter in the global crackdown on organized gangs…

1
Innovating Treg Therapies for ALS and Alzheimer’s with Coya Therapeutics CEO Dr. Arun Swaminathan 39:10

2M ago39:10

39:10

Join us as we celebrate a major milestone — the 200th episode of the Xtalks Life Science Podcast! From groundbreaking biotech innovations to exclusive interviews with life science industry innovators and leaders, we've covered it all. Thank you for tuning in each week! We look forward to continuing to bring the latest and greatest across the pharma…

1
Patriot Confederation - Casey Whalen Interview (March 18, 2025) 1:01:20

2M ago1:01:20

1:01:20

Every patriot has an obligation to question authority. Those who are honest are not concerned with your watchful vigilance and those with integrity are not concerned with your discernment. Every American is obligated to voice their concerns and stand up for their freedoms and liberties. Ladies and gentlemen, we are the men in the arena, we are the …

1
Tom MacDonald | The Hangover Gang Edition of PPN 1:36:21

2M ago1:36:21

1:36:21

Tom MacDonald has built his career on truth, resilience, and refusing to be silenced. In an industry controlled by corporations and driven by agendas, he stands out as an independent artist who refuses to be owned. He’s faced smears, censorship, and attacks from the media, the music industry, and the woke mob—all because he dares to speak his mind.…

1
Swatted for Being a Patriot – The Mike Engleman Story (E75) 1:14:33

2M ago1:14:33

1:14:33

On today’s episode of 2 Guys 1 Coup, we bring you an exclusive interview with Mike Engleman, known as @RealHickory on X. Mike is the latest conservative patriot to fall victim to the terrifying and dangerous tactic of swatting—a criminal act where radical leftists make false emergency calls to send armed authorities to the homes of America First su…

1
Security Threats, Political Battles, and the Greatest Game Shows (E74) 1:31:44

2M ago1:31:44

1:31:44

In today’s episode, we welcome Wayne Black—author, security expert, and founder of Wayne Black & Associates, a top-tier security consulting firm based in Miami. Wayne joins us to discuss his book, School (In)Security, which tackles the vulnerabilities in our education system, as well as his latest project addressing security concerns at houses of w…

1
The Path to Healthy Aging: Pioneering Therapies for Age-Related Diseases with Rejuvenate Biomed's Ann Beliën 26:42

2M ago26:42

26:42

In this episode, Vera spoke with Ann Beliën, PhD, founder and CEO of Rejuvenate Biomed, a biotech company leveraging AI-driven platforms to develop therapies for age-related diseases and promote healthy aging. Rejuvenate Biomed is aiming to transform the treatment landscape for diseases such as sarcopenia, neuromuscular, metabolic and neurodegenera…

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