Mobility is an essential component to the vibrant, equitable, and sustainable cities of our future. To build this future, we need to do more than invest in technology. We need to invest in the people who will make the hard decisions around transportation, land use, housing, economic development, and other aspects of urban life. Josh Cohen, National Policy Director at TransLoc, wants to start that conversation by building relationships with and sharing ideas from today’s leaders who are imagi ...
…
continue reading
Translocal Podcasts
Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.
…
continue reading
Welcome to ‘Safari Conversations’ – the Singita Podcast. 30 years ago, our Founder, Luke Bailes, had a dream of creating a pioneering ecotourism brand that could help save pristine wilderness areas in Africa for future generations. The first chapter of this story started when we built Singita Ebony Lodge, in the Sabi Sand, in 1993. But truly, it began long before that, on a piece of land his grandfather owned and where they spent holidays as a family at Castleton. So much has happened in the ...
…
continue reading
Set around specific themes, The Animal Highlight offers glimpses into the wonderful and complex worlds of animals. This is a spinoff of The Animal Turn Podcast, a podcast that unpacks important concepts in animal studies.
…
continue reading
Join me for a weekly talk-through of IELTS topics to help you learn about the issues, vocabulary, tips and strategies you need to prepare. Find all my tips on my website ieltsetc.com and join the Members Academy for all the downloads, step-by-step online courses, and support to get you a Band 7+ in the #ielts test.
…
continue reading
There's a lot of talk about conservation, but this really is the hands-on kind. Follow wildlife conservation in the field, as Roy Dennis, based in the Highlands of Scotland, works with his team on the restoration of species in the UK and abroad.
…
continue reading
The Best of the Outdoors Podcast is optimized to bring listeners the best in hunting, fishing, shooting, bowfishing, and other outdoor activities from Texas and beyond. Hosted and Produced by Dustin Vaughn Warncke, Owner of Warncke Enterprises, a Media Production Marketing Agency. Reach out to Dustin via TEXT at (512) 497-7674.
…
continue reading
Ever have a skunk spray under your home? Or wake up to find bats in your attic have flown into the bedroom? Wildlife and people are intimately linked in a constant give and take. Sometimes these animals find their way into our homes and create all kinds of conflict while just trying to carve out a niche for themselves. On the Maine Wildlife Management Podcast we're discussing nuisance wildlife removal and home damage repair solutions that are practical for you whether a DIY or hiring a Wildl ...
…
continue reading
1
236: XPD translocation and genetic disease etiology
19:54
19:54
Play later
Play later
Lists
Like
Liked
19:54️ Episode 236: XPD translocation and genetic disease etiology In this episode of PaperCast Base by Base, we explore Computational modeling reveals how ATP-driven conformational cycles of the XPD helicase drive directional 5′→3′ translocation on single-stranded DNA and how mutations disrupt this process to cause disease Study Highlights: The authors…
…
continue reading
1
244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis
17:38
17:38
Play later
Play later
Lists
Like
Liked
17:38️ Episode 244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis In this episode of PaperCast Base by Base, we explore Mitochondrial NEK7 is imported via MTS peptides, binds SDHB to stabilize complex II conformation, prevent reverse electron transport and ROS, and thereby protects against spontaneous and experi…
…
continue reading
1
243: Genome-wide UVB GxE study finds 162 vitamin D variants
17:41
17:41
Play later
Play later
Lists
Like
Liked
17:41️ Episode 243: Genome-wide UVB GxE study finds 162 vitamin D variants In this episode of PaperCast Base by Base, we explore A GWIS of 338,977 UK Biobank White British participants using a cumulative weighted ambient UVB measure identified 307 independent loci for 25-hydroxyvitamin D, including 162 novel variants Study Highlights: The study linked a…
…
continue reading
1
242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats
17:40
17:40
Play later
Play later
Lists
Like
Liked
17:40️ Episode 242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats In this episode of PaperCast Base by Base, we explore A single intramuscular injection of an AAV9 vector encoding feline anti‑Müllerian hormone (fcMISv2) in prepubertal kittens produced sustained supraphysiological AMH, was well tolerated, and prevented breeding‑induced ovul…
…
continue reading
1
241: Wagyu T2T reveals a cattle X neocentromere
18:36
18:36
Play later
Play later
Lists
Like
Liked
18:36️ Episode 241: Wagyu T2T reveals a cattle X neocentromere In this episode of PaperCast Base by Base, we explore A telomere-to-telomere Wagyu assembly uncovers a natural neocentromere on the cattle X formed by inverted repeats and transposable element expansion, adds hundreds of new genes, and improves variant discovery Study Highlights: The UOA_Wag…
…
continue reading
1
240: CYFIP1 controls cortical axon development by modulating calcium
18:46
18:46
Play later
Play later
Lists
Like
Liked
18:46️ Episode 240: CYFIP1 controls cortical axon development by modulating calcium In this episode of PaperCast Base by Base, we explore Reduction of CYFIP1 delays callosal axon growth and arborization by lowering intracellular calcium and impairing mitochondrial function Study Highlights: In vivo, Cyfip1+/- mice show delayed callosal axon growth at P5…
…
continue reading
1
239: Genomic Adaptations of the Svalbard Reindeer
19:21
19:21
Play later
Play later
Lists
Like
Liked
19:21️ Episode 239: Genomic Adaptations of the Svalbard Reindeer In this episode of PaperCast Base by Base, we explore Comparative whole-genome analyses identify 150 differentiated genomic regions and candidate genes linked to fat metabolism, energy conservation, cold tolerance, reduced body size, fur morphology, and circadian rhythm that likely underpi…
…
continue reading
1
238: Germline polymorphisms shape antibody light chain repertoires
18:14
18:14
Play later
Play later
Lists
Like
Liked
18:14️ Episode 238: Germline polymorphisms shape antibody light chain repertoires In this episode of PaperCast Base by Base, we explore Long-read sequencing of IGK and IGL paired with AIRR-seq shows that common germline SNVs, SVs, and alleles drive inter-individual differences in light chain gene usage and CDR3 properties Study Highlights: The authors c…
…
continue reading
1
237: Tracing enteric pathogens in Africa with metagenomics and WGS
20:00
20:00
Play later
Play later
Lists
Like
Liked
20:00️ Episode 237: Tracing enteric pathogens in Africa with metagenomics and WGS In this episode of PaperCast Base by Base, we explore This study combines whole-genome sequencing and metagenomics to map the diversity, abundance, and genomic relationships of enteric foodborne pathogens across human, animal, food and environmental samples in four African…
…
continue reading
1
235: Maternal H3K9 methyltransferases control aRMAE in C. elegans
17:56
17:56
Play later
Play later
Lists
Like
Liked
17:56️ Episode 235: Maternal H3K9 methyltransferases control aRMAE in C. elegans In this episode of PaperCast Base by Base, we explore Using dual-color reporters in C. elegans, the study shows maternal H3K9 methyltransferases MET-2 and SET-25 antagonistically regulate autosomal random monoallelic expression initiated in the early embryo Study Highlights…
…
continue reading
1
234: MTHFR genotype and methionine metabolism predict COVID-19 severity
20:27
20:27
Play later
Play later
Lists
Like
Liked
20:27️ Episode 234: MTHFR genotype and methionine metabolism predict COVID-19 severity In this episode of PaperCast Base by Base, we explore IMPACC longitudinal metabolomics and genomics analyses show that disruptions in one‑carbon/methionine metabolism together with MTHFR C677T genotype at hospital admission improve prediction of severe COVID‑19 and lo…
…
continue reading
1
233: Mechanistic basis of NuA3 recognition and H3K14 acetylation
18:48
18:48
Play later
Play later
Lists
Like
Liked
18:48️ Episode 233: Mechanistic basis of NuA3 recognition and H3K14 acetylation In this episode of PaperCast Base by Base, we explore Cryo-EM structures of the yeast NuA3 complex reveal how a cooperative Sas3–Nto1 binding cleft recognizes the H3 tail and directs acetylation of H3K14 Study Highlights: The authors report cryo-EM structures of NuA3 in apo,…
…
continue reading
1
232: Lamin A/C steers fork restart via H3K9me3 and PARylation
17:58
17:58
Play later
Play later
Lists
Like
Liked
17:58️Episode 232: Lamin A/C steers fork restart via H3K9me3 and PARylation In this episode of PaperCast Base by Base, we explore Nucleoplasmic Lamin A/C, together with LAP2α, enforces active replication fork slowing during mild replication stress by promoting local H3K9me3 and ADP-ribosylation to restrain RECQ1-mediated restart and protect genome stabi…
…
continue reading
1
231: Transcription start sites as a germline mutational hotspot
17:01
17:01
Play later
Play later
Lists
Like
Liked
17:01️Episode 231: Transcription start sites as a germline mutational hotspot In this episode of PaperCast Base by Base, we explore This study identifies a pronounced germline mutational hotspot centered on transcription start sites (TSSs) driven in part by early embryonic mosaic variants and transcription-associated DNA damage Study Highlights: Extreme…
…
continue reading
1
230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome
18:27
18:27
Play later
Play later
Lists
Like
Liked
18:27️Episode 230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome In this episode of PaperCast Base by Base, we explore A recurrent de novo MIDEAS p.Tyr654Ser variant disrupts an autoinhibitory loop in the MiDAC complex, increasing HDAC1 deacetylase activity and causing a multisystem neurodevelopmental disorder Study Highlig…
…
continue reading
1
229: Inhibiting PCBP2 condensates in Alzheimer’s
19:55
19:55
Play later
Play later
Lists
Like
Liked
19:55️Episode 229: Inhibiting PCBP2 condensates in Alzheimer’s In this episode of PaperCast Base by Base, we explore Elevated PCBP2 forms liquid-like condensates that sequester mitochondrial and RNA-binding proteins, stabilize BACE1 mRNA, and promote amyloid pathology while the small molecule CN-0928 reduces PCBP2 via INTS1 to lower Aβ and improve cogni…
…
continue reading
1
228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity
18:02
18:02
Play later
Play later
Lists
Like
Liked
18:02️ Episode 228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity In this episode of PaperCast Base by Base, we explore Structural and functional characterization of two group 2 H3 HA stem antibodies, 2F02 and AG2-G02, shows distinct non-overlapping epitopes, protection in mice, and antigenic changes driven by HA2 position 32 that …
…
continue reading
1
227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation
16:21
16:21
Play later
Play later
Lists
Like
Liked
16:21️ Episode 227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation In this episode of PaperCast Base by Base, we explore This study shows that spontaneous RPE differentiation eliminates most aneuploid human pluripotent stem cells but permits expansion of cells with chromosome 1q gains when they are co-cultured with wild-type cells …
…
continue reading
1
226: FGF4 protects podocytes in diabetic kidney disease
16:09
16:09
Play later
Play later
Lists
Like
Liked
16:09️ Episode 226: FGF4 protects podocytes in diabetic kidney disease In this episode of PaperCast Base by Base, we explore This study shows that podocyte-derived FGF4 is reduced in DKD and that recombinant FGF4 preserves podocyte survival and glomerular function in diabetic models via FGFR1-AMPK-FOXO1 signaling Study Highlights: FGF4 expression is dow…
…
continue reading
1
225: VRK-1 and BAF-1 release meiotic chromosomes
17:13
17:13
Play later
Play later
Lists
Like
Liked
17:13️ Episode 225: VRK-1 and BAF-1 release meiotic chromosomes In this episode of PaperCast Base by Base, we explore VRK-1 phosphorylates BAF-1 to remove chromatin from the nuclear periphery during early meiotic prophase in C. elegans, and failure of this step impairs pairing and synapsis and generates heritable genome lesions Study Highlights: The aut…
…
continue reading
1
224: AntennAlive — wireless in-body sensing with engineered bacteria
18:41
18:41
Play later
Play later
Lists
Like
Liked
18:41️ Episode 224: AntennAlive — wireless in-body sensing with engineered bacteria In this episode of PaperCast Base by Base, we explore A bio-hybrid, battery-free implant converts engineered bacterial activity into microwave backscatter signals by controlled degradation of a biodegradable antenna Study Highlights: The AntennAlive system uses a magnesi…
…
continue reading
1
223: Torsion Regulates DNA Replication Stalling and Restart
16:26
16:26
Play later
Play later
Lists
Like
Liked
16:26️ Episode 223: Torsion Regulates DNA Replication Stalling and Restart In this episode of PaperCast Base by Base, we explore New single-molecule angular optical trap assays reveal that DNA torsion directly controls T7 replisome stalling and reactivation Study Highlights: A high-resolution, label-free angular optical trap (AOT) assay was developed to…
…
continue reading
1
222: snaR-A hijacks splicing to drive proliferation
17:57
17:57
Play later
Play later
Lists
Like
Liked
17:57️ Episode 222: snaR-A hijacks splicing to drive proliferation In this episode of PaperCast Base by Base, we explore This episode examines how the cancer-associated Pol III transcript snaR-A binds core splicing factors, localizes near nuclear speckles, perturbs U2-dependent splicing to increase intron retention, and promotes cell proliferation linke…
…
continue reading
1
221: Allele-resolved nanopore tour of the human placental methylome
20:23
20:23
Play later
Play later
Lists
Like
Liked
20:23️ Episode 221: Allele-resolved nanopore tour of the human placental methylome In this episode of PaperCast Base by Base, we explore Using phased long-read nanopore and short-read sequencing across eight trios, the study maps allele-specific DNA methylation and transcription in female human placentas, identifies hundreds of DMRs and novel imprinted …
…
continue reading
1
220: The AML cellular state space reveals NPM1 immune evasion subtypes
15:48
15:48
Play later
Play later
Lists
Like
Liked
15:48️Episode 220: The AML cellular state space reveals NPM1 immune evasion subtypes In this episode of PaperCast Base by Base, we explore Single-cell and bulk sequencing of 120 AML cases reveal two NPM1-mutated subtypes with distinct immune evasion mechanisms and divergent responses to hematopoietic stem cell transplantation Study Highlights: Bulk RNA-…
…
continue reading
1
219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain
16:41
16:41
Play later
Play later
Lists
Like
Liked
16:41️Episode 219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain In this episode of PaperCast Base by Base, we explore Targeted multi-region lipidomics with proteomic and mitochondrial data reveals region- and stage-specific lipid alterations in Parkinson’s disease that converge on mitochondrial dysfunction Study Highlights: The study q…
…
continue reading
1
218: SIM1 and the multi-ancestry genomics of erectile dysfunction
19:37
19:37
Play later
Play later
Lists
Like
Liked
19:37️Episode 218: SIM1 and the multi-ancestry genomics of erectile dysfunction In this episode of PaperCast Base by Base, we explore A large multi-ancestry GWAS meta-analysis identifies a dominant SIM1-linked locus and multiple genetic connections between electronic health record-defined erectile dysfunction and cardiometabolic, psychiatric, and substa…
…
continue reading
1
Conscious Travel - A Ripple Effect That Continues After Your Visit to Rwanda
26:24
26:24
Play later
Play later
Lists
Like
Liked
26:24Every great story is made up of many smaller ones. Ross Couper (Singita’s Resident Content Creator) chats to Martin Tuyisenge (Singita’s Community Liaison Manager) about the ripple effect of every guest’s stay on local livelihoods and conservation at Singita Kwitonda and Kataza House. Rwanda is truly a bucket list destination, for gorillas, golden …
…
continue reading
1
217: Multiscale triads of meiotic crossover patterning
17:47
17:47
Play later
Play later
Lists
Like
Liked
17:47️Episode 217: Multiscale triads of meiotic crossover patterning In this episode of PaperCast Base by Base, we explore FFT and inverse-FFT analysis of Zip3/Zip2, Hop1 and Zip1 on yeast pachytene chromosomes reveals two interdigitated tiers of evenly spaced protein triads that correspond to canonical and minority crossovers and are differentially reg…
…
continue reading
1
216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair
18:27
18:27
Play later
Play later
Lists
Like
Liked
18:27️ Episode 216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair In this episode of PaperCast Base by Base, we explore This episode reviews a study showing that 53BP1-RIF1 and DNA-PKcs have different genetic relationships across blunt end joining, deletion patterns, HDR, and radiosensitivity Study Highlights: Using EJ7-GFP …
…
continue reading
1
215: Protein Set Transformer for high-diversity viromics
20:07
20:07
Play later
Play later
Lists
Like
Liked
20:07️ Episode 215: Protein Set Transformer for high-diversity viromics In this episode of PaperCast Base by Base, we explore Protein Set Transformer (PST) is a protein-based genome language model that represents genomes as sets of proteins to improve genome and protein representations across diverse viral datasets Study Highlights: PST embeds proteins …
…
continue reading
1
214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion
18:21
18:21
Play later
Play later
Lists
Like
Liked
18:21️ Episode 214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion In this episode of PaperCast Base by Base, we explore This study shows that an asymmetric transbilayer distribution of PI(4,5)P2 lowers the energy barrier for lipidic pore formation and accelerates unconventional secretion of Fibroblast Growth Factor 2 Study Highlights: The authors gen…
…
continue reading
1
213: BRAIN-MAGNET: a functional atlas for non-coding variants
20:29
20:29
Play later
Play later
Lists
Like
Liked
20:29️ Episode 213: BRAIN-MAGNET: a functional atlas for non-coding variants In this episode of PaperCast Base by Base, we explore BRAIN-MAGNET couples a ChIP-STARR-seq atlas of 148,198 neural regulatory elements with a validated convolutional neural network to predict enhancer activity and prioritize disease-relevant non-coding variants Study Highlight…
…
continue reading
1
212: Zonal control of mutant β-catenin tumorigenesis
16:47
16:47
Play later
Play later
Lists
Like
Liked
16:47️ Episode 212: Zonal control of mutant β-catenin tumorigenesis This study shows that hepatic zonation determines whether mutant β-catenin drives proliferation and liver cancer by forcing differentiation to a non-permissive zone 3 fate or, when reversed, enabling MAPK- and mTOR-dependent growth Study Highlights: β-catenin exon 3 mutations cooperate …
…
continue reading
️ Episode 211: Retention Elements in Cancer Cells In this episode of PaperCast Base by Base, we explore the discovery of genetic elements that promote the retention of extrachromosomal DNA (ecDNA) in cancer cells, enhancing their survival and evolution. Study Highlights: Researchers identified a family of genomic elements known as retention element…
…
continue reading
1
210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma
18:45
18:45
Play later
Play later
Lists
Like
Liked
18:45️ Episode 210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma In this episode of PaperCast Base by Base, we explore how tumour-reactive CD8 T cells organize into stable clusters with melanoma cells and antigen-presenting cells, and how these structures can be isolated from patient samples to boost anti-tumour immunity. Study Highlights: The …
…
continue reading
1
209: PERT: Prime Editing tRNAs for Nonsense Mutations
16:54
16:54
Play later
Play later
Lists
Like
Liked
16:54️ Episode 209: PERT: Prime Editing tRNAs for Nonsense Mutations In this episode of PaperCast Base by Base, we explore how prime editing can reprogram endogenous tRNAs into potent suppressor tRNAs, enabling a single therapeutic strategy to rescue many different genetic diseases caused by premature stop codons. Study Highlights: The authors introduce…
…
continue reading
1
208: ZAK, Collided Ribosomes, and the Stress Switch
15:55
15:55
Play later
Play later
Lists
Like
Liked
15:55️ Episode 208: ZAK, Collided Ribosomes, and the Stress Switch In this episode of PaperCast Base by Base, we explore how collided ribosomes activate the MAP3K ZAK to drive the ribotoxic stress response and shape cell fate decisions under translational stress. Study Highlights: Using biochemistry, cryo-electron microscopy and crosslinking-based RNA m…
…
continue reading
1
207: Semantic Design of de novo Genes with Evo
15:05
15:05
Play later
Play later
Lists
Like
Liked
15:05️ Episode 207: Semantic Design of de novo Genes with Evo In this episode of PaperCast Base by Base, we explore how a genomic language model called Evo can use genomic context to design entirely new DNA sequences that encode functional genes and multi-component defence systems. Study Highlights: Researchers trained the Evo genomic language model on …
…
continue reading
1
206: Wild Birds and the North American H5N1 Epizootic
17:17
17:17
Play later
Play later
Lists
Like
Liked
17:17️ Episode 206: Wild Birds and the North American H5N1 Epizootic In this episode of PaperCast Base by Base, we explore how wild migratory birds have shaped the ecology and spread of the 2021–2023 highly pathogenic H5N1 epizootic across North America, and what this means for wildlife conservation and poultry health. Study Highlights: Using 1,818 haem…
…
continue reading
1
205: Ancient RNA Expression Profiles from the Woolly Mammoth
17:19
17:19
Play later
Play later
Lists
Like
Liked
17:19️ Episode 205: Ancient RNA Expression Profiles from the Woolly Mammoth In this episode of PaperCast Base by Base, we explore how ancient RNA preserved in permafrost can reveal tissue-specific gene expression and regulatory dynamics in the extinct woolly mammoth. Study Highlights: Researchers analyzed skeletal muscle and skin from ten Late Pleistoce…
…
continue reading
1
204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators
16:39
16:39
Play later
Play later
Lists
Like
Liked
16:39️ Episode 204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators In this episode of PaperCast Base by Base, we explore how the StealTHY CRISPR platform sidesteps Cas9 immunogenicity to uncover metastasis drivers in immunocompetent and humanized cancer models. Study Highlights: Researchers show that standard CRISPR-Cas9 tools and xenogeneic re…
…
continue reading
1
203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors
18:08
18:08
Play later
Play later
Lists
Like
Liked
18:08️ Episode 203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors In this episode of PaperCast Base by Base, we explore how benign and malignant tumors follow different evolutionary trajectories across birds and mammals, and what this reveals about cancer defenses across the tree of life. Study Highlights: The authors combine necropsy d…
…
continue reading
1
202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues
17:08
17:08
Play later
Play later
Lists
Like
Liked
17:08️ Episode 202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues In this episode of PaperCast Base by Base, we explore how Stereo-seq V2 delivers high-resolution spatial mapping of total RNA in FFPE samples, from mouse brain to breast cancer and tuberculosis lung tissue. Study Highlights: The authors introduce Stereo-seq V2, a random-priming…
…
continue reading
1
201: Sex, Smoking, and Somatic Selection in the Bladder
14:52
14:52
Play later
Play later
Lists
Like
Liked
14:52️ Episode 201: Sex, Smoking, and Somatic Selection in the Bladder In this episode of PaperCast Base by Base, we explore how ultradeep duplex DNA sequencing of normal human bladder tissue reveals sex- and smoking-related biases in the selection of somatic mutations and cancer driver clones. Study Highlights: Researchers applied ultradeep duplex DNA …
…
continue reading
1
200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline
18:48
18:48
Play later
Play later
Lists
Like
Liked
18:48️ Episode 200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline In this episode of PaperCast Base by Base, we explore how ultra-accurate duplex sequencing of human sperm reveals widespread positive selection in the male germline and its consequences for mutation burden and disease risk in offspring. Study Highlights: This …
…
continue reading
1
199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity
13:57
13:57
Play later
Play later
Lists
Like
Liked
13:57️ Episode 199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity In this episode of PaperCast Base by Base, we explore how loss-of-function mutations in the endolysosomal exonuclease PLD4 cause a monogenic form of systemic lupus erythematosus, reshaping our understanding of nucleic acid sensing and interferon-driven autoimmunity…
…
continue reading
1
198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells
15:47
15:47
Play later
Play later
Lists
Like
Liked
15:47️ Episode 198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells In this episode of PaperCast Base by Base, we explore how physical forces in the tumor microenvironment can push melanoma cells to switch from a pigment-producing, proliferative state into an invasive, drug-tolerant one, focusing on new work that links mechanical co…
…
continue reading
1
Just You, Nature, and a Villa in Africa - Insider tips on Singita's private retreats
40:01
40:01
Play later
Play later
Lists
Like
Liked
40:01If you’ve ever wondered what it’s really like to have an entire villa - or the Serengeti - to yourself, then this episode is for you. Our Product Manager, Kim Anderson, sits down with Donna Louw (Private Villa Manager & Wholeness) and Betty Mollel (Villa Manager) to spill the (freshly brewed) tea on what really makes Singita’s private villas in Afr…
…
continue reading
1
197: Somatic Mutation and Selection at Population Scale
15:11
15:11
Play later
Play later
Lists
Like
Liked
15:11️ Episode 197: Somatic Mutation and Selection at Population Scale In this episode of PaperCast Base by Base, we explore how ultra-accurate NanoSeq duplex sequencing reveals the hidden landscape of somatic mutations and clonal selection across blood and oral epithelium in over a thousand adults. Study Highlights: This study introduces improved whole…
…
continue reading