Best Transcriptomics Podcasts (2025)

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Integrated Solutions for Serial Sectioning and Cryo-EM with UC Enuity 51:44

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17d ago51:44

51:44

Discover integrated solutions for precise serial sectioning and cryo-EM sample prep—supporting seamless workflows from ultramicrotomy to 3D electron microscopy. In this podcast, you will learn: • How to streamline serial sectioning for volume EM using the UC Enuity and AT module; • How to achieve in-situ targeting under cryogenic conditions for cry…

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Inequalities in sickle cell therapies - Ep 4.1 55:14

22d ago55:14

55:14

In this extended episode of the HemaSphere podcast, based on a must-read Perspective "Can health inequalities in sickle cell disease be addressed through novel therapies?", our host Scientific Editor Charles de Bock discusses sickle cell disease with co-authors, covering both expert and lived-patient perspectives. They explore the complexities of l…

1
Whole-brain Spatial Transcriptomics at Cellular Resolution 50:09

1M ago50:09

50:09

Learn how to perform a powerful new tissue-clearing method, designed for whole-brain 3D spatial RNA imaging at single cell resolution, and able to provide uniform staining while enhancing tissue transparency in whole organs across multiple species. In this webinar, you will learn: • A groundbreaking tissue-clearing technique for precise whole-brain…

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Defining Lineage in Ambiguous Leukemia: A Transcriptomic View Ep 3.7 35:42

2M ago35:42

35:42

Dr. Anikó Sijs-Szabó & Roger Mulet Lázaro, PhD, join Dr. Charles de Bock to unpack the challenges of diagnosing and treating acute leukemias of ambiguous lineage (ALAL). Discover how RNA sequencing, machine learning, and collaboration are shaping the future of precision medicine in hematology. 🎧 Listen and then read the full open-access article on …

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Radiotherapy induced neurocognitive decline 16:05

2M ago16:05

16:05

Description: Dr. Iyad Alnahhas interviews Dr. Charlotte Sleurs about her and her team's recent manuscript entitled: "Radiotherapy-induced neurocognitive decline among adult intracranial tumor patients: A voxel-based approach", published online in Neuro-Oncology in May 2025.By Drs. Iyad Alnahha and Charlotte Sleurs

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Detecting Rare T-Cell Responses at Scale with ELISpot and FluoroSpot 1:04:09

2M ago1:04:09

1:04:09

Detecting rare antigen-specific T-cell responses requires assays that are both sensitive and scalable. Traditional methods like flow cytometry often struggle with high-throughput needs or with preserving precious sample material. In this episode of Listen In, you’ll discover how ELISpot and FluoroSpot assays overcome these challenges. These cell-ba…

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EHA/EBMT Survey on Grading and Management of ICAHT - Ep 3.7 40:58

3M ago40:58

40:58

Join our host HemaSphere Scientific Editor Dr Charles de Bock as he chats with Dr Kai Rejeski, first author of this 2025 HemaSphere Top Cited –Clinical Award-winning paper. The conversation delves into the complexities of CAR-T therapy, particularly focusing on the associated toxicities and the need for a structured grading system. EHA/EBMT Survey …

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QOL and cognitive functioning in patients with oligodendroglioma 18:22

3M ago18:22

18:22

Dr. Iyad Alnahhas interviews Drs. Florien Boele and Martin Klein about their recent manuscript entitled: "Health-related quality of life and cognitive functioning in survivors of oligodendroglioma: An international cross-sectional investigation", published online in Neuro-Oncology in July 2025.By Drs. Iyad Alnahhas, Florien Boele, Martin Klein

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Post-operative radiation in recurrent grade 1 meningiomas 19:39

3M ago19:39

19:39

Dr. Iyad Alnahhas interviews Drs. Felix Sahm and Maximilian Deng about their recent manuscript entitled: "Postoperative radiotherapy in subtotally-resected recurrent WHO grade 1 meningiomas with intermediate/ high-risk molecular profiles", published online in Neuro-Oncology in May 2025.By Drs. Felix Sahm, Maximilian Deng, Iyad Alnahhas

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Tackling NUP98 Rearranged AML in Pediatric Oncology - Ep 3.5 41:07

4M ago41:07

41:07

Host Dr Charles de Bock speaks with Prof Michel Zwaan and Prof Olaf Heidenreich, co-authors from the 2025 HemaSphere Award - Top Cited: Biology paper, "The MLL-Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML." The conversation delves into the complexities of #AML, particularly focusing on NUP98 rearranged AML and the therap…

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mRNA CAR T against GD2 in high-grade glioma models 29:43

4M ago29:43

29:43

Dr. Maya Graham interviews Dr. Jessica Foster about her and her team's recent manuscript, entitled "Transient mRNA CAR T cells targeting GD2 provide dose-adjusted efficacy against diffuse midline glioma and high-grade glioma models". This work was published online in Neuro-Oncology in May 2025.By Drs Maya Graham, Jessica Foster, Iyad Alnahhas

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From Surplus to Savings: Tackling Unused Lab Products in Life Sciences 30:44

5M ago30:44

30:44

In the life sciences, an astounding amount of unused products and materials end up in landfills instead of contributing to research progress. This issue arises across the product lifecycle, from liquidated biotech start-ups that abandon equipment to over-purchasing and pipeline deprioritization at successful firms. Even well-intentioned suppliers e…

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Part 2 - Metabolism in hematology - Ep 3.4 28:52

5M ago28:52

28:52

In this second part of a 2-part episode, Dr Charles De Bock engages with Prof Dr Petya Apostolova and Dr Jörg Büscher to explore the intricate relationship between metabolism and hematology, particularly focusing on #AML. They discuss the challenges and advancements in metabolomics, the importance of integrating multi-omics approaches, and the futu…

1
Part 1 - Metabolism in hematology - Ep 3.4 29:51

5M ago29:51

29:51

In this 2-part episode of the HemaSphere podcast, host Dr Charles de Bock and guests Dr Jörg Büscher and Prof Dr Petya Apostolova discuss the critical role of metabolism in cellular function, particularly in the context of hematology and cancer research. The discussion highlights the technological advancements in metabolic analysis and their impact…

1
A transcriptomic atlas of CNS tumors 35:22

6M ago35:22

35:22

Dr. Evan Noch interviews Dr. Akshitkumar Mistry about his and his team's recent manuscript entitled "A clinically annotated transcriptomic atlas of nervous system tumors", published online in Neuro-Oncology in May 2025 Link to the paper: https://academic.oup.com/neuro-oncology/advance-article/doi/10.1093/neuonc/noaf130/8151442…

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Automated Hepatocyte Counting: New Technology for Simple, Reliable Counts 30:07

6M ago30:07

30:07

Automated counting of certain cell types is notoriously challenging due to their irregular shapes, variable nuclei number, autofluorescence, and often high amounts of debris in samples. However, with the latest developments in cell-counting hardware and app technology, automated counting of even challenging cells is simpler than ever. In this episo…

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Wenqing Li on transcriptome risk scores to decipher susceptibility genes for risk stratification of gastric cancer 21:18

6M ago21:18

21:18

Dr. Wenqing Li joins Peng Zhang to discuss a recent study integrating genetics and transcriptomics for risk stratification of gastric cancer. The conversation explores the global epidemiology of gastric cancer, its high prevalence and mortality rates, particularly in East Asia and China, and the complex interplay of genetic and environmental risk f…

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Machine learning for AML-MRD - Ep 3.3 29:24

6M ago29:24

29:24

In this episode of the HemaSphere podcast, host Charles de Bock and guest Tim Mocking, PhD, discuss the role of machine learning in the assessment of measurable residual disease (MRD) in acute myeloid leukemia (AML). They explore the challenges of MRD detection, the potential of machine learning to improve accuracy and efficiency, and the importanc…

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Gut microbiome in primary CNS lymphoma 15:04

6M ago15:04

15:04

Dr. Iyad Alnahhas interviews Drs. Isaias Hernandez-Verdin and Agusti Alentorn about their recent manuscript entitled: "Gut microbiome modulates the outcome in primary central nervous system lymphoma patients undergoing chemotherapy: An ancillary study from the BLOCAGE trial", published online in Neuro-Oncology in March 2025 Link: https://academic.o…

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Pioneering Biomarker Discovery In Mucinomics Through Mass Spectrometry 1:02:40

7M ago1:02:40

1:02:40

In this episode of Listen In, we showcase cutting-edge mass spectrometric analysis of mucins, including the characterization of mucinases, enrichment techniques, and complete mucinomic mapping of translationally relevant mucin proteins. Mucins are a diverse family of high molecular weight glycoproteins that play critical roles in protecting and lub…

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Germline analysis of diffuse midline glioma 29:55

7M ago29:55

29:55

Dr. Evan Noch interviews Dr. Marion Mateos about her and her team's recent manuscript entitled: "Germline analysis of an international cohort of pediatric diffuse midline glioma patients", published online in Neuro-Oncology in March 2025.By Drs. Evan Noch, Marion Mateos, Iyad Alnahhas

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2 of 2: Navigating Neutropenia: New Guidelines Explained - Ep 3.2 28:05

7M ago28:05

28:05

In this episode of the HemaSphere podcast, host Dr Charles De Bock discusses the newly published Guidelines on the treatment of neutropenias with co-authors Dr. Francesca Fioredda and Dr. Eleni Papadaki. They explore the importance of these international guidelines, the challenges faced in gathering evidence, and the consensus-building process amon…

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How to Multiplex Any Assay: User Experience of the xMAP INTELLIFLEX® 1:02:16

7M ago1:02:16

1:02:16

In this episode, learn about latest advancements in multiplex assay technology. Hear from real user experience how the advanced xMAP INTELLIFLEX® DR-SE Instrument revolutionizes assay multiplexing, enabling simultaneous rapid data acquisition for multiple sample parameters to expand the depth and breadth of your research. Watch the full presentatio…

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The proteomic landscape of diffuse midline glioma 16:55

7M ago16:55

16:55

Dr. Iyad Alnahhas interviews Drs. Cynthia Hawkins and Arun Vadivel about their recent manuscript entitled: "The proteomic landscape of diffuse midline glioma highlights the therapeutic potential of non-histone protein methyltransferases", published online in Neuro-Oncology in February 2025. More Information…

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Single‐cell DNA and surface protein - Ep 3.1 34:17

8M ago34:17

34:17

In this episode of the HemaSphere podcast, host Charles De Bock engages with HemaSphere Editor in Chief Professor Jan Cools, Professor Heidi Segers, and Doctor Margo Aertgeerts to discuss their recent study on acute lymphoblastic leukemia (ALL). They explore the advancements in treatment, particularly for high-hyperdiploid ALL, the challenges of re…

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Inside Immunoassays: Strategies to Maximize Your Immunoassay Data and Insights 37:24

8M ago37:24

37:24

Immunoassays are pivotal in scientific research, enabling the precise identification and measurement of specific analytes. They pave the way for investigations into disease mechanisms, discovering biomarkers, and evaluating the efficacy of potential therapeutic interventions. The key reagents included in an immunoassay can significantly impact reli…

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Radio-Pathomic maps and MR perfusion 20:25

8M ago20:25

20:25

Dr. Iyad Alnahhas interviews Dr. Peter LaViolette about his and his team's recent manuscript entitled: "Multi-Site Retrospective Analysis of Diffusion and Perfusion MRI Correlates to Glioma Characteristics Derived from Radio-Pathomic Maps", published online in Neuro-Oncology in February 2025.By Drs. Iyad Alnahhas, Peter LaViolette

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SIPs with Standards 21:00

8M ago21:00

21:00

Stable Isotope Probing (SIP) is a powerful technique for studying microbial communities. These experiments can show which microbes are handling specific nutrients, or what they're doing with those nutrients, and even how quickly. But there's a catch: SIP labwork and analysis can be very demanding. The JGI offers SIP analysis to make these experimen…

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Two distinct fetal-type signatures characterize JMML - Ep 2.8 36:59

9M ago36:59

36:59

In this episode of the HemaSphere podcast, host Charles de Bock engages with Professor Hélène Cavé and Dr. Marion Strullu to discuss their recent study on juvenile myelomonocytic leukemia (JMML). They delve into the complexities of diagnosing JMML, the genetic mutations associated with the disease, and the prognostic factors that influence patient …

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AI-Powered 3D Organoid Analysis 1:02:09

9M ago1:02:09

1:02:09

Multicolor 3D fluorescent confocal microscopy presents significant challenges in image acquisition and data analysis. However, AI is making a massive impact on 3D spatial biology. This episode of Listen In explores the incorporation of AIVIA, an AI-powered image analysis software, into workflows to address these challenges in analyzing multicolor f…

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CSF proteomics in glioma 44:15

9M ago44:15

44:15

Description: Dr. Evan Noch interviews Drs. Cecile Riviere-Cazaux and Terry Burns about their recent manuscript entitled: "A field resource for the glioma cerebrospinal fluid proteome: impacts of resection and location on biomarker discovery", published online in Neuro-Oncology in December 2024. Link: https://doi.org/10.1093/neuonc/noae277…

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Vorasidenib in IDH mutant glioma 42:44

10M ago42:44

42:44

Description: Dr. Ankush Bhatia interviews Drs. Macarena de la Fuente and Mehdi Touat about their recent manuscript entitled: "The role of vorasidenib in the treatment of isocitrate dehydrogenase-mutant glioma" published online in Neuro-Oncology in December 2024. Link: https://doi.org/10.1093/neuonc/noae259…

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Alisa Clyne and Callie Weber on the impacts of APOE-ε4 and exercise training on brain microvascular endothelial cell barrier function and metabolism 14:52

10M ago14:52

14:52

Prof Alisa Clyne and Dr Callie Weber from the University of Maryland speak to Dr Gita Thapaliya about an eBioMedicine article examining the impacts of APOE-ε4 and exercise training on brain function and metabolism. Read the full article: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00523-1/fulltext?dgcid=buzzsprout_icw_podcast_…

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High-Throughput and Wide-Range Protein Concentration Determination of Monoclonal Antibodies 27:57

10M ago27:57

27:57

In this episode of Listen In, explore high-throughput and wide-range protein concentration analysis that can deliver a 20-fold improvement in time and budget savings. Protein concentration is an obligatory critical quality attribute necessary to determine total protein content in biopharmaceutical formulations. Concentration determination is necess…

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KL-50 in post TMZ MMR-deficient GBM 21:33

10M ago21:33

21:33

Dr. Iyad Alnahhas interviews Dr. Craig Horbinski about his and his team's recent manuscript entitled "The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma", published online in Neuro-Oncology in December 2024.…

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Measurable disease per FET-PET vs MRI in GBM 14:06

11M ago14:06

14:06

Dr. Iyad Alnahhas interviews Dr. Nathalie Albert about her and her team's recent manuscript entitled: "Measurable disease as baseline criterion for response in glioblastoma: A comparison of PET-based (PET RANO 1.0) and MRI-based (RANO) assessments", published online in Neuro-Oncology in January 2025.…

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Revolutionizing Pediatric Cancer Research with PDXs - Ep 2.7 35:54

11M ago35:54

35:54

In this episode of the HemaSphere podcast, host Dr Charles de Bock discusses the critical role of mouse models in understanding leukemogenesis and hematopoiesis with Prof Richard Lock. They explore the significance of patient-derived xenografts (PDXs) in preclinical testing, the challenges faced in generating PDXs for acute myeloid leukemia (AML), …

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Pre-radiation chemotherapy in GBM 13:42

11M ago13:42

13:42

Dr. Iyad Alnahhas interviews Dr. Danielle Bazer about her and her team's recently published manuscript, entitled: Using a Pre-Radiation Window to Identify Potentially Active Cytotoxic Agents in Adults with Newly Diagnosed Glioblastoma", published online in Neuro-Oncology in November 2024.By Dr. Iyad Alnahhas, Dr. Danielle Bazer

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High 5hmC predicts worse OS - Ep 2.6 25:15

12M ago25:15

25:15

In this episode of the HemaSphere podcast, host Charles de Bock discusses the latest research on myelodysplastic syndrome (MDS) with Dr Francesca Tiso and Dr Florentien in 't Hout from Radboud University Medical Center, co-authors of a recent paper published in HemaSphere. The conversation covers the clinical presentation of MDS, treatment options,…

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cIMPACT-NOW Update 8: grading of meningiomas 43:16

1y ago43:16

43:16

Dr. Rachna Malani interviews Drs. Felix Sahm and Arie Perry about their recent manuscript entitled: "cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas", published online in Neuro-Oncology in August 2024 Read MoreBy Drs. Rachna Malani, Felix Sahm, Arie Perry, Iyad Alnahhas

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Multiplexing Magic: How MULTI-seq Revolutionizes Single-Cell RNA Sequencing 48:51

1y ago48:51

48:51

Learn more about the capabilities of MULTI-seq in single-cell sequencing in this episode of Listen In. Developed by the Gartner Lab at UCSF, this innovative multiplexing method increases sample and cell throughput while minimizing cost and improving your data quality. From modest experiments to expansive 96-plex studies and beyond, MULTI-seq enable…

1
Multi-View Light Sheet Microscopy to Track Cell Lineages in Tissue Morphogenesis 56:51

1y ago56:51

56:51

A major question in developmental biology is understanding how cellular fate decisions are regulated precisely in space and time. Fortunately, we can now begin to observe these processes with modern imaging approaches, which allow the tracking of cell fate decision events and cellular rearrangements by live 3D time-lapse microscopy. This developmen…

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Informed consent is almost impossible - Ep 2.5 39:11

1y ago39:11

39:11

This podcast episode delves into the complexities of informed consent in healthcare, particularly in the context of hematology. The discussion with host Dr Charles de Bock features insights from Dr Stephen Hibbs and Dr Louise Caldwell, authors of the HemaTopics "Informed consent is almost impossible” and guest Mark Dawson, a patient family member, …

1
Residual tumor volume and survival after CCNU/TMZ in GBM 13:18

1y ago13:18

13:18

Dr. Iyad Alnahhas interviews Drs. Thomas Zeyen and Johannes Weller about their recent manuscript entitled: "Quantitative assessment of residual tumor is a strong and independent predictor of survival in methylated glioblastoma following radiochemotherapy with CCNU/TMZ", published online in Neuro-Oncology in October 2024.…

1
Enhancing 3D Spatial Biology with AI: Simplified Insights for All 1:09:11

1y ago1:09:11

1:09:11

In this episode, learn how AI-powered segmentation, spatial analysis, and phenotyping can help you gain new insights for 3D images with complex morphological measurements featuring up to 15 biomarkers. See how to characterize tissue microenvironments and examine the differences between normal and disease tissues without the need to code or train De…

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Accelerate Scientific Progress: The Power of Reproducibility, Collaboration and New Imaging Technologies 1:12:31

1y ago1:12:31

1:12:31

Imaging scientists have a critical educational role in improving rigor and reproducibility by sharing their technical expertise and providing intellectual contributions in all aspects of image-based science. They participate in creating, developing, and disseminating guidelines, resources, and tools to improve image-based research. In this episode,…

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Alterations in RNA splicing between meningioma DNA methylation groups 33:46

1y ago33:46

33:46

Dr. Evan Noch interviews Drs. Nathan Leclair, David Raleigh and Olga Anczukow about their recent manuscript entitled: "RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups", published online in Neuro-Oncology in August 2024.By Drs. Evan Noch, Nathan Leclair, David Raleigh, Olga Anczukow, Iyad Alnahhas

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Boyi Yang on green space and human health 9:08

1y ago9:08

9:08

Dr. Boyi Yang joins Peng Zhang to discuss the credibility of the relationship between green space and human health. Read the full article: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00297-4/fulltext?dgcid=buzzsprout_icw_podcast_generic_ebiom Continue this conversation on social! Follow us today at... https://thelancet.bsky.so…

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Inside Immunoassays: Best Practices for Accurate and Reliable Results 56:26

1y ago56:26

56:26

Immunoassays play an indispensable role in scientific research. They facilitate the detection and quantification of specific analytes, enabling in-depth investigations into disease mechanisms, biomarker discovery, and evaluation of the potential of therapeutic interventions. Sample selection and preparation are of utmost importance, as they have a …

1
Windows On Neurovascular Pathologies 1:03:18

1y ago1:03:18

1:03:18

The brain is an immune-privileged organ, meaning it is protected from the entry of pathogens, blood circulating factors, and immune cells by a physical barrier called the blood-brain barrier (BBB). But pathological events such as ischemia (stroke), trauma (traumatic brain injury), or tumor growth (gliomas and brain metastasis), activate the vascula…