A urology podcast, focussing on prostate cancer, kidney cancer, bladder cancer, testis and penile cancer. Join Professor Declan Murphy and Dr Renu Eapen from Peter MacCallum Cancer Centre in Melbourne for this regular dive into the world of genitourinary (GU) Oncology and Urology. Regular guests from all over the world, from every walk of life. Find out more gucast.org
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Testis Cancer Podcasts
Broadcasting the latest developments in GU cancer Hosted by Brian Rini and Tom Powles Brian Rini MD is a Professor of Cancer Research and Professor of Medicine (Hematology/Oncology), Vanderbilt-Ingram Cancer Center Tom Powles is the Director of Barts Cancer Centre, St Bartholomew's Hospital and Professor of Genitourinary Oncology, Queen Mary University of London
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Episode 438: The History of Testis Cancer Treatment
39:22
39:22
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39:22Christian Kollmannsberger joins us to walk through decades of advances in advanced testis cancer.
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Bye bye gadolinium! PRIME demonstrates bpMRI as good as mpMRI
28:29
28:29
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28:29Big news today with the publication in JAMA of the eagerly anticipated PRIME study, a prospective multicentre trial comparing biparametric (bp) with multiparametric (mp) MRI in men suspected of having prostate cancer. Of course, mpMRI includes contrast enhanced sequences following injection of gadolinium, adding time, cost, plus the burden of gadol…
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Free Live Robotic Surgery Event! 25th September 2025
5:21
5:21
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5:21A quick pod to promote the totally free WRSE12 Live Robotic Surgery Event coming up later this month! A 12 hour festival of incredible robotic surgery performed by top surgeons from around the world, with a special focus on real time digital pathology using the very promising Histolog technology that we recently featured on GU Cast. Live surgeries …
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Renaming Gleason 6 prostate cancer | The campaign continues!!!
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35:29
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35:29One of our most popular podcasts ever was the one called "Gleason 6 prostate cancer | Why we should rename it (and why we can't)!", posted in December 2022, and featuring Urologists Scott Eggener (Chicago) and Matt Cooperberg), plus Pathologist Eva Comperat (Paris/Vienna). In fact, we still get so many hits on this and active comments on our YouTub…
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Episode 437: Uromigos Japan - バルバーサ (Erdafitinib)を実臨床でどう使うか!
44:36
44:36
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44:36Erdafitinibがついに承認されましたが、依然として多くのCQが残されています。日常診療に役立つ最新のデータをもとに、その活用法についてディスカッションしました。
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The Inaugural GU Cast Journal Club! With Carlos Delgado & Elena Berg
35:48
35:48
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35:48Here it is, the first of our new series called GU Cast Journal Club! A dedicated GU Cast Journal Club has been suggested by many of our listeners and viewers over the years, and we are really pleased to kick off today with the first monthly episode. And we are particularly pleased to introduce our GU Cast Journal Club Editors, Dr Carlso Delgado (Me…
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Episode 436: The History of IO in RCC - Part 2
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36:29
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36:29We continue our conversation with Mike Atkins and David McDermott, discussing IO-based combination therapy in RCC.
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Episode 435: The History of IO in RCC - Part 1
27:52
27:52
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27:52The fathers of IO therapy in RCC - Michael Atkins and David McDermott - join us to take a tour through IO development in RCC over the last 20 years.
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Let's talk...penile cancer | With Asif Muneer & Nathan Lawrentschuk
31:57
31:57
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31:57Now this a topic we are ashamed to say we have barely covered in five plus years of GU Cast! A well overdue deep dive into the management of penile cancer, the rarest of all GU cancers, and fair to say the one that gets the least attention, not just from us, but from those who found research/education/novel therapies etc. We are joined in studio by…
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Episode 434: IMPACT series - A Walk Through the History of VEGF TKI Development in RCC
48:51
48:51
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48:51Danny Heng joins to tour through VEGF TKI drug development from sorafenib to tivozanib and everything in between.
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Three hot topics in testis cancer | With Christian Kollmannsberger & Ben Tran
43:24
43:24
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43:24Refresh your knowledge of testis cancer with this punchy pod with testis cancer gurus, Prof Christian Kollmannsberger (Vancouver Cancer Centre, Vancouver), and Prof Ben Tran (Peter MacCallum Cancer Centre, Melbourne). We pick their brains on three topical areas in testis cancer; 1. Adjuvant chemo - balancing early gains vs late effects. How can we …
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Renu was in Taipei recently and caught up with Prof Jacob Pang, Urologist and President of the Urological Association of Asia Annual meeting which takes place in Taipei from 14-17 August 2025. Find out why you should attend in this quick pod! UAA 2025 Congress websiteBy Professor Declan Murphy & Dr Renu Eapen
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Episode 433: Uromigos Japan - 改訂版ASCO mCRPCガイドライン
39:46
39:46
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39:465月に改訂されたASCOのmCRPC薬物療法のガイドラインについて3人でディスカッションしました!!評価はいかに?
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Cardio-oncology and Lions rugby | With Dr Alex Lyon
36:20
36:20
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36:20What do Lions Rugby and Cardio-oncology have in common?? Well tune in to this episode of GU Cast to find out! The incidence of cardiovascular disease is high in our patients with advanced prostate cancer (more than maybe we appreciate), plus fundamental treatments such as androgen deprivation therapy (ADT) and androgen receptor pathway inhibitors (…
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Episode 432: ASCO 2025 Rapid Oral Session RCC/Bladder Recap
27:49
27:49
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27:49Karie Runcie, MD joins us after chairing the ASCO 2025 rapid oral session to discuss the rcc/bladder presentations.
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Another in our series of Themed Podcasts focussing on GU Oncology in China. We are joined by our China Editor, Dr Yao Zhu (Fudan University, Shanghai), and Prof Xuedong Wei (Soochow University, Jiangsu). to find out what the current treatment landscape is for mHSPC in China. Is it ADT/ARPI doublets for all?? Anyone still give chemo? Who gets a PSMA…
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Episode 431: IMPACT series - Axel Bex on Impactful RCC Clinical Trials
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43:59
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43:59Axel Bex joins the show to discuss trials that he thinks have impacted RCC. We also discuss consolidative approaches, neoadjuvant trials and what can impact an academic career.
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UPDATED - The definitive PSMA systematic reviews!
35:22
35:22
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35:22Those two gigantic PSMA review papers in European Urology - Perera et al 2016 and Perera et al 2020 - have been cited more than 2000 times and have been the definitive reference for anyone writing about PSMA PET/CT in the past ten years. And they have just been updated in two new papers just published in European Urology! Previous first author (Mar…
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Episode 430: Structured Exercise Improves DFS/OS after Adjuvant Therapy in Colorectal Cancer - Does This Apply to GU Cancers?
45:46
45:46
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45:46Chris Booth joins the show to discuss his recent NEJM paper that demonstrated significant DFS and OS improvements with a structured exercise program after adjuvant chemo in colorectal cancer. We discuss implications for GU and other malignancies.
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A beachside interview with Michael Hofman to hear all the PSMA theranostic highlights at ASCO this year! Yes we left our suburban studio in Melbourne and wandered down to St Kilda beach to track down Michael for a beer and a chat. Even in mid-Winter we enjoyed sitting out in a beachside shack at the Beachcomber Cafe and Beach Bar. Michael shot some…
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ASCO2025の注目演題を取り上げ解説、ディスカッションしました!
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Beyond Neurosafe | Histolog intra-op margin assessment
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32:47
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32:47What is Histolog?? Well, now that intra operative margin assessment is a such a hot topic in prostate cancer surgery after the Neurosafe RCT read-out, we thought we would dive into one of the other new technologies for doing something similar, but without the pragmatic challenges of frozen section. The idea is to assess the surgical margin of the p…
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Joe Biden, Koalas, Red wine and EMR Delinquency | With Ketan Badani
30:49
30:49
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30:49A wonderful meandering chat with Ketan Badani (Urologist, Mt Sinai, NYC)! We took him for a wine tour in the Yarra Valley, stopping for a pod chat at Rochford Winery about screening for prostate cancer in older men, plus a great tour around Healesviile Sanctuary to introduce Ketan to some Australian wildlife. Then back in Melbourne we had another c…
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Advanced kidney cancer for Dummies! With Danny Heng & Lewis Au
46:12
46:12
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46:12A Masterclass in advanced kidney cancer today with the great Danny Heng (University of Calgary, Canada), and our own Lewis Au (Peter MacCallum Cancer Centre, Melbourne). Both popped into the GU Cast studio while Danny was in Australia doing some lectures and visiitng us at Peter Mac. We challenged Danny and Lewis to simplify three hot topics in kid…
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En-COMPASSing collaborative research | With Veeru Kasi & team
21:25
21:25
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21:25Meet the young new faces of collaborative urological research!! GU Cast host Declan Murphy discusses the latest in international collaborative trials with A/Prof Veeru Kasivisvanathan, Dr Alexander Ng, and highly ambitious medical students, Miss Aishwarya Shah and Mr Alexander Dudko. They discuss their latest research from the COMPASS group includi…
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Brian, Tom and Silke discuss their highlights form ASCO 2025
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Episode 427: Emerging Data in Non-muscle Invasive Bladder Cancer (NMIBC)
40:27
40:27
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40:27Josh Meeks joins us to give stellar overview of the emerging data in this space. We also discuss the recent ODAC ruling for lower risk patients.
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The ABC of mHSPC | With Fred Saad & Andrew Weickhardt
37:43
37:43
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37:43When Fred Saad (Urologist, University of Montreal, Montreal) and Andrew Weickhardt (Medical Oncologist, Austin Health, Melbourne) popped into our studio recently we decided to pick their brains on a few hot topics in mHSPC - we called it the ABC of mHSPC! Fred was in Melbourne to visit Peter Mac and do some educational talks and we loved welcoming …
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Episode 426 - ASCO 2025: AMPLITUDE Phase 3 of PARPi in mHSPC
37:22
37:22
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37:22Gert Attard joins us to discuss this practice-changing data and the highlight of ASCO 2025
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What's new in this year's EAU Prostate Cancer Guideline Update?
43:50
43:50
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43:50A big welcome back to EAU Guideline gurus, Dr Derya Tilki (Martini-Klinik, Hamburg, Germany), and Dr Gianluca Giannarini (Santa Maria della Misericordia University Hospital, Udine, Italy), for an overview of the major headlines from this year's EAU Guideline update. Derya is Deputy Chair of the EAU Prostate Cancer Guideline Committee and has picked…
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Episode 425: ASCO 2025 - AI-enabled selection of patients for benefit of ADT + ARPI
19:39
19:39
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19:39Nick James discusses intriguing data from STAMPEDE to us AI to analyze pathology slides to predict benefit from ADT + abiraterone
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Episode 424: ASCO 2025 - Emergency podcast on the prostate rapid oral session
30:10
30:10
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30:10Jorge Garcia joins us to discuss the process of selecting abstracts for oral presentation and select highlights from this session.
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Episode 423: ASCO 2025 - Casdatifan plus Cabo in refractory RCC
30:49
30:49
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30:49Toni Choueiri discusses this combination cohort of HIF inhibition plus VEGF-R inhibition.
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Episode 422: ACSO 2025 - ctDNA data from NIAGARA
32:40
32:40
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32:40Matt Galsky discusses the ASCO 2025 data regarding ctDNA from the NIAGARA neoadjuvant chemo +/- durvalumab study.
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Episode 421: ASCO 2025 - Maintenance Avelumab +/- SG in Advanced Bladder Cancer
34:49
34:49
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34:49Jeannie Hoffman-Censits discusses her randomized phase 2 adding SG to maintenence avelumab in mUC.
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Episode 420: ASCO 2025 - CheckMate 901: Ipi/Nivo vs chemo for Cis-ineligible metastatic urothelial cancer
24:18
24:18
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24:18Michiel Van Der Heijden joins us to discuss the Ipi/Nivo vs chemo randomization in this trial from his ASCO 2025 presentation
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Episode 419: ASCO 2025 - Correlate data from the IMmotion 010 RCC adjuvant study
23:49
23:49
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23:49Monty Pal discusses more correlates from this trial including matched baseline and progression tissue samples.
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Episode 418: ASCO 2025 - Biomarkers in RCC
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44:55
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44:55David McDermott joins us on the heels of his outstanding discussion of the clinical science symposium on RCC biomarkers.
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Unravelling PSMA Biology | ProsTIC/PCF Global Webinar
1:27:32
1:27:32
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1:27:32For serious PSMA theranostics enthusiasts!!! We bring you the ninth of our collaborative PSMA webinars over the past five years, in collaboration with our team at ProsTIC and at the Prostate Cancer Foundation in the US. A truly outstanding faculty presenting today including Misha Beltran, Marty Pomper, Ed Kwan and Louise Emmett. Co-hosted by Declan…
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Episode 417: ASCO25 GUの注目演題について3人でDiscussion!!
34:29
34:29
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34:29Practice Changing? 独断と偏見で選んだ注目演題について結果の予想も含めて議論しました。
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Silke, Tom and Brian discuss what they are looking forward to at ASCO 2025
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In the OR with the da Vinci SP Single Port robot at London Bridge Hospital
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30:36What is the da Vinci Single Port (SP) robot and is it any good? Is it easy to transition from the multiport robot to a single port robot? What about Retzius-sparing prostatectomy using the SP robot? GU Cast hosts Declan Murphy and Renu Eapen learn the answers to these questions and more when we visit top prostate cancer surgeons Dr Declan Cahill an…
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日本と海外の違いはあるのか?mHSPCとmCRPCのUromigos Scoreについて激論!!
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Episode 414: Uromigos score en cáncer de próstata metastasico - más allá de las guías clínicas
28:23
28:23
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28:23Edición especial en castellano con Alfonso Gómez de Liaño y Guillermo de Velasco. David Lorente da su visión sobre el nuevo Uromigos Score, que clasifica distintas opciones de tratamiento en varios escenarios de cáncer de próstata metastásico
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Episode 413: The Uromigos Score for Advanced Prostate Cancer
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37:02
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37:02Silke and Chris joins us to discuss our latest 'Uromigos Score' in which experts score the value of treatments for advanced prostate cancer. Several interesting themes emerge.
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China reaction to EAU Prostate Cancer Guideline Update
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41:52Like very many countries around the world our friends in China are big fans of the EAU Guidelines, and are always tuned in when the updated Prostate Cancer Guidelines is released every year. So as part of our China Themed Episode Series, supported by our Gold Partners Bayer China, we are discussing some key updates to this year's Guideline with our…
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Episode 410: AUA 2025 - BOND-003 Cohort C: Cretostimogene in BCG-Unresponsive NMIBC
28:52
28:52
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28:52Mark Tyson from Mayo Clinic joins the podcast to discuss this replicating adenovirus and a high CR rate in BCG-unresponsive NMIBC
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Episode 412: AUA 2025 - TAR-200 Monotherapy in BCG-Unresponsive NMUIBC from SunRISe-1
37:20
37:20
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37:20Joe Jacob joins the show to discuss the longer-term follow up of this cohort from SunRISe-1. We discuss definitions of CR and regulatory issues around drug approval in this space as well.
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Episode 411: Live from EIKCS in Amsterdam - RCC Highlights
20:26
20:26
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20:26Viktor Grunwald joins to discuss the new data session from EIKCS
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A bit of a break from the usual GU Oncology routine today folks! Declan was back at Guy's Hospital recently doing a talk and heard a remarkable story told by one of the Urology Fellows, Dr Joachim Jimie. A quite spectacular mid-air crisis, and some great life lessons in there also. Declan could not resist the opportunity to grab Jimie and tell the …
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