Best Synthego Podcasts (2025)

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Agilent v Synthego (Fed. Cir., June 11, 2025) 2023-2186 18:50

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11d ago18:50

18:50

This Federal Circuit opinion concerns an appeal from Agilent Technologies, Inc. against Synthego Corp., concerning the patentability of gene-editing technology related to CRISPR-Cas systems. Agilent appealed decisions by the Patent Trial and Appeal Board, which found all claims of Agilent's U.S. Patent Nos. 10,337,001 and 10,900,034 unpatentable du…

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OPTIS v. Apple (Fed. Cir., June 16, 2025) 2022-1904 11:53

8d ago11:53

11:53

This opinion concerns an appeal in the case of Optis Cellular Technology, LLC v. Apple Inc., heard by the United States Court of Appeals for the Federal Circuit. The core of the dispute involves Optis's claims that Apple infringed on five of its standard-essential patents (SEPs) related to LTE technology, used in iPhones, iPads, and Watches. The co…

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Ancora v. Roku (Fed. Cir., June 16, 2025) 2023-1674 16:40

9d ago16:40

16:40

This opinion from the United States Court of Appeals for the Federal Circuit details an appeal involving Ancora Technologies, Inc. against Roku, Inc., VIZIO, Inc., and Nintendo Co., Ltd. The core of the dispute revolves around the patentability of Ancora's U.S. Patent No. 6,411,941, which concerns software for restricting unauthorized use of licens…

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USAA v. PNC Bank (Fed. Cir., June 12, 2025) 2023-1639 11:37

12d ago11:37

11:37

This is a Federal Circuit opinion regarding a patent dispute between United Services Automobile Association (USAA) and PNC Bank N.A., heard by the United States Court of Appeals for the Federal Circuit. The core of the appeal concerns the patent eligibility of USAA's "Digital Camera Processing System" patent, specifically U.S. Patent No. 10,769,598…

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Fraunhofer-Gesellschaft v. Sirius XM Radio (Fed. Cir., June 9, 2025) 2023-2267 13:11

13d ago13:11

13:11

This is an opinion from the United States Court of Appeals for the Federal Circuit concerning a patent infringement case between Fraunhofer-Gesellschaft and Sirius XM Radio Inc. The core issue revolves around equitable estoppel, a legal defense where a party is prevented from asserting a claim due to their misleading conduct and another party's det…

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Dolby Laboratories Licensing v. Unified Patents (Fed. Cir., June 5, 2025) 2023-2110 13:39

14d ago13:39

13:39

This Federal Circuit opinion relates to an appeal from Dolby Laboratories Licensing Corporation (Dolby) against Unified Patents, LLC (Unified) regarding a patent dispute. The core issue revolves around Dolby's lack of standing to appeal the Patent Trial and Appeal Board's (Board) decision, as determined by the U.S. Court of Appeals for the Federal …

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Alnylam v. Moderna, (Fed. Cir., June 4, 2025) 2023-2357 15:44

15d ago15:44

15:44

This Federal Circuit opinion concerns an appeal by Alnylam Pharmaceuticals, Inc., against Moderna, Inc., regarding a patent infringement lawsuit concerning Moderna’s COVID-19 vaccine, SPIKEVAX®. The core of the dispute revolves around the interpretation of the patent term “branched alkyl” within Alnylam's U.S. Patent Nos. 11,246,933 and 11,382,979,…

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Sigray v. Carl Zeiss: Patent Anticipation and Obviousness (Fed. Cir., May 23, 2025) 2023-2211 9:56

23d ago9:56

9:56

This is an opinion from the United States Court of Appeals for the Federal Circuit regarding a patent dispute between Sigray, Inc. and Carl Zeiss X-Ray Microscopy, Inc. The case involves U.S. Patent No. 7,400,704, owned by Zeiss, which covers X-ray imaging systems with projection magnification. Sigray challenged the patent's validity through an int…

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Rebecca Curtin v. United Trademark Holdings (Fed. Cir., May 22, 2025) 2023-2140 7:37

28d ago7:37

7:37

This is an opinion from the Federal Circuit addressing whether a consumer, Rebecca Curtin, had the legal right, or statutory standing, to oppose a trademark registration for "RAPUNZEL" covering dolls and toy figures. The case explores the requirements for bringing an opposition under 15 U.S.C. § 1063 of the Lanham Act, particularly focusing on whet…

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In re Foster (Fed. Cir., May 7, 2025) 2023-1527 7:45

1M ago7:45

7:45

This podcast is for entertainment purposes only and does not create an attorney-client relationship. The AI-generated hosts are not attorneys and are not providing legal advice. The choice of a lawyer is an important decision and should not be based solely upon advertisements.By Randy Noranbrock

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Regents of the University of California v. Broad Institute (Fed. Cir., May 12, 2025) 2022-1594 10:08

1M ago10:08

10:08

This is an opinion from the United States Court of Appeals for the Federal Circuit regarding a patent interference proceeding between The Regents of the University of California and The Broad Institute. The core dispute involves priority of invention for a CRISPR-Cas9 system using single-guide RNA for editing DNA in eukaryotic cells. The court revi…

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Ingenico v. IOENGINE (Fed. Cir., May 7, 2025) 2023-1367 11:40

1M ago11:40

11:40

This is a decision on an appeal before the United States Court of Appeals for the Federal Circuit in the case of Ingenico Inc. v. IOENGINE, LLC. The core issue is IOENGINE's appeal of a jury verdict and subsequent court decisions which found certain patent claims invalid due to prior art, specifically a device known as the DiskOnKey System, includi…

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In re Kostic (Fed. Cir., May 6, 2025) 2023-1437 7:54

2M ago7:54

7:54

This episode is about an opinion from the United States Court of Appeals for the Federal Circuit in the case of IN RE: MIODRAG KOSTIC, GUY VANDEVELDE, concerning their appeal from a United States Patent and Trademark Office decision. The case centers on a reissue application for U.S. Patent No. 8,494,950, titled "System for Conducting an Exchange o…

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Fintiv v. PayPal (Fed. Cir., April 30, 2025) 2023-2312 9:45

2M ago9:45

9:45

This is an opinion by the United States Court of Appeals for the Federal Circuit concerning a patent infringement lawsuit between Fintiv, Inc. and PayPal Holdings, Inc. Fintiv sued PayPal, asserting infringement of four patents related to a "cloud-based transaction system". The core issue on appeal is the district court's ruling that certain claim …

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PT Medisafe Technologies v. USPTO (Fed. Cir., April 29, 2025) 2023-1573 8:17

2M ago8:17

8:17

This is an opinion from the United States Court of Appeals for the Federal Circuit regarding PT Medisafe Technologies' attempt to register a dark green color for medical examination gloves as a trademark. The court affirmed the decision of the Trademark Trial and Appeal Board, which had denied registration because the proposed color mark was found …

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Qualcomm v. Apple (Fed. Cir., April 23, 2025) 2023-1208 9:40

2M ago9:40

9:40

This is an opinion from the United States Court of Appeals for the Federal Circuit concerning an appeal involving Qualcomm Incorporated and Apple Inc., with the United States Patent and Trademark Office as an intervenor. The core issue revolves around Apple's challenge to a Qualcomm patent (U.S. Patent No. 8,063,674) in an inter partes review (IPR)…

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Recentive Analytics v. Fox Corp. (Fed. Cir., April 18, 2025) 2023-2437 8:27

2M ago8:27

8:27

This episode is about a United States Court of Appeals for the Federal Circuit opinion regarding a patent dispute between Recentive Analytics, Inc. and Fox Corp. The core issue on appeal is the patent eligibility of Recentive's patents, which relate to using machine learning for generating television broadcast schedules and network maps. The distri…

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Sage Products, LLC v. Stewart (Fed. Cir., April 15, 2025) 2023-1603 9:26

2M ago9:26

9:26

This episode is about an opinion from the United States Court of Appeals for the Federal Circuit regarding a patent dispute between Sage Products, LLC and the Acting Under Secretary of Commerce for Intellectual Property. Sage appealed the Patent Trial and Appeal Board's decision that certain claims in two of its patents were unpatentable based on p…

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In re Forest (Fed. Cir., April 3, 2025) 2023-1178 9:59

3M ago9:59

9:59

This is a decision from the United States Court of Appeals for the Federal Circuit regarding an appeal by Donald K. Forest. The central issue is whether the Patent Office can grant a patent, specifically U.S. Patent Application No. 15/391,116, after its potential twenty-year term has already expired. The court ultimately dismisses Forest's appeal, …

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In re Riggs (Fed. Cir., March 24, 2025) 2022-1945 9:23

3M ago9:23

9:23

This episode is about an opinion from the United States Court of Appeals for the Federal Circuit addresses a dispute concerning a patent application for an integrated logistics system. The core issue revolves around whether a prior published patent application, referred to as Lettich, can be considered prior art against the current application. The…

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Maquet Cardiovascular v. Abiomed (Fed. Cir., Mar 21, 2025) 2023-2045 13:11

3M ago13:11

13:11

This Federal Circuit opinion details an appeal by Maquet Cardiovascular against a district court's judgment that Abiomed did not infringe Maquet's U.S. Patent No. 10,238,783, which concerns intravascular blood pump systems. The appeal specifically challenges the lower court's interpretation of certain terms within the patent claims, arguing that th…

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Imran House and Junyun Lai Discuss CRISPR Screening in Immuno-Oncology 26:06

1+ y ago26:06

26:06

Imran House, Ph.D. and Junyun Lai Ph.D. are Senior Scientists at the biotech start-up, oNKo-Innate in Melbourne, Australia that focuses on developing immuno-oncology therapies. In this episode, they discussed what they do at oNKo-innate, their career transitions from leaving academics to entering the biotech industry, and how CRISPR is impacting ca…

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Mark DeWitt and Don Kohn Discuss Their ex vivo CRISPR-based Therapy to Cure Sickle Cell Anemia 33:24

1+ y ago33:24

33:24

Dr. Mark DeWitt Ph.D., Associate Director at Mammoth Biosciences, and Dr. Don Kohn M.D., distinguished professor and Director of the UCLA Human Gene and Cell Therapy Program and CIRM grantee sat down with us to discuss their latest clinical trials to cure sickle cell anemia, how synthetic guides accelerated their journey from the bench to the clini…

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Dina Simkin Breaks Down Epilepsy Cell Modeling 27:24

2y ago27:24

27:24

Dina Simkin, Professor of Neurology at Northwestern University, joins us in this episode of CRISPR Cuts. Dr. Simkin talks about her path to becoming a researcher, art, and the importance of patient and isogenic iPSC models to study genetically linked forms of epilepsies.By Synthego

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Sunil Sharma and Raffaella Soldi Talk CRISPR For Unbiased Drug Screening for Rare Pediatric Cancers 24:43

2y ago24:43

24:43

Dr. Sunil Sharma and Dr. Raffaella Soldi of the Translational Genomics Research Institute chat about using CRISPR arrayed screens to identify novel drug targets for Ewing's Sarcoma, outlooks for the future of cancer therapies, and the Arizona heat.By Synthego

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Stephanie Cherqui Discusses Clinical Development of CRISPR Therapies for Rare Diseases 20:27

2+ y ago20:27

20:27

Professor Stephanie Cherqui, UCSD, has worked on the development of cell therapies for two rare genetic diseases, cystinosis and Friedreich’s ataxia. In this interview, Dr. Cherqui chats about her experience working on rare diseases, developing a CRISPR-edited therapy for Friedreich's ataxia, navigating regulatory challenges in cell and gene therap…

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Christian Groendahl On Pioneering a CRISPR-based Microbial Gene Therapy 29:11

2+ y ago29:11

29:11

Tune in to hear Christian Groendahl, CEO of SNIPR Biome, talk about CRISPR editing in prokaryotes, their novel E. coli-targeting CRISPR therapy trials, and his experiences and vision leading a start up.By Synthego

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Bryan Dechairo Envisions an Accessible Future for CRISPR Diagnostics 35:29

3y ago35:29

35:29

In this episode, Bryan Dechairo, CEO of Sherlock Biosciences, talks about the impact of technology advances in the field of CRISPR diagnostics, his experiences leading Sherlock Biosciences, and his team’s mission of accessibility.By Synthego

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Ayal Hendel Talks About CRISPR in Bubble Boy Disease 35:46

3y ago35:46

35:46

Dr. Ayal Hendel, a genome-editing pioneer and group leader at Bar Ilan University in Israel, was one of the first researchers to use modified synthetic sgRNA to edit primary cells with CRISPR. In this episode, Dr. Hendel shares his perspectives on the recent CRISPR advancements and his work on the bubble boy disease.…

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Jimi Olaghere Opens up About His Sickle Cell Disease and CRISPR Trial 39:59

3y ago39:59

39:59

Jimi has dealt with sickle cell disease, a genetic disorder with serious implications, his entire life. Undergoing a CRISPR gene editing trial turned his hope for a cure into reality with promising results from the early phases. Tune in to learn about Jimi's journey in this episode.By Synthego

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TJ Cradick Speaks About Their HIV CRISPR Therapy in Trials 23:40

3y ago23:40

23:40

TJ Cradick, Chief Scientific Officer at Excision Bio, discusses their CRISPR HIV therapy that recently proceeded into clinical trials in this episode and their ongoing work on other viral diseases.By Synthego

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Bryce Olson Relays His Experience on Personalized Therapies for Cancer Patients 42:37

3+ y ago42:37

42:37

After being diagnosed with aggressive prostate cancer, Bryce Olson quickly learned the science behind it and has leveraged NGS to understand his tumor genomics and find opportunities in personalized therapies. Hear the patient perspective for the first time on our podcast through Bryce's narration of his experience and pursuit of next generation ce…

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Neville Sanjana Discusses Ways to Enhance CRISPR-Cas13 Knockdown in Human Cells 32:52

3+ y ago32:52

32:52

In this collaboration episode with NEB, we interview Dr. Neville Sanjana, a core faculty member at the New York Genome Center, about his recent publication in which chemically modified guide RNAs were used to enhance CRISPR-Cas13 knockdown in human cells.By Synthego

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Kiana Aran Chats About her Nature Award and New Non-Profit 41:09

3+ y ago41:09

41:09

In this episode, we chat with Dr. Kiana Aran, the CSO of Cardea Bio and associate professor at Keck Graduate Institute, who recently won the Nature Research Award for Inspiring Women in Science. Dr. Aran talks about her experience being a nominee and award winner, her early days and scientific journey, and the launch of her new non-profit, Aran Neb…

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6 Women CRISPR Leaders Get Candid About Their Journeys to the Top 1:02:44

3+ y ago1:02:44

1:02:44

We chatted with six female leaders in the CRISPR—Alison van Eenennaam, Ph.D., Kiana Aran, Christina Trojel-Hansen, Ph.D., Laura Lambert, Ph.D., Elena Miñones Moyano, Ph.D., and Samantha Maragh, Ph.D.— about their professional journeys. Tune in to this episode for a candid and honest discussion on a broad range of topics, including their experiences…

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Jesse Boehm Discusses Tackling Rare Cancers Using CRISPR 30:35

4y ago30:35

30:35

In this CRISPR Cuts episode, Dr. Jesse Boehm, the Chief Scientific Officer of the Break Through Cancer Foundation and principal investigator at the Broad Institute, talks about his work on rare cancers. He also covers how CRISPR technology is transforming cancer research.By Synthego

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NIH Scientists Discuss the iNDI Project for Alzheimer's Disease Modeling 37:14

4y ago37:14

37:14

The Inducible Pluripotent Stem Cell Neurodegeneration Initiative (iNDI), an NIH effort, aims to standardize disease models for Alzheimer’s and related dementias. Hear the principal contributors, Dr. Michael E. Ward and Dr. Mark R. Cookson, scientists at the NIH, talk about the inception of the iNDI project, the challenges and opportunities, and the…

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Joe Miano Talks About Prime Editing in Mice 19:41

4y ago19:41

19:41

Prime editing is a new genome engineering tool that emerged just a couple of years back. Right from the get-go, this technology made waves as a potential alternative to CRISPR. Now, the first comparative study in mice is out. Dr. Joe Miano, Professor at the Augusta University in Georgia, talks about their collaborative work comparing traditional CR…

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IGI Researchers Are Using CRISPR to Reduce Cyanide in Cassava 26:30

4y ago26:30

26:30

Did you know cassava can cause cyanide poisoning if it is not processed correctly and consumed with a protein-poor diet? In this episode, we chat with IGI researchers, Jess Lyons and Michael Gomez about their work on using CRISPR to reduce cyanide in cassava and improve its food safety.By Synthego

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Kevin Davies Chats About His Latest Book "Editing Humanity" 32:13

4y ago32:13

32:13

Kevin Davies, the executive editor of The CRISPR Journal, has closely watched the genetics space evolve over the last decades. His expertise and experience were the perfect foundation for his latest book "Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing." In this episode, Kevin discusses his motivation for the book, along w…

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Michael Friend Advocates For Diversity in CRISPR 18:52

4+ y ago18:52

18:52

In this episode, Michael Friend, CEO of Minority Coalition for Precision Medicine, discusses the lack of diversity in genome editing field and covers potential solutions for ensuring an inclusive future, particularly for black scientists.By Synthego

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CRISPR Forecast 2021 with Paul Dabrowski and Robert Deans 17:49

4+ y ago17:49

17:49

In this episode, Paul Dabrowski, CEO of Synthego, and Robert Deans, CSO of Synthego, discuss the CRISPR silver linings of 2020 and predict the directions and milestones for gene editing in 2021.By Synthego

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CRISPR Office Hours with Hamid Ghanadaan 35:58

5y ago35:58

35:58

The COVID-19 pandemic is a unique situation for lab scientists, many of whose work has come to a standstill. Hamid Ghanadaan, CEO of Linus, discusses the impact of COVID-19 on science and the next steps for scientists, based on their survey of >1000 scientists.By Synthego

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Ryan Pawell Talks About Indee Labs’ CRISPR Delivery Technology for Affordable Immunotherapies 12:59

5y ago12:59

12:59

The mission of Indee Labs, a Berkeley biotech, is to deliver CRISPR reagents into cells using microfluidics for developing affordable cell and gene therapies in the future. We interviewed Ryan Pawell, Founder and CEO of Indee Labs, about the concept of using microfluidics for CRISPR delivery, their mission and ongoing projects, and the convergence …

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Making of a CRISPR Film: Behind the Scenes with Producers of Human Nature 37:33

5y ago37:33

37:33

What is the process to make a science film? In this episode, Sarah Goodwin and Elliot Kirschner, producers of Human Nature, a documentary on CRISPR, offer glimpses into making of the film.By Synthego

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Leading St. Jude's Genome Engineering Capabilities: A Chat with Shondra Miller 10:13

5+ y ago10:13

10:13

Shondra Miller shares her experience of starting a shared genome engineering resource at the St. Jude Children's Research Hospital. Learn more about her research projects and her views on the past, present, and future of the genome editing field in this podcast episode.By Synthego

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The Potential of CRISPR Editing in Stem Cells: An Interview with Bill Skarnes 13:06

5+ y ago13:06

13:06

Dr. Bill Skarnes, Professor at The Jackson Laboratory, chats about how CRISPR edited stem cells are becoming a gold standard to study gene function and disease modeling.By Synthego

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CRISPR in Fungi: An Interview with Rebecca Shapiro 18:07

6y ago18:07

18:07

Rebecca Shapiro, Assistant Professor at the University of Guelph, talks about CRISPR genome editing in fungal pathogens to understand their disease-causing mechanism. Her lab also works on gene drives in fungi for studying large scale genetic interactions and developing ways for treating fungal biofilms.…

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Paul Dabrowski Gets Candid About the Past, Present, and Future of Synthego 22:15

6y ago22:15

22:15

In this interview, Paul Dabrowski, CEO of Synthego, talks about how Synthego got started, his mantra behind leading the company, and future directions. He also offers insights into Synthego’s unique capabilities⁠—the powerful combination of engineering and biology that enable scaling.By Synthego

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Dana Foss is Solving the CRISPR Delivery Problem to Advance Therapeutics 16:15

6y ago16:15

16:15

CRISPR has great potential in therapeutics, but CRISPR delivery in vivo remains a challenge. Researcher Dana Foss discusses her lab’s novel approach for specific delivery of CRISPR components in cells and tissues.By Synthego