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a16z Podcast

Andreessen Horowitz

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The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
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Catch up on the biggest stories of the day from Washington with interviews and analysis from leading journalists. Posted weekdays at 6:30 pm ET. From C-SPAN, the network that brings you the "Q&A" podcast.
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The SIREN Podcast

Social Interventions Research and Evaluation Network

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Welcome to the official podcast channel of the Social Interventions Research and Evaluation Network (SIREN) at the University of California, San Francisco.
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Announcing our new show, Monitoring the Situation, hosted by a16z General Partners Erik Torenberg and Katherine Boyle, with guest Eddie Lazzarin, CTO of a16z crypto. In this first episode, we ask how American Dynamism, consumer, games, and crypto all fit together, from Palmer/Oculus to Marc Andreessen’s Techno-Optimist Manifesto, while also explori…
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In this weekend's episode, three segments from this past week's Washington Journal. First, a discussion with former Democratic Congressmen Tim Roemer – and Republican Congressman Charles Boustany from the non-profit group Issue One -- on efforts to reduce political polarization in the U.S. Then, Former FCC Chair Tom Wheeler discusses the Jimmy Kimm…
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While Congress is out of session, and President Donald Trump spent the day in New York at the Ryder Cup golf tournament, Washington Today look at some of the major stories this past week, including: *Former FBI Director James Comey is indicted for lying to Congress. President Trump says it is justice and not revenge against a political opponent. *D…
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White House prepares for widespread layoffs of federal workers at government agencies if there is a government shutdown starting October 1st, the new fiscal year. We will hear from the House Democratic leader Hakeem Jeffries, President Donald Trump, and talk with Reuters congressional reporter Bo Erickson (10); President Trump signs a deal tofacili…
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What comes after vibe coding? Maybe vibe researching. OpenAI’s Chief Scientist, Jakub Pachocki, and Chief Research Officer, Mark Chen, join a16z general partners Anjney Midha and Sarah Wang to go deep on GPT-5—how they fused fast replies with long-horizon reasoning, how they measure progress once benchmarks saturate, and why reinforcement learning …
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A gunman kills two detainees at an U.S. Immigration and CustomsEnforcement facility in Dallas in what the FBI Director Kash Patel says lookslike a politically motivated attack. Sen. Ted Cruz (R-TX) says of this, andother recent attacks, "This violence is wrong and needs to stop"; ABClate night talk show host Jimmy Kimmel returns to the airwaves aft…
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Should the US put a price on H-1B visas, or would that block the flow of new talent? Are AI coding agents actually making teams way more productive, or is it just hype? And in the AI platform shift, will the big winners be incumbents or new AI-native startups? Erik Torenberg is joined by Box co-founder and CEO Aaron Levie, a16z board partner Steven…
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President Donald Trump speaks at the opening the 80th session of the United Nations on his “America First” agenda, criticizing the UN for being ineffective at preventing or stopping wars and Europe for his immigration policies; President also meets in New York City with Ukrainian President Volodymyr Zelensky and in a post said Ukraine should be abl…
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Dr. Jay Bhattacharya is one of the country’s top medical experts and a 24-year professor of medicine at Stanford. After being censored and deplatformed during COVID for his role in opposing harsh lockdowns, he was appointed Director of the National Institutes of Health by President Trump in 2025. a16z General Partners Erik Torenberg, Vineeta Agarwa…
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President Donald Trump joins federal health officials to announce that pain reliever acetaminophen, the active ingredient in Tylenol, used by pregnant women, is linked to rising cases of autism, and that the drug Leucovorin is a potential treatment for autism; Disney says late night host Jimmy Kimmel is returning to the air on ABC, less than a week…
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Nvidia’s $5 billion investment in Intel is one of the biggest surprises in semiconductors in years. Two longtime rivals are now teaming up, and the ripple effects could reshape AI, cloud, and the global chip race. To make sense of it all, Erik Torenberg is joined by Dylan Patel, chief analyst at SemiAnalysis, joins Sarah Wang, general partner at a1…
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In this episode of Honestly with Bari Weiss, we share a special conversation featuring a16z general partner Katherine Boyle in the wake of Charlie Kirk’s shocking assassination. Katherine reflects on what courage means in a culture where words and debate are increasingly met with violence. Drawing on faith, history, and her own response to recent t…
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In this weekend's episode, three segments from this past week's Washington Journal. First, a conversation on how Americans are viewing the economy right now with Heather Long - Washington Post columnist and chief economist for Navy Federal Credit Union. Then, we speak with National Constitution Center President & CEO Jeffrey Rosen about the history…
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Senate fails to pass two versions of a government funding extension to avoid a shutdown At the end of the month: a Republican one that the House passed today that funds the government for another 7 weeks, and a Democratic one that does that but also extends Obamacare insurance subsidies; House passes a resolution to honor the life and legacy of Cha…
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President Donald Trump meets with British Prime Minister Keir Starmer on the final day of his state visit to Great Britain. The two announce what they call a "U.K.-U.S. Tech Prosperity Deal" and answer questions at a news conference about the wars in Ukraine & Gaza. We hear from the leaders and talk about the state visit with C-SPAN's Westminster C…
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Federal Reserve announces an interest rate cut of a quarter percentage point, lowering borrowing costs for the first time since December. Newest Fed Governor Stephen Miran, who has taken a leave of absence from his job as chair of the White House Council of Economic Advisers, votes for a bigger cut of 0.5%; U.S. House begins work on the federal gov…
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The web is unhealthy, and AI agents are about to rewrite how we shop. In this episode, a16z General Partner Alex Rampell and Partner Justine Moore explore how AI agents will change commerce and the implications for Google’s business model, affiliate marketing, online shopping, and more. Timecodes: 0:00 Introduction 0:12 The Role of AI Agents in Com…
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FBI Director Kash Patel testifies before the Senate Judiciary Committee about accusations the agency is being politicized, whether all the Epstein files will be released and his handling of the investigation into the shooting death of conservative activist Charlie Kirk; Utah County's Attorney General says the suspect in the Kirk shooting is being c…
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OpenAI’s Codex has already shipped hundreds of thousands of pull requests in its first month. But what is it really, and how will coding agents change the future of software? In this episode, General Partner Anjney Midha goes behind the scenes with one of Codex’s product leads- Alexander Embiricos - to unpack its origin story, why its PR success ra…
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President Donald Trump announces he’s sending the National Guard into Memphis, Tennessee to combat crime; Vice President JD Vance host the late Charlie Kirk's daily radio show; talks continue in Congress to keep the government open and funded past the end of the month. Learn more about your ad choices. Visit megaphone.fm/adchoices…
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Can we make science as fast as software? In this episode, Erik Torenberg talks with Patrick Hsu (cofounder of Arc Institute) and a16z general partner Jorge Conde about Arc’s “virtual cells” moonshot, which uses foundation models to simulate biology and guide experiments. They discuss why research is slow, what an AlphaFold-style moment for cell bio…
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In this weekend's episode, three segments from this past week's Washington Journal. First – we chat with Punchbowl News congressional reporter Max Cohen about the prospects for a potential government shutdown in a few short weeks – and the political and policy obstacles to a potential deal. Then: Vaccine expert Dr. Paul Offit discusses his recent r…
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Gov. Spencer Cox (R-UT) announces the arrest in the shooting death of conservative activist Charlie Kirk of 22-year-old suspect Tyler Robinson of Utah; President Donald Trump says he will send National Guard to Memphis, Tennessee, the next city he is targeting with federal resources to reduce crime; former White House Press Secretary Karine Jean Pi…
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In this conversation from Lenny’s Podcast, Ben Horowitz joins Lenny to discuss the psychological muscle every founder needs, why hesitation can be fatal for CEOs, when it’s time to replace a founder, and how to normalize failure while building confidence. They also explore the Databricks founding story, investing in Adam Neumann after WeWork, wheth…
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FBI releases photos of a person of interest in the shooting death of conservative political activist Charlie Kirk and asks the public for help in identifying him. FBI also gives an update on the evidence recovered sofar, including the suspected firearm used; President Donald Trump announces he will award Charlie Kirk a posthumous Presidential Medal…
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The $13T U.S. mortgage market serves 50M homeowners but still runs on decades-old software. In this episode, a16z GP Angela Strange hosts Tim Mayopoulos (ex-CEO of Fannie Mae and ex-president of Blend), Mike Yu (co-founder and CEO of Vesta), and Andrew Wang (co-founder and CEO of Valon) to unpack why standardization and regulation slow change, and …
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Conservative activist Charlie Kirk is shot and killed at an event at Utah Valley University; Senate Minority Leader Chuck Schumer (D-NY) forces a vote in the Senate on an amendment to release all the files related to the case of convicted sex offender Jeffrey Epstein; NATO Secretary General Mark Rutte says Russia flying drones over Poland "reckless…
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Why do some consumer products explode into networks that reshape the internet, while others fade away? Today on the podcast, a16z general partners Anish Acharya and Chris Dixon take on that question. Anish invests in AI-native consumer products and the next wave of consumer tech. Chris is best known for his work in Web3 and network economies, and h…
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Trump Administration's Make America Health Again (MAHA) Commission releases a report with strategies to fight childhood chronic disease that focuses more on nutrition and lifestyle changes rather than government regulations; White House says President Donald Trump would be willing to bring in a handwriting expert to show that it is not his signatur…
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What happens when AI collides with salesmanship, streaming-era sports, and healthcare? In this episode, Erik Torenberg is joined by Mark Cuban, entrepreneur, Dallas Mavericks co-owner, and founder of Cost Plus Drugs. Topics include fiery group chats and how dissent sharpens thinking, the sales playbook of modern politics, and concrete fixes for U.S…
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News from the Supreme Court today….In a 6-3 decision, it blocked a federal judge’s ruling that restricted federal officers’ ability to conduct immigration stops in the Los Angeles area…. The Court also received… a formal request from the White House to let it hold back 4 billion dollars of congressionally approved foreign aid. The appeal comes afte…
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Who’s speaking up for startups in Washington, D.C.? In this episode, Matt Perault (Head of AI Policy, a16z) and Collin McCune (Head of Government Affairs, a16z) unpack the “Little Tech Agenda” for AI- why AI rules should regulate harmful use, not model development; how to keep open source open; the roles of the federal government vs states in regul…
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Stainless founder Alex Rattray joins a16z partner Jennifer Li to talk about the future of APIs, SDKs, and the rise of MCP (Model Context Protocol). Drawing on his experience at Stripe—where he helped redesign API docs and built code-generation systems—Alex explains why the SDK is the API for most developers, and why high-quality, idiomatic librarie…
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In this weekend's episode, three segments from this past week's Washington Journal. Congress returned to Washington this week – and immediately was consumed by the Epstein files controversy and the looming government funding deadline at the end of the month. We talk with two lawmakers – on opposites sides of the aisle -- about potential Congression…
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Labor Department says the U.S. added just 22,000 jobs in August, lower than expectations, and the unemployment rate goes up to 4.3%. President Donald Trump says the real jobs numbers will be next year, after his policies have a chance to take effect; Sen. Elissa Slotkin (D-MI) talks about her vision of keeping the needs of the U.S. middle class fro…
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Taken from The Oprah Podcast, this special episode brings together Shaka Senghor, a16z cofounder Ben Horowitz, and Oprah Winfrey for a powerful conversation on resilience and transformation. Shaka, a resilience expert, motivational speaker, and bestselling author of Writing My Wrongs, shares his journey from incarceration to redemption along with i…
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Health & Human Services Secretary Robert F. Kennedy, Jr. defends his vaccine policy changes and firing of top officials at the Centers for Disease Control & Prevention, before the Senate Finance Committee. Almost all the committee's Democrats are calling on him to resign. Secretary Kennedy is also asked about studies on the causes of autism, and ab…
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Is non-consensus investing overrated—or the secret to venture returns? a16z General Partner Erik Torenberg is joined by Martín Casado (General Partner, a16z) and Leo Polovets (General Partner, Humba Ventures) to unpack the debate that lit up venture Twitter/X: should founders and VCs chase consensus, or run from it? They explore what “consensus” re…
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Survivors of sexual abuse by the late Jeffrey Epstein tell their emotional, personal stories in a news conference on Capitol Hill with Members of Congress of both parties who have been calling for the release of all the Justice Department files in the investigation of Epstein; President Donald Trump again calling that effort on the Epstein files a …
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Jack Altman sits down with Martin Casado, General Partner at a16z, to unpack the shifting dynamics of venture capital and why media matters more than ever. They cover a16z’s evolution from generalists to specialized platforms, the rise of AI infrastructure, and why today’s fiercest battles are often for talent, not market share. Timecodes: 0:00 Int…
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President Donald Trump says, "we're going in" and "I didn't say when",when asked if he plans to send the National Guard to Chicago to combat crime. Gov. JB Pritzker (D-IL) responds; a federal judge rules President Trump and Defense Secretary Pete Hegseth violated federal law by using the U.S. military to help carry out law enforcement activities in…
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What if the future of media isn’t controlled by algorithms or legacy institutions—but by independent voices building directly with their audiences? In this episode, Erik Torenberg is joined by Chris Best, cofounder and CEO of Substack, along with a16z general partners Katherine Boyle and Andrew Chen. We trace the origin story of Substack and its cu…
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Venture capital has powered companies like Facebook and TikTok—but what if that same urgency fueled America’s defense and industrial base? Katherine Boyle, General Partner at Andreessen Horowitz and cofounder of the firm’s American Dynamism practice, argues this is the biggest business opportunity of our time. In this conversation from The Shawn Ry…
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In this weekend's episode, three segments from this past week's Washington Journal. First, a discussion with Competitive Enterprise Institute's Ryan Young, about the Trump Administration's purchase of a 10% stake in the Intel corporation. Then, Nadia Bilbassy-Charters (bill-bey-zee) of Al Arabiya News Channel and Jacob Magid (MAG-id) of the Times o…
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On the 20th anniversary of Hurricane Katrina devastating Louisiana,Mississippi and other parts of the Gulf Coast, tributes to those lost, pride in the rebuilding and recovery, and thoughts of preparing for future storms; President Donald Trump says he will cut $4.9 billion for foreign aid through a 'pocket rescission', which will not give Congress …
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Health Secretary Robert F. Kennedy, Jr. says the Centers for Disease Control and Prevention Director Susan Monarez was removed from her position because she did not align with President Donald Trump's “Make America Healthy Again” (MAHA) agenda. She is challenging the dismissal and her lawyers say she chose "protecting the public over serving a poli…
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In this interview from the 20VC podcast, Martin Casado (a16z General Partner) joins Harry Stebbings to unpack the state of AI, the rise of coding models, the future of open vs. closed source, and how value is shifting across the stack. Martin offers a candid view of the opportunities and dangers shaping AI and venture capital today. Resources: Find…
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A gunman kills two children and injures 17 other children and adults at a Catholic school in Minneapolis during a mass celebrating the first day of school before killing himself. FBI Director Kash Patel says it is being investigated as an act of domestic terrorism and hate crime against Catholics; Washington, DC Mayor Muriel Bowser says the three w…
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What are real consumers actually doing with AI today? In this episode, a16z consumer investors Olivia Moore and Justine Moore break down the fifth edition of our Consumer AI 100, a biannual ranking of the most used AI-native web and mobile products across the globe. Timecodes: 0:00 Introduction 1:45 New Companies & Trends 3:32 Companionship & Creat…
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Lawyers for Federal Reserve Governor Lisa Cook say she will sue after President Donald Trump said he is firing her after allegation of mortgage fraud. Cook says the president does not have that power; President Trump says he wants anyone who commits a murder in Washington, DC to be given the death penalty. DC Council repealed the death penalty in 1…
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