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Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health ...
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Ever wanted to know how music affects your brain, what quantum mechanics really is, or how black holes work? Do you wonder why you get emotional each time you see a certain movie, or how on earth video games are designed? Then you’ve come to the right place. Each week, Sean Carroll will host conversations with some of the most interesting thinkers in the world. From neuroscientists and engineers to authors and television producers, Sean and his guests talk about the biggest ideas in science, ...
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Join depth psychotherapist and Jungian scholar, John Price, in an exploration of extraordinary stories and phenomena that lurk beneath the surface of normal and everyday life. Listen in as John interviews experts, dilettantes, sinners, and saints to explore their professional and personal perspective on the underlying purpose of the mysteries which lurk within the seemingly mundane nature of day-to-day life. John received his Master’s degree in clinical psychology and his Doctorate degree in ...
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In this episode of The Sacred Speaks, John sits down with Adele Getty—spiritual teacher, author, and cultural bridge—to explore the urgent, timeless wisdom of her book A Sense of the Sacred. Though written nearly 30 years ago, Adele’s work feels more relevant than ever in a world hungry for meaning, ritual, and reconnection with the more-than-human…
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What if I told you that an 18-year-old athlete had a testosterone level of 26 - when it should be near 1,000? In this episode of Extend, I sit down with Layne Kilpatrick, a pharmacist with over 30 years of experience who has been sounding the alarm about environmental toxins for years. We dive into the alarming decline in testosterone levels, how m…
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The world is becoming pixelated. As computers and other digital devices become ubiquitous, human knowledge and communication and information is gradually being converted into, and manipulated as, strings of bits. What does that really mean, and what are the ramifications going forward? Alvy Ray Smith is a computer scientist, co-founder of Pixar, an…
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Did you know that functional practitioners have been using GLP-1 peptides safely for years—long before the Ozempic phenomenon hit mainstream medicine? In this episode of Extend, I talk with Dr. Tracey Stroup, a naturopathic doctor and peptide therapy expert, who reveals how the pharmaceutical industry's approach to semaglutide created unnecessary c…
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What if the symptoms you've been told to "just deal with" during perimenopause could actually be addressed? In this episode of Extend, I sit down with Cynthia Thurlow, a nurse practitioner who left traditional cardiology to focus on women's health and metabolic medicine. We explore why the medical system has failed women during menopause, the criti…
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It is not manifestly obvious that universities should be where most scholarly research is performed. One could imagine systems that separated out the tasks of "teaching students" and "generating new knowledge." But it turns out that combining them yields spectacular synergies, both from letting students experience cutting-edge research and from kee…
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The top 10 grossing drugs only help 1 in 4 to 1 in 25 people who take them. Yet they're still considered "evidence-based" and prescribed to millions. In this episode of Extend, I talk with Dr. Nick Norwitz, who reveals why you can't rely on population averages to fix your individual health problems. We explore why the medical system isn't designed …
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What if everything you've been told about preventing heart disease is only half the story? In this episode of Extend, I sit down with Dr. Joel Kahn, a pioneering preventive cardiologist who's spent decades challenging the traditional approach to cardiovascular medicine. We explore why the 1961 Framingham risk factors represent an incomplete picture…
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Welcome to the August 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the quest…
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Why can't you open that jar anymore? Why does getting up from a chair feel harder than it used to? In this episode of Extend, I sit down with Dr. Amy Shah to explore the strength crisis happening to women in perimenopause. We dive into the simple tests that reveal where you're losing ground—and why most women are shocked by their results. We also s…
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In this unforgettable episode, Dr. John Price sits down with writer, ritualist, and mytho-technologist Sean Manseau, whose work bridges depth psychology, psychedelics, performance, and esoteric theology. Together, they explore Entheogenic Fitness Training (EFT)—a radical spiritual system designed for the metamodern age.EFT combines physical resista…
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What if I told you there's an organ in your body with more cells than the Milky Way has stars—and most doctors barely think about it? In this episode of Extend, I sit down with Dr. Zain Kassam, a gastroenterologist turned microbiome researcher who's pioneering how we understand the trillions of organisms living in and on us. We dive into why your g…
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The search for a foundational theory of quantum mechanics that all physicists can agree on remains active. Over the last century a number of contenders have emerged, including Many-Worlds, pilot-wave theories, and others, but all of them have aspects that many people object to. Jacob Barandes has taken up the challenge, proposing a new formulation …
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Oxidative stress. Toxin overload. Immune dysfunction. These aren't separate problems—they're all symptoms of your body working overtime on one exhausting job. In this episode of Extend, I sit down with Dr. Nayan Patel, a pharmacist who's dedicated his career to understanding glutathione—the molecule your body produces more than any other. We break …
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Low energy, brain fog, and poor recovery aren’t just part of getting older—they’re often signs that your cells are underperforming. And one major reason? They’re starved for oxygen. In this episode of Extend, I talk with Dr. Scott Sherr, a hyperbaric medicine specialist who helps patients and doctors worldwide use oxygen therapy to restore cellular…
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When we think of the capacities that distinguish humans from other species, we generally turn to intelligence and its byproducts, including our technological prowess. But our intelligence is highly connected to our ability to use language, which is in turn closely related to our capacities as social creatures. Philosopher Philip Pettit would encour…
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Fatigue, brain fog, joint pain, blood pressure that won’t budge, these aren’t isolated symptoms. They’re your cells signaling that something’s off. In this episode of Extend, I sit down with Dr. Bill Rawls, a board-certified OB/GYN who now focuses entirely on cellular health. We explore why most chronic illness isn’t about your diagnosis, it’s abou…
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In this episode of The Sacred Speaks, I sit down with Dr. Gregory Shaw—renowned scholar of Neoplatonism and author of Hellenic Tantra and Theurgy and the Soul—to explore a forgotten path of spiritual transformation: theurgy.Together, we investigate:What theurgy actually is—not as abstract philosophy, but as a living practice.How modern culture’s lo…
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Your doctor says your health problems are genetic, so you're destined for the same fate. But what if that's completely wrong? In this episode of Extend, I'm joined by Professor Tim Spector, one of the world's leading microbiome researchers, to reveal the truth: your gut bacteria have more control over your health than your genes do. We explore Tim'…
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Quantum field theory is the basis for our most successful theories of fundamental physics. And yet, there are things we don't understand about it. Some of these puzzles are relatively well-known, while others are less celebrated. David Tong joins us to talk about some of the more interesting and perplexing aspects of quantum field theory. He also d…
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What if the real reason you’re gaining weight, feeling wired, or struggling to nourish your family isn’t about willpower—but the culture you live in? On this episode of Extend, I’m joined by Shawn Stevenson—nutritionist, bestselling author, and host of The Model Health Show—to explore how our food environment, not personal discipline, is fueling th…
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Welcome to the July 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questio…
  continue reading
 
Back pain is one of the most common health issues—but it’s also one of the most misunderstood. In this episode of Extend, I’m joined by Dr. Grant Elliott, a physical therapist and founder of RehabFix, to unpack the real reasons people stay stuck in chronic pain and what it actually takes to recover. We break down why most diagnoses like sciatica or…
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You’re bloated. Tired. Anxious. Maybe even burnt out. You’ve tried the diets, the supplements, the meditation apps… But you’re still not healing. Why? In this episode of Extend, I’m joined by Elissa Goodman, a holistic health expert and cancer survivor, to explore the deep connection between gut health, inflammation, and overall well-being. We dive…
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Our universe started out looking very simple: hot, dense, smooth, rapidly expanding. According to our best current model, it will end up looking simple once again: cold, dark, empty. It's in between -- now, roughly speaking -- that things look complex. I have been working to understand the stages by which complexity comes into existence, thrives, a…
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What if your bloating, fatigue, or fertility struggles aren’t separate issues, but signs of a deeper imbalance no one’s connected yet? In this episode of Extend, I’m joined by Dr. Robin Berzin, founder of Parsley Health, and we dig into how functional medicine uncovers the why behind your symptoms and why conventional care keeps missing it. We talk…
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