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Breakthroughs

Northwestern University Feinberg School of Medicine

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Breakthroughs is a podcast about groundbreaking research and the scientists leading these discoveries at Northwestern University Feinberg School of Medicine. We are driven by our mission to transform the practice of medicine and profoundly impact human health beyond the individual patient. We believe better answers only come from discovery.
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Hidden Forces

Demetri Kofinas

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Get the edge with Hidden Forces where media entrepreneur and financial analyst Demetri Kofinas gives you access to the people and ideas that matter, so you can build financial security and always stay ahead of the curve.
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In the Front Row with Mike Vaccaro is your front row seat to one-on-one conversations with sports figures. Our guests are hall of famers, gold medalists, record holders, trailblazers and more. We share stories from all sports and eras to bring you amazing guests with incredible accounts of the moments that made them the athlete and person they are today.
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On Talking Additive, we sit down with business leaders, innovators, and allies to discuss the impact of adopting 3D printing in their businesses. How does adopting additive manufacturing positively benefit a business today, how is the role of 3D printing evolving within design, manufacturing, education, and our lives, and what will be possible in the future?
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In Episode 441 of Hidden Forces, Demetri Kofinas speaks with Adam Posen, president of the Peterson Institute for International Economics, about the profound transformations underway in the global economy driven by America’s transition away from being the world’s primary insurance provider for international security to its most enterprising racketee…
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Part 1: After discussing CrimeCon 2025, the Ellen Greenberg case, and the upcoming Wildlife CSI, Jill dives into one of the most twisted and convoluted true crime stories ever told! Dave Kroupa, recently single, joins an online dating platform where he meets Liz and then Cari. Not seeking a serious relationship, he finds amazing chemistry with Cari…
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Rowdy Gaines splashed into life in Florida, but it wasn’t until his teenage years that he dove into competitive swimming. With a thirst for knowledge, he devoured books on the sport and quickly rose through the ranks. His talent caught the eye of Auburn, where he became a 5-time NCAA Champion and snagged the title of 1981 SEC Athlete of the Year. A…
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In Episode 440 of Hidden Forces, Demetri Kofinas speaks with Paul Kingsnorth, a novelist, essayist, and former environmental activist who first came on many people’s radars during the Covid-19 pandemic with the publication of his viral three-part series “The Vaccine Moment.” His current work explores the intersection of technology, culture, and the…
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In a lively conversation, Jill discussed the new true crime book by the hosts of the Murder Sheet podcast, Áine Cain and Kevin Greenlee, titled Shadow of the Bridge: The Delphi Murders and the Dark Side of the American Heartland. Áine Cain, the investigative journalist, and Kevin Greenlee, the renowned attorney, explore the tragic Delphi 2017 murde…
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In Episode 439 of Hidden Forces, Demetri Kofinas speaks with Douglas Rushkoff, a pioneering media theorist, best-selling author, and leading voice on how digital technologies shape societies, economies, and cultures. Rushkoff and Kofinas spend the first hour of their conversation tracing the arc of Douglas’ career, from his upbringing in a communal…
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Retired law enforcement supervisor and accomplished author Rod Sadler joins Jill for an engaging discussion about his latest book, Depraved Obsession. Their conversation delves into the shocking murders of teenagers Kenny Myers and Shawn Moore, shedding light on the sadistic serial killer who terrorized the community and shattered countless lives. …
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In Episode 438 of Hidden Forces, Demetri Kofinas speaks with Charles Calomiris, former Chief Economist at the Office of the Comptroller of the Currency, about his forthcoming paper “How Stablecoins Will Transform Banking,” which is based on a presentation he delivered at the Hoover Institution’s annual monetary policy conference this past May. Deme…
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From growing up on the sidelines of the NFL to becoming one of baseball’s most reliable first basemen, JT Snow’s journey is filled with unforgettable stories. The son of Los Angeles Rams great Jack Snow, JT grew up meeting NFL legends before carving his own path on the diamond—earning six Gold Gloves and becoming a fan favorite with the San Francis…
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In Episode 437 of Hidden Forces, Demetri Kofinas speaks with Marvin Barth, founder of Thematic Markets and former Chief Economist for International Affairs at the U.S. Treasury, who previously served at the Federal Reserve and the Bank for International Settlements and has led global macro and FX strategy on both the sell side and the buy side. Mar…
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Now on her third pope, Diane Montagna is one of the most respected Vaticanologists of our time. Known for her contributions to periodicals such as the National Catholic Register and Humanitas: Christian Anthropological Review, as well as the Catholic Herald, she has also worked as Rome correspondent for LifeSiteNews and the English edition of Alete…
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On August 27, 2025, at 8:30 AM, Minneapolis, Minnesota, faced a tragic incident at the Annunciation Church and Catholic School in Minneapolis, with 2 killed and 17 injured as per the latest news report. As we grapple with the pain and sorrow, taking the time to understand the facts may offer solace and support to someone in need. In her trilogy, "A…
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Part 3: The trial of James Holmes unfolds with gripping tension as the jury deliberates whether he was insane during the tragic act that claimed 12 innocent lives and inflicted countless injuries. Should they find him sane, a critical question looms: Is the death penalty warranted? The atmosphere in the courtroom is charged with emotion as courageo…
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We're resharing an episode from October 2022. How are habits – both good and bad – formed in the brain, and what role do habits play in diseases of the brain? These are some of the questions neuroscientist, Talia Lerner, PhD, is investigating in her lab. Her recent study, published in Cell Reports, may change the overall understanding of how habits…
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In Episode 436 of Hidden Forces, Demetri Kofinas speaks with economist, policy adviser, and investor Sony Kapoor about why developed world demographics, debt, and political sclerosis will crush forward returns for investors who fail to rebalance their portfolios for the new investment paradigm. Kapoor and Kofinas spend the first hour of their conve…
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Episode 435 is the eighth episode in the Hundred Year Pivot podcast series. In it, Demetri Kofinas and Grant Williams speak with leading realist scholar Jonathan Kirshner about how eroding cultural norms, weakened political guardrails, deepening polarization, and the collapse of shared narratives and belief structures are leading to a break-down in…
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Part 2: Neuroscience graduate student James Holmes is in therapy with psychiatrists Dr. Lynne Fenton and Dr. Robert Feinstein. He struggles with anxiety and intrusive, violent thoughts, but withholds crucial information from his psychiatrists, including his purchase of weapons. His lack of transparency leaves the psychiatrists concerned but unable …
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In Episode 434 of Hidden Forces, Demetri Kofinas speaks with Bruno Maçães, a geopolitical strategist and the former Minister of European Affairs for Portugal, whose latest book titled "World Builders" explores the intersection of technology and geopolitics. In the first hour, Bruno puts forward a radical new theory of geopolitics and technology tha…
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In Episode 433 of Hidden Forces, Demetri Kofinas speaks with Sam Freedman, a former senior policy advisor in the UK's Department for Education, political analyst, and the author of "Failed State," a timely exploration of the deep-rooted dysfunction within British governance and how to fix it. In their conversation, Sam Freedman examines the origins…
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YAY! One of our favorite true crime authors, BR Bates, is back to discuss her new book with you, The Crack City Strangler- The Homicides of Serial Killer Benjamin Atkins. Jill and BR dive into the case, deconstructing Benjamin ‘Tony’ Atkins’s childhood, its impact on his life, which devolved into serial murder. Possibly one of the fastest serial ki…
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Uniting scientists and harnessing the power of the immune system to fight disease is at the heart of the Center for Human Immunobiology (CHI). Stephanie Eisenbarth, MD, PhD, leads the center, and she is also the chief of Allergy and Immunology in the Department of Medicine. Since this episode was first recorded in fall 2022, Eisenbarth's team has l…
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In Episode 432 of Hidden Forces, Demetri Kofinas speaks with Vincent Deluard, Director of Global Macro Strategy at StoneX Group, where he advises large institutional investors on asset allocation, economic forecasting, and quantitative modeling informed by historical patterns and structural economic analysis. Vincent Deluard and Demetri spend the f…
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Episode 431 is the seventh episode in the Hundred Year Pivot podcast series. In it, Demetri Kofinas and Grant Williams speak with Edward Chancellor, a financial historian, award-winning journalist, and the author of “Devil Take the Hindmost: A History of Financial Speculation." Eddie, Grant, and Demetri discuss how excessively interventionist monet…
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Part 1: Just in time for Crimecon Denver 2025~ July 20, 2012: The Century 16 Theater in Aurora, Colorado, transformed into a scene of unimaginable horror when a man donned in a gas mask and body armor unleashed gunfire upon the 400 men, women, and children immersed in the thrill of the new Batman movie. In mere moments, the aisles turned into river…
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In Episode 430 of Hidden Forces, Demetri Kofinas speaks with Vance Spencer and Michael Anderson. Mike and Vance are the founders of Framework Ventures, one of the largest venture capital firms in crypto and one of the earliest and biggest investors in Decentralized Finance (DeFi). Kofinas, Spencer, and Anderson spend the first hour surveying the cu…
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In Episode 429 of Hidden Forces, Demetri Kofinas speaks with Weston Nakamura, a Tokyo-based financial analyst and the creator of “Across the Spread,” a market analysis and information service that identifies key market developments from the Asia-Pacific trading session, exploring their impact on equities, bonds, currencies, and commodities across g…
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Sacred Voices is a choir made up of members who were originally part of the Sistine Chapel Choir and now constitute a touring ambassadorial choir, dedicated in part to sustaining the vision of Domenico Bartolucci, who was for decades the Sistine Chapel Choir’s conductor and director. Alessandro Biciocci is the Secretary General of the Bartolucci Fo…
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In Episode 428 of Hidden Forces, Demetri Kofinas speaks with Joseph Wang, Chief Investment Officer at Monetary Macro and the founder of Fed Guy, an educational media platform that provides financial market analysis to investors and policymakers informed by a deep understanding of monetary mechanics and public policy. Joseph and Demetri spend the fi…
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Part 3: History tells us that Mary Jane Kelly, a victim of Jack the Ripper, was a prostitute. Now, discover the details of her life and her loves. In 2ndcast, Jill examines several suspects and provides an analysis of the DNA testing conducted in 2014 on the shawl found at the crime scene of Catherine Eddowes. Does this evidence confirm the identit…
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In Episode 427 of Hidden Forces, Demetri Kofinas speaks with Le Shrub, the author of the Shrubstack Substack who in his previous life was part of a famous team known for putting on “The Big Short” during the 2008 Great Financial Crisis. This recording is the result of a phone call Demetri made to Le Shrub to catch up on markets and life after retur…
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Western Georgia, 1946. Years after Prohibition ended, illegal stills are still in operation, fueled by vast amounts of money and corruption, far removed from the portrayal of good old boy exploits seen on TV and in movies. In this era of moonshine and deceit, it is the responsibility of the Georgia Revenue Agents to identify and shut down these ill…
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An experimental drug called NU-9 was invented at Northwestern University by Richard Silverman, PhD. It has been approved for clinical trials for the treatment of ALS and found to improves neuron health in animal models of Alzheimer's disease according to a new Northwestern Medicine study published in PNAS. This discovery is giving scientists hope t…
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In Episode 426 of Hidden Forces, Demetri Kofinas speaks with Stephen Walt, Professor of International Affairs at Harvard University's John F. Kennedy School of Government, about American grand strategy, the Trump Doctrine of Coercive Primacy, and the implications of Washington’s new Gunboat Diplomacy in the Middle East. Stephen is a prominent membe…
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Part 2: The exploration of the lives of Elizabeth Stride and Catherine 'Kate' Eddowes, who were murdered by Jack the Ripper in 1888, begins in earnest. The Ripper mythos labels them as 'unfortunates,' which tramples on their true stories. These women were beloved daughters, sisters, students, wives, mothers, and business owners, all struggling to n…
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In Episode 425 of Hidden Forces, Demetri Kofinas speaks with geopolitical and intelligence analyst Dmitri Alperovitch about the new security dynamics and economic opportunities that arise from America’s and Israel’s attacks on Iran, the risks of strategic overreach, and whether U.S. actions do more to compel or deter a Chinese invasion of Taiwan. I…
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WILDLIFE CSI is an exciting new initiative! I had an incredible opportunity to spend time with majestic giraffes, striking zebras, powerful rhinos, elegant roan antelopes, graceful impalas, rare addaxes, sturdy bison, and even adorable puppies, all while joining forces with Sheryl ‘Mac’ McCollum, Dr. Laura Pettler, and the esteemed forensic patholo…
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David Alton, the Catholic crossbench peer and former MP, joins Dr Gavin Ashenden to discuss the recent vote for abortion up to and during birth. They reflect on the hijacking by MPs of the Crime and Policing Bill to decriminalise abortion for any reason and at any stage in pregnancy, and also the passage of the Terminally Ill Adults (End of Life) t…
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In Episode 424 of Hidden Forces, Demetri Kofinas speaks with Kamran Bokhari, Senior Director at the New Lines Institute for Strategy & Policy, who has served in the U.S. State Department and as a Senior Consultant with the World Bank. Bokhari first appeared on the podcast shortly after the October 7th attacks to discuss the violence ignited by Hama…
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A Northwestern Medicine clinical trial led by Rod Passman, MD, could improve the way we care for millions of people with atrial fibrillation, but it is facing an unexpected challenge. There has been a pause in federal funding to Northwestern University that could impact this study's progress. While the trial has not been ordered to stop, all Nation…
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In Episode 423 of Hidden Forces, Demetri Kofinas speaks with Joseph Torigian, an expert on the politics of authoritarian regimes and the Chinese Communist Party, with a particular focus on elite power struggles, civil-military relations, and grand strategy. Torigian is also the author of a widely discussed new book titled “The Party’s Interests Com…
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