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Welcome to NADDPOD! Join Dungeon Master Brian Murphy as he leads players Emily Axford, Caldwell Tanner and Jake Hurwitz on a comedic, actual-play adventure through the realms of Bahumia and Beyond. The show also features a score composed and performed by Emily Axford. This team has created a variety of D&D campaigns, as well as numerous other series such as DUNGEON COURT and 8-BIT BOOK CLUB. They also occasionally hit the road and roll dice live on stage.
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I create SCP themed narrations & adaptations (contact [email protected] for business enquiries) . You could support me, if you want - patreon.com/thevolgun - Content relating to the SCP Foundation, including the SCP Foundation logo, is licensed under Creative Commons Sharealike 3.0 and all concepts originate from http://www.scp-wiki.net and its authors. This podcast, being derived from this content, is hereby also released under Creative Commons Sharealike 3.0.
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Base by Base

Gustavo Barra

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Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.
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Architect Tips

Jeffrey Palermo

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Architect Tips by Clear Measure Created to help .NET development teams move fast, deliver quality, and run their systems with confidence. This series is led by Chief Architect Jeffrey Palermo as well as other Clear Measure team members, publishing short clips of helpful tips to empower you to achieve more! Visit www.clearmeasure.com to view other content and learn more.
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Prototype and See is a podcast produced by HLH Rapid, hosted by Co-founder and Director James Murphy. Hear from designers, engineers and veterans in some of the world's most innovative companies as they share their stories of success and failures and the ups and downs of bringing new products to market.
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Crimes and Cantrips

Gwen Malmquist, Miri Baker, Beatrix Ryle, Fennix

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Crimes and Cantrips is a narrative-focused TTRPG actual play audio podcast. We roll dice to tell stories about queer characters making ✨choices✨. This podcast is organized as a series of one-shots and mini-campaigns; different campaigns may feature different cast members. Our public episodes are free, and bonus content such as prologues, outtakes, GM notes, and cast discussions are featured on our Patreon.
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Listen to a Board Certified Dermatologist with over 25 years of experience give expert information about all Dermatology topics both medical and cosmetic. We get to the important points fast and you can use what you learn to help your skin issues or to ask the right questions at your next dermatology appointment.
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️ Episode 238: Germline polymorphisms shape antibody light chain repertoires In this episode of PaperCast Base by Base, we explore Long-read sequencing of IGK and IGL paired with AIRR-seq shows that common germline SNVs, SVs, and alleles drive inter-individual differences in light chain gene usage and CDR3 properties Study Highlights: The authors c…
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Source -► http://www.scp-wiki.net/scp-953Support me -► https://www.patreon.com/thevolgunJoin my DISCORD! -► https://discord.gg/YQZe9X7Buy my Merch? -► https://www.redbubble.com/people/TheVolgun Follow me on Instagram! ► https://www.instagram.com/thevolgun/╾╾╾ ►! Author & Credits !◄ "DrClef" ⤏ http://www.scp-wiki.net/drclef-member-pageCreative commo…
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Abby and Patrick are joined by therapist and sexuality educator Lucie Fielding. First, the three talk about Lucie’s path to clinical work and the significance of her book, Trans Sex, just out in a revised Second Edition. They then turn to Freud’s classic, Three Essays on the Theory of Sexuality (1905), putting that text, and the broader legacy of F…
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️ Episode 239: Genomic Adaptations of the Svalbard Reindeer In this episode of PaperCast Base by Base, we explore Comparative whole-genome analyses identify 150 differentiated genomic regions and candidate genes linked to fat metabolism, energy conservation, cold tolerance, reduced body size, fur morphology, and circadian rhythm that likely underpi…
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I’ve had a lot of conversations about AI over the past couple years—some insightful, some overhyped, and a few that left me questioning whether we’re even talking about the same technology. But every now and then, I get the opportunity […] The post Agentic AI and the Art of Asking Better Questions appeared first on TechSpective.…
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️ Episode 237: Tracing enteric pathogens in Africa with metagenomics and WGS In this episode of PaperCast Base by Base, we explore This study combines whole-genome sequencing and metagenomics to map the diversity, abundance, and genomic relationships of enteric foodborne pathogens across human, animal, food and environmental samples in four African…
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️ Episode 236: XPD translocation and genetic disease etiology In this episode of PaperCast Base by Base, we explore Computational modeling reveals how ATP-driven conformational cycles of the XPD helicase drive directional 5′→3′ translocation on single-stranded DNA and how mutations disrupt this process to cause disease Study Highlights: The authors…
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Source -► http://www.scp-wiki.net/scp-4666Support me -► https://www.patreon.com/thevolgunJoin my DISCORD! -► https://discord.gg/YQZe9X7Buy my Merch? -► https://www.redbubble.com/people/TheVolgun Follow me on Instagram! ► https://www.instagram.com/thevolgun/╾╾╾ ►! Author !◄ "Hercules Rockefeller" ╾╾╾ ►! Video Info !◄ Item #: SCP-4666Object Class: Ke…
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️ Episode 235: Maternal H3K9 methyltransferases control aRMAE in C. elegans In this episode of PaperCast Base by Base, we explore Using dual-color reporters in C. elegans, the study shows maternal H3K9 methyltransferases MET-2 and SET-25 antagonistically regulate autosomal random monoallelic expression initiated in the early embryo Study Highlights…
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Subscribe to get access to the full episode, the episode reading list, and all premium episodes! www.patreon.com/OrdinaryUnhappiness It’s part two of our mailbag episode – which means Abby, Patrick, and Dan get to field yet more amazing listener questions! Topics include the many relationships, and problems of translation, between psychoanalysis an…
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️ Episode 234: MTHFR genotype and methionine metabolism predict COVID-19 severity In this episode of PaperCast Base by Base, we explore IMPACC longitudinal metabolomics and genomics analyses show that disruptions in one‑carbon/methionine metabolism together with MTHFR C677T genotype at hospital admission improve prediction of severe COVID‑19 and lo…
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There’s a question I’ve been sitting with lately: Are we prepared for what AI is about to expose in our organizations—not just technically, but operationally? In this episode of the TechSpective Podcast, I sit down with Kavitha Mariappan, Rubrik’s Chief […] The post Building Security for a World That’s Already Changed appeared first on TechSpective…
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Spaghetti Town opens its doors once again as artist and professor J. Schiek walks in and joins the Lords of Spaghetti. They talk about the societal perception of a dress code. Schiek talks about his cover for Polar Destroyer 2 and how art became his profession. Have you ever wondered what life is like in Idaho? Schiek also talks about the differenc…
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️ Episode 233: Mechanistic basis of NuA3 recognition and H3K14 acetylation In this episode of PaperCast Base by Base, we explore Cryo-EM structures of the yeast NuA3 complex reveal how a cooperative Sas3–Nto1 binding cleft recognizes the H3 tail and directs acetylation of H3K14 Study Highlights: The authors report cryo-EM structures of NuA3 in apo,…
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The Triplets attend a Hogliday Fey Soirée hosted by Onyx’s new patron! Nyack gets a fat lip, Jens goes full Grinch and Onyx has a meal to remember as the Trinyvale X Strahd crossover continues! Need the perfect gift for the NaddPole in your life? RADIO CITY LIVE SHOW TICKETS ARE AVAILABLE NOW! CREDITS Editing by Brian Murphy Production and Sound De…
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There’s something happening in cybersecurity right now that’s both exciting and a little disorienting. As generative and agentic AI take over headlines, conference keynotes, and investor decks, it’s easy to assume we’re on the verge of some great leap forward. […] The post Cybersecurity’s Quiet Revolution: What We’re Missing While Chasing the Hype …
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️Episode 232: Lamin A/C steers fork restart via H3K9me3 and PARylation In this episode of PaperCast Base by Base, we explore Nucleoplasmic Lamin A/C, together with LAP2α, enforces active replication fork slowing during mild replication stress by promoting local H3K9me3 and ADP-ribosylation to restrain RECQ1-mediated restart and protect genome stabi…
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️Episode 231: Transcription start sites as a germline mutational hotspot In this episode of PaperCast Base by Base, we explore This study identifies a pronounced germline mutational hotspot centered on transcription start sites (TSSs) driven in part by early embryonic mosaic variants and transcription-associated DNA damage Study Highlights: Extreme…
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️Episode 230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome In this episode of PaperCast Base by Base, we explore A recurrent de novo MIDEAS p.Tyr654Ser variant disrupts an autoinhibitory loop in the MiDAC complex, increasing HDAC1 deacetylase activity and causing a multisystem neurodevelopmental disorder Study Highlig…
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️Episode 229: Inhibiting PCBP2 condensates in Alzheimer’s In this episode of PaperCast Base by Base, we explore Elevated PCBP2 forms liquid-like condensates that sequester mitochondrial and RNA-binding proteins, stabilize BACE1 mRNA, and promote amyloid pathology while the small molecule CN-0928 reduces PCBP2 via INTS1 to lower Aβ and improve cogni…
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My Patreon -► https://www.patreon.com/thevolgunSource -► https://scp-wiki.wikidot.com/scp-012-exAuthor -► "S D Locke" - https://scp-wiki.wikidot.com/shaggydredlocksBuy my Merch? -► https://www.redbubble.com/people/TheVolgun All of my links! -► https://beacons.ai/thevolgun╾╾╾ ►! Video Info !◄ Item #: SCP-012-EXObject Class: ExplainedSpecial Containm…
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️ Episode 228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity In this episode of PaperCast Base by Base, we explore Structural and functional characterization of two group 2 H3 HA stem antibodies, 2F02 and AG2-G02, shows distinct non-overlapping epitopes, protection in mice, and antigenic changes driven by HA2 position 32 that …
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Abby and Patrick are joined by writer Grace Byron, author of the fantastic new novel Herculine. Alternately hilarious and terrifying, Herculine is the story of a young trans woman who leaves a frustrating life in New York City to join an erstwhile high school lover in a trans separatist commune in rural Indiana. But the community proves far from pe…
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️ Episode 227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation In this episode of PaperCast Base by Base, we explore This study shows that spontaneous RPE differentiation eliminates most aneuploid human pluripotent stem cells but permits expansion of cells with chromosome 1q gains when they are co-cultured with wild-type cells …
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Naughty or Nice, the age old question. Jakub got a letter in the mail and Alex seems upset he wasn't included, which makes Jakub uncomfortable. Alex goes on a deep dive on why he is the way he is and how its perceived socially, at least in his eyes. He tries to explain his reasonings in navigating a conversation and how it varies from Jakub. Is Twi…
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To stop a strange ritual, the Triplets travel to the western edge of Barovia and come face-to-face with the Mother of All Evil! Nyack gets a new hat, Jens ruins a card game and Onyx wages maternal combat as the Trinyvale X Strahd Crossover continues! RADIO CITY MUSIC HALL TICKETS ARE ALMOST SOLD OUT! GET YOURS NOW! CREDITS Editing by Brian Murphy P…
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️ Episode 226: FGF4 protects podocytes in diabetic kidney disease In this episode of PaperCast Base by Base, we explore This study shows that podocyte-derived FGF4 is reduced in DKD and that recombinant FGF4 preserves podocyte survival and glomerular function in diabetic models via FGFR1-AMPK-FOXO1 signaling Study Highlights: FGF4 expression is dow…
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Every once in a while, a conversation forces you to stop and rethink something you thought you already understood. Recording this latest TechSpective Podcast episode with Semperis CEO Mickey Bresman did exactly that—and it has everything to do with how […] The post The Identity Problem No One Saw Coming—Until AI Exposed It appeared first on TechSpe…
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️ Episode 225: VRK-1 and BAF-1 release meiotic chromosomes In this episode of PaperCast Base by Base, we explore VRK-1 phosphorylates BAF-1 to remove chromatin from the nuclear periphery during early meiotic prophase in C. elegans, and failure of this step impairs pairing and synapsis and generates heritable genome lesions Study Highlights: The aut…
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️ Episode 224: AntennAlive — wireless in-body sensing with engineered bacteria In this episode of PaperCast Base by Base, we explore A bio-hybrid, battery-free implant converts engineered bacterial activity into microwave backscatter signals by controlled degradation of a biodegradable antenna Study Highlights: The AntennAlive system uses a magnesi…
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️ Episode 223: Torsion Regulates DNA Replication Stalling and Restart In this episode of PaperCast Base by Base, we explore New single-molecule angular optical trap assays reveal that DNA torsion directly controls T7 replisome stalling and reactivation Study Highlights: A high-resolution, label-free angular optical trap (AOT) assay was developed to…
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️ Episode 222: snaR-A hijacks splicing to drive proliferation In this episode of PaperCast Base by Base, we explore This episode examines how the cancer-associated Pol III transcript snaR-A binds core splicing factors, localizes near nuclear speckles, perturbs U2-dependent splicing to increase intron retention, and promotes cell proliferation linke…
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My Patreon -► https://www.patreon.com/thevolgunSource -► https://scp-wiki.wikidot.com/scp-3812Author -► "DJkaktus" - https://scp-wiki.wikidot.com/djkaktusBuy my Merch? -► https://www.redbubble.com/people/TheVolgun All of my links! -► https://beacons.ai/thevolgun╾╾╾ ►! Video Info !◄ Keter-Class Containment Proposal Brief2: SCP-3812 is to be constant…
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️ Episode 221: Allele-resolved nanopore tour of the human placental methylome In this episode of PaperCast Base by Base, we explore Using phased long-read nanopore and short-read sequencing across eight trios, the study maps allele-specific DNA methylation and transcription in female human placentas, identifies hundreds of DMRs and novel imprinted …
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Subscribe to get access to the full episode, the episode reading list, and all premium episodes! www.patreon.com/OrdinaryUnhappiness It’s another mailbag episode (part one of two)! Abby, Patrick, and Dan respond to listener questions about everything from the utility of psychoanalytic concepts in everyday life to the complexities of Melanie Klein t…
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️Episode 220: The AML cellular state space reveals NPM1 immune evasion subtypes In this episode of PaperCast Base by Base, we explore Single-cell and bulk sequencing of 120 AML cases reveal two NPM1-mutated subtypes with distinct immune evasion mechanisms and divergent responses to hematopoietic stem cell transplantation Study Highlights: Bulk RNA-…
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The doors are open this week and frequent citizen Mike Clyburn walks through. Jakub makes a confession and the three of them recap their Thanksgiving festivities. Hope soup wasn't on your menu! Jakub almost lost a limb and Alex had the worst lunch ever. Mike then poses a quick quiz on the open ended meanings of time phrases. Alex also brings up Can…
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️Episode 219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain In this episode of PaperCast Base by Base, we explore Targeted multi-region lipidomics with proteomic and mitochondrial data reveals region- and stage-specific lipid alterations in Parkinson’s disease that converge on mitochondrial dysfunction Study Highlights: The study q…
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️Episode 218: SIM1 and the multi-ancestry genomics of erectile dysfunction In this episode of PaperCast Base by Base, we explore A large multi-ancestry GWAS meta-analysis identifies a dominant SIM1-linked locus and multiple genetic connections between electronic health record-defined erectile dysfunction and cardiometabolic, psychiatric, and substa…
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Dungeon Court is back in session! Join Justices Murphy, Tanner and Axford, along with Bailiff Jake, as they pass judgement on your trials at the table! CREDITS: Sound Mixing and Editing by Trevor Lyon Dungeon Court Theme Song by Sam Weiller See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do…
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Every once in a while, I end up in a conversation that hits at exactly the right moment—when the industry is shifting, the vocabulary is changing, and everyone is quietly circling the same questions. This new episode of the TechSpective […] The post Exploring the Future of Identity Security and Agentic AI appeared first on TechSpective.…
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️Episode 217: Multiscale triads of meiotic crossover patterning In this episode of PaperCast Base by Base, we explore FFT and inverse-FFT analysis of Zip3/Zip2, Hop1 and Zip1 on yeast pachytene chromosomes reveals two interdigitated tiers of evenly spaced protein triads that correspond to canonical and minority crossovers and are differentially reg…
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️ Episode 216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair In this episode of PaperCast Base by Base, we explore This episode reviews a study showing that 53BP1-RIF1 and DNA-PKcs have different genetic relationships across blunt end joining, deletion patterns, HDR, and radiosensitivity Study Highlights: Using EJ7-GFP …
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️ Episode 215: Protein Set Transformer for high-diversity viromics In this episode of PaperCast Base by Base, we explore Protein Set Transformer (PST) is a protein-based genome language model that represents genomes as sets of proteins to improve genome and protein representations across diverse viral datasets Study Highlights: PST embeds proteins …
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️ Episode 214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion In this episode of PaperCast Base by Base, we explore This study shows that an asymmetric transbilayer distribution of PI(4,5)P2 lowers the energy barrier for lipidic pore formation and accelerates unconventional secretion of Fibroblast Growth Factor 2 Study Highlights: The authors gen…
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️ Episode 213: BRAIN-MAGNET: a functional atlas for non-coding variants In this episode of PaperCast Base by Base, we explore BRAIN-MAGNET couples a ChIP-STARR-seq atlas of 148,198 neural regulatory elements with a validated convolutional neural network to predict enhancer activity and prioritize disease-relevant non-coding variants Study Highlight…
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️ Episode 212: Zonal control of mutant β-catenin tumorigenesis This study shows that hepatic zonation determines whether mutant β-catenin drives proliferation and liver cancer by forcing differentiation to a non-permissive zone 3 fate or, when reversed, enabling MAPK- and mTOR-dependent growth Study Highlights: β-catenin exon 3 mutations cooperate …
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Tuck into a delicious special all about food in Red Dwarf, featuring food journalist and author Andrew Webb. As both a big fan of the show and an expert on cuisine, Andrew is the perfect guest to guide us through the Dwarf’s gastronomic delights. It’s all here: vending machines, dog food, curry, triple fried egg chill chutney sandwiches and a glass…
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️ Episode 211: Retention Elements in Cancer Cells In this episode of PaperCast Base by Base, we explore the discovery of genetic elements that promote the retention of extrachromosomal DNA (ecDNA) in cancer cells, enhancing their survival and evolution. Study Highlights: Researchers identified a family of genomic elements known as retention element…
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