Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We believe that the current practice of medicine is disease care, not health care. We believe that eve ...
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Optispan Podcasts
We’re a team of doctors with a combined 100 years of experience and a passion for helping patients find long-term vitality using our new approach to medicine. Instead of just trying to lengthen your lifespan, we aim to lengthen your healthspan.
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Debunking 10 Longevity Myths You Still Believe | 126
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37:50Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein systematically breaks down ten of the most persistent myths in the health and aging space. From the truth about biological age tests and resveratrol to the real role of genetics and supplements…
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Inside the Offshore Clinics Developing Gene Therapy to Fight Aging | 125
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2:00:49Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Meet the founders (Ivan Morgunov, Anna Vakhrusheva) of Unlimited Bio, a biotech company developing gene therapies in special economic zones, operating outside of traditional FDA regulation. This episode explores their model, the scie…
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Testosterone, Rapamycin & Diet Myths: A Scientist's AMA | 124
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40:32Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/In this Ask Me Anything episode, longevity scientist Dr. Matt Kaeberlein tackles viewer questions on controversial topics like testosterone therapy and the longevity drug rapamycin. He also offers his science-based perspective on die…
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#65 - Dr. Mark Mattson | Neuroscience, Intermittent Fasting, and Brain Health
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1:06:48Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Mark Mattson, one of the world’s leading neuroscientists and a pioneer in the study of aging, brain health, and neurodegenerative diseases. Dr. Mattson is Chief of the Laboratory of Neurosciences at the National Institute on Aging and Professor of Neuroscience…
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A Geroscience Roundtable: de Grey, Kennedy & Kaeberlein on the Path to Longevity Escape Velocity | 123
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1:06:39Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Join longevity pioneers Dr. Aubrey de Grey, Dr. Brian Kennedy, and Dr. Matt Kaeberlein for a rare, unfiltered discussion on the future of aging. They debate the timeline for longevity escape velocity, the promise of new damage-repair…
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Longevity Conference Attendees Hospitalized After Using Peptides? | 122
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1:04:05Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Following a breaking news story about hospitalizations at a longevity conference, scientist Dr. Matt Kaeberlein shares his firsthand experience from the event. He reveals the dangerous mix of legitimate science, unregulated therapies…
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I'm Taking TESTOSTERONE: My Story, Mistakes & Insights From a Longevity Perspective | 120
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55:19Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein shares his personal and candid journey with testosterone therapy, from initial symptoms and hesitation to the mistakes he made starting out. This conversation breaks down the real-world benefit…
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A Physicist's Radical Theory of Why We Age
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1:12:26Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Physicist Jan Gruber presents a radical theory of aging, describing it as a gradual loss of resilience against random, stochastic events. This new model challenges how we think about biological clocks and could revolutionize the way …
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Doctors Reveal Their Blueprint for Lifelong Health (4 Pillars & Key Blood Tests) | 118
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1:30:05Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt sits down with Dr. Nicki Byrne and Dr. Kevin White to break down the four essential pillars for a long and healthy life: eat, move, sleep, and connect. They also reveal the specific blood tests that go beyond a standard chec…
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#64 - Dr. Yanina Pepino | The Neuroscience of Taste, Sweeteners, and Metabolic Health
1:28:24
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1:28:24Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Yanina Pepino, a renowned professor of Ingestive Behavior at the University of Illinois. With a background in medicine and a research trajectory that spans Washington University’s Center for Human Nutrition to her current work in sensory biology, Dr. Pepino br…
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#63 - Dr. Dominic D'Agostino | Advancing Metabolic Therapies Through Ketosis and Resilience Research
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1:11:35Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they speak with Dr. Dominic D’Agostino, Associate Professor at the University of South Florida and research scientist at the Institute for Human and Machine Cognition (IHMC). Renowned for his work on metabolic therapies, Dr. D’Agostino has led pioneering research into how nutrit…
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Rapamycin Improves Autophagy? | Analyzing Longevity News | 117
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43:00Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity expert Dr. Matt Kaeberlein breaks down three new scientific studies on the popular anti-aging drug rapamycin and the supplement taurine. Discover which research shows real promise for conditions like chronic fatigue and whi…
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Ask a Longevity Scientist: Testosterone, "Miracle" Supplements & Falling for the Hype | 116
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53:01Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein tackles your burning questions on testosterone therapy, trending supplements like astaxanthin and C15, hyperbaric oxygen, and more. Get science-backed insights and learn what truly matters for starting your health…
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#62 - Dr. Jens Juul Holst | Discovering the Hormone That Changed Metabolic Medicine
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1:04:38Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they speak with Dr. Jens Juul Holst, the renowned Danish physiologist and co-discoverer of GLP-1 (glucagon-like peptide-1), one of the most significant hormones in metabolic disease research. A professor of medical physiology at the University of Copenhagen and former scientific…
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Scientist Fact-Checks Controversial Medical Takes: Dr. Mike React
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1:08:23Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein reacts to controversial takes on supplements, MRIs, protein, and rapamycin from Dr. Eric Topol. This video breaks down the evidence behind popular health trends, helping you separate science from hype.0:00 - Setti…
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Gut Microbiome Expert: The HIDDEN Side Of Health You're MISSING | Dr. Sean Gibbons | 114
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1:23:33Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Sean Gibbons, a leading microbiome expert, sits down with me to decode the complex world of your gut bacteria. Learn about good vs. bad bacteria, the impact of antibiotics and aging, and how diet and probiotics can influence your…
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#61- SSD Interviews Brady Holmer | Exercise Physiology | Science Communication
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1:19:47Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Brady Holmer, an exercise physiologist, researcher, and science communicator whose work bridges the gap between exercise science and public health. With a background in integrative physiology and cardiovascular research, Brady brings a rigorous yet accessible pers…
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LiveLong Conference: Takeaways on Longevity Science & Hype | 113
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29:51Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Matt Kaeberlein & Dr. Kevin White share takeaways from the LiveLong Experience conference, covering Therapeutic Plasma Exchange (TPE) insights, Hormone Replacement Therapy (HRT) debates, longevity science, and navigating misinformati…
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This Simple Test Can Reveal Your Risk Of Heart Disease | 112
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40:16Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Matt Kaeberlein reviews his personal Cleerly CCTA scan results with Prime Health Associates founder Dr. Kevin White, analyzing soft vs. calcified heart plaque, assessing cardiovascular risk, and discussing the value of early detectio…
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The Hidden Health Toll Of Grief (and the 4 Tasks that Actually Work). | Emma Payne | 111
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1:13:17Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Help Texts CEO Emma Payne discusses the profound impact of grief on health (physical/mental), effective coping strategies (Warden's Tasks), and how text-based support can help navigate loss and foster post-traumatic growth.0:00 Intro…
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Rapamycin: The Worst Longevity Idea Ever Conceived? | 110
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43:04Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter: https://www.optispan.life/Dr. Matt Kaeberlein fact-checks Dr. Chris Masterjohn's essay calling rapamycin the "Worst Longevity Idea Ever," correcting misinformation about side effects (cataracts, glucose, heart) and benefits using scientific data from mouse and human stud…
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#60- SSD Interviews Dr. Richard Miller | Delayed Aging
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44:39Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Richard Miller, a distinguished physician-scientist and one of the most influential figures in aging research. As a Professor of Pathology at the University of Michigan and Director of the Paul F. Glenn Center for Aging Research, Dr. Miller has spent decades u…
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Siim Land: Biohacking Longevity, Health Span Truths & Cutting Through the Hype | 109
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1:18:28Subscribe to our channel: https://www.youtube.com/@optispanBiohacking expert Siim Land joins Matt Kaeberlein to discuss optimizing health span with science-based lifestyle tips (diet, exercise, sleep), key biomarkers, and navigating longevity misinformation & biological age clock hype.0:00 Introduction: Meet Siim Land2:41 Defining Longevity: Health…
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The Science of Aging Well: "A Practical Approach to HealthSpan Medicine" | 108
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16:12Subscribe to our channel: https://www.youtube.com/@optispanSign up for the Optispan Newsletter: https://www.optispan.life/Read or get your copy of Matt's Scientific American Article: https://www.scientificamerican.com/custom-media/healthspan/In this episode, Dr. Matt Kaeberlein reads and discusses his insightful article, "A Practical Approach to He…
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#59 - SSD Interviews Dr. Thomas Dayspring | Exploring Lipid Science | Cardiovascular Risk
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1:15:15Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Thomas Dayspring, a renowned expert in clinical lipidology and a leading educator in cardiovascular risk assessment. With over 37 years of medical practice and decades of experience consulting on complex lipid disorders, Dr. Dayspring has been at the forefront…
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Longevity Experts Discuss Their Health Advice & Approach | Dr. Marcus Ranney & Dr. Brian Kennedy | 107
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56:38Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein is joined by Dr. Marcus Ranney and Dr. Brian Kennedy, leading experts in longevity science. Recorded at the Rise for Aging Conference in Bangalore, India, they discuss India’s growing role in longevity research, the impact of AI in aging and healthcare, and unique health…
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#58 - SSD Interviews Dr. Matt Kaeberlein | Optispan | Dog Aging Project
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1:01:34Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Matt Kaeberlein, a leading biogerontologist and expert in the biology of aging. As the CEO of Optispan, Inc. and Co-Director of the Dog Aging Project, Dr. Kaeberlein has dedicated his career to understanding the mechanisms of aging and developing interventions…
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Brain Aging & Alzheimer’s Prevention: The Future of Cognitive Health Testing | Dr. Christin Glorioso | 106
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1:00:35Subscribe to our channel: https://www.youtube.com/@optispan Dr. Matt Kaeberlein & Dr. Christin Glorioso, founder of NeuroAge Therapeutics, explore groundbreaking advancements in brain aging and Alzheimer's prevention. Learn how cutting-edge brain age testing—combining MRI, cognitive assessments, blood biomarkers, and genetics—can predict Alzheimer’…
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Gut Health: Science-Backed Tips For Leaky Gut, IBS, & Your Microbiome | Dr. Mary Pardee | 105
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1:15:32Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein & Dr. Mary Pardee sit down to discuss insights on gut health, digestion, and common GI issues like IBS and constipation. This video covers practical approaches to improving gut function, debunking myths, and identifying effective solutions for long-term wellness, all whi…
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The Truth About Biological Age Tests | 104
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14:33Subscribe to our channel: https://www.youtube.com/@optispanMatt Kaeberlein dives into the controversial world of biological age tests. Many direct-to-consumer tests claim to measure your biological age, but are they accurate or useful? Based on extensive research and clinical experience, we uncover why these tests are statistically meaningless, lac…
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#57 - SSD Interviews Dr. Emeran Mayer | Pioneer of the Brain-Gut Connection and Microbiome Research
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45:55Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Emeran Mayer, a world-renowned gastroenterologist, neuroscientist, and pioneer in the field of brain-gut microbiome research. As the Executive Director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience at UCLA, Dr. Mayer has dedicated his …
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Dr. Kevin White: Concierge Medicine & Its Impacts On Living Longer & Healthier Lives | 103
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50:54Subscribe to our channel: https://www.youtube.com/@optispan In this episode, we dive into concierge medicine, how it differs from traditional primary care, and why more people are opting for personalized healthcare. Dr. Kevin White shares insights on longevity medicine, proactive health strategies, and the benefits of direct physician access. We di…
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Thomas Delauer: NEW Nutrition, Exercise, and Mindset Shifts In 2025 | 102
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42:42Subscribe to our channel: https://www.youtube.com/@optispanThomas DeLauer & I (Dr. Matt Kaeberlein) discusses his evolving perspectives on nutrition, exercise, and health optimization. Thomas shares how his views on insulin, low-carb diets, and fructose have shifted, his approach to training for strength and longevity, and the importance of sleep, …
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My Biggest Health & Longevity Breakthroughs at 54 | 101
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21:21Subscribe to our channel: https://www.youtube.com/@optispanI share the top health and longevity strategies that have transformed my energy, fitness, and well-being at 54 - From hormone optimization (TRT) and resistance training to diet improvements, alcohol reduction, and preventative diagnostics.0:00 - Reflections on Turning 54 & Longevity Mindset…
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Dr. Greg Fahy: Thymus Regeneration & Boosting The Immune System For Longevity | 100
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1:31:13Subscribe to our channel: https://www.youtube.com/@optispanDr. Greg Fahy discusses his groundbreaking research on thymus regeneration, immune system rejuvenation, and the role of growth hormone, DHEA, and metformin in reversing aging-related immune decline. He explains the TRIM protocol, the impact of thymic involution on longevity, and the potenti…
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#56 - SSD Interviews Dr. Martin Moore-Ede | Sleep Health Expert
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1:02:29Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Martin Moore-Ede, a pioneering scientist in circadian biology and a global expert on the health effects of light exposure. With over 40 years of groundbreaking research on circadian rhythms, Dr. Moore-Ede has transformed our understanding of sleep disorders, f…
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The Benefits Of Testosterone Replacement Therapy (TRT) For Men - Dr. Kevin White | 99
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58:44Subscribe to our channel: https://www.youtube.com/@optispanIs testosterone therapy right for you? In this episode, Matt Kaeberlein & Kevin White explore the benefits, risks, and misconceptions of testosterone replacement therapy (TRT). Learn about low testosterone symptoms, when to get tested, and the differences between primary and secondary hypog…
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The Effects of Rapamycin on APOE4 Carriers & Brain Function | 98
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42:12Subscribe to our channel: https://www.youtube.com/@optispanIn this video we discuss current studies relating to Rapamycin use and it's effects on brain function, specifically for APOE4 carriers. This data may (or may not) provide evidence to support the claim that Rapamycin can be beneficial for those with the APOE4 variant.0:00 - Introduction1:58 …
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Crypto-Powered Science: How Blockchain & DAOs Are Reimagining Longevity Research | 97
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1:00:50Subscribe to our channel: https://www.youtube.com/@optispanIn this video I sit down with the COO of Molecule AG, Benji Leibowitz, to discuss how blockchain and cryptocurrency can be applied to intellectual property (IP) in biotech research, particularly in funding longevity studies. The discussion covers concepts like DAOs (Decentralized Autonomous…
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Peter Attia: Training, Eating & Optimizing To Live Longer & Healthier In 2025 | 96
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1:17:45Subscribe to our channel: https://www.youtube.com/@optispanIn this video I sit down with Dr. Peter Attia to explore strategies for improving healthspan and lifespan, focusing on practical interventions like exercise, nutrition, and emerging therapies. Topics we discuss include defining healthspan (physical, cognitive, and emotional health), the ben…
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These Supplements Help Dogs Live Longer? | 95
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21:46Subscribe to our channel: https://www.youtube.com/@optispanIn this video of Longevity this Week, Matt, Nick, and Mitchell sit down to discuss longevity supplements for pets, scientific evidence backing them, supplement industry ethics, and broader implications in the longevity field.0:00 - Introduction to Longevity Supplements for Pets0:16 - Supple…
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Aging "Hotspot" Found in Brain? Hypochondriacs Don't Live as Long? | 94
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26:22Subscribe to our channel: https://www.youtube.com/@optispanWe explore the psychological and health implications of hypochondriasis, especially in the context of biological age testing and wearables. We then delve into how anxiety and fixation on health metrics can influence behavior and potentially exacerbate health risks. This discussion transitio…
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#55 - SSD Interviews Dr. Deanna Minich | The Rainbow Diet
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1:02:19Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Deanna Minich, a pioneering nutrition scientist, functional medicine practitioner, and author with over two decades of experience in academia, clinical practice, and the dietary supplement industry. With a Ph.D. in Medical Sciences (nutrition focus) from the U…
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Correcting the Record on Past Videos: Biological Age Tests, Full Body MRI's & More | 93
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38:31Subscribe to our channel: https://www.youtube.com/@optispanMatt & Nick cover past episode fixes, address audience comments, and share updates about the channel and what you can expect to see from the channel moving forward into the New Year. 00:00 Intro & Setting New Years Goals 07:34 Full body MRI's11:55 DrugAge Database1:17:22 Biological Age Test…
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LIVE AMA: Longevity Scientists Answer Your Health & Longevity Questions LIVE | 92
1:38:48
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1:38:48Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, Matt and Brian Kennedy delve into the potential benefits and side effects of interventions like Rapamycin, the role of biomarkers, and optimal approaches to enhancing healthspan and cognitive function. Together they highlight the challenges of supplement use, aging research…
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My Review of Peter Attia’s AMA: What I Agree & Disagree With | 91
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46:08Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, Matt shares his thoughts on Peter Attia's AMA , exploring areas of agreement and differing perspectives on health and longevity. Topics include the significance of grip strength, biomarkers for health assessment, exercise strategies while traveling, and advancements in long…
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Longevity Scientists Answer 30 MORE of Your Health & Longevity Questions | 90 PART 2
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1:16:01Subscribe to our channel: https://www.youtube.com/@optispanIn this Q&A, Matt and Brian Kennedy cover a range of topics on caloric restriction, lifespan studies, interventions like rapamycin, and the importance of control groups in research. They critique the validity of certain longevity claims, discusses the complexities of aging mechanisms, and q…
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#54 - SSD Interviews Dr. Christopher Labos | Does Coffee Cause Cancer?
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1:10:23Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Christopher Labos, a cardiologist, epidemiologist, and acclaimed science communicator who bridges the gap between medicine and the public. With a medical degree and cardiology training from McGill University, along with a Master’s in Epidemiology, Dr. Labos ha…
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MEGA Q&A: We Answer 30 of Your Health & Longevity Questions | 90 PART 1
1:27:55
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1:27:55Subscribe to our channel: https://www.youtube.com/@optispanIn this Part 1 episode, Matt and Brian Kennedy cover various aspects of aging research, including the connection between the immune system and aging, the role of inflammation, the potential of supplements and wearables in healthspan, and insights on longevity interventions. They also discus…
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I Got a Full Body MRI: IS IT WORTH IT? I Share My Results | 89
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29:29Subscribe to our channel: https://www.youtube.com/@optispanIn this episode of the Optispan Podcast, Matt Kaeberlein shares his experience of undergoing a whole body MRI, discussing its potential as a screening and preventative tool for health optimization. He covers the benefits and drawbacks of whole body MRIs, shares specific details about his ex…
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