Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We believe that the current practice of medicine is disease care, not health care. We believe that eve ...
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Optispan Podcasts
1
6 Months on TRT Changed My Body (THIS Is My Takeaway)
50:02
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50:02This is an AMA episode where Dr Matt answers the pressing questions audience had. In this episode, Matt shares candid updates on his TRT journey and physique, debates rapamycin protocols vs. extreme fasting, and separates the scary headlines from the science on microplastics and "magic" mushrooms. Plus: why he wakes up at 4:30 AM, the truth about H…
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The Dangerous Truth About The Peptide Craze (I Tried It)
53:00
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53:00This podcast episode is part three of a travel series where Matt recounts his recent trips to longevity and healthspan conferences in Geneva, Chicago, and Mauritius. He shares his experiences with jet lag, workouts, and the contrasting cultures of these events, from the more "alternative medicine" feel of the Geneva summit to the more scientificall…
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1
New Discovery: This Molecule Could Beat Rapamycin in Longevity
1:09:01
1:09:01
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1:09:01Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Dive into the future of longevity research with Dr. Ben Blue, CEO of Ora Biomedical. We explore how Ora's high-throughput "Wormbot" platform is conducting the world's largest unbiased search for longevity interventions, moving beyond the narrow focus on …
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Happy thanksgiving from the Optispan Team!
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Longevity Problem: 70% Of All Deaths Are Caused By Aging - Dr. Andrew Steele
2:07:38
2:07:38
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2:07:38Longevity scientist Dr. Andrew Steele sits down with Dr. Matt Kaeberlein to make the provocative case that aging should be treated as humanity's greatest challenge, even bigger than climate change. In this deep conversation, they explore why two-thirds of all deaths are caused by aging, the cutting-edge science that's already extending healthy life…
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Scientist Reacts: Why Megadosing Creatine Is A Waste Of Time
58:42
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58:42Creatine is being called a "cognitive super-drug" that feels like "speed without the speed." Influencers are telling you to mega-dose 20 grams a day for brain power, bone health, and more. But what does the science actually say?In this episode, we go beyond the hype and fact-check the wildest creatine claims taking over the internet. I break down t…
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1
We'll Pay $101 Million If You Prove You Can Reverse Aging
1:33:18
1:33:18
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1:33:18Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Join me for a fascinating conversation with Dr. Jamie Justice, Executive Director of the $101 Million XPRIZE Healthspan. In this podcast, we discuss the world of longevity science, from the ambitious goals of this global competition to the lessons learne…
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Dr. Stanfield Mortgaged His House For $150k To Prove Longevity Drug Works
1:13:00
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1:13:00In this in-depth conversation, Dr. Brad Stanfield sits down with Dr Matt Kaeberlein to discuss his journey from a primary care physician in New Zealand to a leading voice in the evidence-based longevity space. We cover the launch and philosophy behind his YouTube channel, the challenges and exciting results of his self-funded rapamycin clinical tri…
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Don't Fall For This Scam: Matt's Deepfake PSA
9:43
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9:43Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use…
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1
You Might Have The Heart Attack Gene. Here Are The Signs
42:23
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42:23Joel Jamison is back for another deep dive, and this episode is packed with actionable insights, personal health revelations, and answers to your burning questions. We cover everything from the legitimacy of new health tech to Joel's ongoing journey with a shocking calcium score and what he's doing about it. If you have a family history of heart di…
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1
The $40 Cure They Don't Want You to Know About
1:47:39
1:47:39
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1:47:39In this podcast, I sit down with Dr. Jon Berner to explore two of the most promising yet misunderstood therapeutic agents: Lithium and Rapamycin. We begin with a groundbreaking discussion on Lithium, moving far beyond its traditional use in psychiatry. We break down the recent landmark study in Nature that positions lithium as a potential powerhous…
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Longevity Lie: Doctor Reveals Why Anti-Aging Supplements Don’t Work
1:48:07
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1:48:07Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Join me for an in-depth conversation with Dr. Alex and Dr. Jan from the YEARS Healthspan Clinic in Berlin. They pull back the curtain on what a truly evidence-based, scientific approach to longevity medicine looks like, moving beyond the hype and "snake …
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Blood Cleaning: Cuts Age Biomarkers 2.6 Years in 90 Days!
1:26:12
1:26:12
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1:26:12Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Ever heard of a medical procedure that’s been called an “oil change for your blood”?In this episode, I sit down with Dr. Brad Younggren to explore Therapeutic Plasma Exchange (TPE), a cutting-edge intervention that just might help extend healthspan, redu…
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1
Doctor Reveals: The Dark Side of the Longevity Industry
53:35
53:35
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53:35Just back from the tour of the longevity world! In this episode, we discuss my recent travels to two major conferences: the high-end Longevity Investors Conference in Gstaad, Switzerland, and the academic GJAM Conference in Jena, Germany. We unpack the stark contrasts between these two worlds, from the venues and treatment of attendees to the funda…
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1
Why 400+ Alzheimer's Drugs Failed (Here's What Works)
1:30:15
1:30:15
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1:30:15Alzheimer’s is often talked about but rarely understood in full. For decades, most research has focused on amyloid plaques, but what if that’s only part of the story? In this deep-dive, Dr. Cory, from the Institute for Systems Biology explains a new way of looking at Alzheimer’s: It is not simply a plaque problem, but as a breakdown in the brain’s …
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Female Biohacker: Why Women Need Different Longevity Protocols (Simple Steps)
1:00:32
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1:00:32Ever wondered how simple, consistent practices can transform your health? In this episode, Kayla Barnes shares her personal journey from growing up on a standard diet to discovering the science-backed habits that help manage toxin exposure, support heart and brain health, and reduce stress.She talks about:• How her environment affected her toxin le…
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1
AI Medicine: ChatGPT Reads Blood Tests Faster Than Your Doctor
1:23:38
1:23:38
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1:23:38Subscribe to our channel: https://www.youtube.com/@optispan Get Our Newsletter (It's Free): https://www.optispan.life/ Most people take supplements without ever checking if their body actually needs them. Is that smart… or just expensive guesswork? In this podcast, Dr. Matt Kaeberlein sits down with Ryan Ware to unpack the truth about supplements, …
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Is Creatine Harming Your Kidneys? The Blood Test Myth Explained.
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9:13Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Many people taking creatine get alarming results on standard kidney function tests, suggesting their kidneys are failing. This video explains why the popular supplement can create a false positive, debunks the myth of kidney damage, …
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Elite Performance: How Pro Athletes Use HRV to Train Smarter (Not Harder)
1:38:34
1:38:34
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1:38:34In this episode, Dr. Matt Kaeberlein sits down with Joel Jamieson to explore the science of heart rate variability and how it connects to longevity, recovery, and performance. Joel shares his journey from training elite fighters to becoming a global authority on HRV training, emphasizing that healthspan is built on consistency, balance, and resilie…
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Magic Mushrooms: The Next Anti-Aging Drug?
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32:45Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/A new scientific paper reports that psilocybin, the compound in magic mushrooms, can extend lifespan in mice. A longevity scientist breaks down the data, exploring the study's strengths and weaknesses and discussing the potential bio…
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A Scientific-Backed Discussion On Fighting Cognitive Decline
1:24:46
1:24:46
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1:24:46Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Today Dr. Kevin White and Erik Nelson join us for a deep-dive conversation as they unveil a new, multi-faceted program designed to halt and even reverse cognitive decline. They break down the key diagnostics, lifestyle pillars, and a…
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Debunking 10 Longevity Myths You Still Believe | 126
37:50
37:50
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37:50Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein systematically breaks down ten of the most persistent myths in the health and aging space. From the truth about biological age tests and resveratrol to the real role of genetics and supplements…
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Inside the Offshore Clinics Developing Gene Therapy to Fight Aging | 125
2:00:49
2:00:49
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2:00:49Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Meet the founders (Ivan Morgunov, Anna Vakhrusheva) of Unlimited Bio, a biotech company developing gene therapies in special economic zones, operating outside of traditional FDA regulation. This episode explores their model, the scie…
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Testosterone, Rapamycin & Diet Myths: A Scientist's AMA | 124
40:32
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40:32Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/In this Ask Me Anything episode, longevity scientist Dr. Matt Kaeberlein tackles viewer questions on controversial topics like testosterone therapy and the longevity drug rapamycin. He also offers his science-based perspective on die…
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A Geroscience Roundtable: de Grey, Kennedy & Kaeberlein on the Path to Longevity Escape Velocity | 123
1:06:39
1:06:39
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1:06:39Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Join longevity pioneers Dr. Aubrey de Grey, Dr. Brian Kennedy, and Dr. Matt Kaeberlein for a rare, unfiltered discussion on the future of aging. They debate the timeline for longevity escape velocity, the promise of new damage-repair…
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Longevity Conference Attendees Hospitalized After Using Peptides? | 122
1:04:05
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1:04:05Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Following a breaking news story about hospitalizations at a longevity conference, scientist Dr. Matt Kaeberlein shares his firsthand experience from the event. He reveals the dangerous mix of legitimate science, unregulated therapies…
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I'm Taking TESTOSTERONE: My Story, Mistakes & Insights From a Longevity Perspective | 120
55:19
55:19
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55:19Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein shares his personal and candid journey with testosterone therapy, from initial symptoms and hesitation to the mistakes he made starting out. This conversation breaks down the real-world benefit…
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1
A Physicist's Radical Theory of Why We Age
1:12:26
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1:12:26Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Physicist Jan Gruber presents a radical theory of aging, describing it as a gradual loss of resilience against random, stochastic events. This new model challenges how we think about biological clocks and could revolutionize the way …
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Doctors Reveal Their Blueprint for Lifelong Health (4 Pillars & Key Blood Tests) | 118
1:30:05
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1:30:05Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt sits down with Dr. Nicki Byrne and Dr. Kevin White to break down the four essential pillars for a long and healthy life: eat, move, sleep, and connect. They also reveal the specific blood tests that go beyond a standard chec…
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Rapamycin Improves Autophagy? | Analyzing Longevity News | 117
43:00
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43:00Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity expert Dr. Matt Kaeberlein breaks down three new scientific studies on the popular anti-aging drug rapamycin and the supplement taurine. Discover which research shows real promise for conditions like chronic fatigue and whi…
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Ask a Longevity Scientist: Testosterone, "Miracle" Supplements & Falling for the Hype | 116
53:01
53:01
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53:01Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein tackles your burning questions on testosterone therapy, trending supplements like astaxanthin and C15, hyperbaric oxygen, and more. Get science-backed insights and learn what truly matters for starting your health…
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1
Scientist Fact-Checks Controversial Medical Takes: Dr. Mike React
1:08:23
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1:08:23Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein reacts to controversial takes on supplements, MRIs, protein, and rapamycin from Dr. Eric Topol. This video breaks down the evidence behind popular health trends, helping you separate science from hype.0:00 - Setti…
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Gut Microbiome Expert: The HIDDEN Side Of Health You're MISSING | Dr. Sean Gibbons | 114
1:23:33
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1:23:33Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Sean Gibbons, a leading microbiome expert, sits down with me to decode the complex world of your gut bacteria. Learn about good vs. bad bacteria, the impact of antibiotics and aging, and how diet and probiotics can influence your…
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LiveLong Conference: Takeaways on Longevity Science & Hype | 113
29:51
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29:51Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Matt Kaeberlein & Dr. Kevin White share takeaways from the LiveLong Experience conference, covering Therapeutic Plasma Exchange (TPE) insights, Hormone Replacement Therapy (HRT) debates, longevity science, and navigating misinformati…
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This Simple Test Can Reveal Your Risk Of Heart Disease | 112
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40:16Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Matt Kaeberlein reviews his personal Cleerly CCTA scan results with Prime Health Associates founder Dr. Kevin White, analyzing soft vs. calcified heart plaque, assessing cardiovascular risk, and discussing the value of early detectio…
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The Hidden Health Toll Of Grief (and the 4 Tasks that Actually Work). | Emma Payne | 111
1:13:17
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1:13:17Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Help Texts CEO Emma Payne discusses the profound impact of grief on health (physical/mental), effective coping strategies (Warden's Tasks), and how text-based support can help navigate loss and foster post-traumatic growth.0:00 Intro…
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Rapamycin: The Worst Longevity Idea Ever Conceived? | 110
43:04
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43:04Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter: https://www.optispan.life/Dr. Matt Kaeberlein fact-checks Dr. Chris Masterjohn's essay calling rapamycin the "Worst Longevity Idea Ever," correcting misinformation about side effects (cataracts, glucose, heart) and benefits using scientific data from mouse and human stud…
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Siim Land: Biohacking Longevity, Health Span Truths & Cutting Through the Hype | 109
1:18:28
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1:18:28Subscribe to our channel: https://www.youtube.com/@optispanBiohacking expert Siim Land joins Matt Kaeberlein to discuss optimizing health span with science-based lifestyle tips (diet, exercise, sleep), key biomarkers, and navigating longevity misinformation & biological age clock hype.0:00 Introduction: Meet Siim Land2:41 Defining Longevity: Health…
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The Science of Aging Well: "A Practical Approach to HealthSpan Medicine" | 108
16:12
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16:12Subscribe to our channel: https://www.youtube.com/@optispanSign up for the Optispan Newsletter: https://www.optispan.life/Read or get your copy of Matt's Scientific American Article: https://www.scientificamerican.com/custom-media/healthspan/In this episode, Dr. Matt Kaeberlein reads and discusses his insightful article, "A Practical Approach to He…
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Longevity Experts Discuss Their Health Advice & Approach | Dr. Marcus Ranney & Dr. Brian Kennedy | 107
56:38
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56:38Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein is joined by Dr. Marcus Ranney and Dr. Brian Kennedy, leading experts in longevity science. Recorded at the Rise for Aging Conference in Bangalore, India, they discuss India’s growing role in longevity research, the impact of AI in aging and healthcare, and unique health…
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Brain Aging & Alzheimer’s Prevention: The Future of Cognitive Health Testing | Dr. Christin Glorioso | 106
1:00:35
1:00:35
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1:00:35Subscribe to our channel: https://www.youtube.com/@optispan Dr. Matt Kaeberlein & Dr. Christin Glorioso, founder of NeuroAge Therapeutics, explore groundbreaking advancements in brain aging and Alzheimer's prevention. Learn how cutting-edge brain age testing—combining MRI, cognitive assessments, blood biomarkers, and genetics—can predict Alzheimer’…
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Gut Health: Science-Backed Tips For Leaky Gut, IBS, & Your Microbiome | Dr. Mary Pardee | 105
1:15:32
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1:15:32Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein & Dr. Mary Pardee sit down to discuss insights on gut health, digestion, and common GI issues like IBS and constipation. This video covers practical approaches to improving gut function, debunking myths, and identifying effective solutions for long-term wellness, all whi…
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The Truth About Biological Age Tests | 104
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14:33Subscribe to our channel: https://www.youtube.com/@optispanMatt Kaeberlein dives into the controversial world of biological age tests. Many direct-to-consumer tests claim to measure your biological age, but are they accurate or useful? Based on extensive research and clinical experience, we uncover why these tests are statistically meaningless, lac…
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Dr. Kevin White: Concierge Medicine & Its Impacts On Living Longer & Healthier Lives | 103
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50:54Subscribe to our channel: https://www.youtube.com/@optispan In this episode, we dive into concierge medicine, how it differs from traditional primary care, and why more people are opting for personalized healthcare. Dr. Kevin White shares insights on longevity medicine, proactive health strategies, and the benefits of direct physician access. We di…
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Thomas Delauer: NEW Nutrition, Exercise, and Mindset Shifts In 2025 | 102
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42:42Subscribe to our channel: https://www.youtube.com/@optispanThomas DeLauer & I (Dr. Matt Kaeberlein) discusses his evolving perspectives on nutrition, exercise, and health optimization. Thomas shares how his views on insulin, low-carb diets, and fructose have shifted, his approach to training for strength and longevity, and the importance of sleep, …
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My Biggest Health & Longevity Breakthroughs at 54 | 101
21:21
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21:21Subscribe to our channel: https://www.youtube.com/@optispanI share the top health and longevity strategies that have transformed my energy, fitness, and well-being at 54 - From hormone optimization (TRT) and resistance training to diet improvements, alcohol reduction, and preventative diagnostics.0:00 - Reflections on Turning 54 & Longevity Mindset…
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Dr. Greg Fahy: Thymus Regeneration & Boosting The Immune System For Longevity | 100
1:31:13
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1:31:13Subscribe to our channel: https://www.youtube.com/@optispanDr. Greg Fahy discusses his groundbreaking research on thymus regeneration, immune system rejuvenation, and the role of growth hormone, DHEA, and metformin in reversing aging-related immune decline. He explains the TRIM protocol, the impact of thymic involution on longevity, and the potenti…
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The Benefits Of Testosterone Replacement Therapy (TRT) For Men - Dr. Kevin White | 99
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58:44Subscribe to our channel: https://www.youtube.com/@optispanIs testosterone therapy right for you? In this episode, Matt Kaeberlein & Kevin White explore the benefits, risks, and misconceptions of testosterone replacement therapy (TRT). Learn about low testosterone symptoms, when to get tested, and the differences between primary and secondary hypog…
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The Effects of Rapamycin on APOE4 Carriers & Brain Function | 98
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42:12Subscribe to our channel: https://www.youtube.com/@optispanIn this video we discuss current studies relating to Rapamycin use and it's effects on brain function, specifically for APOE4 carriers. This data may (or may not) provide evidence to support the claim that Rapamycin can be beneficial for those with the APOE4 variant.0:00 - Introduction1:58 …
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Crypto-Powered Science: How Blockchain & DAOs Are Reimagining Longevity Research | 97
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1:00:50Subscribe to our channel: https://www.youtube.com/@optispanIn this video I sit down with the COO of Molecule AG, Benji Leibowitz, to discuss how blockchain and cryptocurrency can be applied to intellectual property (IP) in biotech research, particularly in funding longevity studies. The discussion covers concepts like DAOs (Decentralized Autonomous…
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